Methods and compositions for the identification and assessment of prostate cancer therapies and the diagnosis of prostate cancer

ABSTRACT

The invention concerns two classes of differentially regulated genes: 1) genes that are more highly expressed in prostate cancer cells treated with testosterone than in untreated prostate cancer cells; and 2) genes that are more highly expressed in prostate cancer cells treated with bicalutamide, an anti-androgenic compound, than in untreated prostate cancer cells. Disclosed are methods for selecting and monitoring the effectiveness of therapeutic agents used for the treatment of prostate cancer. Also disclosed are methods for identifying novel therapeutic agents for the treatment of prostate cancer and methods and compositions for preventing, treating, and diagnosing prostate cancer.

RELATED APPLICATION INFORMATION

This application claims priority from provisional application Ser. No. 60/079,303, filed Mar. 25, 1998, and from provisional application Ser. No. 60/068,821, filed Dec. 24, 1997.

BACKGROUND OF THE INVENTION

Prostate cancer is the most commonly diagnosed cancer in American men and the second most common cause of death from cancer in American men.

Androgen withdrawal, by castration or through the use of an anti-androgenic drug, is the preferred treatment method for prostate cancer.

Bicalutamide (casodex) is a relatively potent, orally active anti-androgenic drug. Approximately 80% of the prostate cancer patients treated with bicalutamide respond to the treatment; however, most patients eventually relapse.

Prostate cancer, like other cancers, can be viewed as a breakdown in the communication between tumor cells and their environment, including their normal neighboring cells. Growth-stimulatory and growth-inhibitory signals are routinely exchanged between cells within a tissue. Normally, cells do not divide in the absence of stimulatory signals, and, likewise, will cease dividing in the presence of inhibitory signals. In a cancerous or neoplastic state, a cell acquires the ability to “override” these signals and to proliferate under conditions in which a normal cell would not grow.

In general, tumor cells must acquire a number of distinct aberrant traits in order to proliferate in an abnormal maimer. Reflecting this requirement is the fact that the genomes of certain well-studied tumors carry several different independently altered genes, including activated oncogenes and inactivated tumor suppressor genes.

In addition to abnormal cell proliferation, cells must acquire several other traits for tumor progression to occur. For example, early on in tumor progression, cells must evade the host immune system. Further, as tumor mass increases, the tumor must acquire vasculature to supply nourishment and remove metabolic waste. Additionally, cells must acquire an ability to invade adjacent tissue. In many cases cells ultimately acquire the capacity to metastasize to distant sites.

It is apparent that the complex process of tumor development and growth must involve multiple gene products. It is therefore important to define the role of specific genes involved in tumor development and growth and identify those genes and gene products that can serve as targets for the diagnosis, prevention and treatment of cancers.

In the realm of cancer therapy it often happens that a therapeutic agent that is initially effective for a given patient becomes, overtime, ineffective or less effective for that patient. The very same therapeutic agent may continue to be effective over a long period of time for a different patient. Further, a therapeutic agent which is effective, at least initially, for some patients is completely ineffective or even harmful for other patients. Accordingly, it would be useful to identify genes and/or gene products that represent prognostic markers with respect to a given therapeutic agent or class of therapeutic agents. It then may be possible to determine which patients will benefit from particular therapeutic regimen and, importantly, determine when, if ever, the therapeutic regime begins to lose its effectiveness. The ability to make such predictions would make it possible to cease a therapeutic regime which has lost its effectiveness well before its loss of effectiveness becomes apparent by conventional measures.

SUMMARY OF THE INVENTION

The invention features methods for selecting and monitoring the effectiveness of therapeutic agents used for the treatment of prostate cancer. The invention also features methods for identifying novel therapeutic agents for the treatment of prostate cancer. The invention also features methods and compositions diagnosing prostate cancer and methods and compositions for preventing, treating, and diagnosing prostate cancer.

The invention is based, in part, on the identification of two classes of differentially regulated genes: 1) genes that are more highly expressed in prostate cancer cells treated with testosterone than in untreated prostate cancer cells; and 2) genes that are more highly expressed in prostate cancer cells treated with bicalutamide, an anti-androgenic compound, than in untreated prostate cancer cells. Genes which are more highly expressed in testosterone-treated prostate cancer cells than untreated prostate cancer cells are listed in Table 1 (SEQ ID NOS:1-40 and 86-130). Genes which are more highly expressed in bicalutamide-treated prostate cancer cells than untreated prostate cancer cells are listed in Table 2 (SEQ ID NOS:41-85 and 131-191).

By examining the expression of one or more of these identified genes in a sample of prostate cancer cells, it is possible to determine whether a selected compound, e.g., an anti-androgenic compound, can be used to treat the prostate cancer. Importantly, this determination can be made on a patient by patient basis. Thus, one can determine whether or not a particular prostate cancer treatment is likely to benefit a particular patient. The invention also features methods for determining whether a particular prostate cancer has become refractory to treatment with an anti-androgenic compound or other therapeutic agent.

The invention also features diagnostic methods and prognostic methods which can be used to identify patients having or at risk for developing prostate cancer. The identified differentially expressed genes whose expression is increased in the presence of testosterone and/or the products of such genes can be used to identify cells exhibiting or predisposed development of prostate cancer thereby diagnosing individuals having, or at high risk for developing, prostate cancer. The detection of the differential expression of identified genes can be used to select therapies before the benign cells attain a malignant state and to design a preventive intervention in pre-neoplastic cells in individuals at high risk.

In the various methods of the invention, gene expression can be measured at the mRNA or protein level. Alternatively, expression can be measured indirectly by measuring the activity of the protein encoded by the identified gene.

The differentially expressed genes identified herein are potential targets for the development of therapeutic compounds. Genes that are expressed at a higher level in prostate cancer cells in the presence of testosterone than in the absence of testosterone are identified. Because testosterone is required for growth and survival of prostate cancer cells, genes whose expression is increased in the presence of testosterone are potential therapeutic targets. Thus, identifying compounds which reduce the expression of such a gene or reduce the activity of the product of such a gene forms the basis for the development of new therapeutic agents. In addition, as noted above, increased expression of these genes can serve as a prognostic or diagnostic indicator of prostate cancer. Moreover, where increased expression of these genes is observed during the course of a therapy, it can be expected that the therapy is or has become relatively ineffective.

Also identified are genes that are expressed in prostate cancer cells at a high level in the presence of the anti-androgenic drug bicalutamide than in the absence of bicalutamide. Because bicalutamide is known to inhibit the growth of prostate cancer cells, genes whose expression is increased in the presence of bicalutamide are potential therapeutic targets. Thus, identifying compounds which increase the expression of such a gene or increase the activity of the product of such a gene forms the basis for the development of new therapeutic agents. In addition, increased expression of these genes can serve as a indicator that a given therapy is effective.

The invention provides methods for the identification of compounds that modulate the expression of genes or the activity of gene products involved in prostate cancer as well as methods for the treatment of prostate cancer. Such methods can, for example, involve the administration of such modulatory compounds to individuals exhibiting symptoms or markers of prostate cancer.

This invention is based, in part, on systematic search strategies coupled with sensitive and high throughput gene expression assays, to identify genes differentially expressed in prostate tumor cells treated with different drugs. The search strategies and assays used herein permit the identification of all genes, whether known or novel, which are differentially expressed in, e.g., testosterone-treated prostate cancer cells relative to untreated prostate cancer cells.

This comprehensive approach and evaluation permits the discovery of novel genes and gene products, as well as the identification of an array of genes and gene products (whether novel or known) that are influenced by drugs and natural products which are known to influence the growth and survival of prostate cancer cells. Thus, the present invention makes possible the identification and characterization of targets useful for rationale drug design and for the prognosis, diagnosis, monitoring, treatment, and prevention of prostate cancer.

In some respects the differentially expressed genes described herein can be used in the same manner and prostate specfic antigen, a commonly used marker for prostate cancer and pre-cancerous conditions related to prostate cancer.

“Differential expression,” as used herein, refers to both quantitative, as well as qualitative, differences in the expression pattern of a gene in tumor cells treated with a particular drug and untreated tumor cells. Differentially expressed genes can represent “fingerprint genes,” and/or “target genes.”

“Fingerprint gene,” as used herein, refers to a differentially expressed gene whose expression pattern can be utilized as part of a prognostic or diagnostic marker for the evaluation of prostate cancer or which, alternatively, can be used in methods for identifying compounds useful for the treatment of prostate cancer or evaluating the effectiveness of a prostate cancer treatment. For example, the effect of the compound on the fingerprint gene expression pattern normally displayed in connection with prostate cancer can be used to evaluate the efficacy of the compound as a treatment for prostate cancer or can, additionally, be used to monitor patients undergoing clinical evaluation for the treatment of prostate cancer.

A “fingerprint pattern,” as described herein, is the pattern generated when the expression pattern of a series (which can range from two up to all the fingerprint genes which exist for a given state) of fingerprint genes is determined. A fingerprint pattern can be used in the same diagnostic, prognostic and compound identification methods as the expression of a single fingerprint gene.

A “target gene,” as described herein, is a differentially expressed gene involved in prostate cancer such that modulation of the level of target gene expression or of target gene product activity can act to prevent and/or ameliorate symptoms of the prostate cancer. Compounds that modulate the expression of the target gene or the activity of the target gene product can be used in the treatment of prostate cancer. Still further, compounds that modulate the expression of the target gene or activity of the target gene product can be used in treatments to deter benign cells from developing into prostate cancer cells. Still further, compounds that modulate the expression of the target gene or activity of the target gene product can be used to design a preventive intervention in pre-neoplastic cells in individuals at high risk.

DESCRIPTION OF THE FIGURES

FIG. 1 depicts the nucleotide sequence of SEQ ID NO: 1.

DETAILED DESCRIPTION OF THE INVENTION

The invention is based, in part, on the identification of genes that are differentially expressed in prostate cancer cells treated with selected compounds. By evaluating the expression pattern of a variety of genes in the presence and absence of a selected compound it is possible to create a profile of the response of prostate cancer cells to the selected compound.

1. Identification of Differentially Expressed Genes

Described below are examples of methods which can be used to identify differentially expressed genes, i.e., genes whose expression in prostate cancer cells is altered by a selected compound, e.g., testosterone.

Differential expression refers to both quantitative, as well as qualitative differences the expression pattern of a gene or group of genes. Thus, a differentially expressed gene can qualitatively have its expression increased or decreased in, for example, testosterone-treated prostate cancer cells versus untreated prostate cancer cells.

In some cases, the difference in expression between treated and untreated (control) cells may be qualitative rather than quantitative. Thus, the expression of a selected gene might be detectable using a certain assay method in the presence of a given drug and undetectable using the same assay in the absence of the drug.

Alternatively, a differentially expressed gene can exhibit an expression level which differs, i.e., is quantitatively increased or decreased in treated cells versus control cells.

The degree to which expression differs need only be large enough to be visualized via standard characterization techniques, such as, for example, a differential display technique. Other standard, well-known characterization techniques by which expression differences can be visualized include, but are not limited to, quantitative reverse transcriptase (RT)-coupled PCR and Northern analyses and RNase protection techniques and methods which employ arrays of nucleic acid molecules, e.g., cDNAs linked to a solid support, e.g., a Gene Expression Micro-Array™ (Synteni, Inc.; Fremont, Calif.).

a) Approaches to the Identification of Differentially Expressed Genes

There are a variety of approaches (or paradigms) which can be used to identify differentially expressed genes. In all cases, drug-treated and untreated cells (or cells treated with different drugs) are compared. The paradigms differ in the source of the cells that are differentially treated. Thus, the cells can be differentially treated in vitro prostate cancer cells, e.g., a cells of a prostate cancer cell line (an “in vitro paradigm”), differentially treated representatives of an animal model of prostate cancer (an “in vivo paradigm”), or differentially treated prostate cancer patients (a “clinical paradigm”).

Once a particular differentially expressed gene has been identified through the use of one paradigm, its expression pattern can be further characterized, for example, by studying its expression in a different paradigm. A gene can, for example, be regulated one way, i.e., can exhibit one differential gene expression pattern, in a given paradigm, but can be regulated differently in another paradigm. The use, therefore, of multiple paradigms can be helpful in distinguishing the roles and relative importance of particular genes in prostate cancer.

In an in vitro paradigm, differentially expressed genes are detected by comparing the pattern of gene expression between the experimental (drug-treated) prostate cancer cells and control (untreated or treated with a different drug) prostate cancer cells.

In an in vivo paradigm, animal models of prostate cancer can be utilized to discover differentially expressed genes. A variety of animal models can be used in an in vivo paradigms. Matched animal are treated with a drug or left untreated (or treated with a different drug).

In a clinical paradigm samples from surgical and biopsy specimens are used. Such specimens can represent normal tissue, primary, secondary or metastasized tumors obtained from patients. Surgical specimens can be procured under standard conditions involving freezing and storing in liquid nitrogen (see, for example, Karmali et al., 1983, Br. J. Cancer 48:689-696.) RNA from specimen cells is isolated by, for example, differential centrifugation of homogenized tissue, and analyzed for differential expression relative to other specimen cells, preferably cells obtained from the same patient at a different time, e.g., before drug treatment, during treatment with a different drug, or at an earlier time during treatment with the same drug.

b) Methods for Identifying Differentially Expressed Genes

In order to identify differentially expressed genes, RNA, either total or mRNA, can be isolated from cells utilized in paradigms such as those described above. Any RNA isolation technique which does not select against the isolation of mRNA can be utilized for the purification of such RNA samples (see, e.g., Ausubel et al., eds., 1987-1997, Current Protocols in Molecular Biology, John Wiley & Sons, Inc. New York). Additionally, large numbers of tissue samples can readily be processed using techniques well known to those of skill in the art, such as, for example, the single-step RNA isolation process of Chomczynski (1989, U.S. Pat. No. 4,843,155).

Transcripts within the collected RNA samples which represent RNA produced by differentially expressed genes can be identified by utilizing a variety of methods which are well known to those of skill in the art. For example, differential screening (Tedder et al., 1988, Proc. Natl. Acad. Sci. USA 85:208-212), subtractive hybridization (Hedrick et al., 1984, Nature 308:149-153; Lee et al., 1984, Proc. Natl. Acad. Sci. USA 88:2825), and, preferably, differential display (Liang and Pardee 1993, U.S. Pat. No. 5,262,311), can be utilized to identify nucleic acid sequences derived from genes that are differentially expressed.

Differential screening involves the duplicate screening of a cDNA library in which one copy of the library is screened with a total cell cDNA probe corresponding to the mRNA population of sample while a duplicate copy of the cDNA library is screened with a total cDNA probe corresponding to the mRNA population of a second sample. For example, one cDNA probe can correspond to a total cell cDNA probe of a cell or tissue derived from a control sample, while the second cDNA probe can correspond to a total cell cDNA probe of the same cell type derived from an experimental (e.g, drug-treated) sample. Those clones which hybridize to one probe but not to the other potentially represent clones derived from genes differentially expressed in the cell of interest in control versus experimental samples.

Subtractive hybridization techniques generally involve the isolation of mRNA taken from two different sources, e.g., treated and untreated cells, the hybridization of the mRNA or single-stranded cDNA reverse-transcribed from the isolated mRNA, and the removal of all hybridized, and therefore double-stranded, sequences. The remaining non-hybridized, single-stranded cDNAs, potentially represent clones derived from genes that are differentially expressed in the two mRNA sources. Such single-stranded cDNAs are then used as the starting material for the construction of a library comprising clones derived from differentially expressed genes.

Differential display is a procedure which, utilizing the well-known polymerase chain reaction (PCR; the experimental embodiment set forth in Mullis 1987, U.S. Pat. No. 4,683,202), allows for the identification of sequences derived from genes which are differentially expressed. First, isolated RNA is reverse-transcribed into single-stranded cDNA, utilizing standard techniques which are well known to those of skill in the art. Primers for the reverse transcriptase reaction can include, but are not limited to, oligo dT-containing primers, preferably of the 3′ primer type of oligonucleotide described below. Next, this technique uses pairs of PCR primers, as described below, which allow for the amplification of clones representing a random subset of the RNA transcripts present within any given cell. Utilizing different pairs of primers allows each of the mRNA transcripts present in a cell to be amplified. Among such amplified transcripts can be identified those which have been produced from differentially expressed genes.

The 3′ oligonucleotide primer of the primer pairs can contain an oligo dT stretch of 10-13 dT nucleotides at its 5′ end, preferably 11, which hybridizes to the poly(A) tail of mRNA or to the complement of a cDNA reverse transcribed from an mRNA poly(A) tail. Second, in order to increase the specificity of the 3′ primer, the primer can contain one or more, preferably two, additional nucleotides at its 3′ end. Because, statistically, only a subset of the mRNA derived sequences present in the sample of interest will hybridize to such primers, the additional nucleotides allow the primers to amplify only a subset of the mRNA derived sequences present in the sample of interest. This is preferred in that it allows more accurate and complete visualization and characterization of each of the bands representing amplified sequences.

The 5′ primer can contain a nucleotide sequence expected, statistically, to have the ability to hybridize to cDNA sequences derived from the tissues of interest. The nucleotide sequence can be an arbitrary one, and the length of the 5′ oligonucleotide primer can range from about 9 to about 15 nucleotides, with about 13 nucleotides being preferred.

Additionally, arbitrary primer sequences cause the lengths of the amplified partial cDNAs produced to be variable, thus allowing different clones to be separated by using standard denaturing sequencing gel electrophoresis.

PCR reaction conditions should be chosen which optimize amplified product yield and specificity, and, additionally, produce amplified products of lengths which can be resolved utilizing standard gel electrophoresis techniques. Such reaction conditions are well known to those of skill in the art, and important reaction parameters include, for example, length and nucleotide sequence of oligonucleotide primers as discussed above, and annealing and elongation step temperatures and reaction times.

The pattern of clones resulting from the reverse transcription and amplification of the mRNA of two different cell types is displayed via sequencing gel electrophoresis and compared. Differences in the two banding patterns indicate potentially differentially expressed genes.

Once potentially differentially expressed gene sequences have been identified via bulk techniques such as, for example, those described above, the differential expression of such putatively differentially expressed genes should be corroborated. Corroboration can be accomplished via, for example, such well-known techniques as Northern analysis, quantitative RT-coupled PCR or RNase protection.

Upon corroboration, the differentially expressed genes can be further characterized, and can be identified as target and/or fingerprint genes.

Amplified sequences of differentially expressed genes obtained through differential display can be used to isolate the full length clones of the corresponding gene. The full-length coding portion of the gene can readily be isolated, without undue experimentation, by molecular biological techniques well known in the art. For example, the isolated differentially expressed amplified fragment can be labeled and used to screen a cDNA library. Alternatively, the labeled fragment can be used to screen a genomic library.

PCR technology can also be utilized to isolate full-length cDNA sequences. Thus, the isolated amplified gene fragments (of about at least 10 nucleotides, preferably longer, of about 15 nucleotides) obtained through differential display have their 5′ terminal end at some random point within the gene and have 3′ terminal ends at a position corresponding to the 3′ end of the transcribed portion of the gene. Once nucleotide sequence information from an amplified fragment is obtained, the remainder of the gene (i.e., the 5′ end of the gene, when utilizing differential display) can be obtained using, for example, RT-PCR.

A reverse transcription reaction can then be performed on the RNA using an oligonucleotide primer complementary to the mRNA that corresponds to the amplified cloned fragment, for the priming of first strand synthesis. Because the primer is anti-parallel to the mRNA, extension will proceed toward the 5′ end of the mRNA. The resulting RNA/DNA hybrid can then be “tailed” with guanines using a standard terminal transferase reaction, the hybrid can be digested with RNAase H, and second strand synthesis can then be primed with a poly-C primer. Using the two primers, the 5′ portion of the gene is then amplified using PCR. Sequences obtained can then be isolated and recombined with previously isolated sequences to generate a full-length cDNA of the differentially expressed gene. For a review of cloning strategies and recombinant DNA techniques which can be used, see, e.g., Sambrook et al., 1989, Molecular Cloning, A Laboratory Manual, Cold Springs Harbor Press, N.Y.; and Ausubel et al., supra.

II. Examples of the Identification of Differentially Expressed Genes

Described below is the identification of two classes of genes which are differentially expressed in prostate cancer cells.

The first example concerns the identification of 40 genes whose expression is increased in prostate cancer cells in the presence of testosterone. It is known that testosterone is required for the growth and survival of prostate cancer cells. Accordingly, genes whose expression is increased in the presence of testosterone can be used as markers to identify prostate cancers which might be successfully treated by the use of an anti-androgenic drug. In addition, these genes can be used as markers to identify prostate cancers which may have become refractory to anti-androgenic treatment. Because higher expression of these genes is associated with testosterone-exposed prostate cancer cells, they can be used as diagnostic and prognostic markers to identify individuals suffering from or at risk for developing prostate cancer. These genes and the proteins they encode can also be used to identify novel therapeutic agents for treatment of prostate cancer and as diagnostic markers.

The second example concerns the identification of 45 genes whose expression is increased in prostate cancer cells in the presence of bicalutamide, an anti-androgenic compound that is commonly used to treat prostate cancer. Because the increased expression of these genes in prostate cancer cells is associated with a successful treatment for prostate cancer, these genes can be used as markers to identify novel therapeutic compounds and to monitor the course/effectiveness of a therapy, particularly an anti-androgenic therapy.

a) EXAMPLE 1 Identification of Genes Whose Expression is Increased in the Presence of Testosterone

LNCaP cells were grown T162 flasks coated with Matrigel in RPMI-1640 medium supplemented with 10% FBS and 50 nM testosterone. Prior to testosterone treatment, the cells were pre-incubated for 24.5 hours in dye-free RPMI-1640 containing 2% charcoal stripped serum.

Five T162 flasks of pretreated cells were treated with testosterone-containing medium (dye-free RPMI-1640, 2% CSS, 100 nM testosterone, 0.09% DMSO). After 25 hours of incubation in testosterone-containing medium, the cells were detached from the flasks with trypsin and pelleted. Five T162 flasks of pretreated cells were used as a control. Untreated cells were collected in the same manner.

Total RNA was prepared from the cell pellets using the RNeasy protocol (Qiagen). Approximately 260 μg of total RNA was obtained from each cell pellet. Next, polyA+ RNA was prepared form approximately 240 μg of each total RNA sample using the Oligotex protocol (Qiagen), approximately 6 μg of polyA+ RNA was obtaining from each 240 μg total RNA sample, and 2 μg of each polyA+ RNA sample was used for the generation of subtraction libraries using the PCR-select protocol (Clontech; Palo Alto, Calif.).

The PCR products representing partial cDNAs of putatively differentially expressed mRNAs were subcloned into pCR2.1 (InVitrogen) and transformed into INValphaF¹ cells.

The differentially expressed genes were then identified by screening on a Gene Expression Micro-Array™ (Synteni, Inc.; Fremont, Calif.).

Table 1 is a list of identified genes whose expression is greater in testosterone-treated prostate cancer cells than untreated prostate cancer cells. Generally the genes are listed in ranked order. In some cases only a partial sequence is presented in the corresponding figure. The various methods described herein can employ complete sequences or fragments thereof.

TABLE 1 Fold Increase In SEQ ID Gene mRNA NO. Monoamine oxidase 5.5  1 Neprilysin 2.8  2 Cell division control protein 2 homolog (X05360) *  3 Cell division protein kinase 6 3.1  4 5-hydroxytryptamine 2C receptor *  5 Aryl hydrocarbon receptor nuclear translocator 4.6  6 Guanine nucleotide exchange factor MSS4 2.7  7 (U74324) (−76 nucleotide) DNA mismatch repair protein MSH2 *  8 HEK2 protein tyrosine kinase receptor 2.6  9 Ras-like GTP-binding protein RAN 2.6 10 UDP glucuronosyltransferase precursor 2.8 11 (UGT2B15) BM28 mRNA/DNA replication licensing factor 2.4 12 (huMCM2) Yeast guanine nucleotide-binding protein beta 2.4 13 subunit-like protein Thyroid receptor interactor (TRIP7) (L40357) 2.4 14 (−92 nucleotide) Pyruvate kinase (M26252) = human TCB gene 2.3 15 encoding cytosolic thyroid hormone-binding protein EXT1 = putative tumor suppressor/hereditary 2.4 16 mult. exostoses candidate gene Phospholipase A2 (M22430) 2.7 17 UDP-glucuronosyltransferase 2B7 precursor 3.9 18 WILMS' tumor protein (X51630) * 19 Apolipoprotein B-100 precursor (XO4506) * 20 Forkhead protein FREAC-2 * 21 S-adenosylmethionine decarboxylase 2.3 22 Kinesin-related protein 4.8 23 Spectrin alpha chain 3.5 24 KIAA0018 gene (D13643) 3.3 25 Myeloblast KIAA0130 gene (D50920) 3.3 26 Brain-expressed HHCPA78 homolog (S73591) 3   27 Vacuolar ATP synthase subunit AC39; or bovine 3.1 28 (P17694) NADH-ubiquinone oxidoreductase 49 kD subunit Gelsolin precursor 2.8 29 Ankyrin G (ANK-3) (U13616) 2.7 30 High mobility group protein HMG1 (X12597) 2.6 31 S-adenosylmethionine decarboxylase proenzyme 2.5 32 (M21154) p0071 protein (X81889) 2.4 33 F02A9.5 homolog * 34 Eukaryotic initiation factor 1A 2.4 35 L-lactate dehydrogenase M chain 3   36 (X02152, M17516) Cytochrome b5 3.3 37 Fibronectin (S00848, transformation-associated 2.8 38 human fragment) Tubulin beta 1 chain 2.8 39 Histone H2AZ 2.5 40 STS (WI 12919) 7.7 86 ESTs {344156} 5.9 87 STS (WI-8530) 5   88 ESTs {128990} 5   89 ESTs {26259} 5   90 ESTs {48537} 4.5 91 ESTs {221118} 4.4 92 ESTs {195079} 4.3 93 ESTs {242643} 4.1 94 ESTs {41700} 4   95 ESTs {301487} 3.8 96 ESTs {469725} 3.7 97 Immunoglobulin rearranged H-chain V-region 3.6 98 (C-D-J Hg) ESTs {249347} 3.5 99 ESTs {135326} 3.4 100  ESTs {177150} 3.1 101  ESTs {375900} 3.1 102  ESTs {46287} 3   103  ESTs {264293} 3   104  ESTs {429349} 3   105  ESTs {128055} 2.8 106  ESTs {415795} 2.8 107  ESTs {364618} 2.7 108  ESTs {52371} 2.6 109  ESTs {471083} 2.6 110  ESTs {23605} 2.5 111  ESTs {32161} 2.5 112  ESTs {364477} 2.5 113  54 kDa progesterone receptor-associated 2.5 114  immunophilin FKBP54 ESTs {488092} 2.5 115  ESTs {151339} 2.4 116  ESTs {174787} 2.4 117  ESTs {230447} 2.4 118  ESTs {131591} 2.3 119  ESTs {141115} 2.3 120  Simian T-cell lymphotropic virus type I DNA 2.3 121  for tax/rex region ESTs {51591} 2.3 122  ESTs {297463} 2.3 123  ESTs {180082} 2.1 124  ESTs {133211} * 125  Thymopoietin alpha * 126  ESTs {52092} * 127  ESTs {238656} * 128  ESTs {428502} * 129  Zinc finger protein * 130 

b) EXAMPLE 2 Identification of Genes Whose Expression is Increased in the Presence of Bicalutamide

LNCaP cells were grown in T162 flasks coated with Matrigel in RPMI-1640 medium supplemented with 10% FBS and 50 nM testosterone. Prior to bicalutamide treatment, cells were preincubated for 24.5 hours in dye-free RPMI-1640 containing 2% charcoal stripped serum.

Five T162 flasks of pretreated cells were treated with bicalutamide-containing medium (dye-free RPMI-1640, 2% CSS, 100 nM bicalutamide in DMSO). After 25 hours of incubation in bicalutamide-containing medium, LNCaP cells were detached from the flasks with trypsin and pelleted. Five T162 flasks of pretreated cells were used as a control. Untreated cells were collected in the same manner.

Total RNA was prepared from the cell pellets using the RNeasy protocol (Qiagen). Approximately 260 μg of total RNA was obtained form each cell pellet. Next, polyA+ RNA was prepared form approximately 240 μg of each total RNA sample using the Oligotex protocol (Qiagen), approximately 6 μg of polyA+ RNA was obtaining from each 240 μg total RNA sample, and 2 μg of each polyA+ RNA sample was used for the generation of subtraction libraries using the PCR-select protocol (Clontech; Palo Alto, Calif.).

The PCR products representing partial cDNAs of putatively differentially expressed mRNAs were subcloned into pCR2.1 (InVitrogen) and transformed into INValphaF¹ cells.

The diffentially expressed genes were then identified by screening on a Gene Expression Micro-Array™ (Synteni, Inc.; Fremont, Calif.).

Table 2 is a list of identified genes whose expression is greater in bicalutamide-treated prostate cancer cells than untreated prostate cancer cells. Generally the genes are listed in ranked order. In some cases only a partial sequence is presented in the corresponding figure. The various methods described herein can employ complete sequences or fragments thereof.

TABLE 2 FOLD INCREASE SEQ ID GENE IN mRNA NO. Cyclin-dependent kinase inhibitor 1 {268652} 4.5 41 Activating transcription factor 3 (ATF3) 11.5  42 {428248} Defender against cell death 1 {488974} 2.9 43 Transcription factor ITF-2 {380738} * 44 CCAAT/Enhancer binding protein BETA * 45 {357095} CLCN3 {346749} 2.4 46 Phosphotyrosine independent ligand p62 for the 5.8 47 Lck SH2 domain {510278} Seryl-tRNA synthetase {510431} 4.3 48 D53 (hD53) {510461} 3.8 49 Unknown human protein {512334} 3.5 50 Thioredoxin reductase {510377} 2.6 51 Tryptophanyl-tRNA synthetase {510220} * 52 ORF and HepG2 (identical sequence) {510258} 5.3 53 4F2 cell-surface antigen heavy chain {510504} 8.1 54 Asparagine synthetase {510206} 2.8 55 pM5 {509550} 2.3 56 Archain {488510} 2.3 57 Gravin {488106} 2.8 58 Metallothionein-II (mt-II) {484963} * 59 Signal recognition particle receptor alpha subunit 2.6 60 {358710} Phosphoenolpyruvate carboxykinase {363272} 3.4 61 Protein translation factor SUI1 homolog 2.7 62 {365542} NADPH-flavin reductase {365775} 3.7 63 Peptidyl-prolyl CIS-trans isomerase B precursor 2.5 64 {376399} Aspartate aminotransferase {417270} 3.1 65 OS-9 precursor {417136} 2.7 66 KIAA0025 and PIGHEP3 homologous region 5.3 67 {418227} Glucosamine-fructose-6-phosphate 3.2 68 aminotransferase {469633} ADP-ribosylation factor 1 {471384} 3.1 69 Glycyl-tRNA synthetase {471164} 3.6 70 Prion protein (PrP) {470074} 3.1 71 Mitochondrial serine hydroxymethyltransferase 2.4 72 {344080} Alanyl-TRNA synthetase {343998} 3.8 73 bZIP protein NF-IL3A {343273} * 74 Interleukin-8 precursor {328692} * 75 Translocon-associated protein {324179} 2.5 76 Proto-oncogene tyrosine-protein kinase FYN * 77 {323555} Translation initiation factor 5 (elF5) {299843} 2.3 78 RESTIN {291620} 2.3 79 Transcription elongation factor S-II {257458} 2.8 80 Human clone 137308 {252491} 2.6 81 Glutamate-cysteine ligase regulatory subunit 4.1 82 {245939} Fatty aldehyde dehydrogenase {208950} 3.1 83 MHC class I HLA-Bw58 gene {203448} 2.3 84 Mitochondrial NDA (P)+ dependent malic 2.5 85 enzyme {109375} ESTs {44552} * 131  ESTs {381626} * 132  ESTs {486242} * 133  Tryptophanyl tRNA sythestase (IFNWRS) * 134  {489453} AU-rich element RNA-binding protein AUF1 * 135  {510536} GADD 153 = Growth arrest and DNA-damage 11.1  136  inductor gene {362009} KIAA0025 gene {30476} 6.7 137  Phosphotyrosine independent ligand p62 for the 6.4 138  Lck SH2 domain {471392} 150 kDa oxygen-regulated protein ORP150 5.9 139  {486858} 78 KD Glucose regulated protein precursor 4   140  {366350} Smad 1 {345928} 3.9 141  EST28g11 WATM1 {486703} 3.8 142  ESTs {322080} 3.7 143  Seryl-tRNA sythetase {129892} 3.6 144  HU-K4 {470677} 3.6 145  ESTs {126530} 3.5 146  ESTs {429327} 3.5 147  Vascular endothelial growth factor (VEGF (165)) 3.2 148  {488697} ESTs {50914} 3.1 149  ESTs {279847} 3.1 150  ESTs {361548} 3.1 151  ESTs {364730} 3.1 152  ESTs {470212} 3.1 153  ESTs {471210} 3.1 154  ESTs {289300} 3   155  ESTs {427725} 3   156  ESTs {428217} 2.9 157  rfp transforming protein {485268} 2.8 158  ESTs {487420} 2.8 159  60S RIBOSOMAL PROTEIN L18A {509699} 2.8 160  ESTs {31943} 2.7 161  ESTs {376271} 2.7 162  ESTs {469642} 2.7 163  ESTs {471826} 2.7 164  KIAA0262 {485008} 2.7 165  ESTs {292082} 2.6 166  ESTs {365557} 2.6 167  Immunogloblin light chain (lambda) {119218} 2.5 168  ELP-1 {147979} 2.5 169  TRAMP protein {149355} 2.5 170  ESTs {294078} 2.5 171  ESTs {291005} 2.5 172  ESTs {365907} 2.5 173  ESTs {427801} 2.5 174  ESTs {469515} 2.5 175  Tral mRNA for human homologue of murine 2.5 176  tumor rejection antigen gp96 {509486} Biotin-[propionyl-CoA-carboxylase 2.4 177  (ATP-hydrolysing)] {176590} Tral mRNA for human homologue of murine 2.4 178  tumor rejection antigen gp96 {242829} Cancellous bone osteoblast mRNA for GS3786 2.4 179  {486005} ESTs {509583} 2.4 180  ESTs {44551} 2.3 181  ESTs {245853} 2.3 182  ESTs {306075} 2.3 183  ESTs {322143} 2.3 184  ESTs {322749} 2.3 185  ESTs {359877} 2.3 186  ESTs {360446} 2.3 187  ESTs {360789} 2.3 188  Protein tyrosine kinase t-Rorl {418257} 2.3 189  ESTs {486712} 2.3 190  ESTs {489106} 2.3 191 

III. The Use of Differentially Expressed Genes in Selecting and Monitoring Prostate Cancer Therapies

The expression level of identified differentially expressed genes may be used to assess patients undergoing clinical evaluation for the treatment of prostate cancer. Thus, the identified genes can be used to select an appropriate therapy for an individual and to monitor an ongoing therapy. They may also be utilized as surrogate markers to monitor clinical human trials of a drug being tested for their efficacy as a prostate cancer treatment. In either case, one or more of the identified differentially expressed genes may be utilized as a marker.

One can determine whether a given patient will benefit from anti-androgenic therapy by examining the expression level of one or more of the differentially expressed genes identified herein as being expressed at a higher level in prostate cancer cells in the presence of testosterone than in the absence of testosterone. If one or more of these genes is more highly expressed in the patient's prostate cancer cells than in normal prostate cells, the prostate cancer cells are more likely to respond to anti-androgenic therapy. As used herein, “anti-androgenic therapy” refers broadly to any therapy which interferes with or blocks the synthesis or action of an androgen. Similarly, “anti-testosterone therapy” refers broadly to any therapy which interferes with or blocks the synthesis or action of testosterone. Such therapies can, for example, block ligand receptor binding (e.g., binding of testosterone to its receptor), receptor signalling (e.g., signal transduction mediated by the binding of testosterone to its receptor), or the activity or expression of a downstream regulated gene.

Accordingly, the invention features a method for determining whether a compound, e.g., an anti-androgenic compound can be used to treat prostate cancer in a patient. The method includes:

a) obtaining a patient biological sample;

b) determining the normalized expression level of one or more genes selected from the group consisting of SEQ ID NOS:1-40, 86-130 in the patient sample;

c) comparing the normalized expression level of the selected one or more genes determined in step b) with the normalized expression level of the selected one or more genes in a non-prostate cancer biological sample; and

d) identifying that a compound can be used to treat prostate cancer in the patient when the normalized expression level of the selected one or more genes in the patient sample is greater than the normalized expression level of the selected one or more genes in the non-prostate cancer sample.

A non-prostate cancer biological sample is a sample of prostate cells, serum, interstitial fluid, blood, or seminal fluid from an individual which is not suffering from prostate cancer or a cell line, e.g., a prostate cell line which is not a prostate cancer cell line.

If the normalized expression of the selected one or more genes in the patient sample is not greater than the normalized expression of the selected one or more genes in the non-prostate cancer cell sample, it is less likely that an anti-androgenic therapy will be successful.

The invention also features a method for determining whether a compound, e.g., an anti-androgenic compound, can be used to treat prostate cancer in a patient, which method includes:

a) obtaining a patient biological sample;

b) determining the normalized expression level of one or more genes elected from the group consisting of SEQ ID NOS:1-40, 86-130 in the patient sample;

c) comparing the normalized expression level of the selected one or more genes determined in step b) with the normalized expression level of the selected one or more genes in a non-prostate cancer sample; and

d) identifying that a compound cannot be used to treat prostate cancer in the patient when the normalized expression level of the selected one or more genes in the patient sample is equal to or less than the normalized expression level of the selected one or more genes in the non-prostate cancer biological sample.

Generally, it is preferable to assess the expression of two, five or more, or even ten or more of the genes that are expressed at a higher level in prostate cancer cells treated with testosterone. Thus, it is preferable to assess the expression of a panel of differentially expressed genes.

In these assays, as well as other assays involving comparison of “normalized” expression levels, normalization refers to correcting the expression level of a differentially expressed gene by comparing its expression to the expression of a gene which is not differentially expressed in response to the selected compound, e.g., a gene that is not differentially expressed in prostate cancer cells in response to testosterone. Suitable genes for nromalization include housekeeping genes, e.g., the actin gene. This normalization allows one to compare the expression level in one sample, e.g., a patient sample, to another sample, e.g., a non-prostate cancer sample.

The expression level can be measured in a number of ways, including: measuring the mRNA encoded by each of the selected one or more genes; measuring the amount of protein encoded by each of the selected one or more genes; and measuring the activity of the protein encoded by each of the selected one or more genes.

Preferably, the expression level of several different selected genes from the group consisting of SEQ ID NOS:1-40, 86-130 are compared. For example, the expression of the gene of SEQ ID NO: 1 is compared in the two samples, and the expression of the gene of SEQ ID NO:2 is compared in the two samples. Preferably the selected genes are five or more genes selected from the group consisting of SEQ ID NOS:1-40, 86-130 or ten or more genes selected from the group consisting of SEQ ID NOS:1-40, 86-130.

The patient biological sample can be derived from, e,g., patient prostate cells, patient serum, patient interstitial fluid, patient blood, or patient seminal fluid. A sample of prostate cancer cells can be obtained by needle biopsy or other method used to biopsy or sample prostate cells.

As discussed above, the identified genes can also be used as markers to assess whether a prostate tumor has become refractory to an ongoing treatment (e.g., anti-androgenic treatment). When a tumor is no longer responding to a treatment the expression profile of the tumor cells is more closely resemble the expression profile of testosterone-treated prostate cancer cells than bicalutamide-treated prostate cancer cells.

Accordingly, the invention features methods for determining whether an anti-androgen treatment should be continued in a prostate cancer patient. One such method includes:

a) obtaining a patient biological sample;

b) determining the normalized expression level of one or more genes selected from the group consisting of SEQ ID NOS:1-40, 86-130 in the patient sample;

c) comparing the normalized expression level of the selected one or more genes determined in step b) with the normalized expression level of the selected one or more genes in a non-prostate cancer biological sample; and

d) discontinuing treatment when the normalized expression level of the selected one or more genes in the patient sample is greater than the normalized expression level of the selected one or more genes in the non-prostate cancer sample.

Another method for determining whether an anti-androgen treatment should be continued in a prostate cancer patient includes:

a) obtaining a patient biological sample;

b) determining the normalized expression level of one or more genes selected from the group consisting of SEQ ID NOS:1-40, 86-130 in the patient sample;

c) comparing the normalized expression level determined in step b) with the normalized expression level of the selected one or more genes in a non-prostate cancer biological sample; and

d) continuing treatment when the normalized expression of the selected one or more genes in the patient sample is equal to or less than the normalized expression of the selected one or more genes in the non-prostate cancer sample.

Preferably, the expression level of several different selected genes from the group consisting of SEQ ID NOS: 1-40, 86-130 are compared. For example, the expression of the gene of SEQ ID NO: 1 is compared in the two samples, and the expression of the gene of SEQ ID NO:2 is compared in the two samples. Preferably the selected genes are five or more genes selected from the group consisting of SEQ ID NOS:1-40, 86-130 or ten or more genes selected from the group consisting of SEQ ID NOS:1-40, 86-130.

The patient biological sample can be derived from, e,g., patient prostate cells, patient serum, patient interstitial fluid, patient blood, or patient seminal fluid.

In the context of clinical trials, test patients can be administered compounds suspected of being effective for treatment of prostate cancer. Control patients can be given a placebo. Tumor cells or biopsies can be drawn from each patient after a determined period of treatment. RNA can be isolated and subjected to expression analysis as described above.

Yet another method for determining whether a treatment should be continued in a prostate cancer patient includes:

a) obtaining a patient biological sample,

b) determining the normalized expression level of one or more genes selected from the group consisting of SEQ ID NOS: 41-85, 131-191 in the patient sample;

c) comparing the normalized expression level of the selected one or more genes determined in step b) with the normalized expression level of the selected one or more genes in a non-prostate cancer biological sample; and

d) discontinuing treatment when the normalized expression level of the selected one or more genes in the patient sample is less than or equal to the normalized expression level of the selected one or more genes in the non-prostate cancer sample.

Yet another method for determining whether a treatment should be continued in a prostate cancer patient includes:

a) obtaining a patient biological sample;

b) determining the normalized expression level of one or more genes selected from the group consisting of SEQ ID NOS:41-85, 131-191 in the patient sample;

c) comparing the normalized expression level determined in step b) with the normalized expression level of the selected one or more genes in a non-prostate cancer biological sample; and

d) continuing treatment when the normalized expression of the selected one or more genes in the patient sample is greater than the normalized expression of the selected one or more genes in the non-prostate cancer sample.

Preferably, the expression level of several different selected genes from the group consisting of SEQ ID NOS: 41-85, 131-191 are compared. For example, the expression of the gene of SEQ ID NO: 41 is compared in the two samples, and the expression of the gene of SEQ ID NO:42 is compared in the two samples. Preferably the selected genes are five or more genes selected from the group consisting of SEQ ID NOS:41-85, 131-191 or ten or more genes selected from the group consisting of SEQ ID NOS:41-85, 131-191.

The patient biological sample can be derived from, e,g., patient prostate cells, patient serum, patient interstitial fluid, patient blood, or patient seminal fluid.

In the context of clinical trials, test patients can be administered compounds suspected of being effective for treatment of prostate cancer. Control patients can be given a placebo. Tumor cells or biopsies can be drawn from each patient after a determined period of treatment. RNA can be isolated and subjected to expression analysis as described above.

The identified differentially expressed genes can also be used to determine whether a compound can be used to treat prostate cancer either generally or in a specific patient. In this approach the expression of one or more of the differentially expressed genes identified herein is measured in prostate cancer cells in the presence and absence of the candidate therapeutic compound.

If the gene(s) whose expression is assessed is of the class that is expressed at a higher level in the in the presence bicalutamide than in the absence of bicalutamide (SEQ ID NOS:41-85, 131-191), and it is observed that the gene(s) is more highly expressed in the presence of the candidate compound than in the absence of the candidate compound, then the candidate compound is likely to be a useful therapeutic agent. Thus, the invention features methods for determining whether a compound can be used to treat prostate cancer. The method includes:

a) measuring the expression level of one or more genes selected from the group consisting of SEQ ID NOS:41-85, 131-191 in a prostate cancer cell sample in the presence and absence of the compound; and

b) identifying the compound as useful for treating prostate cancer when the expression level of the selected one or more genes in the presence of the compound is greater than the expression level of the selected one or more genes in the absence of the compound.

If the gene(s) whose expression is assessed in the screening assay is of the class that is expressed at a higher level in the in the presence testosterone than in the absence of testosterone (SEQ ID NOS:1-40, 86-130), and it is observed that the gene(s) is not more highly expressed in the presence of the candidate compound than in the absence of the candidate compound, then the candidate compound is likely to be a useful therapeutic. Thus, the invention features a method for determining whether a compound can be used to treat prostate cancer, which method includes:

a) measuring the expression level of one or more genes selected from the group consisting of SEQ ID NOS:1-40, 86-130 in prostate cancer cell sample in the presence and absence of the compound; and

b) identifying the compound, as useful for treating prostate cancer when the expression level of the selected one or more genes in the presence of the compound is less than the expression level of the selected one or more genes in the absence of the compound.

Of course, the above-described screening method can entail measuring gene expression in a prostate cancer cell line or in prostate cancer cells isolated from a selected patient. Thus, the method can be used to identify therapeutic compounds which are expected to be generally useful as well and to identify therapeutic compounds which are expected to be beneficial for a particular patient.

It should also be recognized that there can be considerable benefit in assessing the expression of two or more, five or more, or even ten or more identified differentially expressed genes when screening candidate therapeutic agents.

IV. The Use of Differentially Expressed Genes in Diagnosing Prostate Cancer

A variety of methods can be employed for the diagnosis of prostate cancer. Such methods can, for example, utilize reagents such as fingerprint gene nucleotide sequences and antibodies directed against differentially expressed fingerprint gene products. Specifically, such reagents can be used, for example, for the detection of the detection of either over- or under-expression a differentially expressed gene or the presence of a mutation in a differentially expressed gene that is a target gene.

An identified differentially expressed gene which is expressed at a higher level in prostate cancer cells in the presence of testosterone than the absence of testosterone can be used as diagnostic markers. Thus, the invention features a method for determining whether a person has or is at risk of developing prostate cancer, which method includes:

A method for determining whether an individual has or at risk for developing prostate cancer, comprising:

a) obtaining a biological sample from the individual;

b) determining the normalized expression level of one or more genes selected from the group consisting of SEQ ID NOS:1-40, 86-130 in the individual sample;

c) comparing the normalized expression level of the selected one or more genes determined in step b) with the normalized expression level of the selected one or more genes in a non-prostate cancer biological sample; and

d) indentifying the individual as having or being at risk for developing prostate cancer when the normalized expression level of the selected one or more genes in the individual sample is greater than the normalized expression level of the selected one or more genes in the non-prostate cancer sample.

The methods described herein can be performed, for example, by utilizing pre-packaged diagnostic kits comprising at least one specific fingerprint gene nucleic acid or anti-fingerprint gene antibody reagent described herein, which can be conveniently used, e.g., in clinical settings, to diagnose patients exhibiting symptoms of prostate cancer.

a) Detection of Fingerprint Gene Nucleic Acids

DNA or RNA from the cell type or tissue to be analyzed can easily be isolated using procedures which are well known to those in the art. Diagnostic procedures can also be performed in situ directly upon tissue sections (fixed and/or frozen) of patient tissue obtained from biopsies or resections, such that no nucleic acid purification is necessary. Nucleic acid reagents such as those described above can be used as probes and/or primers for such in situ procedures (see, for example, Nuovo, 1992, PCR in situ Hybridization: Protocols and Applications, Raven Press, NY).

Fingerprint gene nucleotide sequences, either RNA or DNA, can, for example, be used in hybridization or amplification assays of biological samples to detect genes and expression patterns associated with prostate cancer. Such assays can include, but are not limited to, Southern or Northern analyses, single stranded conformational polymorphism analyses, in situ hybridization assays, and, polymerase chain reaction analyses. Such analyses can reveal both quantitative aspects of the expression pattern of the fingerprint gene, and qualitative aspects of the fingerprint gene expression and/or gene composition. That is, such techniques can include, for example, point mutations, insertions, deletions, chromosomal rearrangements, and/or activation or inactivation of gene expression.

Preferred diagnostic methods for the detection of fingerprint gene-specific nucleic acid molecules can involve for example, contacting and incubating nucleic acids, derived from the cell type or tissue being analyzed, with one or more labeled nucleic acid reagents under conditions favorable for the specific annealing of these reagents to their complementary sequences within the nucleic acid molecule or interest. Preferably, the lengths of these nucleic acid reagents are at least 15 to 30 nucleotides. After incubation, all non-annealed nucleic acids are removed from the nucleic acid:fingerprint RNA molecule hybrid. The presence of nucleic acids from the target tissue which have hybridized, if any such molecules exist, is then detected. Using such a detection scheme, the nucleic acid from the tissue or cell type of interest can be immobilized, for example, to a solid support such as a membrane, or a plastic surface such as that on a microtiter plate or polystyrene beads. In this case, after incubation, non-annealed, labeled fingerprint nucleic acid reagents are easily removed. Detection of the remaining, annealed, labeled nucleic acid reagents is accomplished using standard techniques well-known to those in the art.

Alternative diagnostic methods for the detection of fingerprint gene specific nucleic acid molecules can involve their amplification, e.g., by PCR (the experimental embodiment set forth in Mullis, 1987, U.S. Pat. No. 4,683,202), ligase chain reaction (Barany, 1991, Proc. Natl. Acad. Sci. USA 88:189-193), self sustained sequence replication (Guatelli et al., 1990, Proc. Natl. Acad. Sci. USA 87:1874-1878), transcriptional amplification system (Kwoh et al., 1989, Proc. Natl. Acad. Sci. USA 86:1173-1177), Q-Beta Replicase (Lizardi et al., 1988, Bio/Technology 6:1197), or any other nucleic acid amplification method, followed by the detection of the amplified molecules using techniques well known to those of skill in the art. These detection schemes are especially useful for the detection of nucleic acid molecules if such molecules are present in very low numbers.

In one embodiment of such a detection scheme, a cDNA molecule is obtained from an RNA molecule of interest (e.g., by reverse transcription of the RNA molecule into cDNA). Cell types or tissues from which such RNA can be isolated include any tissue in which wild type fingerprint gene is known to be expressed. A sequence within the cDNA is then used as the template for a nucleic acid amplification reaction, such as a PCR amplification reaction, or the like. The nucleic acid reagents used as synthesis initiation reagents (e.g., primers) in the reverse transcription and nucleic acid amplification steps of this method are chosen from among the fingerprint gene nucleic acid reagents. The preferred lengths of such nucleic acid reagents are at least 19-30 nucleotides. For detection of the amplified product, the nucleic acid amplification can be performed using radioactively or non-radioactively labeled nucleotides. Alternatively, enough amplified product can be made such that the product can be visualized by standard ethidium bromide staining or by utilizing any other suitable nucleic acid staining method.

In addition to methods which focus primarily on the detection of one nucleic acid sequence, fingerprint profiles can also be assessed in such detection schemes. Fingerprint profiles can be generated, for example, by utilizing a differential display procedure, as discussed above, Northern analysis, and/or RT-PCR. Any of the fingerprint gene sequences described above can be used as probes and/or PCR primers for the generation and corroboration of such fingerprint profiles.

b) Detection of Fingerprint Gene Products

Antibodies directed against wild-type or mutant fingerprint gene products can also be used in prostate cancer diagnostics and prognostics. Such diagnostic methods, can be used to detect abnormalities in the level of fingerprint gene protein expression, or abnormalities in the structure and/or tissue, cellular, or subcellular location of fingerprinting gene protein. Structural differences can include, for example, differences in the size, electronegativity, or antigenicity of the mutant fingerprint gene protein relative to the normal fingerprint gene protein.

Protein from the tissue or cell type to be analyzed can easily be isolated using techniques which are well known to those of skill in the art. The protein isolation methods employed herein can, for example, be such as those described in Harlow and Lane (Harlow and Lane, 1988, Antibodies: A Laboratory Manual, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.), which is incorporated herein by reference in its entirety.

Preferred diagnostic methods for the detection of wild-type or mutant fingerprint gene peptide molecules can involve, for example, immunoassays wherein fingerprint gene peptides are detected by their interaction with an anti-fingerprint gene specific peptide antibody.

For example, antibodies, or fragments of antibodies, useful in the present invention can be used to quantitatively or qualitatively detect the presence of wild-type or mutant fingerprint gene peptides. This can be accomplished, for example, by immunofluorescence techniques employing a fluorescently labeled antibody (see below) coupled with light microscopic, flow cytometric, or fluorimetric detection. Such techniques are especially preferred if the fingerprint gene peptides are expressed on the cell surface.

The antibodies (or fragments thereof) useful in the present invention can, additionally, be employed histologically, as in immunofluorescence or immunoelectron microscopy, for in situ detection of target gene peptides. In situ detection can be accomplished by removing a histological specimen from a patient, and applying thereto a labeled antibody of the present invention. The antibody (or fragment) is preferably applied by overlaying the labeled antibody (or fragment) onto a biological sample. Through the use of such a procedure, it is possible to determine not only the presence of the fingerprint gene peptides, but also their distribution in the examined tissue. Using the present invention, those of ordinary skill will readily perceive that any of a wide variety of histological methods (such as staining procedures) can be modified in order to achieve such in situ detection.

Immunoassays for wild-type or mutant fingerprint gene peptides typically comprise incubating a biological sample, such as a biological fluid, a tissue extract, freshly harvested cells, or cells which have been incubated in tissue culture, in the presence of a detectably labeled antibody capable of identifying fingerprint gene peptides, and detecting the bound antibody by any of a number of techniques well-known in the art.

The biological sample can be brought in contact with and immobilized onto a solid phase support or carrier such as nitrocellulose, or other solid support which is capable of immobilizing cells, cell particles or soluble proteins. The support can then be washed with suitable buffers followed by treatment with the detectably labeled fingerprint gene specific antibody. The solid phase support can then be washed with the buffer a second time to remove unbound antibody. The amount of bound label on solid support can then be detected by conventional means.

Suitable solid phase supports or carriers include any support capable of binding an antigen or an antibody. Well-known supports or carriers include glass, polystyrene, polypropylene, polyethylene, dextran, nylon, amylases, natural and modified celluloses, polyacrylamides, gabbros, and magnetite. The nature of the carrier can be either soluble to some extent or insoluble for the purposes of the present invention. The support material can have virtually any possible structural configuration so long as the coupled molecule is capable of binding to an antigen or antibody. Thus, the support configuration can be spherical, as in a bead, or cylindrical, as in the inside surface of a test tube, or the external surface of a rod. Alternatively, the surface can be flat such as a sheet, test strip, etc. Preferred supports include polystyrene beads. Those skilled in the art will know many other suitable carriers for binding antibody or antigen, or will be able to ascertain the same by use of routine experimentation.

The binding activity of a given lot of anti-wild type or mutant fingerprint gene peptide antibody can be determined according to well-known methods. Those skilled in the art will be able to determine operative and optimal assay conditions for each determination by employing routine experimentation.

One of the ways in which the fingerprint gene peptide-specific antibody can be detectably labeled is by linking the same to an enzyme and use in an enzyme immunoassay (EIA). The enzyme which is bound to the antibody will react with an appropriate substrate, preferably a chromogenic substrate, in such a manner as to produce a chemical moiety which can be detected, for example, by spectrophotometric, fluorimetric or by visual means. Enzymes which can be used to detectably label the antibody include, but are not limited to, malate dehydrogenase, staphylococcal nuclease, delta-5-steroid isomerase, yeast alcohol dehydrogenase, alpha-glycerophosphate, dehydrogenase, triose phosphate isomerase, horseradish peroxidase, alkaline phosphatase, asparaginase, glucose oxidase, beta-galactosidase, ribonuclease, urease, catalase, glucose-6-phosphate dehydrogenase, glucoamylase and acetylcholinesterase. The detection can be accomplished by colorimetric methods which employ a chromogenic substrate for the enzyme. Detection can also be accomplished by visual comparison of the extent of enzymatic reaction of a substrate in comparison with similarly prepared standards.

Detection can also be accomplished using any of a variety of other immunoassays. For example, by radioactively labeling the antibodies or antibody fragments, it is possible to detect fingerprint gene wild type or mutant peptides through the use of a radioimmunoassay (RIA). The radioactive isotope can be, detected by such means as the use of a gamma counter or a scintillation counter or by autoradiography.

It is also possible to label the antibody with a fluorescent compound. When the fluorescently labeled antibody is exposed to light of the proper wave length, its presence can then be detected due to fluorescence. Among the most commonly used fluorescent labeling compounds are fluorescein isothiocyanate, rhodamine, phycoerythrin, phycocyanin, allophycocyanin, o-phthaldehyde and fluorescamine.

The antibody can also be detectably labeled using fluorescence emitting metals such as ¹⁵²Eu, or others of the lanthanide series. These metals can be attached to the antibody using such metal chelating groups as diethylenetriaminepentacetic acid (DTPA) or ethylenediaminetetraacetic acid (EDTA).

The antibody also can be detectably labeled by coupling it to a chemiluminescent compound. The presence of the chemiluminescent-tagged antibody is then determined by detecting the presence of luminescence that arises during the course of a chemical reaction. Examples of particularly useful chemiluminescent labeling compounds are luminol, isoluminol, theromatic acridinium ester, imidazole, acridinium salt and oxalate ester.

Likewise, a bioluminescent compound can be used to label the antibody of the present invention. Bioluminescence is a type of chemiluminescence found in biological systems in, which a catalytic protein increases the efficiency of the chemiluminescent reaction. The presence of a bioluminescent protein is determined by detecting the presence of luminescence. Important bioluminescent compounds for purposes of labeling are luciferin, luciferase and aequorin.

V. Characterization of Differentially Expressed Genes

Differentially expressed genes can be further characterized by using techniques known to those skilled in the art.

Such characterization can yield information regarding the biological function of the identified genes. An assessment of the biological function of the differentially expressed genes, in addition, will allow for their designation as target and/or fingerprint genes.

Specifically, any of the differentially expressed genes whose further characterization indicates that a modulation of the gene's expression or a modulation of the gene product's activity can reduce symptoms of prostate cancer are designated “target genes.” Such target genes and target gene products can be used to identify therapeutics. A differentially expressed genes whose further characterization indicates that it does not influence growth or viability of prostate cancer cells, but whose expression pattern contributes to a gene expression “fingerprint” pattern correlative of, for example, the effectiveness of a drug is designated a “fingerprint gene.” Such genes can be used as diagnostic markers and as markers for assessing the effectiveness or potential effectiveness of a therapeutic agent.

A variety of techniques can be utilized to further characterize the identified genes. First, the nucleotide sequence of the identified genes, which can be obtained by utilizing standard techniques well known to those of skill in the art, can be used to further characterize such genes. For example, the sequence of the identified genes can reveal homologies to one or more known sequence motifs which can yield information regarding the biological function of the identified gene product.

Second, an analysis of the tissue and/or cell type distribution of the mRNA produced by the identified genes can be conducted, utilizing standard techniques well known to those of skill in the art. Such techniques can include, for example, Northern analyses, RT-coupled PCR and RNase protection techniques. Such analyses provide information as to whether the identified genes are expressed in tissues expected to contribute to prostate cancer. Such analyses can also provide quantitative information regarding steady state mRNA regulation, yielding data concerning which of the identified genes exhibits a high level of regulation in, preferably, tissues which can be expected to contribute to prostate cancer. Additionally, standard in situ hybridization techniques can be utilized to provide information regarding which cells within a given tissue express the identified gene. Such an analysis can provide information regarding the biological function of an identified gene in instances wherein only a subset of the cells within the tissue is thought to be relevant to prostate cancer.

Third, the sequences of the identified genes can be used, utilizing standard techniques, to place the genes onto genetic maps, e.g., mouse (Copeland and Jenkins 1991, Trends in Genetics 7:113-118) and human genetic maps (Cohen et al., 1993, Nature 366:698-701). Such mapping information can yield information regarding the genes' importance to human disease by, for example, identifying genes which map within genetic regions to which predisposition to prostate cancer also maps.

Fourth, the biological function of the identified genes can be more directly assessed by utilizing relevant in vivo and in vitro systems. In vivo systems can include, but are not limited to, animal systems which naturally exhibit symptoms of prostate cancer or ones which have been engineered to exhibit such symptoms.

The role of identified gene products can be determined by transfecting cDNAs encoding these gene products into appropriate cell lines, such as, for example, a prostate cancer cell line and analyzing the effect of the gene product on cell growth.

In further characterizing the biological function of the identified genes, the expression of these genes can be modulated within the in vivo and/or in vitro systems, i.e., either over-expressed or under-expressed, and the subsequent effect on the system then assayed. Alternatively, the activity of the product of the identified gene can be modulated by either increasing or decreasing the level of activity in the in vivo and/or in vitro system of interest, and assessing the effect of such modulation.

The information obtained through such characterizations can suggest relevant methods for the treatment of prostate cancer. For example, treatment can include a modulation of gene expression and/or gene product activity. Characterization procedures such as those described herein can indicate where such modulation should involve an increase or a decrease in the expression or activity of the gene or gene product of interest.

a) Expression of Proteins Encoded by Differentially Expressed Genes

A variety of host-expression vector systems can be utilized to express the differentially expressed gene coding sequences of the invention. Such host-expression systems represent vehicles by which the coding sequences of interest can be produced and subsequently purified, but also represent cells which can, when transformed or transfected with the appropriate nucleotide coding sequences, exhibit the differentially expressed gene protein in situ. These include but are not limited to microorganisms such as bacteria (e.g., E. coli and B. subtilis) transformed with recombinant bacteriophage DNA, plasmid DNA or cosmid DNA expression vectors containing differentially expressed gene protein coding sequences; yeast (e.g., Saccharomyces and Pichia) transformed with recombinant yeast expression vectors containing the differentially expressed gene protein coding sequences; insect cell systems infected with recombinant virus expression vectors (e.g., baculovirus) containing the differentially expressed gene protein coding sequences; plant cell systems infected with recombinant virus expression vectors (e.g., cauliflower mosaic virus, CaMV; tobacco mosaic virus, TMV) or transformed with recombinant plasmid expression vectors (e.g., Ti plasmid) containing differentially expressed gene protein coding sequences; or mammalian cell systems (e.g., COS, CHO, BHK, 293, 3T3) harboring recombinant expression constructs containing promoters derived from the genome of mammalian cells (e.g., metallothionein promoter) or from mammalian viruses (e.g., the adenovirus late promoter; the vaccinia virus 7.5K promoter).

In bacterial systems, a number of expression vectors can be advantageously selected depending upon the use intended for the differentially expressed gene protein being expressed. For example, when a large quantity of such a protein is to be produced, for the generation of antibodies or to screen peptide libraries, for example, vectors which direct the expression of high levels of fusion protein products that are readily purified can be desirable. Such vectors include, but are not limited, to the E. coli expression vector pUR278 (Ruther et al., 1983, EMBO J. 2:1791), in which the differentially expressed-gene protein coding sequence can be ligated individually into the vector in frame with the lacZ coding region so that a fusion protein is produced; pIN vectors (Inouye & Inouye, 1985, Nucleic Acids Res. 13:3101-3109; Van Heeke & Schuster, 1989, J. Biol. Chem. 264:5503-5509); and the like. pGEX vectors can also be used to express foreign polypeptides as fusion proteins with glutathione S-transferase (GST). In general, such fusion proteins are soluble and can easily be purified from lysed cells by adsorption to glutathione-agarose beads followed by elution in the presence of free glutathione. The pGEX vectors are designed to include thrombin or factor Xa protease cleavage sites so that the cloned target gene protein can be released from the GST moiety.

In an insect system, Autographa californica nuclear polyhedrosis virus (AcNPV) is used as a vector to express foreign genes. The virus grows in Spodoptera frugiperda cells. The differentially expressed gene coding sequence can be cloned individually into non-essential regions (for example the polyhedrin gene) of the virus and placed under control of an AcNPV promoter (for example, the polyhedrin promoter). Successful insertion of differentially expressed gene coding sequence will result in inactivation of the polyhedrin gene and production of non-occluded recombinant virus (i.e., virus lacking the proteinaceous coat coded for by the polyhedrin gene). These recombinant viruses are then used to infect Spodoptera frugiperda cells in which the inserted gene is expressed (e.g., see Smith et al., 1983, J. Viol. 46:584; Smith, U.S. Pat. No. 4,215,051).

In mammalian host cells, a number of viral-based expression systems can be utilized. In cases where an adenovirus is used as an expression vector, the differentially expressed gene coding sequence of interest can be ligated to an adenovirus transcription/translation control complex, e.g., the late promoter and tripartite leader sequence. This chimeric gene can then be inserted in the adenovirus genome by in vitro or in vivo recombination. Insertion in a non-essential region of the viral genome (e.g., region E1 or E3) will result in a recombinant virus that is viable and capable of expressing differentially expressed gene protein in infected hosts (e.g., see Logan & Shenk, 1984, Proc. Natl. Acad. Sci. USA 81:3655-3659). Specific initiation signals can also be required for efficient translation of inserted differentially expressed gene coding sequences. These signals include the ATG initiation codon and adjacent sequences. In cases where an entire identified gene, including its own initiation codon and adjacent sequences, is inserted into the appropriate expression vector, no additional translational control signals can be needed. However, in cases where only a portion of the identified coding sequence is inserted, exogenous translational control signals, including, perhaps, the ATG initiation codon, must be provided. Furthermore, the initiation codon must be in phase with the reading frame of the desired coding sequence to ensure translation of the entire insert. These exogenous translational control signals and initiation codons can be of a variety of origins, both natural and synthetic. The efficiency of expression can be enhanced by the inclusion of appropriate transcription enhancer elements, transcription terminators, etc., (see Bittner et al., 1987, Methods in Enzymol. 153:516-544).

In addition, a host cell strain can be chosen which modulates the expression of the inserted sequences, or modifies and processes the gene product in the specific fashion desired. Such modifications (e.g., glycosylation) and processing (e.g., cleavage) of protein products can be important for the function of the protein. Different host cells have characteristic and specific mechanisms for the post-translational processing and modification of proteins. Appropriate cell lines or host systems can be chosen to ensure the correct modification and processing of the foreign protein expressed. To this end, eukaryotic host cells which possess the cellular machinery for proper processing of the primary transcript, glycosylation, and phosphorylation of the gene product can be used. Such mammalian host cells include but are not limited to CHO, VERO, BHK, HeLa, COS, MDCK, 293, 3T3, W138, etc.

For long-term, high-yield production of recombinant proteins, stable expression is preferred. For example, cell lines which stably express the differentially expressed gene protein can be engineered. Rather than using expression vectors which contain viral origins of replication, host cells can be transformed with DNA controlled by appropriate expression control elements (e.g., promoter, enhancer, sequences, transcription terminators, polyadenylation sites, etc.), and a selectable marker. Following the introduction of the foreign DNA, engineered cells can be allowed to grow for 1-2 days in an enriched media, and then are switched to a selective media. The selectable marker in the recombinant plasmid confers resistance to the selection and allows cells to stably integrate the plasmid into their chromosomes and grow to form foci which in turn can be cloned and expanded into cell lines. This method can advantageously be used to engineer cell lines which express the identified gene protein. Such engineered cell lines can be particularly useful in screening and evaluation of compounds that affect the endogenous activity of the differentially expressed gene protein.

A number of selection systems can be used, including, but not limited to, the herpes simplex virus thymidine kinase (Wigler et al., 1977, Cell 11:223), hypoxanthine-guanine phosphoribosyltransferase (Szybalska & Szybalski, 1962, Proc. Natl. Acad. Sci. USA 48:2026), and adenine phosphoribosyltransferase (Lowy et al., 1980, Cell 22:817) genes in tk⁻, hgprt⁻ or aprt⁻ cells, respectively. Also, antimetabolite resistance can be used as the basis of selection for dhfr, which confers resistance to methotrexate (Wigler et al., 1980, Natl. Acad. Sci. USA 77:3567; O'Hare et al., 1981, Proc. Natl. Acad. Sci. USA 78:1527); gpt, which confers resistance to mycophenolic acid (Mulligan & Berg, 1981, Proc. Natl. Acad. Sci. USA 78:2072); neo, which confers resistance to the aminoglycoside G-418 (Colberre-Garapin et al., 1981, J. Mol. Biol. 150:1); and hygro, which confers resistance to hygromycin (Santerre et al., 1984, Gene 30:147) genes.

An alternative fusion protein system allows for the ready purification of non-denatured fusion proteins expressed in human cell lines (Janknecht et al., 1991, Proc. Natl. Acad. Sci. USA 88:8972-8976). In this system, the gene of interest is subcloned into a vaccinia recombination plasmid such that the gene's open reading frame is translationally fused to an amino-terminal tag consisting of six histidine residues. Extracts from cells infected with recombinant vaccinia virus are loaded onto ni2+ nitriloacetic acid-agarose columns and histidine-tagged proteins are selectively eluted with imidazole-containing buffers.

When used as a component in assay systems such as that described herein, the differentially expressed gene protein can be labeled, either directly or indirectly, to facilitate detection of a complex formed between the differentially expressed gene protein and a test substance. Any of a variety of suitable labeling systems can be used including but not limited to radioisotopes such as ¹²⁵I; enzyme labeling systems that generate a detectable colorimetric signal or light when exposed to substrate; and fluorescent labels.

Where recombinant DNA technology is used to produce the differentially expressed gene protein for such assay systems, it can be advantageous to engineer fusion proteins that can facilitate labeling, solubility, immobilization and/or detection.

Indirect labeling involves the use of a third protein, such as a labeled antibody, which specifically binds to either a differentially expressed gene product. Such antibodies include but are not limited to polyclonal, monoclonal, chimeric, single chain, Fab fragments and fragments produced by a Fab expression library.

b) Antibodies Specific for Differentially Expressed Gene Products

Described below are methods for the production of antibodies capable of specifically recognizing one or more differentially expressed gene products. Such antibodies can include, but are not limited to polyclonal antibodies, monoclonal antibodies (mAbs), humanized or chimeric antibodies, single chain antibodies, Fab fragments, F(ab′)₂ fragments, fragments produced by a FAb expression library, anti-idiotypic (anti-Id) antibodies, and epitope-binding fragments of any of the above. Such antibodies can be used, for example, in the detection of a fingerprint or target gene product in a biological sample, or, alternatively, as a method for the inhibition of abnormal target gene activity. Thus, such antibodies can be utilized as treatment methods, and/or can be used as pat of diagnostic techniques whereby patients can be tested for abnormal levels of fingerprint or target gene proteins, or for the presence of abnormal forms of the such proteins.

For the production of antibodies to a differentially expressed gene, various host animals can be immunized by injection with a differentially expressed gene protein, or a portion thereof. Such host animals can include but are not limited to rabbits, mice, and rats, to name but a few. Various adjuvants can be used to increase the immunological response, depending on the host species, including but not limited to Freund's (complete and incomplete), mineral gels such as aluminum hydroxide, surface active substances such as lysolecithin, pluronic polyols, polyanions, peptides, oil emulsions, keyhole limpet hemocyanin, dinitrophenol, and potentially useful human adjuvants such as BCG (Bacilli Calmette-Guerin) and Corynebacterium parvum.

Polyclonal antibodies are heterogeneous populations of antibody molecules derived from the sera of animals immunized with an antigen, such as target gene product, or an antigenic functional derivative thereof. For the production of polyclonal antibodies, host animals such as those described above, can be immnunized by injection with differentially expressed gene product supplemented with adjuvants as also described above.

Monoclonal antibodies, which are homogeneous populations of antibodies to a particular antigen, can be obtained by any technique which provides for the production of antibody molecules by continuous cell lines in culture. These include, but are not limited to the hybridoma technique of Kohler and Milstein, (1975, Nature 256:495-497; and U.S. Pat. No. 4,376,110), the human B-cell hybridoma technique (Kosbor et al., 1983, Immunology Today 4:72; Cole et al., 1983, Proc. Natl. Acad. Sci. USA 80:2026-2030), and the BV-hybridoma technique (Cole et al., 1985, Monoclonal Antibodies And Cancer Therapy, Alan R. Liss, Inc., pp. 77-96). Such antibodies can be of any immunoglobulin class including IgG, IgM, IgE, IgA, IgD and any subclass thereof. The hybridoma producing the mAb of this invention can be cultivated in vitro or in vivo. Production of high titers of mAbs in vivo makes this the presently preferred method of production.

In addition, techniques developed for the production of “chimeric antibodies” (Morrison et al., 1984, Proc. Natl. Acad. Sci., 81:6851-6855; Neuberger et al., 1984, Nature, 312:604-608; Takeda et al., 1985, Nature, 314:452-454; U.S. Pat. No. 4,816,567) by splicing the genes from a mouse antibody molecule of appropriate antigen specificity together with genes from a human antibody molecule of appropriate biological activity can be used. A chimeric antibody is a molecule in which different portions are derived from different animal species, such as those having a variable region derived from a murine mAb and a human immunoglobulin constant region.

Alternatively, techniques described for the production of single chain antibodies (U.S. Pat. No. 4,946,778; Bird, 1988, Science 242:423-426; Huston et al., 1988, Proc. Natl. Acad. Sci. USA 85:5879-5883; and Ward et al., 1989, Nature 334:544-546) and for making humanized monoclonal antibodies (U.S. Pat. No. 5,225,539, which is incorporated herein by reference in its entirety) can be utilized to produce anti-differentially expressed gene product antibodies.

Antibody fragments which recognize specific epitopes can be generated by known techniques. For example, such fragments include but are not limited to: the F(ab′)₂ fragments which can be produced by pepsin digestion of the antibody molecule and the Fab fragments which can be generated by reducing the disulfide bridges of the F(ab′)₂ fragments. Alternatively, Fab expression libraries can be constructed (Huse et al., 1989, Science, 246:1275-1281) to allow rapid and easy identification of monoclonal Fab fragments with the desired specificity.

c) In vitro and In vivo Systems for Gene Characterization

Described below are in vitro and in vivo systems which can be used to further characterize differentially Expressed Genes. These system can also be used as part of screening strategies designed to identify compounds which are capable of preventing and/or ameliorating symptoms of prostate cancer. Thus, these systems can be used to identify drugs, pharmaceuticals, therapies and interventions which can be effective in treating prostate cancer and to determine the in vivo efficacy of drugs, pharmaceuticals, therapies and interventions.

1) In Vitro Systems

Cells that contain and express target gene sequences and exhibit cellular phenotypes associated with prostate cancer, can be utilized to identify compounds that exhibit an ability to prevent and/or treat prostate cancer.

Further, the fingerprint pattern of gene expression of cells of interest can be analyzed and compared to the normal fingerprint pattern. Those compounds which cause cells exhibiting cellular phenotypes of prostate cancer to produce a fingerprint pattern more closely resembling a normal fingerprint pattern for the cell of interest can be considered candidates for further testing regarding an ability to ameliorate the symptoms of prostate cancer.

Cells which will be utilized for such assays can, for example, include LNCap cells. In addition, purified primary or secondary tumor cells derived from either transgenic or non-transgenic tumor cells can be used.

Further, cells which can be used for such assays can also include recombinant, transgenic cell lines. While primary cultures derived from the metastasis in transgenic animals can be utilized, the generation of continuous cell lines is preferred. For examples of techniques which can be used to derive a continuous cell line from a transgenic animal, see Small et al., 1985, Mol. Cell Biol. 5:642-648.

Alternatively, cells of a cell type known to be involved in prostate cancer can be transfected with sequences capable of increasing or decreasing the amount of target gene expression within the cell. For examples target gene sequences can be introduced into, and over expressed in, the genome of the cell of interest, or, if endogenous target gene sequences are present, they can either be overexpressed or, alternatively, be disrupted in order to underexpress or inactivate target gene expression.

In order to overexpress a target gene sequence, the coding portion of the target gene sequence can be ligated to a regulatory sequence which is capable of driving gene expression in the cell type of interest. Such regulatory regions will be well known to those of skill in the art.

For under expression of an endogenous target gene sequence, such a sequence can be isolated and engineered such that when reintroduced into the genome of the cell type of interest, the endogenous target gene alleles will be inactivated. Preferably, the engineered target gene sequence is introduced via gene targeting such that the endogenous target sequence is disrupted upon integration of the engineered target gene sequence into the cell's genome.

Transfection of target gene sequence nucleic acid can be accomplished by utilizing standard techniques (see, e.g., Ausubel, supra). Transfected cells should be evaluated for the presence of the recombinant target gene sequences, for expression and accumulation of target gene mRNA, and for the presence of recombinant target gene protein production. In instances wherein a decrease in target gene expression is desired, standard techniques can be used to demonstrate whether a decrease in endogenous target gene expression and/or in target gene product production is achieved.

2) In Vivo Systems

In vivo systems of prostate cancer can be either non-recombinant animals or recombinantly engineered transgenic animals. Such models may be generated, for example, by introducing tumor cells into syngeneic mice using techniques such as implanting prostatic cancer cells into the prostate gland. After an appropriate period of time, the tumors which result from these injections can be counted and analyzed.

For the generation of animal models of prostate cancer, cells derived from, for example, a prostate cancer cell line may be implanted into the prostate of an animal and the resulting tumors may be analyzed and compared to, for example, normal tissue.

The role of identified gene products (i.e., those encoded by target genes) can be determined by transfecting cDNAs encoding such gene products into the appropriate cell line and analyzing its effect on the cells' ability to induce prostate cancer in animal models such as these. The role of the identified gene products may be further analyzed by, for example, culturing cells derived from the tumors which develop in the animal models, introducing these cultured cells into animals, and subsequently measuring the level of identified gene product present in the resulting tumor cells. In this manner, cell line variants are developed which can be useful in analyzing the role of quantitative and/or qualitative differences in the expression of the identified genes on the cells' ability to induce prostate cancer.

Recombinant animal models for prostate cancer can be engineered by utilizing, for example, target gene sequences such as those described herein in conjunction with techniques for producing transgenic animals that are well known to those of skill in the art. For example, target gene sequences can be introduced into, and overexpressed in, the genome of the animal of interest, or, if endogenous target gene sequences are present, they can either be overexpressed or, alternatively, can be disrupted in order to underexpress or inactivate target gene expression.

In order to overexpress a target gene sequence, the coding portion of the target gene sequence can be ligated to a regulatory sequence which is capable of driving gene expression in the animal and cell type of interest. Such regulatory regions will be well known to those of skill in the art.

In order to obtain underexpression of an endogenous target gene sequence, such a sequence can be introduced into the genome of the animal of interest such that the endogenous target gene alleles will be inactivated. Preferably, an engineered sequence comprising at least part of the target gene sequence is utilized and is introduced, via gene targeting, such that the endogenous target sequence is disrupted upon integration of the engineered target gene sequence into the animal's genome.

Animals of any species, including, but not limited to, mice, rats, rabbits, guinea pigs, pigs, micro-pigs, goats, and-non-human primates, e.g., baboons, monkeys, and chimpanzees can be used to generate animal models of prostate cancer.

Any technique known in the art can be used to introduce a target gene transgene into animals to produce the founder lines of transgenic animals. Such techniques include, but are not limited to pronuclear microinjection (Hoppe and Wagner, 1989, U.S. Pat. No. 4,873,191); retrovirus mediated gene transfer into germ lines (Van der Putten et al., 1985, Proc. Natl. Acad. Sci., USA 82:6148-6152); gene targeting in embryonic stem cells (Thompson et al., 1989, Cell 56:313-321); electroporation of embryos (Lo, 1983, Mol Cell. Biol. 3:1803-1814); and sperm-mediated gene transfer (Lavitrano et al., 1989, Cell 57:717-723).

The present invention provides for transgenic animals that carry the transgene in all their cells, as well as animals which carry the transgene in some, but not all their cells, i.e., mosaic animals. The transgene can be integrated, either as a single transgene or in concatamers, e.g., head-to-head tandems or head-to-tail tandems. The transgene can also be selectively introduced into and activated in a particular cell type using known techniques (Lasko et al., 1992, Proc. Natl. Acad. Sci. USA 89:6232-6236). The regulatory sequences required for depend upon the particular cell type of interest, and will be apparent to those of skill in the art.

When it is desired that the target gene transgene be integrated into the chromosomal site of the endogenous target gene, gene targeting is preferred. Briefly, when such a technique is to be utilized, vectors containing some nucleotide sequences homologous to the endogenous target gene of interest are designed for the purpose of integrating, via homologous recombination with chromosomal sequences, into and disrupting the function of, the nucleotide sequence of the endogenous target gene. The transgene can also be selectively introduced into a particular cell type, thus inactivating the endogenous gene of interest in only that cell type, by following, for example, the teaching of Gu et al. (1994, Science 265:103-106). The regulatory sequences required for such a cell-type specific inactivation will depend upon the particular cell type of interest, and will be apparent to those of skill in the art.

Once transgenic animals have been generated, the expression of the recombinant target gene and protein can be assayed utilizing standard techniques. Initial screening can be accomplished by Southern blot analysis or PCR techniques to analyze animal tissues to assay whether integration of the transgene has taken place. The level of mRNA expression of the transgene in the tissues of the transgenic animals can also be assessed using techniques which include, but are not limited to, Northern blot analysis of tissue samples obtained from the animal, in situ hybridization analysis, and RT-coupled PCR. Samples of target gene-expressing tissue, can also be evaluated immunocytochemically using antibodies specific for the transgenic product of interest.

The target gene transgenic animals that express target gene mRNA or target gene transgene peptide (detected immunocytochemically, using antibodies directed against target gene product epitopes) at easily detectable levels should then be further evaluated to identify those animals which display prostate cancer characteristics.

Additionally, specific cell types within the transgenic animals can be analyzed for cellular phenotypes characteristic of prostate cancer. Such cellular phenotypes can include, for example, differential gene expression characteristic of prostate cancer cells. Further, such cellular phenotypes can include as assessment of a particular cell type fingerprint profile and its comparison to known fingerprint profiles of the particular cell type in animals exhibiting prostate cancer. Such transgenic animals serve as suitable model systems for prostate cancer.

Once target gene transgenic founder animals are produced (i.e., those animals which express target gene proteins in cells or tissues of interest, and which, preferably, exhibit prostate cancer characteristics), they can be bred, inbred, outbred, or crossbred to produce colonies of the particular animal. Examples of such breeding strategies include but are not limited to: outbreeding of founder animals with more than one integration site in order to establish separate lines: inbreeding of separate lines in order to produce compound target gene transgenics that express the target gene transgene of interest at higher levels because of the effects of additive expression of each target gene transgene; crossing of heterozygous transgenic animals to produce animals homozygous for a given integration site in order to both augment expression and eliminate the possible need for screening of animals by DNA analysis; crossing of separate homozygous lines to produce compound heterozygous or homozygous lines; breeding animals to different inbred genetic backgrounds so as to examine effects of modifying alleles on expression of the target gene transgene and the development of symptoms of prostate cancer. One such approach is to cross the target gene transgenic founder animals with a wild-type strain to produce an F1 generation that exhibits symptoms of prostate cancer. The F1 generation can then be inbred in order to develop a homozygous line, if it is found that homozygous target gene transgenic animals are viable.

d) Identification of Compounds that Interact with a Target Gene Product

The following assays are designed to identify compounds that bind to target gene products, compounds that bind to other cellular proteins that interact with a target gene product, and compounds that interfere with the interaction of the target gene product with other cellular proteins.

Such compounds can include, but are not limited to, other cellular proteins. Specifically, such compounds can include, but are not limited to, peptides, such as, for example, soluble peptides, including, but not limited to Ig-tailed fusion peptides, comprising extracellular portions of target gene product transmembrane receptors, and members of random peptide libraries (see, e.g., Lam et al., 1991, Nature 354:82-84; Houghton et al., 1991, Nature 354:84-86), made of D-and/or L-configuration amino acids, phosphopeptides (including, but not limited to, members of random or partially degenerate phosphopeptide libraries; see, e.g., Songyang et al., 1993, Cell 72:767-778), antibodies (including, but not limited to, polyclonal, monoclonal, humanized, anti-idiotypic, chimeric or single chain antibodies, and FAb, F(ab′)₂ and FAb expression libary fragments, and epitope-binding fragments thereof), and small organic or inorganic molecules.

Compounds identified via assays such as those described herein can be useful, for example, in elaborating the biological function of the target gene product, and for ameliorating symptoms of prostate cancer. For example, in instances in which prostate cancer is associated with lower expression of a target gene product, and/or lower target gene product activity, compounds that interact with the target gene product can include ones which increase the activity of the target gene product. Such compounds would bring about an effective increase in the level of target gene activity, thus ameliorating symptoms of prostate cancer. Conversely, in instances in which a mutation within a target gene cause aberrant target gene products to be made which have a deleterious effect that leads to prostate cancer, compounds that bind target gene product can be identified that inhibit the activity of the target gene product.

1) Screening Assays for Compounds and Cellular Proteins that Bind to a Target Gene Product

In vitro systems can be designed to identify compounds capable of binding the target gene products of the invention. Compounds identified can be useful, for example, in modulating the activity of wild type and/or mutant target gene products, preferably mutant target gene proteins, can be useful in elaborating the biological function of the target gene product, can be utilized in screens for identifying compounds that disrupt normal target gene interactions, or can in themselves disrupt such interactions.

The principle of the assays used to identify compounds that bind to the target gene product involves preparing a reaction mixture of the target gene protein and the test compound under conditions and for a time sufficient to allow the two components to interact and bind, thus forming a complex which can be removed and/or detected in the reaction mixture. These assays can be conducted in a variety of ways. For example, one method to conduct such an assay would involve anchoring target gene product or the test substance onto a solid phase and detecting target gene product/test compound complexes anchored on the solid phase at the end of the reaction. In one embodiment of such a method, the target gene product can be anchored onto a solid surface, and the test compound, which is not anchored, can be labeled, either directly or indirectly.

In practice, microtiter plates can conveniently be utilized as the solid phase. The anchored component can be immobilized by non-covalent or covalent attachments. Non-covalent attachment can be accomplished by simply coating the solid surface with a solution of the protein and drying. Alternatively, an immobilized antibody, preferably a monoclonal antibody, specific for the protein to be immobilized can be used to anchor the protein to the solid surface. The surfaces can be prepared in advance and stored.

In order to conduct the assay, the nonimmobilized component is added to the coated surface containing the anchored component. After the reaction is complete, unreacted components are removed (e.g., by washing) under conditions such that any complexes formed will remain immobilized on the solid surface. The detection of complexes anchored on the solid surface can be accomplished in a number of ways. Where the previously immobilized component is pre-labeled, the detection of label immobilized on the surface indicates that complexes were formed. Where the previously nonimmobilized component is not pre-labeled, an indirect label can be used to detect complexes anchored on the surface; e.g., using a labeled antibody specific for the immobilized component (the antibody, in turn, can be directly labeled or indirectly labeled with a labeled anti-Ig antibody).

Alternatively, a reaction can be conducted in a liquid phase, the reaction products separated from unreacted components, and complexes detected; e.g., using an immobilized antibody specific for target gene or the test compound to anchor any complexes formed in solution, and a labeled antibody specific for the other component of the possible complex to detect anchored complexes.

Any method suitable for detecting protein-protein interactions can be employed for identifying novel target product-cellular or extracellular protein interactions. In such a case, the target gene serves as the known “bait” gene.

2) Assays for Compounds that Interfere with the Binding of a Target Gene Product to a Second Cellular Protein

The target gene products of the invention can, in vivo, interact with one or more cellular or extracellular macromolecules, such as proteins. For the purposes of this discussion, such cellular and extracellular macromolecules are referred to herein as “binding partners.” Compounds that disrupt such interactions can be useful in regulating the activity of the target gene product, especially mutant target gene products. Such compounds can include, but are not limited to molecules such as antibodies, peptides, and small molecules.

The basic principle of the assay systems used to identify compounds that interfere with the interaction between the target gene product and its cellular or extracellular binding partner or partners involves preparing a reaction mixture containing the target gene product, and the binding partner under conditions and for a time sufficient to allow the two products to interact and bind, thus forming a complex. In order to test a compound for inhibitory activity, the reaction mixture is prepared in the presence and absence of the test compound. The test compound can be initially included in the reaction mixture, or can be added at a time subsequent to the addition of target gene and its cellular or extracellular binding partner. Control reaction mixtures are incubated without the test compound or with a placebo. The formation of any complexes between the target gene product and the cellular or extracellular binding partner is then detected. The formation of a complex in the control reaction, but not in the reaction mixture containing the test compound, indicates that the compound interferes with the interaction of the target gene product and the interactive binding partner. Additionally, complex formation within reaction mixtures containing the test compound and normal target gene product can also be compared to complex formation within reaction mixtures containing the test compound and mutant target gene product. This comparison can be important in those cases wherein it is desirable to identify compounds that disrupt interactions of mutant but not normal target gene products.

The assay for compounds that interfere with the interaction of the target gene products and binding partners can be conducted in a heterogeneous or homogeneous format. Heterogeneous assays involve anchoring either the target gene product or the binding partner onto a solid phase and detecting complexes anchored on the solid phase at the end of the reaction. In homogeneous assays, the entire reaction is carried out in a liquid phase. In either approach, the order of addition of reactants can be varied to obtain different information about the compounds being tested. For example, test compounds that interfere with the interaction between the target gene products and the binding partners, e.g., by competition, can be identified by conducting the reaction in the presence of the test substance; i.e., by adding the test substance to the reaction mixture prior to or simultaneously with the target gene product and interactive cellular or extracellular binding partner. Alternatively, test compounds that disrupt preformed complexes, e.g., compounds with higher binding constants that displace one of the components from the complex, can be tested by adding the test compound to the reaction mixture after complexes have been formed. The various formats are described briefly below.

In a heterogeneous assay system, either the target gene product or the interactive cellular or extracellular binding partner, is anchored onto a solid surface, while the non-anchored species is labeled, either directly or indirectly. In practice, microtitre plates are conveniently utilized. The anchored species can be immobilized by non-covalent or covalent attachments. Non-covalent attachment can be accomplished simply by coating the solid surface with a solution of the target gene product or binding partner and drying. Alternatively, an immobilized antibody specific for the species to be anchored can be used to anchor the species to the solid surface. The surfaces can be prepared in advance and stored.

In order to conduct the assay, the partner of the immobilized species is exposed to the coated surface with or without the test compound. After the reaction is complete, unreacted components are removed (e.g., by washing) and any complexes formed will remain immobilized on the solid surface. The detection of complexes anchored on the solid surface can be accomplished in a number of ways. Where the non-immobilized species is pre-labeled, the detection of label immobilized on the surface indicates that complexes were formed. Where the non-immobilized species is not pre-labeled, an indirect label can be used to detect complexes anchored on the surface; e.g., using a labeled antibody specific for the initially non-immobilized species (the antibody, in turn, can be directly labeled or indirectly labeled with a labeled anti-Ig antibody). Depending upon the order of addition of reaction components, test compounds which inhibit complex formation or which disrupt preformed complexes can be detected.

Alternatively, the reaction can be conducted in a liquid phase in the presence or absence of the test compound, the reaction products separated from unreacted components, and complexes detected; e.g., using an immobilized antibody specific for one of the binding components to anchor any complexes formed in solution, and a labeled antibody specific for the other partner to detect anchored complexes. Again, depending upon the order of addition of reactants to the liquid phase, test compounds which inhibit complex or which disrupt preformed complexes can be identified.

In an alternate embodiment of the invention, a homogeneous assay can be used. In this approach, a preformed complex of the target gene product and the interactive cellular or extracellular binding partner product is prepared in which either the target gene products or their binding partners are labeled, but the signal generated by the label is quenched due to complex formation (see, e.g., U.S. Pat. No. 4,109,496 which utilizes this approach for immunoassays). The addition of a test substance that competes with and displaces one of the species from the preformed complex will result in the generation of a signal above background. In this way, test substances which disrupt target gene product-cellular or extracellular binding partner interaction can be identified.

In a particular embodiment, the target gene product can be prepared for immobilization using recombinant DNA techniques. For example, the target gene coding region can be fused to a glutathione-S-transferase (GST) gene using a fusion vector such as pGEX-5X-1, in such a manner that its binding activity is maintained in the resulting fusion product. The interactive cellular or extracellular product can be purified and used to raise a monoclonal antibody, using methods routinely practiced in the art. This antibody can be labeled with the radioactive isotope ¹²⁵I, for example, by methods routinely practiced in the art. In a heterogeneous assay, e.g., the GST-Target gene fusion product can be anchored to glutathione-agarose beads. The interactive cellular or extracellular binding partner product can then be added in the presence or absence of the test compound in a manner that allows interaction and binding to occur. At the end of the reaction period, unbound material can be washed away, and the labeled monoclonal antibody can be added to the system and allowed to bind to the complexed components. The interaction between the target gene product and the interactive cellular or extracellular binding partner can be detected by measuring the amount of radioactivity that remains associated with the glutathione-agarose beads. A successful inhibition of the interaction by the test compound will result in a decrease in measured radioactivity.

Alternatively, the GST-target gene fusion product and the interactive cellular or extracellular binding partner product can be mixed together in liquid in the absence of the solid glutathione-agarose beads. The test compound can be added either during or after the binding partners are allowed to interact. This mixture can then be added to the glutathione-agarose beads and unbound material is washed away. Again the extent of inhibition of the binding partner interaction can be detected by adding the labeled antibody and measuring the radioactivity associated with the beads.

These same techniques can be employed using peptide fragments that correspond to the binding domains of the target gene product and the interactive cellular or extracellular binding partner (in case where the binding partner is a product), in place of one or both of the full length products. Any number of methods routinely practiced in the art can be used to identify and isolate the protein's binding site. These methods include, but are not limited to, mutagenesis of one of the genes encoding one of the products and screening for disruption of binding in a co-immunoprecipitation assay. Compensating mutations in the gene encoding the second species in the complex can be selected. Sequence analysis of the genes encoding the respective products will reveal the mutations that correspond to the region of the product involved in interactive binding. Alternatively, one product can be anchored to a solid surface using methods described above, and allowed to interact with and bind to its labeled binding partner, which has been treated with a proteolytic enzyme, such as trypsin. After washing, a short, labeled peptide comprising the binding domain can remain associated with the solid material, which can be isolated and identified by amino acid sequencing. Also, once the gene coding for the cellular or extracellular binding partner product is obtained, short gene segments can be engineered to express peptide fragments of the product, which can then be tested for binding activity and purified or synthesized.

VI. Treatment of Prostate Cancer by Modulation of Differentially Expressed Genes or Gene Products

Prostate cancer can be treated by modulating the expression of a target gene or the activity of a target gene product. The modulation can be of a positive or negative nature, depending on the specific situation involved, but each modulatory event yields a net result in which prostate cancer symptoms are ameliorated.

“Negative modulation,” refers to a reduction in the level and/or activity of target gene product relative to the level and/or activity of the target gene product in the absence of the modulatory treatment.

“Positive modulation,” refers to an increase in the level and/or activity of target gene product relative to the level and/or activity of target gene product in the absence of modulatory treatment.

It is possible that prostate cancer can be caused, at least in part, by an abnormal level of gene product, or by the presence of a gene product exhibiting abnormal activity. As such, the reduction in the level and/or activity of such gene products would bring about the amelioration of prostate cancer symptoms.

Alternatively, it is possible that prostate cancer can be brought about, at least in part, by the absence or reduction of the level of gene expression, or a reduction in the level of a gene product's activity. As such, an increase in the level of gene expression and/or the activity of such gene products would bring about the amelioration of prostate cancer symptoms.

a) Negative Modulatory Techniques

As discussed, above, successful treatment of prostate cancer can be brought about by techniques which serve to inhibit the expression or activity of target gene products.

For example, compounds, e.g., a compound identified using an assays described above, which proves to exhibit negative modulatory activity, can be used in accordance with the invention to prevent and/or ameliorate symptoms of prostate cancer. Such molecules can include, but are not limited to peptides, phosphopeptides, small organic or inorganic molecules, or antibodies (including, for example, polyclonal, monoclonal, humanized, anti-idiotypic, chimeric or single chain antibodies, and FAb, F(ab′)₂ and FAb expression library fragments, and epitope-binding fragments thereof).

Further, antisense and ribozyme molecules which inhibit expression of the target gene can also be used in accordance with the invention to reduce the level of target gene expression, thus effectively reducing the level of target gene activity. Still further, triple helix molecules can be utilized in reducing the level of target gene activity.

Among the compounds which can exhibit the ability to prevent and/or ameliorate symptoms of prostate cancer are antisense, ribozyme, and triple helix molecules. Such molecules can be designed to reduce or inhibit either wild type, or if appropriate, mutant target gene activity. Techniques for the production and use of such molecules are well known to those of skill in the art.

Anti-sense RNA and DNA molecules act to directly block the translation of mRNA by hybridizing to targeted mRNA and preventing protein translation. With respect to antisense DNA, oligodeoxyribonucleotides derived from the translation initiation site, e.g., between the −10 and +10 regions of the Target gene nucleotide sequence of interest, are preferred.

Ribozymes are enzymatic RNA molecules capable of catalyzing the specific cleavage of RNA. (For a review, see, for example, Rossi, 1994, Current Biology 4:469-471.) The mechanism of ribozyme action involves sequence specific hybridization of the ribozyme molecule to complementary target RNA, followed by a endonucleolytic cleavage. The composition of ribozyme molecules must include one or more sequences complementary to the target gene mRNA and must include the well-known catalytic sequence responsible for mRNA cleavage. For this sequence, see U.S. Pat. No. 5,093,246, which is incorporated by reference herein in its entirety. As such within the scope of the invention are engineered hammerhead motif ribozyme molecules that specifically and efficiently catalyze endonucleolytic cleavage of RNA sequences encoding target gene proteins.

Specific ribozyme cleavage sites within any potential RNA target are initially identified by scanning the molecule of interest for ribozyme cleavage sites which include the following sequences, GUA, GUU, and GUC. Once identified, short RNA sequences of between 15 and 20 ribonucleotides corresponding to the region of the target gene containing the cleavage site can be evaluated for predicted structural features, such as secondary structure, that can render the oligonucleotide sequence unsuitable. The suitability of candidate sequences can also be evaluated by testing their accessibility to hybridization with complementary oligonucleotides, using ribonuclease protection assays.

Nucleic acid molecules to be used in triplex helix formation for the inhibition of transcription should be single stranded and composed of deoxynucleotides. The base composition of these oligonucleotides must be designed to promote triple helix formation via Hoogsteen base pairing rules, which generally require sizeable stretches of either purines or pyrimidines to be present on one strand of a duplex. Nucleotide sequences can be pyrimidine-based, which will result in TAT and CGC⁺ triplets across the three associated strands of the resulting triple helix. The pyrimidine-rich molecules provide base complementarily to a purine-rich region of a single strand of the duplex in a parallel orientation to that strand. In addition, nucleic acid molecules can be chosen that are purine-rich, for example, contain a stretch of G residues. These molecules will form a triple helix with a DNA duplex that is rich in GC pairs, in which the majority of the purine residues are located on a single strand of the targeted duplex, resulting in GGC triplets across the three strands in the triplex.

Alternatively, the potential sequences that can be targeted for triple helix formation can be increased by creating a so called “switchback” nucleic acid molecule. Switchback molecules are synthesized in an alternating 5′-3′, 3′-5′ manner, such that they base pair with first one strand of a duplex and then the other, eliminating the necessity for a sizeable stretch of either purines or pyrimidines to be present on one strand of a duplex.

In instances wherein the antisense, ribozyme, and/or triple helix molecules described herein are utilized to reduce or inhibit mutant gene expression, it is possible that the technique utilized can also efficiently reduce or inhibit the transcription (triple helix) and/or translation (antisense, ribozyme) of mRNA produced by normal target gene alleles such that the possibility can arise wherein the concentration of normal target gene product present can be lower than is necessary for a normal phenotype. In such cases, to ensure that substantially normal levels of target gene activity are maintained, nucleic acid molecules that encode and express target gene polypeptides exhibiting normal target gene activity can be introduced into cells via gene therapy method. Alternatively, in instances in which the target gene encodes an extracellular protein, it can be preferable to co-administer normal target gene protein into the cell or tissue in order to maintain the requisite level of cellular or tissue target gene activity.

Anti-sense RNA and DNA, ribozyme and triple helix molecules of the invention can be prepared by any method known in the art for the synthesis of DNA and RNA molecules. These include techniques for chemically synthesizing oligodeoxyribonucleotides and oligoribonucleotides well known in the art such as, for example, solid phase phosphoramidite chemical synthesis. Alternatively, RNA molecules can be generated by in vitro and in vivo transcription of DNA sequences encoding the antisense RNA molecule. Such DNA sequences can be incorporated into a wide variety of vectors which incorporate suitable RNA polymerase promoters such as the T7 or SP6 polymerase promoters. Alternatively, antisense cDNA constructs that synthesize antisense RNA constitutively or inducibly, depending on the promoter used, can be introduced stably into cell lines.

Various well-known modifications to the DNA molecules can be introduced as a means of increasing intracellular stability and half-life. Possible modifications include but are not limited to the addition of flanking sequences of ribo- or deoxy-nucleotides to the 5′ and/or 3′ ends of the molecule or the use of phosphorothioate or 2′ O-methyl rather than phosphodiesterase linkages within the oligodeoxyribonucleotide backbone.

Antibodies can be generated which are both specific for target gene product and which reduce target gene product activity. Such antibodies may, therefore, by administered in instances whereby negative modulatory techniques are appropriate for the treatment of prostate cancer. Antibodies can be generated using standard techniques against the proteins themselves or against peptides corresponding to portions of the proteins. The antibodies include but are not limited to polyclonal, monoclonal, Fab fragments, single chain antibodies, chimeric antibodies, and the like.

In instances where the target gene protein to which the antibody is directed is intracellular and whole antibodies are used, internalizing antibodies can be preferred. However, lipofectin or liposomes can be used to deliver the antibody or a fragment of the Fab region which binds to the target gene epitope into cells. Where fragments of the antibody are used, the smallest inhibitory fragment which binds to the target protein's binding domain is preferred. For example, peptides having an amino acid sequence corresponding to the domain of the variable region of the antibody that binds to the target gene protein can be used. Such peptides can be synthesized chemically or produced via recombinant DNA technology using methods well known in the art (e.g., see Creighton, 1983, supra; and Sambrook et al., 1989, supra). Alternatively, single chain neutralizing antibodies which bind to intracellular target gene product epitopes can also be administered. Such single chain antibodies can be administered, for example, by expressing nucleotide sequences encoding single-chain antibodies within the target cell population by utilizing, for example, techniques such as those described in Marasco et al. (1993, Proc. Natl. Acad. Sci. USA 90:7889-7893).

b) Positive Modulatory Techniques

As discussed above, successful treatment of prostate cancer symptoms can be brought about by techniques which serve to increase the level of target gene expression or to increase the activity of a target gene product.

For example, compounds, e.g., compounds identified through assays described, which prove to exhibit positive modulatory activity can be used in accordance with the invention to ameliorate prostate cancer symptoms. Such molecules can include, but are not limited to, peptides, phosphopeptides, small organic or inorganic molecules, or antibodies (including, for example, polyclonal, monoclonal, humanized, anti-idiotypic, chimeric or single chain antibodies, and FAb, F(ab′)₂ and FAb expression library fragments, and epitope-binding fragments thereof).

For example, a target gene protein, at a level sufficient to ameliorate prostate cancer symptoms can be administered to a patient exhibiting such symptoms. One of skill in the art will readily know how to determine the concentration of effective, non-toxic doses of the normal target gene protein.

In instances wherein the compound to be administered is a peptide compound, DNA sequences encoding the peptide compound can, alternatively, be directly administered to a patient exhibiting prostate cancer symptoms, at a concentration sufficient to generate the production of an amount of target gene product adequate to ameliorate prostate cancer symptoms. The DNA molecules can be produced, for example, by well-known recombinant techniques.

In the case of peptide compounds which act extracellularly, the DNA molecules encoding such peptides can be taken up and expressed by any cell type, so long as a sufficient circulating concentration of peptide results for the elicitation of a reduction in prostate cancer symptoms.

In the case of compounds which act intracellularly, the DNA molecules encoding such peptides must be taken up and expressed by cells involved in the prostate cancer at a sufficient level to bring about the reduction of prostate cancer symptoms.

Any technique which serves to selectively administer DNA molecules to a cell involved in prostate cancer is, therefore, preferred for the DNA molecules encoding intracellularly acting peptides.

Further, patients can be treated for symptoms of prostate cancer by gene replacement therapy. One or more copies of a normal target gene or a portion of the gene that directs the production of a normal target gene protein with target gene function can be inserted into cells, using vectors which include, but are not limited, to adenovirus, adeno-associated virus, and retrovirus vectors, in addition to other particles that introduce DNA into cells, such as liposomes. Techniques such as those described above can be utilized for the introduction of normal target gene sequences into human cells.

In instances wherein the target gene encodes an extracellular, secreted gene product, such gene replacement techniques may be accomplished either in vivo or in vitro. For such cases, the cell types expressing the target gene is less important than achieving a sufficient circulating concentration of the extracellular molecules for the amelioration of prostate cancer symptoms to occur. In vitro, target gene sequences can be introduced into autologous cells. Those cells expressing the target gene sequence of interest can then be reintroduced, preferably by intravenous administration, into the patient such that there results an amelioration of prostate cancer symptoms.

In instances wherein the gene replacement involves a gene which encodes a product which acts intracellularly, it is preferred that gene replacement be accomplished in vivo. Further, because the cell type in which the gene replacement must occur is the cell type involved in prostate cancer, such techniques must successfully target such prostate cancer cells.

VII. Therapeutic Treatment

The identified compounds that inhibit target gene expression, synthesis and/or activity can be administered to a patient at therapeutically effective doses to prevent, treat or ameliorate prostate cancer. A therapeutically effective dose refers to that amount of the compound sufficient to result in amelioration of symptoms of prostate cancer.

a) Effective Dose

Toxicity and therapeutic efficacy of such compounds can be determined by standard pharmaceutical procedures in cell cultures or experimental animals, e.g., for determining the LD₅₀ (the dose lethal to 50% of the population) and the ED₅₀ (the dose therapeutically effective in 50% of the population). The dose ratio between toxic and therapeutic effects is the therapeutic index and it can be expressed as the ratio LD₅₀/ED₅₀. Compounds which exhibit large therapeutic indices are preferred. While compounds that exhibit toxic side effects can be used, care should be taken to design a delivery system that targets such compounds to the site of affected-tissue in order to minimize potential damage to uninfected cells and, thereby, reduce side effects.

The data obtained from the cell culture assays and animal studies can be used in formulating a range of dosage for use in humans. The dosage of such compounds lies preferably within a range of circulating concentrations that include the ED₅₀ with little or no toxicity. The dosage can vary within this range depending upon the dosage form employed and the route of administration utilized. For any compound used in the method of the invention, the therapeutically effective dose can be estimated initially from cell culture assays. A dose can be formulated in animal models to achieve a circulating plasma concentration range that includes the IC₅₀ (i.e., the concentration of the test compound which achieves a half-maximal inhibition of symptoms) as determined in cell culture. Such information can be used to more accurately determine useful doses in humans. Levels in plasma can be measured, for example, by high performance liquid chromatography.

b) Formulations and Use

Pharmaceutical compositions for use in accordance with the present invention can be formulated in conventional manner using one or more physiologically acceptable carriers or excipients.

Thus, the compounds and their physiologically acceptable salts and solvates can be formulated for administration by inhalation or insufflation (either through the mouth or the nose) or oral, buccal, parenteral or rectal administration.

For oral administration, the pharmaceutical compositions can take the form of, for example, tablets or capsules prepared by conventional means with pharmaceutically acceptable excipients such as binding agents (e.g., pregelatinised maize starch, polyvinylpyrrolidone or hydroxypropyl methylcellulose); fillers (e.g., lactose, microcrystalline cellulose or calcium hydrogen phosphate); lubricants (e.g., magnesium stearate, talc or silica); disintegrants (e.g., potato starch or sodium starch glycolate); or wetting agents (e.g., sodium lauryl sulphate). The tablets can be coated by methods well known in the art. Liquid preparations for oral administration can take the form of, for example, solutions, syrups or suspensions, or they can be presented as a dry product for constitution with water or other suitable vehicle before use. Such liquid preparations can be prepared by conventional means with pharmaceutically acceptable additives such as suspending agents (e.g., sorbitol syrup, cellulose derivatives or hydrogenated edible fats); emulsifying agents (e.g., lecithin or acacia); non-aqueous vehicles (e.g., almond oil, oily esters, ethyl alcohol or fractionated vegetable oils); and preservatives (e.g., methyl or propyl-p-hydroxybenzoates or sorbic acid). The preparations can also contain buffer salts, flavoring, coloring and sweetening agents as appropriate.

Preparations for oral administration can be suitably formulated to give controlled release of the active compound.

For buccal administration the compositions can take the form of tablets or lozenges formulated in conventional manner.

For administration by inhalation, the compounds for use according to the present invention are conveniently delivered in the form of an aerosol spray presentation from pressurized packs or a nebulizer, with the use of a suitable propellant, e.g., dichlorodifluoromethane, trichlorofluoromethane, dichlorotetrafluoroethane, carbon dioxide or other suitable gas. In the case of a pressurized aerosol the dosage unit can be determined by providing a valve to deliver a metered amount. Capsules and cartridges of e.g., gelatin for use in an inhaler or insufflator can be formulated containing a powder mix of the compound and a suitable powder base such as lactose or starch.

The compounds can be formulated for parenteral administration by injection, e.g., by bolus injection or continuous infusion. Formulations for injection can be presented in unit dosage form, e.g., in ampoules or in multi-dose containers, with an added preservative. The compositions can take such forms as suspensions, solutions or emulsions in oily or aqueous vehicles, and can contain formulatory agents such as suspending, stabilizing and/or dispersing agents. Alternatively, the active ingredient can be in powder form for constitution with a suitable vehicle, e.g., sterile pyrogen-free water, before use.

The compounds can also be formulated in rectal compositions such as suppositories or retention enemas, e.g., containing conventional suppository bases such as cocoa butter or other glycerides.

In addition to the formulations described previously, the compounds can also be formulated as a depot preparation. Such long acting formulations can be administered by implantation (for example, subcutaneously or intramuscularly) or by intramuscular injection. Thus, for example, the compounds can be formulated with suitable polymeric or hydrophobic materials (for example as an emulsion in an acceptable oil) or ion exchange resins, or as sparingly soluble derivatives, for example, as a sparingly soluble salt.

The compositions can, if desired, be presented in a pack or dispenser device which can contain one or more unit dosage forms containing the active ingredient. The pack can for example comprise metal or plastic foil, such as a blister pack. The pack or dispenser device can be accompanied by instructions for administration.

Other Embodiments

The present invention is not to be limited in scope by the specific embodiments described which are intended as single illustrations of individual aspects of the invention and functionally equivalent methods and components are within the scope of the invention, in addition to those shown and described herein will become apparent to those skilled in the art from the foregoing description and accompanying drawings. Such modifications are intended to fall within the scope of the appended claims.

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ataccaccaa 1680 gaggaaaata ttgacaagtt taaaggctgt gtcattgggc catgtttaag tgtactggat 1740 ttaactacct ttggcttaat tccaatcatt gttaaagtaa aaacaattca aagaatcacc 1800 taattaattt cagtaagatc aagctccatc ttatttgtca gtgtagatca actcatgtta 1860 attgatagaa taaagccttg tgatcacttt ctgaaattca caaagttaaa cgtgatgtgc 1920 tcatcagaaa c 1931 2 5508 DNA Homo sapiens 2 gattttaggt gatgggcaag tcagaaagtc agatggatat aactgatatc aacactccaa 60 agccaaagaa gaaacagcga tggactcgac tggagatcag cctctcggtc cttgtcctgc 120 tcctcaccat catagctgtg agaatgatcg cactctatgc aacctacgat gatggtattt 180 gcaagtcatc agactgcata aaatcagctg ctcgactgat ccaaaacatg gatgccacca 240 ctgagccttg tagagacttt ttcaaatatg cttgcggagg ctggttgaaa cgtaatgtca 300 ttcccgagac cagctcccgt tacggcaact ttgacatttt aagagatgaa ctagaagtcg 360 ttttgaaaga tgtccttcaa gaacccaaaa ctgaagatat agtagcagtg cagaaagcaa 420 aagcattgta caggtcttgt ataaatgaat ctgctattga tagcagaggt ggagaacctc 480 tactcaaact gttaccagac atatatgggt ggccagtagc aacagaaaac tgggagcaaa 540 aatatggtgc ttcttggaca gctgaaaaag ctattgcaca actgaattct aaatatggga 600 aaaaagtcct tattaatttg tttgttggca ctgatgataa gaattctgtg aatcatgtaa 660 ttcatattga ccaacctcga cttggcctcc cttctagaga ttactatgaa tgcactggaa 720 tctataaaga ggcttgtaca gcatatgtgg attttatgat ttctgtggcc agattgattc 780 gtcaggaaga aagattgccc atcgatgaaa accagcttgc tttggaaatg aataaagtta 840 tggaattgga aaaagaaatt gccaatgcta cggctaaacc tgaagatcga aatgatccaa 900 tgcttctgta taacaagatg agattggccc agatccaaaa taacttttca ctagagatca 960 atgggaagcc attcagctgg ttgaatttca caaatgaaat catgtcaact gtgaatatta 1020 gtattacaaa tgaggaagat gtggttgttt atgctccaga atatttaacc aaacttaagc 1080 ccattcttac caaatattct gccagagatc ttcaaaattt aatgtcctgg agattcataa 1140 tggatcttgt aagcagcctc agccgaacct acaaggagtc cagaaatgct ttccgcaagg 1200 ccctttatgg tacaacctca gaaacagcaa cttggagacg ttgtgcaaac tatgtcaatg 1260 ggaatatgga aaatgctgtg gggaggcttt atgtggaagc agcatttgct ggagagagta 1320 aacatgtggt cgaggatttg attgcacaga tccgagaagt ttttattcag actttagatg 1380 acctcacttg gatggatgcc gagacaaaaa agagagctga agaaaaggcc ttagcaatta 1440 aagaaaggat cggctatcct gatgacattg tttcaaatga taacaaactg aataatgagt 1500 acctcgagtt gaactacaaa gaagatgaat acttcgagaa cataattcaa aatttgaaat 1560 tcagccaaag taaacaactg aagaagctcc gagaaaaggt ggacaaagat gagtggataa 1620 gtggagcagc tgtagtcaat gcattttact cttcaggaag aaatcagata gtcttcccag 1680 ccggcattct gcagcccccc ttctttagtg cccagcagtc caactcattg aactatgggg 1740 gcatcggcat ggtcatagga cacgaaatca cccatggctt cgatgacaat ggcagaaact 1800 ttaacaaaga tggagacctc gttgactggt ggactcaaca gtctgcaagt aactttaagg 1860 agcaatccca gtgcatggtg tatcagtatg gaaacttttc ctgggacctg gcaggtggac 1920 agcaccttaa tggaattaat acactgggag aaaacattgc tgataatgga ggtcttggtc 1980 aagcatacag agcctatcag aattatatta aaaagaatgg cgaagaaaaa ttacttcctg 2040 gacttgacct aaatcacaaa caactatttt tcttgaactt tgcacaggtg tggtgtggaa 2100 cctataggcc agagtatgcg gttaactcca ttaaaacaga tgtgcacagt ccaggcaatt 2160 tcaggattat tgggactttg cagaactctg cagagttttc agaagccttt cactgccgca 2220 agaattcata catgaatcca gaaaagaagt gccgggtttg gtgatcttca aaagaagcat 2280 tgcagccctt ggctagactt gccaacacca cagaaatggg gaattctcta atcgaaagaa 2340 aatgggccct aggggtcact gtactgactt gagggtgatt aacagagagg gcaccatcac 2400 aatacagata acattaggtt gtcctagaaa gggtgtggag ggaggaaggg ggtctaaggt 2460 ctatcaagtc aatcatttct cactgtgtac ataatgctta atttctaaag ataatattac 2520 tgtttatttc tgtttctcat atggtctacc agtttgctga tgtccctaga aaacaatgca 2580 aaacctttga ggtagaccag gatttctaat caaaagggaa aagaagatgt tgaagaatag 2640 agttaggcac cagaagaaga gtaggtgaca ctatagttta aaacacattg cctaactact 2700 agtttttact tttatttgca acatttacag tccttcaaaa tccttccaaa gaattcttat 2760 acacattggg gccttggagc ttacatagtt ttaaactcat ttttgccata catcagttat 2820 tcattctgtg atcatttatt ttaagcactc ttaaagcaaa aaatgaatgt ctaaaattgt 2880 tttttgttgt acctgctttg actgatgctg agattcttca ggcttcctgc aattttctaa 2940 gcaatttctt gctctatctc tcaaaacttg gtatttttca gagatttata taaatgtaaa 3000 aataataatt tttatattta attattaact acatttatga gtaactatta ttataggtaa 3060 tcaatgaata ttgaagtttc agcttaaaat aaacagttgt gaaccaagat ctataaagcg 3120 atatacagat gaaaatttga gactatttaa acttataaat catattgatg aaaagattta 3180 agcacaaact ttagggtaaa aattgcgatt ggacagttgt ctagagatat atatacttgt 3240 ggttttcaaa ttggactttc aaaattaaat ctgtccctga gagtgtctct gataaaaggg 3300 caaatctgca cctatgtagc tctgcatctc ctgtcttttc aggtttgtca tcagatggaa 3360 atattttgat aataaattga aattgtgaac tcattgctcc ctaagactgt gacaactgtc 3420 taactttaga agtgcatttc tgaatagaaa tgggaggcct ctgatggacc ttctagaatt 3480 ataagtcaca aagagttctg gaaaagaact gtttactgct tgataggaat tcatcttttg 3540 aggcttctgt tcctctcttt tcctgttgta ttgactattt tcgttcatta cttgattaag 3600 attttacaaa agaggagcac ttccaaaatt cttatttttc ctaacaaaag atgaaagcag 3660 ggaatttcta tctaaatgat gagtattagt tccctgtctc ttgaaaaatg cccatttgcc 3720 tttaaaaaaa aaagttacag aaatactata acatatgtac ataaattgca taaagcataa 3780 gtatacagtt caataaactt aactttaact gaacaatggc cctgtagcca gcacctgtaa 3840 gaaacagagc agtaccagcg ctctaaaagc acctccttgt cactttatta ctcccagaac 3900 aacaactatc ctgacttcta atatcattca ctagctttgc ctggttttgt cttttatgca 3960 gatagaatca atcagtatgt attcttttgt gcctggcttc tttctctcag ccttacattt 4020 gtgagattcc tctgtattgt gctgattgtg gatcttttca ttctcattgc agaataatgt 4080 tctattgtgg gacttattac aatttgttca tcctattgtt gatgggcact tgagaacttt 4140 ccattttggc gctattacaa atagtgcaac tatgaatgta ctgcatgtta ccatcttact 4200 tgagccttta atggacttat ttcttcaaat ccttccaaaa attattataa gcattgaaat 4260 tatagtttca agccaactgt ggataccctt accctttcct cctttatcac aaccaccgtt 4320 acaagtatac ttatatttcc ctaaaataca tttaaaactt acctaagtga catttgtagt 4380 tggagtaata ggagcttcca gctctaataa aacagctgtc tctaacttat tttatttcca 4440 tcatgtcaga gcaggtgaag agccagaagt gaagagtgac tagtacaaat tataaaaagc 4500 cactagactc ttcactgtta gctttttaaa acattaggct cccatcccta tggaggaaca 4560 actctccagt gcctggatcc cctctgtcta caaatataag attttctggg cctaaaggat 4620 agatcaaagt caaaaatagc aatgcctccc tatccctcac acatccagac atcatgaatt 4680 ttacatggta ctcttgttga gttctataga gccttctgat gtctctaaag cactaccgat 4740 tctttggagt tgtcacatca gataagacat atctctaatt ccatccataa atccagttct 4800 actatggctg agttctggtc aaagaaagaa agtttagaag ctgagacaca aagggttggg 4860 agctgatgaa actcacaaat gatggtagga agaagctctc gacaataccc gttggcaagg 4920 agtctgcctc catgctgcag tgttcgagtg gattgtaggt gcaagatgga aaggattgta 4980 ggtgcaagct gtccagagaa aagagtcctt gttccagccc tattctgcca ctcctgacag 5040 ggtgaccttg ggtatttgca atattccttt gggcctctgc ttctctcacc taaaaaaaga 5100 gaattagatt atattggtgg ttctcagcaa gagaaggagt atgtgtccaa tgctgccttc 5160 ccatgaatct gtctcccagt tatgaatcag tgggcaggat aaactgaaaa ctcccattta 5220 agtgtctgaa tcgagtgaga caaaatttta gtccaaataa caagtaccaa agttttatca 5280 agtttgggtc tgtgctgctg ttactgttaa ccatttaagt ggggcaaaac cttgctaatt 5340 ttctcaaaag catttatcat tcttgttgcc acagctggag ctctcaaact aaaagacatt 5400 tgttattttg gaaagaagaa agactctatt ctcaaagttt cctaatcaga aatttttatc 5460 agtttccagt ctcaaaaata caaaataaaa acaaacgttt ttaatact 5508 3 1050 DNA Homo sapiens 3 gggggggggg ggcacttggc ttcaaagctg gctcttggaa attgagcgga gacgagcggc 60 ttgttgtagc tgccgtgcgg ccgccgcgga ataataagcc gggatctacc ataccattga 120 ctaactatgg aagattatac caaaatagag aaaattggag aaggtaccta tggagttgtg 180 tataagggta gacacaaaac tacaggtcaa gtggtagcca tgaaaaaaat cagactagaa 240 agtgaagagg aaggggttcc tagtactgca attcgggaaa tttctctatt aaaggaactt 300 cgtcatccaa atatagtcag tcttcaggat gtgcttatgc aggattccag gttatatctc 360 atctttgagt ttctttccat ggatctgaag aaatacttgg attctatccc tcctggtcag 420 tacatggatt cttcacttgt taagagttat ttataccaaa tcctacaggg gattgtgttt 480 tgtcactcta gaagagttct tcacagagac ttaaaacctc aaaatctctt gattgatgac 540 aaaggaacaa ttaaactggc tgattttggc cttgccagag cttttggaat acctatcaga 600 gtatatacac atgaggtagt aacactctgg tacagatctc cagaagtatt gctggggtca 660 gctcgttact caactccagt tgacatttgg agtataggca ccatatttgc tgaactagca 720 actaagaaac cacttttcca tggggattca gaaattgatc aactcttcag gattttcaga 780 gctttgggca ctcccaataa tgaagtgtgg ccagaagtgg aatctttaca ggactataag 840 aatacatttc ccaaatggaa accaggaagc ctagcatccc atgtcaaaaa cttggatgaa 900 aatggcttgg atttgctctc gaaaatgtta atctatgatc cagccaaacg aatttctggc 960 aaaatggcac tgaatcatcc atattttaat gatttggaca atcagattaa gaagatgtag 1020 ctttctgaca aaaagtttcc atatgttatg 1050 4 1249 DNA Homo sapiens 4 gaattccgta aagctagacc gatctccggg gagccccgag taggcgagcg gcggccgagc 60 tagttgagcg caccccccgg gcgccccagc gcgccgcggc gggcgcgtcc aggcggcatg 120 gagaaggacg gcctgtgccg cgctgaccag cagtacgaat gcgtggcgga gatcggggag 180 ggcgcctatg ggaaggtgtt caaggcccgc gacttgaaga acggaggccg tttcgtggcg 240 ttgaagcgcg tgcgggtgca gaccggcgag gagggcatgc cgctctccac catccgcgag 300 gtggcggtgc tgaggcacct ggagaccttc gagcacccca acgtggtcag gttgtttgat 360 gtgtgcacag tgtcacgaac agacagagaa accaaactaa ctttagtgtt tgaacatgtc 420 gatcaagact tgaccactta cttggataaa gttccagagc ctggagtgcc cactgaaacc 480 ataaaggata tgatgtttca gcttctccga ggtctggact ttcttcattc acaccgagta 540 gtgcatcgcg atctaaaacc acagaacatt ctggtgacca gcagcggaca aataaaactc 600 gctgacttcg gccttgcccg catctatagt ttccagatgg ctctaacctc agtggtcgtc 660 acgctgtggt acagagcacc cgaagtcttg ctccagtcca gctacgccac ccccgtggat 720 ctctggagtg ttggctgcat atttgcagaa atgtttcgta gaaagcctct ttttcgtgga 780 agttcagatg ttgatcaact aggaaaaatc ttggacgtga ttggactccc aggagaagaa 840 gactggccta gagatgttgc ccttcccagg caggcttttc attcaaaatc tgcccaacca 900 attgagaagt ttgtaacaga tatcgatgaa ctaggcaaag acctacttct gaagtgtttg 960 acatttaacc cagccaaaag aatatctgcc tacagtgccc tgtctcaccc atacttccag 1020 gacctggaaa ggtgcaaaga aaacctggat tcccacctgc cgcccagcca gaacacctcg 1080 gagctgaata cagcctgagg cctcagcagc cgccttaagc tgatcctgcg gagaacaccc 1140 ttggtggctt atgggtcccc ctcagcaagc cctacagagc tgtggaggat tgctatctgg 1200 aggccttcca gctgctgtct tctggacagg ctctgcttct ccaaggaaa 1249 5 4775 DNA Homo sapiens 5 acccgcgcga ggtaggcgct ctggtgcttg cggaggacgc ttccttcctc agatgcaccg 60 atcttcccga tactgccttt ggagcggcta gattgctagc cttggctgct ccattggcct 120 gccttgcccc ttacctgccg attgcatatg aactcttctt ctgtctgtac atcgttgtcg 180 tcggagtcgt cgcgatcgtc gtggcgctcg tgtgatggcc ttcgtccgtt tagagtagtg 240 tagttagtta ggggccaacg aagaagaaag aagacgcgat tagtgcagag atgctggagg 300 tggtcagtta ctaagctaga gtaagatagc ggagcgaaaa gagccaaacc tagccggggg 360 gcgcacggtc acccaaagga ggtcgactcg ccggcgcttc ctatcgcgcc gagctccctc 420 cattcctctc cctccgccga ggcgcgaggt tgcggcgcgc agcgcagcgc agctcagcgc 480 accgactgcc gcgggctccg ctgggcgatt gcagccgagt ccgtttctcg tctagctgcc 540 gccgcggcga ccgctgcctg gtcttcctcc cggacgctag tgggttatca gctaacaccc 600 gcgagcatct ataacatagg ccaactgacg ccatccttca aaaacaacta aaggatgata 660 tgatgaacct agcctgttaa tttcgtcttc tcaattttaa actttggttg cttaagactg 720 aagcaatcat ggtgaacctg aggaatgcgg tgcattcatt ccttgtgcac ctaattggcc 780 tattggtttg gcaatgtgat atttctgtga gcccagtagc agctatagta actgacattt 840 tcaatacctc cgatggtgga cgcttcaaat tcccagacgg ggtacaaaac tggccagcac 900 tttcaatcgt catcataata atcatgacaa taggtggcaa catccttgtg atcatggcag 960 taagcatgga aaagaaactg cacaatgcca ccaattactt cttaatgtcc ctagccattg 1020 ctgatatgct agtgggacta cttgtcatgc ccctgtctct cctggcaatc ctttatgatt 1080 atgtctggcc actacctaga tatttgtgcc ccgtctggat ttctttagat gttttatttt 1140 caacagcgtc catcatgcac ctctgcgcta tatcgctgga tcggtatgta gcaatacgta 1200 atcctattga gcatagccgt ttcaattcgc ggactaaggc catcatgaag attgctattg 1260 tttgggcaat ttctataggt gtatcagttc ctatccctgt gattggactg agggacgaag 1320 aaaaggtgtt cgtgaacaac acgacgtgcg tgctcaacga cccaaatttc gttcttattg 1380 ggtccttcgt agctttcttc ataccgctga cgattatggt gattacgtat tgcctgacca 1440 tctacgttct gcgccgacaa gctttgatgt tactgcacgg ccacaccgag gaaccgcctg 1500 gactaagtct ggatttcctg aagtgctgca agaggaatac ggccgaggaa gagaactctg 1560 caaaccctaa ccaagaccag aacgcacgcc gaagaaagaa gaaggagaga cgtcctaggg 1620 gcaccatgca ggctatcaac aatgaaagaa aagcttcgaa agtccttggg attgttttct 1680 ttgtgtttct gatcatgtgg tgcccatttt tcattaccaa tattctgtct gttctttgtg 1740 agaagtcctg taaccaaaag ctcatggaaa agcttctgaa tgtgtttgtt tggattggct 1800 atgtttgttc aggaatcaat cctctggtgt atactctgtt caacaaaatt taccgaaggg 1860 cattctccaa ctatttgcgt tgcaattata aggtagagaa aaagcctcct gtcaggcaga 1920 ttccaagagt tgccgccact gctttgtctg ggagggagct taatgttaac atttatcggc 1980 ataccaatga accggtgatc gagaaagcca gtgacaatga gcccggtata gagatgcaag 2040 ttgagaattt agagttacca gtaaatccct ccagtgtggt tagcgaaagg attagcagtg 2100 tgtgagaaag aacagcacag tcttttccta cggtacaagc tacatatgta ggaaaatttt 2160 cttctttaat ttttctgttg gtcttaacta atgtaaatat tgctgtctga aaaagtgttt 2220 ttacatatag ctttgcaacc ttgtacttta caatcatgcc tacattagtg agatttaggg 2280 ttctatattt actgtttata ataggtggag actaacttat tttgattgtt tgatgaataa 2340 aatgtttatt tttgctctcc ctcccttctt tccttccttt tttcctttct tccttccttt 2400 ctctctttct tttgtgcata tggcaacgtt catgttcatc tcaggtggca tttgcaggtg 2460 accagaatga ggcacatgac agtggttata tttcaaccac acctaaatta acaaattcag 2520 tggacatttg ttctgggtta acagtaaata tacactttac attcttgctc tgctcatcta 2580 cacatataaa cacagtaaga taggttctgc tttctgatac atctgtcagt gagtcagagg 2640 cagaacctag tcttgttgtt catatagggg caaaaatttg acattgtcag aatgttgtgt 2700 tggtatttac tgcaatgtct gtccctaaac atagtggtat tttaacatag cagctggtta 2760 accgggacta cagaagtgga aggataatga gatgtaatac accaaatagc ttttcacttc 2820 ttaaggacag tgttcaaatt ctgattatta caacaagcaa actgaaatta gtgttttcat 2880 tctggtcctt agtaaattcc taattctatg attaaactgg gaaatgagat cccagagtta 2940 tttcccaacc caggattcaa catcaattgg gttttgatct cagcatcctg gaaatttgtg 3000 tgcttcacac aaagtgaaat tagtattttg agccttatta aaatattttc ttaattatgg 3060 tacctctgtc tataggactt aatttagcag tccatttttg agtaaaactt gtattggaag 3120 tatagatggt agaaactttg gaagttttac ttgattaagg actacagaat tgggccctta 3180 gaatgtgaaa aaaaaaagta attaaaaaga cacttttacc gaactcggga ttacagaaac 3240 acggagtttc catttggatt ttaaacaaaa tttatgtcat tttcagatcc ttccaaactc 3300 tctagtgcag gaaaaggctg cagctaattt gtgaaagtgg caagctcttc attgcactgc 3360 agttatttac cagaagttta aatctttgtt aaaatatagt gttgtgttac aataagtgtt 3420 ggccatcatt tcattcgtgg gcctgctgct ctctaagaat tcagtagcat tttaatagtt 3480 tctaaaccat gaaaagtttt caagcattgc taaagtcagg ccattcagtc tatgctgtgt 3540 gcagagtata caagtgtttc tagtaacagt atttccatac gtgcccattt cacacaactg 3600 tggataaatt ttggaagaat tcatgatgct agttcttacg cttgacagtt acttacacac 3660 ctgagaatgt gcctctcagt atcttaaaat tggttaatga aaaatctgaa tttctaaaac 3720 ccttggtctg tgttctcaac acacagtata gataaatcca atagtctgcc acaagggcag 3780 tggaagagct gctgtatttg aggaaactca tacagtctct atttgatttg caacactggc 3840 caaacatcag tcatttgctt gagcatgccc aaatattaca tgaaagtcaa gtctacctgc 3900 cttgcctgtt aggtctgttg aagtgcatgt taaaataatt atatgaagca gaatgagatg 3960 atttaattct taccgaaatg aaaatggctg aagaaacaca gcatgcattt agcatgagtt 4020 ctgcacatac agatggtgtc ctgcatgtat gccatgtatg ttgcatgaat ccatcgattt 4080 gtattaatgt agggcagaat agctgataga agaaggactg aagaaaatcc ttcagcaatc 4140 cttaaaaaga ccatgcattc agatctgaag tagtgtgagt gttagaaaaa actggaaaca 4200 tctgatttct gaactatcag ggcaagctca tagcacatgt tttacaaaga aacaaaatat 4260 aaatcacaga tttccaaaag tactagcaat aagttgaatg ataatagctc acagcacatt 4320 tgttaatgat tcttgtgtca tcaagtagta gtacttaata gtacccaacc tggtaattat 4380 cctcaagttg tgtgctattc gtaagttctg tgcagtttgg tatgaaacaa atatactcat 4440 ttggatataa atcttaccct tcaatgttaa atctacaaac ttttataaat gttttaaaga 4500 agtccatgtg ataattgtaa aggtgatgaa tttaccatca aacaaatcat tttgatgtat 4560 tattatatat gtatatctgt gtaagacacg tgcaacagac tgccttatat tattttctgt 4620 aattcttctc ctttgtcaaa tggtattttt tgtgaatggt tgcaaagtgt tgtcttattc 4680 ctaattcctg tatgttatcc actacaggtt ttatgagact tcctattaat ttattaaatt 4740 tattaaatgt tgaaaaaaaa aaaaaaaaaa aaaaa 4775 6 2616 DNA Homo sapiens 6 atggcggctc ctcccactgg ggggggggtg gcgcggcggc ggtggcatct gcggccatgg 60 cggcgactac tgccaacccc gaaatgacat cagatgtacc atcactgggt ccagccattg 120 cctctggaaa ctctggacct ggaattcaag gtggaggagc cattgtccag agggctatta 180 agcggcgacc agggctggat tttgatgatg atggagaagg gaacagtaaa tttttgaggt 240 gtgatgatga tcagatgtct aacgataagg agcggtttgc caggtcggat gatgagcaga 300 gctctgcgga taaagagaga cttgccaggg aaaatcacag tgaaattgaa cggcggcgac 360 ggaacaagat gacagcctac atcacagaac tgtcagatat ggtacccacc tgtagtgccc 420 tggctcgaaa accagacaag ctaaccatct tacgcatggc agtttctcac atgaagtcct 480 tgcggggaac tggcaacaca tccactgatg gctcctataa gccgtctttc ctcactgatc 540 aggaactgaa acatttgatc ttggaggcag cagatggctt tctgtttatt gtctcatgtg 600 agacaggcag ggtggtgtat gtgtctgact ccgtgactcc tgttttgaac cagccacagt 660 ctgaatggtt tggcagcaca ctctatgatc aggtgcaccc agatgatgtg gataaacttc 720 gtgagcagct ttccacttca gaaaatgccc tgacagggcg tatcctggat ctaaagactg 780 gaacagtgaa aaaggaaggt cagcagtctt ccatgagaat gtgtatgggc tcaaggagat 840 cgtttatttg ccgaatgagg tgtggcagta gctctgtgga cccagtttct gtgaataggc 900 tgagctttgt gaggaacaga tgcaggaatg gacttggctc tgtaaaggat ggggaacctc 960 acttcgtggt ggtccactgc acaggctaca tcaaggcctg gcccccagca ggtgtttccc 1020 tcccagatga tgacccagag gctggccagg gaagcaagtt ttgcctagtg gccattggca 1080 gattgcaggt aactagttct cccaactgta cagacatgag taatgtttgt caaccaacag 1140 agttcatctc ccgacacaac attgagggta tcttcacttt tgtggatcac cgctgtgtgg 1200 ctactgttgg ctaccagcca caggaactct taggaaagaa tattgtagaa ttctgtcatc 1260 ctgaagacca gcagcttcta agagacagct tccaacaggt agtgaaatta aaaggccaag 1320 tgctgtctgt catgttccgg ttccggtcta agaaccaaga atggctctgg atgagaacca 1380 gctcctttac tttccagaac ccttactcag atgaaattga gtacatcatc tgtaccaaca 1440 ccaatgtgaa gaactctagc caagaaccac ggcctacact ctccaacaca atccagaggc 1500 cacaactagg tcccacagct aatttacccc tggagatggg ctcaggacag ctggcaccca 1560 ggcagcagca acagcaaaca gaattggaca tggtaccagg aagagatgga ctggccagct 1620 acaatcattc ccaggtggtt cagcctgtga caaccacagg accagaacac agcaagcccc 1680 ttgagaagtc agatggttta tttgcccagg atagagatcc aagattttca gaaatctatc 1740 acaacatcaa tgcggatcag agtaaaggca tctcctccag cactgtccct gccacccaac 1800 agctattctc ccagggcaac acattccctc ctaccccccg gccggcagag aatttcagga 1860 atagtggcct agcccctcct gtaaccattg tccagccatc agcttctgca ggacagatgt 1920 tggcccagat ttcccgccac tccaacccca cccaaggagc aaccccaact tggaccccta 1980 ctacccgctc aggcttttct gcccagcagg tggctaccca ggctactgct aagactcgta 2040 cttcccagtt tggtgtgggc agctttcaga ctccatcctc cttcagctcc atgtccctcc 2100 ctggtgcccc aactgcatcg cctggtgctg ctgcctaccc tagtctcacc aatcgtggat 2160 ctaactttgc tcctgagact ggacagactg caggacaatt ccagacacgg acagcagagg 2220 gtgtgggtgt ctggccacag tggcagggcc agcagcctca tcatcgttca agttctagtg 2280 agcaacatgt tcaacaaccg ccagcacagc aacctggcca gcctgaggtc ttccaggaga 2340 tgctgtccat gctgggagat cagagcaaca gctacaacaa tgaagaattc cctgatctaa 2400 ctatgtttcc ccccttttca gaatagaact attggggtga ggataagggg tgggggagaa 2460 aaaatcactg tttgttttta aaaagcaaat ctttctgtaa acagaataaa agttcctctc 2520 ccttcccttc cctcacccct gacatgtacc ccctttccct tctggctgtt cccctgctct 2580 gttgcctcct aaggtaacat ttataaaaaa aaaaaa 2616 7 2392 DNA Homo sapiens 7 gcgatggaac cagcggagca gccgagcgag ttagtgtcag ccgagggccg aaaccggaag 60 gcggtgctgt gccagcgttg cggctcccgg gtgctgcagc cagggaccgc tctcttctct 120 cgccgacagc ttttccttcc ctccatgaga aagaagccag ctctgtctga cggcagcaat 180 cctgacggcg atctcctcca ggaacactgg ctggttgagg acatgttcat ttttgagaat 240 gtgggcttca ccaaggacgt gggcaacatc aagtttctgg tctgcgcaga ctgtgaaatt 300 ggaccaattg gctggcattg cctagatgac aagaacagtt tctatgtggc cttggaacga 360 gtttcccatg agtaactgag gggaggggta ctcagctcca tctccaaaga taaacctact 420 ccccacaaga actggccttt aatgtggtat aactgttccg ctgccttctt gtctgtgcca 480 atataaatac tgagtaccag catgtccatt tgaacatgca gagggttaat cctgcttcct 540 aaagcctcaa gtacatgcct cctgcttagt tcactttgta tcacatttcc taagctccct 600 tttcccccag ttttgggaca ctgtgcttac ctccaaaaat ctcatctctt ccctggcatt 660 ctccctaggc tctgttttgc ccaggggctc ccgctttttc ttgctctaga agagcagtat 720 tcaacctttt agctatgatg acacataaca aaagatgctt atgtactaat agttgaaatc 780 tgcctttttc tcattcaaga aggcatacaa atatctgaga gtgactttgt tgtatggcta 840 cccttgtgat ctacagtaat ttattctttc taaaagtaaa gcattttcaa aactcagtat 900 ttaaaccact aaccagaaac attactttgg atgcatctct aataccatgt ttgagcacct 960 ctgctctagg ttgagaatga cattttattg tgaagatggg tgtggtccct cttcccttga 1020 aatcttgtag tttcttttta tattagctcc tcactgctac agcctagaag gtgagaagca 1080 gattttaacc ccatctggca gccattcaag gaaaacccag ccctggctgt ttactcaggc 1140 tctcttagaa tgagagtgga gggtgtagga tatgagggtt aggcctttgc cacattatac 1200 aaaagtttat aatttgccac atctggacaa gtaactttct tcttttgttc ataggcaaga 1260 cttctttaat ggatagtatc atttactgaa cctactgggc atggtcctca tggagttttg 1320 gttcaactgg aatctctgtg ccaacccagg atacaaactt ccatccagat gcatggatac 1380 aaatttccat agctccgggg ctgctctaac agtttgatat cagcagacgt gtttaagcct 1440 tcaacttgat ttccaattat tccatcattt ctattctgaa atgactcact gtcgtagaag 1500 gaagtttatt atataaccaa ggtttcaggt atcctcctgt caccacctct actattcagg 1560 aggcctaaaa ttgaaataag tactaaacag aaaccttacc atctgaagtc ccttccattg 1620 ttttctagtt gcttcctcat tcctttaccc ccaaactttc taagggctcc ccgactgcag 1680 tgcaaggtgg ccttgggcac agttttgcaa ccaacctact cccctggaaa gatggcttcc 1740 ttctccaatt agcctgaatg agctttagta agcaattgag agaactgtgt ttttccgaca 1800 aacggtcaca tgtccatcgt tatggcatgt gcagaaaaac agagttatcc acacaagtca 1860 ggagcaaaac ccaagtagat gcctctaggg gcacatggcc cctcacatca caagccagaa 1920 cctaagctaa gcatttttta aattgagttt gagactagcc tgggcaacat agtgagaccc 1980 catctctatt taaaaaatga acaaaattac ctgggcatag tggtgtatac ctgtagtccc 2040 tgctacttgg gaggctcagg tgggaggatc acttgagccc caaagatggt ggctgcagta 2100 agccaagatc acaccactgg cactccagcc tgggcaacag agtgagaccc tgtctcaaac 2160 aaacaacaac agtaacaaca aaaaaatata tagcgacttg aataggaaac catagtattt 2220 cattgtttta atttgcattt attttatttc tagtgaaact tttatatacg tatcggtcat 2280 ttctatttcc ttttttgaga actgccaaat gttgccctag tagccaaaaa tatcaggttg 2340 ctattctgcc ttttcagttt gatctgaaag aaataaaggc atttaagcaa tg 2392 8 2947 DNA Homo sapiens 8 ggcgggaaac agcttagtgg gtgtggggtc gcgcattttc ttcaaccagg aggtgaggag 60 gtttcgacat ggcggtgcag ccgaaggaga cgctgcagtt ggagagcgcg gccgaggtcg 120 gcttcgtgcg cttctttcag ggcatgccgg agaagccgac caccacagtg cgccttttcg 180 accggggcga cttctatacg gcgcacggcg aggacgcgct gctggccgcc cgggaggtgt 240 tcaagaccca gggggtgatc aagtacatgg ggccggcagg agcaaagaat ctgcagagtg 300 ttgtgcttag taaaatgaat tttgaatctt ttgtaaaaga tcttcttctg gttcgtcagt 360 atagagttga agtttataag aatagagctg gaaataaggc atccaaggag aatgattggt 420 atttggcata taaggcttct cctggcaatc tctctcagtt tgaagacatt ctctttggta 480 acaatgatat gtcagcttcc attggtgttg tgggtgttaa aatgtccgca gttgatggcc 540 agagacaggt tggagttggg tatgtggatt ccatacagag gaaactagga ctgtgtgaat 600 tccctgataa tgatcagttc tccaatcttg aggctctcct catccagatt ggaccaaagg 660 aatgtgtttt acccggagga gagactgctg gagacatggg gaaactgaga cagataattc 720 aaagaggagg aattctgatc acagaaagaa aaaaagctga cttttccaca aaagacattt 780 atcaggacct caaccggttg ttgaaaggca aaaagggaga gcagatgaat agtgctgtat 840 tgccagaaat ggagaatcag gttgcagttt catcactgtc tgcggtaatc aagtttttag 900 aactcttatc agatgattcc aactttggac agtttgaact gactactttt gacttcagcc 960 agtatatgaa attggatatt gcagcagtca gagcccttaa cctttttcag ggttctgttg 1020 aagataccac tggctctcag tctctggctg ccttgctgaa taagtgtaaa acccctcaag 1080 gacaaagact tgttaaccag tggattaagc agcctctcat ggataagaac agaatagagg 1140 agagattgaa tttagtggaa gcttttgtag aagatgcaga attgaggcag actttacaag 1200 aagatttact tcgtcgattc ccagatctta accgacttgc caagaagttt caaagacaag 1260 cagcaaactt acaagattgt taccgactct atcagggtat aaatcaacta cctaatgtta 1320 tacaggctct ggaaaaacat gaaggaaaac accagaaatt attgttggca gtttttgtga 1380 ctcctcttac tgatcttcgt tctgacttct ccaagtttca ggaaatgata gaaacaactt 1440 tagatatgga tcaggtggaa aaccatgaat tccttgtaaa accttcattt gatcctaatc 1500 tcagtgaatt aagagaaata atgaatgact tggaaaagaa gatgcagtca acattaataa 1560 gtgcagccag agatcttggc ttggaccctg gcaaacagat taaactggat tccagtgcac 1620 agtttggata ttactttcgt gtaacctgta aggaagaaaa agtccttcgt aacaataaaa 1680 actttagtac tgtagatatc cagaagaatg gtgttaaatt taccaacagc aaattgactt 1740 ctttaaatga agagtatacc aaaaataaaa cagaatatga agaagcccag gatgccattg 1800 ttaaagaaat tgtcaatatt tcttcaggct atgtagaacc aatgcagaca ctcaatgatg 1860 tgttagctca gctagatgct gttgtcagct ttgctcacgt gtcaaatgga gcacctgttc 1920 catatgtacg accagccatt ttggagaaag gacaaggaag aattatatta aaagcatcca 1980 ggcatgcttg tgttgaagtt caagatgaaa ttgcatttat tcctaatgac gtatactttg 2040 aaaaagataa acagatgttc cacatcatta ctggccccaa tatgggaggt aaatcaacat 2100 atattcgaca aactggggtg atagtactca tggcccaaat tgggtgtttt gtgccatgtg 2160 agtcagcaga agtgtccatt gtggactgca tcttagcccg agtaggggct ggtgacagtc 2220 aattgaaagg agtctccacg ttcatggctg aaatgttgga aactgcttct atcctcaggt 2280 ctgcaaccaa agattcatta ataatcatag atgaattggg aagaggaact tctacctacg 2340 atggatttgg gttagcatgg gctatatcag aatacattgc aacaaagatt ggtgcttttt 2400 gcatgtttgc aacccatttt catgaactta ctgccttggc caatcagata ccaactgtta 2460 ataatctaca tgtcacagca ctcaccactg aagagacctt aactatgctt tatcaggtga 2520 agaaaggtgt ctgtgatcaa agttttggga ttcatgttgc agagcttgct aatttcccta 2580 agcatgtaat agagtgtgct aaacagaaag ccctggaact tgaggagttt cagtatattg 2640 gagaatcgca aggatatgat atcatggaac cagcagcaaa gaagtgctat ctggaaagag 2700 agcaaggtga aaaaattatt caggagttcc tgtccaaggt gaaacaaatg ccctttactg 2760 aaatgtcaga agaaaacatc acaataaagt taaaacagct aaaagctgaa gtaatagcaa 2820 agaataatag ctttgtaaat gaaatcattt cacgaataaa agttactacg tgaaaaatcc 2880 cagtaatgga atgaaggtaa tattgataag ctattgtctg taatagtttt atattgtttt 2940 atattaa 2947 9 3805 DNA Homo sapiens 9 ggctcggctc ctagagctgc cacggccatg gccagagccc gcccgccgcc gccgccgtcg 60 ccgccgccgg ggcttctgcc gctgctccct ccgctgctgc tgctgccgct gctgctgctg 120 cccgccggct gccgggcgct ggaagagacc ctcatggaca caaaatgggt aacatctgag 180 ttggcgtgga catctcatcc agaaagtggg tgggaagagg tgagtggcta cgatgaggcc 240 atgaatccca tccgcacata ccaggtgtgt aatgtgcgcg agtcaagcca gaacaactgg 300 cttcgcacgg ggttcatctg gcggcgggat gtgcagcggg tctacgtgga gctcaagttc 360 actgtgcgtg actgcaacag catccccaac atccccggct cctgcaagga gaccttcaac 420 ctcttctact acgaggctga cagcgatgtg gcctcagcct cctccccctt ctggatggag 480 aacccctacg tgaaagtgga caccattgca cccgatgaga gcttctcgcg gctggatgcc 540 ggccgtgtca acaccaaggt gcgcagcttt gggccacttt ccaaggctgg cttctacctg 600 gccttccagg accagggcgc ctgcatgtcg ctcatctccg tgcgcgcctt ctacaagaag 660 tgtgcatcca ccaccgcagg cttcgcactc ttccccgaga ccctcactgg ggcggagccc 720 acctcgctgg tcattgctcc tggcacctgc atccctaacg ccgtggaggt gtcggtgcca 780 ctcaagctct actgcaacgg cgatggggag tggatggtgc ctgtgggtgc ctgcacctgt 840 gccaccggcc atgagccagc tgccaaggag tcccagtgcc gcccctgtcc ccctgggagc 900 tacaaggcga agcagggaga ggggccctgc ctcccatgtc cccccaacag ccgtaccacc 960 tccccagccg ccagcatctg cacctgccac aataacttct accgtgcaga ctcggactct 1020 gcggacagtg cctgtaccac cgtgccatct ccaccccgag gtgtgatctc caatgtgaat 1080 gaaacctcac tgatcctcga gtggagtgag ccccgggacc tgggtgtccg ggatgacctc 1140 ctgtacaatg tcatctgcaa gaagtgccat ggggctggag gggcctcagc ctgctcacgc 1200 tgtgatgaca acgtggagtt tgtgcctcgg cagctgggcc tgtcggagcc ccgggtccac 1260 accagccatc tgctggccca cacgcgctac acctttgagg tgcaggcggt caacggtgtc 1320 tcgggcaaga gccctctgcc gcctcgttat gcggccgtga atatcaccac aaaccaggct 1380 gccccgtctg aagtgcccac actacgcctg cacagcagct caggcagcag cctcacccta 1440 tcctgggcac ccccagagcg gcccaacgga gtcatcctgg actacgagat gaagtacttt 1500 gagaagagcg agggcatcgc ctccacagtg accagccaga tgaactccgt gcagctggac 1560 gggcttcggc ctgacgcccg ctatgtggtc caggtccgtg cccgcacagt agctggctat 1620 gggcagtaca gccgccctgc cgagtttgag accacaagtg agagaggctc tggggcccag 1680 cagctccagg agcagcttcc cctcatcgtg ggctccgcta cagctgggct tgtcttcgtg 1740 gtggctgtcg tggtcatcgc tatcgtctgc ctcaggaagc agcgacacgg ctctgattcg 1800 gagtacacgg agaagctgca gcagtacatt gctcctggaa tgaaggttta tattgaccct 1860 tttacctacg aggaccctaa tgaggctgtt cgggagtttg ccaaggagat cgacgtgtcc 1920 tgcgtcaaga tcgaggaggt gatcggagct ggggaatttg gggaagtgtg ccgtggtcga 1980 ctgaaacagc ctggccgccg agaggtgttt gtggccatca agacgctgaa ggtgggctac 2040 accgagaggc agcggcggga cttcctaagc gaggcctcca tcatgggtca gtttgatcac 2100 cccaatataa tccggctcga gggcgtggtc accaaaagtc ggccagttat gatcctcact 2160 gagttcatgg aaaactgcgc cctggactcc ttcctccggc tcaacgatgg gcagttcacg 2220 gtcatccagc tggtgggcat gttgcggggc attgctgccg gcatgaagta cctgtccgag 2280 atgaactatg tgcaccgcga cctggctgct cgcaacatcc ttgtcaacag caacctggtc 2340 tgcaaagtct cagactttgg cctctcccgc ttcctggagg atgacccctc cgatcctacc 2400 tacaccagtt ccctgggcgg gaagatcccc atccgctgga ctgccccaga ggccatagcc 2460 tatcggaagt tcacttctgc tagtgatgtc tggagctacg gaattgtcat gtgggaggtc 2520 atgagctatg gagagcgacc ctactgggac atgagcaacc aggatgtcat caatgccgtg 2580 gagcaggatt accggctgcc accacccatg gactgtccca cagcactgca ccagctcatg 2640 ctggactgct gggtgcggga ccggaacctc aggcccaaat tctcccagat tgtcaatacc 2700 ctggacaagc tcatccgcaa tgctgccagc ctcaaggtca ttgccagcgc tcagtctggc 2760 atgtcacagc ccctcctgga ccgcacggtc ccagattaca caaccttcac gacagttggt 2820 gattggctgg atgccatcaa gatggggcgg tacaaggaga gcttcgtcag tgcggggttt 2880 gcatcttttg acctggtggc ccagatgacg gcagaagacc tgctccgtat tggggtcacc 2940 ctggccggcc accagaagaa gatcctgagc agtatccagg acatgcggct gcagatgaac 3000 cagacgctgc ctgtgcaggt ctgacaccgg ctcccacggg gaccctgagg accgtgcagg 3060 gatgccaagc agccggctgg actttcggac tcttggactt ttggatgcct ggccttaggc 3120 tgtggcccag aagctggaag tttgggaaag gcccaagctg ggacttctcc aggcctgtgt 3180 tccctcccca ggaagtgcgc cccaaacctc ttcatattga agatggatta ggagaggggg 3240 tgatgacccc tccccaagcc cctcagggcc cagaccttcc tgctctccag caggggatcc 3300 ccacaacctc acacttgtct gttcttcagt gctggaggtc ctggcagggt caggctgggg 3360 taagccgggg ttccacaggg cccagccctg gcaggggtct ggccccccag gtaggcggag 3420 agcagtccct ccctcaggaa ctggaggagg ggactccagg aatggggaaa tgtgacacca 3480 ccatcctgaa gccagcttgc acctccagtt tgcacaggga tttgtcctgg gggctgaggg 3540 ccctgtcccc acccccgccc ttggtgctgt cataaaaggg caggcagggg caggctgagg 3600 agttgcccgt tgccccccag agactgactc tcagagccag agatgggatg tgtgagtgtg 3660 tgtgtgtgtg tgtgcgcgcg cgcgcgcgtg tgtgtgtgca cgcactggcc tgcacagaga 3720 gcatgggtga gcgtgtaaaa gcttggccct gtgccctaca gtggggacag ctgggccgac 3780 agcagaataa aggcaataag atgaa 3805 10 541 DNA Homo sapiens misc_feature (1)...(541) n = A,T,C or G 10 tttttttttt ttaggatatt tgnaaataca actttattnc tgnattgcta aacgcaaaag 60 gnaatgggna atgacagtaa caaacaagtt ttcaccactg naatattgtg atgtgactgc 120 agacagtctt atatatgnaa actcaaggga atcaactgcg ttccaaaaca gctaaatatg 180 caggtccaaa caatgaagtt attttttaaa ctgccacatt cactccgaag ncccactcat 240 ctccttcagg catcccacag atgaaggcac atgttccgct tagctagata ataatgaggt 300 gggcacacac gctgcaccgc tgacatcaca ggacagctgc ctataaaact agacttctga 360 cgctgggctc cagcttcatt ctcacaggtc atcatcctca tccgggagag cagttgtctg 420 agcaacctct aagtcgtgct catactgtgc tgccaaagct gggtccatga caactttggt 480 ggggcgagan agggcatggc aacaaattca agttgggttc aatgagttct gcaagcagag 540 g 541 11 1860 DNA Homo sapiens 11 cgtgaacggt cgttgcagag attgcgggcg gctgagacgc cgcctgcctg gcacctagga 60 gcgcagcgga gccccgacac cgccgccgcc gccatggagt ccgagaccga acccgagccc 120 gtcacgctcc tggtgaagag ccccaaccag cgccaccgcg acttggagct gagtggcgac 180 cgcggctgga gtgtgggcca cctcaaggcc cacctgagcc gcgtctaccc cgagcgtccg 240 cgtccagagg accagaggtt aatttattct gggaagctgt tgttggatca ccaatgtctc 300 agggacttgc ttccaaagca ggaaaaacgg catgttttgc atctggtgtg caatgtgaag 360 agtccttcaa aaatgccaga aatcaacgcc aaggtggctg aatccacaga ggagcctgct 420 ggttctaatc ggggacagta tcctgaggat tcctcaagtg atggtttaag gcaaagggaa 480 gttcttcgga acctttcttc ccctggatgg gaaaacatct caaggcctga agctgcccag 540 caggcattcc aaggcctggg tcctggtttc tccggttaca caccctatgg gtggcttcag 600 ctttcctggt tccagcagat atatgcacga cagtactaca tgcaatattt agcagccact 660 gctgcatcag gggcttttgt tccaccacca agtgcacaag agatacctgt ggtctctgca 720 cctgctccag cccctattca caaccagttt ccagctgaaa accagcctgc caatcagaat 780 gctgctcctc aagtggttgt taatcctgga gccaatcaaa atttgcggat gaatgcacaa 840 ggtggcccta ttgtggaaga agatgatgaa ataaatcgag attggttgga ttggacctat 900 tcagcagcta cattttctgt ttttctcagt atcctctact tctactcctc cctgagcaga 960 ttcctcatgg tcatgggggc caccgttgtt atgtacctgc atcacgttgg gtggtttcca 1020 tttagaccga ggccggttca gaacttccca aatgatggtc ctcctcctga cgttgtaaat 1080 caggacccca acaataactt acaggaaggc actgatcctg aaactgaaga ccccaaccac 1140 ctccctccag acagggatgt actagatggc gagcagacca gcccctcctt tatgagcaca 1200 gcatggcttg tcttcaagac tttctttgcc tctcttcttc cagaaggccc cccagccatc 1260 gcaaactgat ggtgtttgtg ctgtagctgt tggaggcttt gacaggaatg gactggatca 1320 cctgactcca gctagattgc ctctcctgga catggcaatg atgagttttt aaaaaacagt 1380 gtggatgatg atatgctttt gtgagcaagc aaaagcagaa acgtgaagcc gtgatacaaa 1440 ttggtgaaca aaaaatgccc aaggcttctc atgtgtttat tctgaagagc tttaatatat 1500 actctatgta gtttaataag cactgtacgt agaaggcctt aggtgttgca tgtctatgct 1560 tgaggaactt ttccaaatgt gtgtgtctgc atgtgtgttt gtacatagaa gtcatagatg 1620 cagaagtggt tctgctggta agatttgatt cctgttggaa tgtttaaatt acactaagtg 1680 tactacttta tataatcaat gaaattgcta gacatgtttt agcaggactt ttctaggaaa 1740 gacttatgta taattgcttt ttaaaatgca gtgctttact ttaaactaag gggaactttg 1800 cggaggtgaa aacctttgct gggttttctg ttcaataaag ttttactatg aatgaccctg 1860 12 3379 DNA Homo sapiens 12 aattccgcgg aatcatcgga atccttcacc atggcatcca gcccggccca gcgtcggcga 60 ggcaatgatc ctctcacctc cagccctggc cgaagctccc ggcgtactga tgccctcacc 120 tccagccctg gccgtgacct tccaccattt gaggatgagt ccgaggggct cctaggcaca 180 gaggggcccc tggaggaaga agaggatgga gaggagctca ttggagatgg catggaaagg 240 gactaccgcg ccatcccaga gctggacgcc tatgaggccg agggactggc tctggatgat 300 gaggacgtag aggagctgac ggccagtcga agggaggcag cagacgggcc atgcggcacg 360 gtgaccggga gctggccggg gctgggcgca tgcgccgtgg gctcctgtat gacagcgatg 420 aggaggacga ggagcgccct gcccgcaagc gccgccagtg gagccggcac ggaggacggc 480 gaggaggacg agcagatgat tgagagcatc gagaacctgg aggatctcaa aggccactct 540 gtgcgcgagt gggtgagcat ggcgggcccc cggctggaga tccaccaccg cttcaagaac 600 ttcctgcgca ctcacgtcga cagccacggc cacaacgtct tcaaggagcg catcagcgac 660 atgtgcaaag agaaccgtga gagcctggtg gtgaactatg aggacttggc agccagggag 720 cacgtgctgg cctacttcct gcctgaggca ccggcggagc tgctgcagat ctttgatgag 780 gctgccctgg aggtggtact ggccatgtac cccaagtacg accgcatcac caaccacatc 840 catgtccgca tctcccacct gcctctggtg gaggagctgc gctcgctgag gcagctgcat 900 ctgaaccagc tgatccgcac cagtggggtg gtgaccagct gcactggcgt cctgccccag 960 ctcagcatgg tcaagtacaa ctgcaacaag tgcaatttcg tcctgggtcc tttctgccag 1020 tcccagaacc aggaggtgaa accaggctcc tgtcctgagt gccagtcggc cggccccttt 1080 gaggtcaaca tggaggagac catctatcag aactaccagc gtatccgaat ccaggagagt 1140 ccaggcaaag tggcggctcg gcggctgccc cgctccaagg acgccattct cctcgcagat 1200 ctggtggaca gctgcaacgc aggagacgag atagagctga ctggcatcta tcacaacaac 1260 tatgatggct ccctcaacac tgccaatggc ttccctgtct ttgccactgt catcctagcc 1320 aaccacgtgg ccaagaagga caacaaggtt gctgtagggg aactgaccga tgaagatgtg 1380 aagatgatca ctagcctctc caaggatcag cagatcggag agaagatctt tgccagcatt 1440 gctccttcca tctatggtca tgaagacatc aagagaggcc ctgctctggc cctgttcgga 1500 ggggagccca aaaacccagg tggcaagcac aaggtacgtg gtgatatcaa cgtgctcttg 1560 tgcggagacc ctggcacagc gaagtcgcag tttctcaagt atattgagaa agtgtccagc 1620 cgagccatct tcaccactgg ccagggggcg tcggctgtgg ccgtcacggc gtatgtccag 1680 cggcaccctg tcagcaggga gtggaccttg gaggctgggg ccctggttct ggctgaccga 1740 ggagtgtgtc tcattgatga atttgacaag atgaatgacc aggacagaac cagcatccat 1800 gaggccatgg agcaacagag catctccatc tcgaaggctg gcatcgtcac ctccctgcag 1860 gctcgctgca cggtcattgc tgccgccaac cccataggag ggcgctacga cccctcgctg 1920 actttctctg agaacgtgga cctcacagag cccatcatct cacgctttga catcctgtgt 1980 gtggtgaggg acaccgtgga cccagtccag gacgagatgc tggcccgctt cgtggtgggc 2040 agccacgtca gacaccaccc cagcaacaag gaggaggagg ggctggccaa tggcagcgct 2100 gctgagcccg ccatgcccaa cacgtatggc gtggagcccc tgccccagga ggtcctgaag 2160 aagtacatca tctacgccaa ggagagggtc cacccgaagc tcaaccagat ggaccaggac 2220 aaggtggcca agatgtacag tgacctgagg aaagaatcta tggcgacagg cagcatcccc 2280 attacggtgc ggcacatcga gtccatgagt catggcggag gcccacgcgc gcatccatct 2340 gcgggactat gtgatcgaag acgacgtcaa catggccatc cgcgtgatgc tggagagctt 2400 catagacaca cagaagttca gcgtcatcgc agcatgcgca agacttttgc ccgctacctt 2460 tcattccggc gtgacaacaa tgagctgttg ctcttcatac tgaagcagtt agtggcagag 2520 caggtgacat atcagcgcaa ccgctttggg gcccagcagg acactattga ggtccctgag 2580 aaggacttgg tggataaggc tcgtcagatc aacatccaca acctctctgc attttatgac 2640 agtgagctct tcaggatgaa caagttcagc cacgacctga aaaggaaaat gatcctgcag 2700 cagttctgag gccctatgcc atccataagg attccttggg attctggttt ggggtggtca 2760 gtgccctctg tgctttatgg acacaaaacc agagcacttg atgaactcgg ggtactaggg 2820 tcagggctta tagcaggatg tctggctgca cctggcatga ctgtttgttt ctccaagcct 2880 gctttgtgct tctcaccttt gggtgggatg ccttgccagt gtgtcttact tggttgctga 2940 acatcttgcc acctccgagt gctttgtctc cactcagtac cttggatcag agctgctgag 3000 ttcaggatgc ctgcgtgtgg tttaggtgtt agccttctta catggatgtc aggagagctg 3060 ctgccctctt ggcgtgagtt gcgtattcag gctgcttttg ctcgctttgg ccagagagct 3120 ggttgaagat gtttgtaatc gttttcagtc tcctgcaggt ttctgtgccc ctgtggtgga 3180 agaggcacga cagtgccagc gcagcgttct gggctcctca gtcgcagggg tgggatgtga 3240 gtcatgcgga ttatccactc gccacagtta tcagctgcca ttgctccctg tctgtttccc 3300 cactctctta tttgtgcatt cggtttggtt tctgtagttt taatttttaa taaagttgaa 3360 taaaatataa aaaaaaaaa 3379 13 767 DNA Homo sapiens misc_feature (1)...(767) n = A,T,C or G 13 agatgaagta gagtgctctg acaaggacga gcccgacctc gatggggatg tgtccagcga 60 ctgccccacc atccgcgtcc cactgacatc cctcaagagc caccagggcg tggtcatcgc 120 ctccgactgg ctggttgggg ggaagcaggc tgtgactgcc tcctgggacc ggacggcaaa 180 cctgtacgac gtggagacgt ccgagctcgt tcactctctg acagggcacg accaggagtt 240 gacgcactgc tgcacacacc ccacccagcg gctcgtggtg acctcctccc gtgacacgac 300 tttccgcctc tgggatttca gggacccctc catccactct tatggaacat ggacatttta 360 atgaatttca tattgcaatg aagacagtca acacttagag acaattatat cgatacaata 420 aaaactgatt ccatggaaca cttataaatg catacatttt cctccaaaga aatatgtttt 480 tcacagactt aagtaacaaa tgatttacat aggattcttc agattccaaa atatgtacag 540 agtttttgtc tctacagaaa ctgatgagca gtggttgaaa aagagttgct ttgcccaaca 600 gcatggctct tatgaaattc ctgtatcata tacagttttc agtaaccaca cattttcccg 660 tctatcatta aatggaattc tgggacacat ccagcatacc nggaccaaac tggttcccac 720 tttnccaaac actggtttca gacgagattc acgtggtngg tttgaac 767 14 500 DNA Homo sapiens 14 tgccgctgca gcagcgcagt tccagtccgt tgctttactt tttgcttcac cgacatagtc 60 attatgccga agagaaagtc tccagagaat acagagggca aagatggatc caaagtaact 120 aaacaggagc ccacaagacg gtctgccaga ttgtcagcga aacctgctcc accaaaacct 180 gaacccaaac caagaaaaac atctgctaag aaagaacctg gagcaaagat tagcagaggt 240 gctaaaggga agaaggagga aaagcaggaa gctggaaagg aaggtactgc accatctgaa 300 aatggtgaaa ctaaagctga agaggcacag aaaactgaat ctgtagataa cgagggagaa 360 tgaattgtca tgaaaaattg gggttgattt tatgtatctc ttgggacaac ttttaaaagc 420 tatttttacc aagtattttg taaatgctaa ttttttagga ctctactagt tggcatacga 480 aaatatataa ggatggacat 500 15 2287 DNA Homo sapiens 15 ggctgaggca gtggctcctt gcacagcagc tgcacgcgcc gtggctccgg atcttcttcg 60 tctttgcagc gtagcccgag tcggtcagcg ccagaggacc tcagcagcca tgtcgaagcc 120 ccatagtgaa gccgggactg ccttcattca gacccagcag ctgcacgcag ccatggctga 180 cacattcctg gagcacatgt gccgcctgga cattgattca ccacccatca cagcccggaa 240 cactggcatc atctgtacca ttggcccagc ttcccgatca gtggagacgt tgaaggagat 300 gattaagtct ggaatgaatg tggctcgtct gaacttctct catggaactc atgagtacca 360 tgcggagacc atcaagaatg tgcgcacagc cacggaaagc tttgcttctg accccatcct 420 ctaccggccc gttgctgtgg ctctagacac taaaggacct gagatccgaa ctgggctcat 480 caagggcagc ggcactgcag aggtggagct gaagaaggga gccactctca aaatcacgct 540 ggataacgcc tacatggaaa agtgtgacga gaacatcctg tggctggact acaagaacat 600 ctgcaaggtg gtggaagtgg gcagcaagat ctacgtggat gatgggctta tttctctcca 660 ggtgaagcag aaaggtgccg acttcctggt gacggaggtg gaaaatggtg gctccttggg 720 cagcaagaag ggtgtgaacc ttcctggggc tgctgtggac ttgcctgctg tgtcggagaa 780 ggacatccag gatctgaagt ttggggtcga gcaggatgtt gatatggtgt ttgcgtcatt 840 catccgcaag gcatctgatg tccatgaagt taggaaggtc ctgggagaga agggaaagaa 900 catcaagatt atcagcaaaa tcgagaatca tgagggggtt cggaggtttg atgaaatcct 960 ggaggccagt gatgggatca tggtggctcg tggtgatcta ggcattgaga ttcctgcaga 1020 gaaggtcttc cttgctcaga agatgatgat tggacggtgc aaccgagctg ggaagcctgt 1080 catctgtgct actcagatgc tggagagcat gatcaagaag ccccgcccca ctcgggctga 1140 aggcagtgat gtggccaatg cagtcctgga tggagccgac tgcatcatgc tgtctggaga 1200 aacagccaaa ggggactatc ctctggaggc tgtgcgcatg cagaacctga ttgcccgtga 1260 ggcagaggct gccatctacc acttgcaatt atttgaggaa ctccgccgcc tggcgcccat 1320 taccagcgac cccacagaag ccaccgccgt gggtgccgtg gaggcctcct tcaagtgctg 1380 cagtggggcc ataatcgtcc tcaccaagtc tggcaggtct gctcaccagg tggccagata 1440 ccgcccacgt gcccccatca ttgctgtgac ccggaatccc cagacagctc gtcaggccca 1500 cctgtaccgt ggcatcttcc ctgtgctgtg caaggaccca gtccaggagg cctgggctga 1560 ggacgtggac ctccgggtga actttgccat gaatgttggc aaggcccgag gcttcttcaa 1620 gaagggagat gtggtcattg tgctgaccgg atggcgccct ggctccggct tcaccaacac 1680 catgcgtgtt gttcctgtgc cgtgatggac cccagagccc ctcctccagc ccctgtccca 1740 cccccttccc ccagcccatc cattaggcca gcaacgcttg tagaactcac tctgggctgt 1800 aacgtggcac tggtaggttg ggacaccagg gaagaagatc aacgcctcac tgaaacatgg 1860 ctgtgtttgc agcctgctct agtgggacag cccagagcct ggctgcccca tcatgtggcc 1920 ccacccaatc aagggaagaa ggaggaatgc tggactggag gcccctggag ccagatggca 1980 agagggtgac agcttccttt cctgtgtgta ctctgtccag ttcctttaga aaaaatggat 2040 gcccagagga ctcccaaccc tggcttgggg tcaagaaaca gccagcaaga gttaggggcc 2100 ttagggcact gggctgttgt tccattgaag ccgactctgg ccctggccct tacttgcttc 2160 tctagctctc taggcctctc cagtttgcac ctgtccccac cctccactca gctgtcctgc 2220 agcaaacact ccaccctcca ccttccattt tcccccacta ctgcagcacc tccaggcctg 2280 ttgccgc 2287 16 3183 DNA Homo sapiens 16 cctccaggcc ccgccgcgcg tcccgggggc cggccccgcg agcgcaggag taaacaccgc 60 cggagtcttg gagccgctgc agaagggaat aaagagagat gcagggattt gtgaggttac 120 ggcgccccag ctgcaagatg cactagccgg ctgaacccgg gatcggctga cttgttggaa 180 ccggagtgct ctgcacggag agtggtggat gagttgaagt tgccttcccg gggctcattt 240 tccacgctgc cgagaggaat ccgagaggca aggcaatcac ttcgtcttgc cattgattgg 300 gtatcgggag cttttttttt ctcccctctc tctttctttt cctccgtctt gttgcatgca 360 agaaaattac agtccgctgc tcgcccgccc tgggtgcgag atattcagcc ccgctctctc 420 ccgtgcattg tgcaacccaa agatgaaaga ccgaagggga gaaagttaaa gaaatcgccc 480 acatgcgctg gatcagtcca cggcttgggg aaaggcatcc agagaaggtg ggagcggaga 540 gtttgaagtc tttacaggcg ggaagatggc ggactggagc tgaaagtgtt gattgggaaa 600 cttgggtgat tcttgtgttt atttacaatc ctcttgaccc aggcaggaca catgcaggcc 660 aaaaaacgct atttcatcct gctctcagct ggctcttgtc tcgccctttt gttttatttc 720 ggaggcttgc agtttagggc atcgaggagc cacagccgga gagaagaaca cagcggtagg 780 aatggcttgc accaccccag tccggatcat ttctggcccc gcttcccgga gcctctgcgc 840 cccttcgttc cttgggatca attggaaaac gaggattcca gcgtgcacat ttccccccgg 900 cagaagcgag atgccaactc cagcatctac aaaggcaaga agtgccgcat ggagtcctgc 960 ttcgatttca ccctttgcaa gaaaaacggc ttcaaagtct acgtataccc acagcaaaaa 1020 ggggagaaaa tcgccgaaag ttaccaaaac attctagcgg ccatcgaggg ctccaggttc 1080 tacacctcgg accccagcca ggcgtgcctc tttgtcctga gtctggatac tttagacaga 1140 gaccagttgt cacctcagta tgtgcacaat ttgagatcca aagtgcagag tctccacttg 1200 tggaacaatg gtaggaatca tttaattttt aatttatatt ccggcacttg gcctgactac 1260 accgaggacg tggggtttga catcggccag gcgatgctgg ccaaagccag catcagtact 1320 gaaaacttcc gacccaactt tgatgtttct attcccctct tttctaagga tcatcccagg 1380 acaggagggg agagggggtt tttgaagttc aacaccatcc ctcctctcag gaagtacatg 1440 ctggtattca aggggaagag gtacctgaca gggataggat cagacaccag gaatgcctta 1500 tatcacgtcc ataacgggga ggacgttgtg ctcctcacca cctgcaagca tggcaaagac 1560 tggcaaaagc acaaggattc tcgctgtgac agagacaaca ccgagtatga gaagtatgat 1620 tatcgggaaa tgctgcacaa tgccactttc tgtctggttc ctcgtggtcg caggcttggg 1680 tccttcagat tcctggaggc tttgcaggct gcctgcgtcc ctgtgatgct cagcaatgga 1740 tgggagttgc cattctctga agtgattaat tggaaccaag ctgccgtcat aggcgatgag 1800 agattgttat tacagattcc ttctacaatc aggtctattc atcaggataa aatcctagca 1860 cttagacagc agacacaatt cttgtgggag gcttattttt cttcagttga gaagattgta 1920 ttaactacac tagagattat tcaggacaga atattcaagc acatatcacg taacagttta 1980 atatggaaca aacatcctgg aggattgttc gtactaccac agtattcatc ttatctggga 2040 gattttcctt actactatgc taatttaggt ttaaagcccc cctccaaatt cactgcagtc 2100 atccatgcgg tgacccccct ggtctctcag tcccagccag tgttgaagct tctcgtggct 2160 gcagccaagt cccagtactg tgcccagatc atagttctat ggaattgtga caagccccta 2220 ccagccaaac accgctggcc tgccactgct gtgcctgtcg tcgtcattga aggagagagc 2280 aaggttatga gcagccgttt tctgccctac gacaacatca tcacagacgc cgtgctcagc 2340 cttgacgagg acacggtgct ttcaacaaca gaggtggatt tcgccttcac agtgtggcag 2400 agcttccctg agaggattgt ggggtacccc gcgcgcagcc acttctggga taactctaag 2460 gagcggtggg gatacacatc aaagtggacg aacgactact ccatggtgtt gacaggagct 2520 gctatttacc acaaatatta tcactaccta tactcccatt acctgccagc cagcctgaag 2580 aacatggtgg accaattggc caattgtgag gacattctca tgaacttcct ggtgtctgct 2640 gtgacaaaat tgcctccaat caaagtgacc cagaagaagc agtataagga gacaatgatg 2700 ggacagactt ctcgggcttc ccgttgggct gaccctgacc actttgccca gcgacagagc 2760 tgcatgaata cgtttgccag ctggtttggc tacatgccgc tgatccactc tcagatgagg 2820 ctcgaccccg tcctctttaa agaccaggtc tctattttga ggaagaaata ccgagacatt 2880 gagcgacttt gaggaatccg gctgagtggg ggaggggaag caagaaggga tgggggtcaa 2940 gctgctctct cttcccagtg cagatccact catcagcaga gccagattgt gccaactatc 3000 caaaaactta gatgagcaga atgacaaaaa aaaaaaaggc caatgagaac tcaactcctg 3060 gctcctggga ctgcaccaga ctgctccaaa ctcacctcac tggcttctgt gtcccaagac 3120 taggttggta cagtttaatt atggaacatt aaataattat ttttgaaaaa aaaaaaaaaa 3180 aaa 3183 17 1016 DNA Homo sapiens 17 atggatacca atgttccgac tggagacggg gagcccgcga gacccgggtc tccagggtct 60 gcccaaggaa gttgctcatg ggagcagacc cctagagcag gatttgaggc caggccaaag 120 agaaccccag agatgaaagg cctcctccca ctggcttggt tcctggcttg tagtgtgcct 180 gctgtgcaag gaggcttgct ggacctaaaa tcaatgatcg agaaggtgac agggaagaac 240 gccctgacaa actacggctt ctacggctgt tactgcggct ggggcggccg aggaaccccc 300 aaggatggca ccgattggtg ctgttgggcg catgaccact gctatgggcg gctggaggag 360 aagggctgca acattcgcac acagtcctac aaatacagat tcgcgtgggg cgtggtcacc 420 tgcgagcccg ggcccttctg ccatgtgaac ctctgtgcct gtgaccggaa gctcgtctac 480 tgcctcaaga gaaacctacg gagctacaac ccacagtacc aatactttcc caacatcctc 540 tgctcctagg cctccccagc gagctcctcc cagaccaaga cttttgttct gtttttctac 600 aacacagagt actgactctg cctggttcct gagagaggct cctaagtcac agacctcagt 660 ctttctcgaa gcttggcgga cccccagggc cacactgtac cctccagcga gtcccaggag 720 agtgactctg gtcataggac ttggtagggt cccagggtcc ctaggcctcc acttctgagg 780 gcagcccctc tggtgccaag agctctcctc caactcaggg ttggctgtgt ctcttttctt 840 ctctgaagac agcgtcctgg ctccagttgg aacactttcc tgagatgcac ttacttctca 900 gcttctgcga tcagattatc atcaccacca ccctccagag aattttacgc aagaagagcc 960 aaattgactc tctaaatctg gtgtatgggt attaaataaa attcattctc aaggct 1016 18 483 DNA Homo sapiens misc_feature (1)...(483) n = A,T,C or G 18 nntttttttt tgtttttaaa aagaattgtt tatttaccga acctggggca tattagatac 60 aaccaatttt aaatttacat cttttaaatc agttttgaag tgtttcacac acacaaaaaa 120 cttggcatgc aacagttgtc ctaaggtgaa agtcacctca ttaataaact gttgcaagtg 180 ttctcaccca aggtggaagt atggtttatc ctgaacatga aaacctgtaa caaatttaaa 240 ttaattatat aaaactcgtt acttgtagtt ttgcccttgc aaagatccaa aaaaaaaaaa 300 aaaaagcaca agtaactaat atgtatcagt cacaacataa tcctggatca tncccatacc 360 aaaaccggat gctcttttaa ttttaaaccc atcatcagag aacaagagaa agtaatttca 420 ttttacacaa aacaagattn acatgtgcca aaaaagaaat accccaaaag aaacaaaaac 480 caa 483 19 3020 DNA Homo sapiens 19 gttcaaggca gcgcccacac ccgggggctc tccgcaaccc gaccgcctgt ccgctccccc 60 acttcccgcc ctccctccca cctactcatt cacccaccca cccacccaga gccgggacgg 120 cagcccaggc gcccgggccc cgccgtctcc tcgccgcgat cctggacttc ctcttgctgc 180 aggacccggc ttccacgtgt gtcccggagc cggcgtctca gcacacgctc cgctccgggc 240 ctgggtgcct acagcagcca gagcagcagg gagtccggga cccgggcggc atctgggcca 300 agttaggcgc cgccgaggcc agcgctgaac gtctccaggg ccggaggagc cgcggggcgt 360 ccgggtctga gcctcagcaa atgggctccg acgtgcggga cctgaacgcg ctgctgcccg 420 ccgtcccctc cctgggtggc ggcggcggct gtgccctgcc tgtgagcggc gcggcgcagt 480 gggcgccggt gctggacttt gcgcccccgg gcgcttcggc ttacgggtcg ttgggcggcc 540 ccgcgccgcc accggctccg ccgccacccc cgccgccgcc gcctcactcc ttcatcaaac 600 aggagccgag ctggggcggc gcggagccgc acgaggagca gtgcctgagc gccttcactg 660 tccacttttc cggccagttc actggcacag ccggagcctg tcgctacggg cccttcggtc 720 ctcctccgcc cagccaggcg tcatccggcc aggccaggat gtttcctaac gcgccctacc 780 tgcccagctg cctcgagagc cagcccgcta ttcgcaatca gggttacagc acggtcacct 840 tcgacgggac gcccagctac ggtcacacgc cctcgcacca tgcggcgcag ttccccaacc 900 actcattcaa gcatgaggat cccatgggcc agcagggctc gctgggtgag cagcagtact 960 cggtgccgcc cccggtctat ggctgccaca cccccaccga cagctgcacc ggcagccagg 1020 ctttgctgct gaggacgccc tacagcagtg acaatttata ccaaatgaca tcccagcttg 1080 aatgcatgac ctggaatcag atgaacttag gagccacctt aaagggagtt gctgctggga 1140 gctccagctc agtgaaatgg acagaagggc agagcaacca cagcacaggg tacgagagcg 1200 ataaccacac aacgcccatc ctctgcggag cccaatacag aatacacacg cacggtgtct 1260 tcagaggcat tcaggatgtg cgacgtgtgc ctggagtagc cccgactctt gtacggtcgg 1320 catctgagac cagtgagaaa cgccccttca tgtgtgctta cccaggctgc aataagagat 1380 attttaagct gtcccactta cagatgcaca gcaggaagca cactggtgag aaaccatacc 1440 agtgtgactt caaggactgt gaacgaaggt tttctcgttc agaccagctc aaaagacacc 1500 aaaggagaca tacaggtgtg aaaccattcc agtgtaaaac ttgtcagcga aagttctccc 1560 ggtccgacca cctgaagacc cacaccagga ctcatacagg taaaacaagt gaaaagccct 1620 tcagctgtcg gtggccaagt tgtcagaaaa agtttgcccg gtcagatgaa ttagtccgcc 1680 atcacaacat gcatcagaga aacatgacca aactccagct ggcgctttga ggggtctccc 1740 tcggggaccg ttcagtgtcc caggcagcac agtgtgtgaa ctgctttcaa gtctgactct 1800 ccactcctcc tcactaaaaa ggaaacttca gttgatcttc ttcatccaac ttccaagaca 1860 agataccggt gcttctggaa actaccaggt gtgcctggaa gagttggtct ctgccctgcc 1920 tacttttagt tgactcacag gccctggaga agcagctaac aatgtctggt tagttaaaag 1980 cccattgcca tttggtctgg attttctact gtaagaagag ccatagctga tcatgtcccc 2040 ctgacccttc ccttcttttt ttatgctcgt tttcgctggg gatggaatta ttgtaccatt 2100 ttctatcatg gaatatttat aggccagggc atgtgtatgt gtctgctaat gtaaactttg 2160 tcatggtttc catttactaa cagcaacagc aagaaataaa tcagagagca aggcatcggg 2220 ggtgaatctt gtctaacatt cccgaggtca gccaggctgc taacctggaa agcaggatgt 2280 agttctgcca ggcaactttt aaagctcatg catttcaagc agctgaagaa agaatcagaa 2340 ctaaccagta cctctgtata gaaatctaaa agaattttac cattcagtta attcaatgtg 2400 aacactggca cactgctctt aagaaactat gaagatctga gatttttttg tgtatgtttt 2460 tgactctttt gagtggtaat catatgtgtc tttatagatg tacatacctc cttgcacaaa 2520 tggaggggaa ttcattttca tcactgggac tgtccttagt gtataaaaac catgctggta 2580 tatggcttca agttgtaaaa atgaaagtga ctttaaaaga aaatagggga tggtccagga 2640 tctccactga taagactgtt tttaagtaac ttaaggacct ttgggtctac aagtatatgt 2700 gaaaaaaatg agacttactg ggtgaggaaa tccattgttt aaagatggtc gtgtgtgtgt 2760 gtgtgtgtgt gtgtgtgttg tgttgtgttt tgttttttaa gggagggaat ttattattta 2820 ccgttgcttg aaattactgt gtaaatatat gtctgataat gatttgctct ttgacaacta 2880 aaattaggac tgtataagta ctagatgcat cactgggtgt tgatcttaca agatattgat 2940 gataacactt aaaattgtaa cctgcatttt tcactttgct ctcaattaaa gtctattcaa 3000 aaggaaaaaa aaaaaaaaaa 3020 20 13993 DNA Homo sapiens 20 atggacccgc cgaggcccgc gctgctggcg ctgctggcgc tgcctgcgct gctgctgctg 60 ctgctggcgg gcgccagggc cgaagaggaa atgctggaaa atgtcagcct ggtctgtcca 120 aaagatgcga cccgattcaa gcacctccgg aagtacacat acaactatga ggctgagagt 180 tccagtggag tccctgggac tgctgattca agaagtgcca ccaggatcaa ctgcaaggtt 240 gagctggagg ttccccagct ctgcagcttc atcctgaaga ccagccagtg caccctgaaa 300 gaggtgtatg gcttcaaccc tgagggcaaa gccttgctga agaaaaccaa gaactctgag 360 gagtttgctg cagccatgtc caggtatgag ctcaagctgg ccattccaga agggaagcag 420 gttttccttt acccggagaa agatgaacct acttacatcc tgaacatcaa gaggggcatc 480 atttctgccc tcctggttcc cccagagaca gaagaagcca agcaagtgtt gtttctggat 540 accgtgtatg gaaactgctc cactcacttt accgtcaaga cgaggaaggg caatgtggca 600 acagaaatat ccactgaaag agacctgggg cagtgtgatc gcttcaagcc catccgcaca 660 ggcatcagcc cacttgctct catcaaaggc atgacccgcc ccttgtcaac tctgatcagc 720 agcagccagt cctgtcagta cacactggac gctaagagga agcatgtggc agaagccatc 780 tgcaaggagc aacacctctt cctgcctttc tcctacaaga ataagtatgg gatggtagca 840 caagtgacac agactttgaa acttgaagac acaccaaaga tcaacagccg cttctttggt 900 gaaggtacta agaagatggg cctcgcattt gagagcacca aatccacatc acctccaaag 960 caggccgaag ctgttttgaa gactctccag gaactgaaaa aactaaccat ctctgagcaa 1020 aatatccaga gagctaatct cttcaataag ctggttactg agctgagagg cctcagtgat 1080 gaagcagtca catctctctt gccacagctg attgaggtgt ccagccccat cactttacaa 1140 gccttggttc agtgtggaca gcctcagtgc tccactcaca tcctccagtg gctgaaacgt 1200 gtgcatgcca acccccttct gatagatgtg gtcacctacc tggtggccct gatccccgag 1260 ccctcagcac agcagctgcg agagatcttc aacatggcga gggatcagcg cagccgagcc 1320 accttgtatg cgctgagcca cgcggtcaac aactatcata agacaaaccc tacagggacc 1380 caggagctgc tggacattgc taattacctg atggaacaga ttcaagatga ctgcactggg 1440 gatgaagatt acacctattt gattctgcgg gtcattggaa atatgggcca aaccatggag 1500 cagttaactc cagaactcaa gtcttcaatc ctgaaatgtg tccaaagtac aaagccatca 1560 ctgatgatcc agaaagctgc catccaggct ctgcggaaaa tggagcctaa agacaaggac 1620 caggaggttc ttcttcagac tttccttgat gatgcttctc cgggagataa gcgactggct 1680 gcctatctta tgttgatgag gagtccttca caggcagata ttaacaaaat tgtccaaatt 1740 ctaccatggg aacagaatga gcaagtgaag aactttgtgg cttcccatat tgccaatatc 1800 ttgaactcag aagaattgga tatccaagat ctgaaaaagt tagtgaaaga agctctgaaa 1860 gaatctcaac ttccaactgt catggacttc agaaaattct ctcggaacta tcaactctac 1920 aaatctgttt ctcttccatc acttgaccca gcctcagcca aaatagaagg gaatcttata 1980 tttgatccaa ataactacct tcctaaagaa agcatgctga aaactaccct cactgccttt 2040 ggatttgctt cagctgacct catcgagatt ggcttggaag gaaaaggctt tgagccaaca 2100 ttggaggctc cttttgggaa gcaaggattt ttcccagaca gtgtcaacaa agctttgtac 2160 tgggttaatg gtcaagttcc tgatggtgtc tctaaggtct tagtggacca ctttggctat 2220 accaaagatg ataaacatga gcaggatatg gtaaatggaa taatgctcag tgttgagaag 2280 ctgattaaag atttgaaatc caaagaagtc ccggaagcca gagcctacct ccgcatcttg 2340 ggagaggagc ttggttttgc cagtctccat gacctccgac tcctgggaaa gctgcttctg 2400 atgggtgccc gcactctgca ggggatcccc cagatgattg gagaggtcat caggaagggc 2460 tcaaagaatg acttttttct tcactacatc ttcatggaga atgcctttga actccccact 2520 ggagctggat tacagttgca aatatcttca tctggagtca ttgctcccgg agccaaggct 2580 ggagtaaaac tggaagtagc caacatgcag gctgaactgg tggcaaaacc ctccgtgtct 2640 gtggagtttg tgacaaatat gggcatcatc attccggact tcgctaggag tggggtccag 2700 atgaacacca acttcttcca cgagtcgggt ctggaggctc atgttgccct aaaagctggg 2760 aagctgaagt ttatcattcc ttccccaaag agaccagtca agctgctcag tggaggcaac 2820 acattacatt tggtctctac caccaaaacg gaggtcatcc cacctctcat tgagaacagg 2880 cagtcctggt cagtttgcaa gcaagtcttt cctggcctga attactgcac ctcaggcgct 2940 tactccaacg ccagctccac agactccgcc tcctactatc cgctgaccgg ggacaccaga 3000 ttagagctgg aactgaggcc tacaggagag attgagcagt attctgtcag cgcaacctat 3060 gagctccaga gagaggacag agccttggtg gataccctga agtttgtaac tcaagcagaa 3120 ggcgcgaagc agactgaggc taccatgaca ttcaaatata atcggcagag tatgaccttg 3180 tccagtgaag tccaaattcc ggattttgat gttgacctcg gaacaatcct cagagttaat 3240 gatgaatcta ctgagggcaa aacgtcttac agactcaccc tggacattca gaacaagaaa 3300 attactgagg tcgccctcat gggccaccta agttgtgaca caaaggaaga aagaaaaatc 3360 aagggtgtta tttccatacc ccgtttgcaa gcagaagcca gaagtgagat cctcgcccac 3420 tggtcgcctg ccaaactgct tctccaaatg gactcatctg ctacagctta tggctccaca 3480 gtttccaaga gggtggcatg gcattatgat gaagagaaga ttgaatttga atggaacaca 3540 ggcaccaatg tagataccaa aaaaatgact tccaatttcc ctgtggatct ctccgattat 3600 cctaagagct tgcatatgta tgctaataga ctcctggatc acagagtccc tcaaacagac 3660 atgactttcc ggcacgtggg ttccaaatta atagttgcaa tgagctcatg gcttcagaag 3720 gcatctggga gtcttcctta tacccagact ttgcaagacc acctcaatag cctgaaggag 3780 ttcaacctcc agaacatggg attgccagac tcccacatcc cagaaaacct cttcttaaaa 3840 agcgatggcc gcgtcaaata taccttgaac aagaacagtt tgaaaattga gattcctttg 3900 ccttttggtg gcaaatcctc cagagatcta aagatgttag agactgttag gacaccagcc 3960 ctccacttca agtctgtggg attccatctg ccatctcgag agttccaagt ccctactttt 4020 accattccca agttgtatca actgcaagtg cctctcctgg gtgttctaga cctctccacg 4080 aatgtctaca gcaacttgta caactggtcc gcctcctaca gtggtggcaa caccagcaca 4140 gaccatttca gccttcgggc tcgttaccac atgaaggctg actctgtggt tgacctgctt 4200 tcctacaatg tgcaaggatc tggagaaaca acatatgacc acaagaatac gttcacacta 4260 tcatgtgatg ggtctctacg ccacaaattt ctagattcga atatcaaatt cagtcatgta 4320 gaaaaacttg gaaacaaccc agtctcaaaa ggtttactaa tattcgatgc atctagttcc 4380 tggggaccac agatgtctgc ttcagttcat ttggactcca aaaagaaaca gcatttgttt 4440 gtcaaagaag tcaagattga tgggcagttc agagtctctt cgttctatgc taaaggcaca 4500 tatggcctgt cttgtcagag ggatcctaac actggccggc tcaatggaga gtccaacctg 4560 aggtttaact cctcctacct ccaaggcacc aaccagataa caggaagata tgaagatgga 4620 accctctccc tcacctccac ctctgatctg caaagtggca tcattaaaaa tactgcttcc 4680 ctaaagtatg agaactacga gctgacttta aaatctgaca ccaatgggaa gtataagaac 4740 tttgccactt ctaacaagat ggatatgacc ttctctaagc aaaatgcact gctgcgttct 4800 gaatatcagg ctgattacga gtcattgagg ttcttcagcc tgctttctgg atcactaaat 4860 tcccatggtc ttgagttaaa tgctgacatc ttaggcactg acaaaattaa tagtggtgct 4920 cacaaggcga cactaaggat tggccaagat ggaatatcta ccagtgcaac gaccaacttg 4980 aagtgtagtc tcctggtgct ggagaatgag ctgaatgcag agcttggcct ctctggggca 5040 tctatgaaat taacaacaaa tggccgcttc agggaacaca atgcaaaatt cagtctggat 5100 gggaaagccg ccctcacaga gctatcactg ggaagtgctt atcaggccat gattctgggt 5160 gtcgacagca aaaacatttt caacttcaag gtcagtcaag aaggacttaa gctctcaaat 5220 gacatgatgg gctcatatgc tgaaatgaaa tttgaccaca caaacagtct gaacattgca 5280 ggcttatcac tggacttctc ttcaaaactt gacaacattt acagctctga caagttttat 5340 aagcaaactg ttaatttaca gctacagccc tattctctgg taactacttt aaacagtgac 5400 ctgaaataca atgctctgga tctcaccaac aatgggaaac tacggctaga acccctgaag 5460 ctgcatgtgg ctggtaacct aaaaggagcc taccaaaata atgaaataaa acacatctat 5520 gccatctctt ctgctgcctt atcagcaagc tataaagcag acactgttgc taaggttcag 5580 ggtgtggagt ttagccatgg gctcaacaca gacatcgctg ggctggcttc agccattgac 5640 atgagcacaa actataattc agactcactg catttcagca atgtcttccg ttctgtaatg 5700 gccccgttta ccatgaccat cgatgcacat acaaatggca atgggaaact cgctctctgg 5760 ggagaacata ctgggcagct gtatagcaaa ttcctgttga aagcagaacc tctggcattt 5820 actttctctc atgattacaa aggctccaca agtcatcatc tcgtgtctag gaaaagcatc 5880 agtgcagctc ttgaacacaa agtcagtgcc ctgcttactc cagctgagca gacaggcacc 5940 tggaaactca agacccaatt taacaacaat gaatacagcc aggacttgga tgcttacaac 6000 actaaagata aaattggcgt ggagcttact ggacgaactc tggctgacct aactctacta 6060 gactccccaa ttaaagtgcc acttttactc agtgagccca tcaatatcaa tgatgcttta 6120 gagatgagag atgccgttga gaagccccaa gaatttacaa ttgttgcttt tgtaaagtat 6180 gataaaaacc aagatgttca ctccattaac ctcccatttt ttgagacctt gcaagaatat 6240 tttgagagga atcgacaaac cattatagtt gtactggaaa acgtacagag aaacctgaag 6300 cacatcaata ttgatcaatt tgtaagaaaa tacagagcag ccctgggaaa actcccacag 6360 caagctaatg attatctgaa ttcattcaat tgggagagac aagtttcaca tgccaaggag 6420 aaactgactg ctctcacaaa aaagtataga attacagaaa atgatataca aattgcatta 6480 gatgatgcca aaatcaactt taatgaaaaa ctatctcaac tgcagacata tatgatacaa 6540 tttgatcagt atattaaaga tagttatgat ttacatgatt tgaaaatagc tattgctaat 6600 attattgatg aaatcattga aaaattaaaa agtcttgatg agcactatca tacccgtgta 6660 aatttagtaa aaacaatcca tgatctacat ttgtttattg aaaatattga ttttaacaaa 6720 agtggaagta gtactgcatc ctggattcaa aatgtggata ctaagtacca aatcagaatc 6780 cagatacaag aaaaactgca gcagcttaag agacacatac agaatataga catccagcac 6840 ctagctggaa agttaaaaca acacattgag gctattgatg ttagagtgct tttagatcaa 6900 ttgggaacta caatttcatt tgaaagaata aatgatgttc ttgagcatgt caaacacttt 6960 gttataaatc ttattgggga ttttgaagta gctgagaaaa tcaatgcctt cagagccaaa 7020 gtccatgagt taatcgagag gtatgaagta gaccaacaaa tccaggtttt aatggataaa 7080 ttagtagagt tggcccacca atacaagttg aaggagacta ttcagaagct aagcaatgtc 7140 ctacaacaag ttaagataaa agattacttt gagaaattgg ttggatttat tgatgatgct 7200 gtcaagaagc ttaatgaatt atcttttaaa acattcattg aagatgttaa caaattcctt 7260 gacatgttga taaagaaatt aaagtcattt gattaccacc agtttgtaga tgaaaccaat 7320 gacaaaatcc gtgaggtgac tcagagactc aatggtgaaa ttcaggctct ggaactacca 7380 caaaaagctg aagcattaaa actgttttta gaggaaacca aggccacagt tgcagtgtat 7440 ctggaaagcc tacaggacac caaaataacc ttaatcatca attggttaca ggaggcttta 7500 agttcagcat ctttggctca catgaaggcc aaattccgag agactctaga agatacacga 7560 gaccgaatgt atcaaatgga cattcagcag gaacttcaac gatacctgtc tctggtaggc 7620 caggtttata gcacacttgt cacctacatt tctgattggt ggactcttgc tgctaagaac 7680 cttactgact ttgcagagca atattctatc caagattggg ctaaacgtat gaaagcattg 7740 gtagagcaag ggttcactgt tcctgaaatc aagaccatcc ttgggaccat gcctgccttt 7800 gaagtcagtc ttcaggctct tcagaaagct accttccaga cacctgattt tatagtcccc 7860 ctaacagatt tgaggattcc atcagttcag ataaacttca aagacttaaa aaatataaaa 7920 atcccatcca ggttttccac accagaattt accatcctta acaccttcca cattccttcc 7980 tttacaattg actttgtaga aatgaaagta aagatcatca gaaccattga ccagatgctg 8040 aacagtgagc tgcagtggcc cgttccagat atatatctca gggatctgaa ggtggaggac 8100 attcctctag cgagaatcac cctgccagac ttccgtttac cagaaatcgc aattccagaa 8160 ttcataatcc caactctcaa ccttaatgat tttcaagttc ctgaccttca cataccagaa 8220 ttccagcttc cccacatctc acacacaatt gaagtaccta cttttggcaa gctatacagt 8280 attctgaaaa tccaatctcc tcttttcaca ttagatgcaa atgctgacat agggaatgga 8340 accacctcag caaacgaagc aggtatcgca gcttccatca ctgccaaagg agagtccaaa 8400 ttagaagttc tcaattttga ttttcaagca aatgcacaac tctcaaaccc taagattaat 8460 ccgctggctc tgaaggagtc agtgaagttc tccagcaagt acctgagaac ggagcatggg 8520 agtgaaatgc tgttttttgg aaatgctatt gagggaaaat caaacacagt ggcaagttta 8580 cacacagaaa aaaatacact ggagcttagt aatggagtga ttgtcaagat aaacaatcag 8640 cttaccctgg atagcaacac taaatacttc cacaaattga acatccccaa actggacttc 8700 tctagtcagg ctgacctgcg caacgagatc aagacactgt tgaaagctgg ccacatagca 8760 tggacttctt ctggaaaagg gtcatggaaa tgggcctcgc ccagattctc agatgaggga 8820 acacatgaat cacaaattag tttcaccata gaaggacccc tcacttcctt tggactgtcc 8880 aataagatca atagcaaaca cctaagagta aaccaaaact tggtttatga atctggctcc 8940 ctcaactttt ctaaacttga aattcaatca caagtcgatt cccagcatgt gggccacagt 9000 gttctaactg ctaaaggcat ggcactgttt ggagaaggga aggcagagtt tactgggagg 9060 catgatgctc atttaaatgg aaaggttatt ggaactttga aaaattctct tttcttttca 9120 gcccagccat ttgagatcac ggcatccaca aacaatgaag ggaatttgaa agttcgtttt 9180 ccattaaggt taacagggaa gatagacttc ctgaataact atgcactgtt tctgagtccc 9240 agtgcccagc aagcaagttg gcaagtaagt gctaggttca atcagtataa gtacaaccaa 9300 aatttctctg ctggaaacaa cgagaacatt atggaggccc atgtaggaat aaatggagaa 9360 gcaaatctgg atttcttaaa cattccttta acaattcctg aaatgcgtct accttacaca 9420 ataatcacaa ctcctccact gaaagatttc tctctatggg aaaaaacagg cttgaaggaa 9480 ttcttgaaaa cgacaaagca atcatttgat ttaagtgtaa aagctcagta taagaaaaac 9540 aaacacaggc attccatcac aaatcctttg gctgtgcttt gtgagtttat cagtcagagc 9600 atcaaatcct ttgacaggca ttttgaaaaa aacagaaaca atgcattaga ttttgtcacc 9660 aaatcctata atgaaacaaa aattaagttt gataagtaca aagctgaaaa atctcacgac 9720 gagctcccca ggacctttca aattcctgga tacactgttc cagttgtcaa tgttgaagtg 9780 tctccattca ccatagagat gtcggcattc ggctatgtgt tcccaaaagc agtcagcatg 9840 cctagtttct ccatcatagg ttctgacgtc cgtgtgcctt catacacatt aatcctgcca 9900 tcattagagc tgccagtcct tcatgtccct agaaatctca agctttctct tccagatttc 9960 aaggaattgt gtaccataag ccatattttt attcctgcca tgggcaatat tacctatgat 10020 ttctccttta aatcaagtgt catcacactg aataccaatg ctgaactttt taaccagtca 10080 gatattgttg ctcatctcct ttcttcatct tcatctgtca ttgatgcact gcagtacaaa 10140 ttagagggca ccacaagatt gacaagaaaa aggggattga agttagccac agctctgtct 10200 ctgagcaaca aatttgtgga gggtagtcat aacagtactg tgagcttaac cacgaaaaat 10260 atggaagtgt cagtggcaaa aaccacaaaa ccggaaattc caattttgag aatgaatttc 10320 aagcaagaac ttaatggaaa taccaagtca aaacctactg tctcttcctc catggaattt 10380 aagtatgatt tcaattcttc aatgctgtac tctaccgcta aaggagcagt tgaccacaag 10440 cttagcttgg aaagcctcac ctcttacttt tccattgagt catctaccaa aggagatgtc 10500 aagggttcgg ttctttctcg ggaatattca ggaactattg ctagtgaggc caacacttac 10560 ttgaattcca agagcacacg gtcttcagtg aagctgcagg gcacttccaa aattgatgat 10620 atctggaacc ttgaagtaaa agaaaatttt gctggagaag ccacactcca acgcatatat 10680 tccctctggg agcacagtac gaaaaaccac ttacagctag agggcctctt tttcaccaac 10740 ggagaacata caagcaaagc caccctggaa ctctctccat ggcaaatgtc agctcttgtt 10800 caggtccatg caagtcagcc cagttccttc catgatttcc ctgaccttgg ccaggaagtg 10860 gccctgaatg ctaacactaa gaaccagaag atcagatgga aaaatgaagt ccggattcat 10920 tctgggtctt tccagagcca ggtcgagctt tccaatgacc aagaaaaggc acaccttgac 10980 attgcaggat ccttagaagg acacctaagg ttcctcaaaa atatcatcct accagtctat 11040 gacaagagct tatgggattt cctaaagctg gatgtcacca ccagcattgg taggagacag 11100 catcttcgtg tttcaactgc ctttgtgtac accaaaaacc ccaatggcta ttcattctcc 11160 atccctgtaa aagttttggc tgataaattc attattcctg ggctgaaact aaatgatcta 11220 aattcagttc ttgtcatgcc tacgttccat gtcccattta cagatcttca ggttccatcg 11280 tgcaaacttg acttcagaga aatacaaatc tataagaagc tgagaacttc atcatttgcc 11340 ctcaccctac caacactccc cgaggtaaaa ttccctgaag ttgatgtgtt aacaaaatat 11400 tctcaaccag aagactcctt gattcccttt tttgagataa ccgtgcctga atctcagtta 11460 actgtgtccc agttcacgct tccaaaaagt gtttcagatg gcattgctgc tttggatcta 11520 aatgcagtag ccaacaagat cgcagacttt gagttgccca ccatcatcgt gcctgagcag 11580 accattgaga ttccctccat taagttctct gtacctgctg gaattgtcat tccttccttt 11640 caagcactga ctgcacgctt tgaggtagac tctcccgtgt ataatgccac ttggagtgcc 11700 agtttgaaaa acaaagcaga ttatgttgaa acagtcctgg attccacatg cagctcaacc 11760 gtacagttcc tagaatatga actaaatgtt ttgggaacac acaaaatcga agatggtacg 11820 ttagcctcta agactaaagg aacacttgca caccgtgact tcagtgcaga atatgaagaa 11880 gatggcaaat atgaaggact tcaggaatgg gaaggaaaag cgcacctcaa tatcaaaagc 11940 ccagcgttca ccgatctcca tctgcgctac cagaaagaca agaaaggcat ctccacctca 12000 gcagcctccc cagccgtagg caccgtgggc atggatatgg atgaagatga cgacttttct 12060 aaatggaact tctactacag ccctcagtcc tctccagata aaaaactcac catattcaaa 12120 actgagttga gggtccggga atctgatgag gaaactcaga tcaaagttaa ttgggaagaa 12180 gaggcagctt ctggcttgct aacctctctg aaagacaacg tgcccaaggc cacaggggtc 12240 ctttatgatt atgtcaacaa gtaccactgg gaacacacag ggctcaccct gagagaagtg 12300 tcttcaaagc tgagaagaaa tctgcagaac aatgctgagt gggtttatca aggggccatt 12360 aggcaaattg atgatatcga cgtgaggttc cagaaagcag ccagtggcac cactgggacc 12420 taccaagagt ggaaggacaa ggcccagaat ctgtaccagg aactgttgac tcaggaaggc 12480 caagccagtt tccagggact caaggataac gtgtttgatg gcttggtacg agttactcaa 12540 aaattccata tgaaagtcaa gaagctgatt gactcactca ttgattttct gaacttcccc 12600 agattccagt ttccggggaa acctgggata tacactaggg aggaactttg cactatgttc 12660 atgagggagg tagggacggt actgtcccag gtatattcga aagtccataa tggttcagaa 12720 atactgtttt cctatttcca agacctagtg attacacttc ctttcgagtt aaggaaacat 12780 aaactaatag atgtaatctc gatgtatagg gaactgttga aagatttatc aaaagaagcc 12840 caagaggtat ttaaagccat tcagtctctc aagaccacag aggtgctacg taatcttcag 12900 gaccttttac aattcatttt ccaactaata gaagataaca ttaaacagct gaaagagatg 12960 aaatttactt atcttattaa ttatatccaa gatgagatca acacaatctt caatgattat 13020 atcccatatg tttttaaatt gttgaaagaa aacctatgcc ttaatcttca taagttcaat 13080 gaatttattc aaaacgagct tcaggaagct tctcaagagt tacagcagat ccatcaatac 13140 attatggccc ttcgtgaaga atattttgat ccaagtatag ttggctggac agtgaaatat 13200 tatgaacttg aagaaaagat agtcagtctg atcaagaacc tgttagttgc tcttaaggac 13260 ttccattctg aatatattgt cagtgcctct aactttactt cccaactctc aagtcaagtt 13320 gagcaatttc tgcacagaaa tattcaggaa tatcttagca tccttaccga tccagatgga 13380 aaagggaaag agaagattgc agagctttct gccactgctc aggaaataat taaaagccag 13440 gccattgcga cgaagaaaat aatttctgat taccaccagc agtttagata taaactgcaa 13500 gatttttcag accaactctc tgattactat gaaaaattta ttgctgaatc caaaagattg 13560 attgacctgt ccattcaaaa ctaccacaca tttctgatat acatcacgga gttactgaaa 13620 aagctgcaat caaccacagt catgaacccc tacatgaagc ttgctccagg agaacttact 13680 atcatcctct aattttttta aaagaaatct tcatttattc ttcttttcca attgaacttt 13740 cacatagcac agaaaaaatt caaactgcct atattgataa aaccatacag tgagccagcc 13800 ttgcagtagg cagtagacta taagcagaag cacatatgaa ctggacctgc accaaagctg 13860 gcaccagggc tcggaaggtc tctgaactca gaaggatggc attttttgca agttaaagaa 13920 aatcaggatc tgagttattt tgctaaactt gggggaggag gaacaaataa atggagtctt 13980 tattgtgtat cat 13993 21 1965 DNA Homo sapiens 21 caattccggg ccgccccgga gaccacctcc tcctcctcgt cgtcgtcctc cgcctcctgc 60 gcctcgtcct cgtcctcctc caattcggcc agcgccccct cggctgcctg caagagcgcg 120 ggcggcggcg gcgcgggcgc cgggagcggg ggcgccaaga aggcgagctc ggggctgcgg 180 cggcccgaga agccgcccta ctcgtacatc gcgctcatcg tcatggccat ccagagctcg 240 cccagcaagc gcctgacgct cagcgagatc taccagttcc tgcaggcgcg cttccccttc 300 ttccgcggcg cctaccaggg ctggaagaac tcggtgcgcc acaatctctc gctcaacgag 360 tgcttcatca agctgcctaa gggcctcggg cggcccggca agggccacta ctggaccatc 420 gacccggcca gcgagttcat gttcgaggag ggctcgttcc gccgccggcc gcgcggcttc 480 aggcggaagt gccaggcgct caagcccatg taccaccgcg tggtgagcgg cttgggcttc 540 ggggcgtcgc tgctgcccca gggcttcgac ttccaggcgc ccccgtcggc gccgctcggc 600 tgccacagcc agggcggcta cggcggcctc gacatgatgc ccgcgggcta cgacgccggc 660 gcgggcgccc ccagccacgc gcaccctcac caccaccacc accaccacgt cccgcacatg 720 tcgcccaacc cgggttccac ctacatggcc agctgcccgg tgcccgcggg acccgggggc 780 gtcggtgcgg ccgggggcgg cggcggcggc gactacgggc cggacagcag cagcagcccg 840 gtaccctcgt ccccggccat ggcgagcgcc atcgaatgcc actcgcccta cacgagccct 900 gcggcgcact ggagctcgcc tggcgcctcg ccttacctca agcagccgcc tgccctgacg 960 cccagcagca accccgccgc ctcggcaggc ctgcactcca gcatgtcctc ctactcgctg 1020 gagcagagct acttgcacca gaacgctcgc gaggacctct cagtgggact gccccgttac 1080 cagcatcact ctactccagt gtgtgacaga aaagatttcg tcctcaactt caatgggatt 1140 tcttctttcc atccctcagc tagcgggtcg tattatcacc atcaccacca gagcgtctgt 1200 caggatatta agccctgcgt catgtgaacg gaaagaggcc aagcgatggc cgctctctcc 1260 tctcccctcc tcagaggggg cagatagaaa ctgggacgga ttcaagtcac atgcacgcgg 1320 atagcagtaa gccacacacc tgccacttag ccagaatgcc caggatcgcg ttggtcactg 1380 ttatttgcct actgctggaa gaaggacaac cgctggcaag gtagcgttcc ccaatctgaa 1440 tacctgcagg ctcccacatg agggagaggg cagactcagg tgggaagatg tgccatgcgt 1500 aaggcatcaa cgtgtatctg tgggatcttc gttgccttca gtaatcaggg tgtgaaaaaa 1560 gcagacaagt tgtgtgtgtg tgtgtgtgtc taagaaaact tgtgtgcttt tcaaaaaggc 1620 agtgctaagc acaagatttc aagaaagcct cttcttgttg cctagctgag tgggagagtc 1680 attttcccca gacactacat ttggatacag gtgccaaaga acattattaa ggaattattt 1740 agaaacaatg tgtctagttt aagaaagtgg ttttcagtat tgtgacaata caacgttttt 1800 acaaggttgt tttctaccac catattttaa agatattttt atgaccgtgt atactcacac 1860 tttgcttgta ttttaaaagg aggatatatt tgcacttatg tatactttta cagtttgcca 1920 aaatattttg ttgtaaaatt ttttttcaat aaaatgtata taaca 1965 22 1805 DNA Homo sapiens 22 aagagactga actgtatctg cctctatttc caaaagactc acgttcaact ttcgctcaca 60 caaagccggg aaaattttat tagtcctttt tttaaaaaaa gttaatataa aattatagca 120 aaaaaaaaaa ggaacctgaa ctttagtaac acagctggaa caatcgcagc ggcggcggca 180 gcggcgggag aagaggttta atttagttga ttttctgtgg ttgttggttg ttcgctagtc 240 tcacggtgat ggaagctgca cattttttcg aagggaccga gaagctgctg gaggtttggt 300 tctcccggca gcagcccgac gcaaaccaag gatctgggga tcttcgcact atcccaagat 360 ctgagtggga catacttttg aaggatgtgc aatgttcaat cataagtgtg acaaaaactg 420 acaagcagga agcttatgta ctcagtgaga gtagcatgtt tgtctccaag agacgtttca 480 ttttgaagac atgtggtacc accctcttgc tgaaagcact ggttcccctg ttgaagcttg 540 ctagggatta cagtgggttt gactcaattc aaagcttctt ttattctcgt aagaatttca 600 tgaagccttc tcaccaaggg tacccacacc ggaatttcca ggaagaaata gagtttctta 660 atgcaatttt cccaaatgga gcaggatatt gtatgggacg tatgaattct gactgttggt 720 acttatatac tctggatttc ccagagagtc gggtaatcag tcagccagat caaaccttgg 780 aaattctgat gagtgagctt gacccagcag ttatggacca gttctacatg aaagatggtg 840 ttactgcaaa ggatgtcact cgtgagagtg gaattcgtga cctgatacca ggttctgtca 900 ttgatgccac aatgttcaat ccttgtgggt attcgatgaa tggaatgaaa tcggatggaa 960 cttattggac tattcacatc actccagaac cagaattttc ttatgttagc tttgaaacaa 1020 acttaagtca gacctcctat gatgacctga tcaggaaagt tgtagaagtc ttcaagccag 1080 gaaaatttgt gaccaccttg tttgttaatc agagttctaa atgtcgcaca gtgcttgctt 1140 cgccccagaa gattgaaggt tttaagcgtc ttgattgcca gagtgctatg ttcaatgatt 1200 acaattttgt ttttaccagt tttgctaaga agcagcaaca acagcagagt tgattaagaa 1260 aaatgaagaa aaaacgcaaa aagagaacac atgtagaagg tggtggatgc tttctagatg 1320 tcgatgctgg gggcagtgct ttccataacc accactgtgt agttgcagaa agccctagat 1380 gtaatgatag tgtaatcatt ttgaattgta tgcattatta tatcaaggag ttagatatct 1440 tgcatgaatg ctctcttctg tgtttaggta ttctctgcca ctcttgctgt gaaattgaag 1500 tggatgtaga aaaaaccttt tactatatga aactttacaa cacttgtgaa agcaactcaa 1560 tttggtttat gcacagtgta atatttctcc aagtatcatc caaaattccc cacagacaag 1620 gctttcgtcc tcattaggtg ttggcctcag cctaaccctc taggactgtt ctattaaatt 1680 gctgccagaa ttttacatcc agttacctcc actttctaga acatattctt tactaatgtt 1740 attgaaacca atttctactt catactgatg tttttggaaa cagcaattaa agtttttctt 1800 ccatg 1805 23 3741 DNA Homo sapiens 23 gaattccgtc atggcgtcgc agccaaattc gtctgcgaag aagaaagagg agaaggggaa 60 gaacatccag gtggtggtga gatgcagacc atttaatttg gcagagcgga aagctagcgc 120 ccattcaata gtagaatgtg atcctgtacg aaaagaagtt agtgtacgaa ctggaggatt 180 ggctgacaag agctcaagga aaacatacac ttttgatatg gtgtttggag catctactaa 240 acagattgat gtttaccgaa gtgttgtttg tccaattctg gatgaagtta ttatgggcta 300 taattgcact atctttgcgt atggccaaac tggcactgga aaaactttta caatggaagg 360 tgaaaggtca cctaatgaag agtatacctg ggaagaggat cccttggctg gtataattcc 420 acgtaccctt catcaaattt ttgagaaact tactgataat ggtactgaat tttcagtcaa 480 agtgtctctg ttggagatct ataatgaaga gctttttgat cttcttaatc catcatctga 540 tgtttctgag agactacaga tgtttgatga tccccgtaac aagagaggag tgataattaa 600 aggtttagaa gaaattacag tacacaacaa ggatgaagtc tatcaaattt tagaaaaggg 660 ggcagcaaaa aggacaactg cagctactct gatgaatgca tactctagtc gttcccactc 720 agttttctct gttacaatac atatgaaaga aactacgatt gatggagaag agcttgttaa 780 aatcggaaag ttgaacttgg ttgatcttgc aggaagtgaa aacattggcc gttctggagc 840 tgttgataag agagctcggg aagctggaaa tataaatcaa tccctgttga ctttgggaag 900 ggtcattact gcccttgtag aaagaacacc tcatgttcct tatcgagaat ctaaactaac 960 tagaatcctc caggattctc ttggagggcg tacaagaaca tctataattg caacaatttc 1020 tcctgcatct ctcaatcttg aggaaactct gagtacattg gaatatgctc atagagcaaa 1080 gaacatattg aataagcctg aagtgaatca gaaactcacc aaaaaagctc ttattaagga 1140 gtatacggag gagatagaac gtttaaaacg agatcttgct gcagcccgtg agaaaaatgg 1200 agtgtatatt tctgaagaaa attttagagt catgagtgga aaattaactg ttcaagaaga 1260 gcagattgta gaattgattg aaaaaattgg tgctgttgag gaggagctga atagggttac 1320 agagttgttt atggataata aaaatgaact tgaccagtgt aaatctgacc tgcaaaataa 1380 aacacaagaa cttgaaacca ctcaaaaaca tttgcaagaa actaaattac aacttgttaa 1440 agaagaatat atcacatcag ctttggaaag tactgaggag aaacttcatg atgctgccag 1500 caagctgctt aacacagttg aagaaactac aaaagatgta tctggtctcc attccaaact 1560 ggatcgtaag aaggcagttg accaacacaa tgcagaagct caggatattt ttggcaaaaa 1620 cctgaatagt ctgtttaata atatggaaga attaattaag gatggcagct caaagcaaaa 1680 ggccatgcta gaagtacata agaccttatt tggtaatctg ctgtcttcca gtgtctctgc 1740 attagatacc attactacag tagcacttgg atctctcaca tctattccag aaaatgtgtc 1800 tactcatgtt tctcagattt ttaatatgat actaaaagaa caatcattag cagcagaaag 1860 taaaactgta ctacaggaat tgattaatgt actcaagact gatcttctaa gttcactgga 1920 aatgatttta tccccaactg tggtgtctat actgaaaatc aatagtcaac taaagcatat 1980 tttcaagact tcattgacag tggccgataa gatagaagat caaaaaaaaa ggaactcaga 2040 tggctttctc agtatactgt gtaacaatct acatgaacta caagaaaata ccatttgttc 2100 cttggttgag tcacaaaagc aatgtggaaa cctaactgaa gacctgaaga caataaagca 2160 gacccattcc caggaacttt gcaagttaat gaatctttgg acagagagat tctgtgcttt 2220 ggaggaaaag tgtgaaaata tacagaaacc acttagtagt gtccaggaaa atatacagca 2280 gaaatctaag gatatagtca acaaaatgac ttttcacagt caaaaatttt gtgctgattc 2340 tgatggcttc tcacaggaac tcagaaattt taaccaagaa ggtacaaaat tggttgaaga 2400 atctgtgaaa cactctgata aactcaatgg caacctggaa aaaatatctc aagagactga 2460 acagagatgt gaatctctga acacaagaac agtttatttt tctgaacagt gggtatcttc 2520 cttaaatgaa agggaacagg aacttcacaa cttattggag gttgtaagcc aatgttgtga 2580 ggcttcaagt tcagacatca ctgagaaatc agatggacgt aaggcagctc atgagaaaca 2640 gcataacatt tttcttgatc agatgactat tgatgaagat aaattgatag cacaaaatct 2700 agaacttaat gaaaccataa aaattggttt gactaagctt aattgctttc tggaacagga 2760 tctgaaactg gatatcccaa caggtacgac accacagagg aaaagttatt tatacccatc 2820 aacactggta agaactgaac cacgtgaaca tctccttgat cagctgaaaa ggaaacagcc 2880 tgagctgtta atgatgctaa actgttcaga aaacaacaaa gaagagacaa ttccggatgt 2940 ggatgtagaa gaggcagttc tggggcagta tactgaagaa cctctaagtc aagagccatc 3000 tgtagatgct ggtgtggatt gttcatcaat tggcggggtt ccatttttcc agcataaaaa 3060 atcacatgga aaagacaaag aaaacagagg cattaacaca ctggagaggt ctaaagtgga 3120 agaaactaca gagcacttgg ttacaaagag cagattacct ctgcgagccc agatcaacct 3180 ttaattcact tgggggttgg caattttatt tttaaagaaa aacttaaaaa taaaacctga 3240 aaccccagaa cttgagcctt gtgtatagat tttaaaagaa tatatatatc agccgggcgc 3300 gtggctctag ctgtaatccc agctaacttt ggaggctgag gcgggtggat tgcttgagcc 3360 caggagtttg agaccagcct ggccaacgtg cgctaaaacc ttcgtctctg ttaaaaatta 3420 gccgggcgtg gtgggcacac tcctgtaatc ccagctactg gggaggctga ggcacgagaa 3480 tcacttgaac ccagaagcgg ggttgcagtg agccaaaggt acaccactac actccagcct 3540 gggcaacaga gcaagactcg gtctcaaaaa taaaatttaa aaaagatata aggcagtact 3600 gtaaattcag ttgaattttg atatctaccc atttttctgt catccctata gttcactttg 3660 tattaaattg ggtttcattt gggatttgca atgtaaatac gtatttctag ttttcatata 3720 aagtagttct tttaggaatt c 3741 24 7672 DNA Homo sapiens 24 gaggctcctc ggtccttcag cacccctcgg cccgacgcac ccacgcccct caccccccga 60 gagccgaaaa tggacccaag tggggtcaaa gtgctggaaa cagcagagga catccaggag 120 aggcggcagc aggtcctaga ccgataccac cgcttcaagg aactctcaac ccttaggcgt 180 cagaagctgg aagattccta tcgattccag ttctttcaaa gagatgctga agagctggag 240 aaatggatac aggaaaaact tcagattgca tctgatgaga attataaaga cccaaccaac 300 ttgcagggaa agcttcagaa gcatcaagca tttgaagctg aagtgcaggc caactcagga 360 gccattgtta agctggatga aactggaaac ctgatgatct cagaagggca ttttgcatct 420 gaaaccatac ggacccgttt gatggagctg caccgccagt gggaattact tttggagaag 480 atgcgagaaa aaggaatcaa actgctgcag gcccagaagt tggtgcagta cttacgagaa 540 tgtgaggacg tgatggactg gatcaatgac aaggaagcaa ttgttacttc tgaagagctg 600 ggccaggatc tggagcatgt agaggtttta cagaagaaat ttgaagagtt tcaaacagat 660 atggctgctc atgaagaaag agttaatgaa gtgaaccagt ttgctgccaa actcatacag 720 gagcagcacc ctgaggagga actgatcaag actaagcagg atgaagtcaa tgcagcctgg 780 cagcggctga agggcctggc tctgcagagg caggggaagc tctttggggc agcagaagtt 840 cagcgcttta acagggatgt ggatgagact atcagttgga ttaaggaaaa ggagcagtta 900 atggcctctg atgattttgg ccgagacctg gcaagtgttc aggctctgct tcggaagcac 960 gagggtctgg agagagatct tgctgctcta gaagacaagg tcaaagccct gtgtgctgag 1020 gctgaccgcc tgcaacagtc ccaccctctg agtgcaacac agattcaagt gaagcgagag 1080 gaactgatta caaactggga gcagatccgc accttggcgg cagagagaca tgcacggctc 1140 aatgattcat acaggcttca acgcttcctt gctgacttcc gtgacctcac cagctgggtg 1200 actgagatga aagccctcat caatgcagat gagcttgcca gtgatgtggc tggggctgaa 1260 gccctgctag atagacacca agagcacaag ggtgaaattg atgcccatga agacagcttc 1320 aaatctgcag atgaatctgg acaggcactg cttgctgctg gtcactatgc ctcagatgaa 1380 gtgagggaga agctgaccgt cctttccgag gagagagcgg cgctgctgga gctgtgggag 1440 ctgcgcaggc agcagtacga gcagtgcatg gacctgcagc tcttctaccg ggacactgag 1500 caggtggaca actggatgag caagcaggag gcgttcctgt tgaatgaaga cttgggagat 1560 tccttggata gtgtggaagc gcttcttaag aagcacgaag actttgagaa atcccttagt 1620 gcccaggagg aaaagattac agcattagat gaatttgcaa ccaagctaat tcagaacaac 1680 cactatgcaa tggaagatgt ggccactcgc cgagatgctc tgttgagccg ccgcaatgcc 1740 cttcacgaga gagccatgcg tcgccgggcc cagctagccg attctttcca tctgcagcag 1800 tttttccgtg attctgatga gctcaagagt tgggtcaatg agaagatgaa aactgccaca 1860 gatgaagctt ataaagatcc atccaaccta caaggaaaag tacagaagca tcaggctttt 1920 gaggctgagc tctcagcaaa ccagagccga attgatgcct tggagaaagc tggccaaaag 1980 ctgattgatg tcaaccacta tgccaaggat gaagtggcag ctcgtatgaa tgaggtgatc 2040 agtttgtgga agaaactgct agaggccact gaactgaaag gaataaagct tcgtgaagcc 2100 aaccagcaac agcaatttaa tcgcaatgtt gaggatattg aattgtggct atatgaagta 2160 gaaggtcact tggcttcgga tgattacggc aaagatctta ccaatgtgca gaacctccag 2220 aagaaacatg ccctgctaga ggcagatgtg gctgctcacc aggaccgaat tgatggcatc 2280 accattcagg cccgccagtt ccaagatgct ggccattttg atgcagaaaa catcaagaag 2340 aaacaggaag ccctcgtggc tcgctatgag gcactcaagg agcccatggt tgcccggaag 2400 cagaagctgg ccgattctct gcggttgcag cagctcttcc gggatgttga ggatgaggag 2460 acgtggattc gagagaaaga gcccattgcc gcatctacca acagaggtaa ggatttaatt 2520 ggggtccaga atctgctaaa gaaacatcaa gccttacaag cagaaattgc tggacatgaa 2580 ccacgcatca aagcagttac acagaagggg aatgccatgg tggaggaagg ccattttgct 2640 gcagaggatg tgaaggccaa gcttcacgag ctgaaccaaa agtgggaggc actgaaagcc 2700 aaagcttccc agcgtcggca ggacctggag gactctctgc aggcccagca gtactttgct 2760 gatgctaacg aggctgaatc ctggatgcgg gagaaggaac ccattgtggg cagcactgac 2820 tatggcaagg acgaagactc tgctgaggct ctactgaaga aacacgaagc tttgatgtca 2880 gatctcagtg cctacggcag cagcatccag gctttgcgag aacaagcaca gtcctgccgg 2940 caacaagtgg cccccacgga tgatgagact gggaaggagc tggtcttggc tctctacgac 3000 tatcaggaga agagtccccg agaggtcacc atgaagaagg gagatatcct taccttactc 3060 aacagcacca acaaggattg gtggaaagtg gaagtgaacg atcgtcaggg ttttgtgccg 3120 gctgcgtacg tgaagaaatt ggaccccgcc cagtcagcct cccgggagaa tctcctggag 3180 gagcaaggca gcatagcact gcggcaggag cagattgaca atcagacacg cataactaag 3240 gaggccggca gtgtatctct gcgtatgaag caggtggaag aactatatca ttctctgctg 3300 gaactgggtg agaagcgtaa aggcatgttg gagaagagtt gcaagaagtt tatgttgttc 3360 cgtgaagcga atgaactaca gcaatggatc aatgagaagg aagccgctct gacaagtgag 3420 gaggtcggag cagacttgga gcaggttgag gtgctccaga agaagtttga tgacttccag 3480 aaggacctga aggccaatga gtcacggttg aaggacatta acaaggtagc tgaagacctg 3540 gagtctgaag gtcttatggc agaggaggtg caggctgtgc aacaacagga agtgtatggc 3600 atgatgccca gggatgaaac tgattccaag acagcctccc cgtggaagtc tgctcgtctg 3660 atggttcaca ccgtggccac ctttaattcc atcaaggagc tgaatgagcg ctggcggtcc 3720 ctacagcagc tggccgagga acggagccag ctcttgggca gcgcccatga agtacagagg 3780 ttccacagag atgctgatga aaccaaagaa tggattgaag agaagaatca agctctaaac 3840 acagacaatt atggacatga tctcgccagt gtccaggccc tgcaacgcaa gcatgagggc 3900 ttcgagaggg accttgcggc tctcggtgac aaggtaaact cccttggtga aacagcagag 3960 cgcctgatcc agtcccatcc cgagtcagca gaagacctgc aggaaaagtg cacagagtta 4020 aaccaggcct ggagcagcct ggggaaacgt gcagatcagc gcaaggcaaa gttgggtgac 4080 tcccacgacc tgcagcgctt ccttagcgat ttccgggacc tcatgtcttg gatcaatgga 4140 atacgggggt tggtgtcctc agatgagcta gccaaggatg tcaccggagc tgaggcattg 4200 ctggagcgac accaggaaca ccggacagaa atcgatgcca gggctggcac tttccaggca 4260 tttgagcagt ttggacagca gctgttggct cacggacact atgccagccc tgagatcaag 4320 cagaaacttg atattcttga ccaggagcgt gcagacctgg agaaggcctg ggttcagcgc 4380 aggatgatgc tggatcagtg ccttgaactg cagctgttcc atcgggactg tgagcaagct 4440 gagaactgga tggctgcccg ggaggccttc ttgaataccg aagacaaagg agactcactg 4500 gacagcgtag aggctctgat caaaaaacat gaagactttg acaaagcgat taacgtccag 4560 gaagagaaga ttgctgctct gcaggccttt gccgaccagc tcatcgctgc cggccattat 4620 gccaagggag acatttctag ccggcgcaat gaggtcttgg acaggtggcg acgtctgaaa 4680 gcccagatga ttgagaaaag gtcaaagcta ggagaatctc aaaccctcca acagttcagc 4740 cgggatgtgg atgagattga ggcttggatc agtgaaaaat tgcaaacagc gagtgatgag 4800 tcgtacaagg atcccaccaa catccagctt tccaagctgc tgagcaagca ccagaagcac 4860 caggcttttg aagcagagct gcatgccaac gctgaccgga tccgtggggt tatcgacatg 4920 ggcaactccc tcattgaacg tggagcctgt gccggcagtg aggatgctgt caaggcccgc 4980 ctggctgcct tagctgacca gtggcagttc ttggtgcaaa agtcagcgga aaagagccag 5040 aaactgaaag aagccaacaa gcagcagaac ttcaacacag ggatcaagga ctttgacttc 5100 tggctgtctg aggtggaggc cctgctggca tccgaagatt atggcaaaga cctggcttct 5160 gtgaacaacc tgctgaaaaa gcatcaactg ctggaagcag atatatctgc ccatgaggat 5220 cgcctgaagg acctgaacag ccaggcagac agcctgatga ccagcagtgc cttcgacacc 5280 tcccaagtaa aggacaagag ggacaccatc aacgggcgct tccagaagat caagagcatg 5340 gcggcctccc ggcgagccaa gctgaatgaa tcccatcgcc tgcaccagtt cttccgggac 5400 atggatgacg aggagtcctg gatcaaggag aagaagctgc tggtgggctc agaggactac 5460 ggccgggacc taactggcgt gcagaacctg aggaagaagc acaagcggct ggaagcagaa 5520 ctggctgcgc atgagccggc tattcagggt gtcctggaca ctggcaagaa gctgtccgat 5580 gacaacacca tcgggaaaga ggagatccag cagcggctgg cgcagtttgt ggagcactgg 5640 aaagagctga agcagctggc agctgcccgg ggtcagcggc tggaagagtc cttggaatat 5700 cagcagtttg tagccaatgt ggaagaggaa gaagcctgga tcaatgagaa aatgaccctg 5760 gtggccagcg aagattatgg cgacactctt gccgccatcc agggcttact gaagaaacat 5820 gaagcttttg agacagactt caccgtccac aaggatcgcg tgaatgatgt ctgcaccaat 5880 ggacaagacc tcattaagaa gaacaatcac catgaggaga acatctcttc aaagatgaag 5940 ggcctgaacg ggaaagtgtc agacctggag aaagctgcag cccagagaaa ggcgaacgtg 6000 gatgagaact cggccttcct tcagttcaac tggaaggcgg acgtggtgga gtcctggatc 6060 ggtgaaaagg agaacagctt gaagacagat gattatggcc gagacctgtc ttctgtgcag 6120 acgctcctca ccaaacagga aacttttgac gctgggctgc aggccttcca gcaggaaggc 6180 attgccaaca tcactgccct caaagatcag cttctcgccg ccaaacacgt tcagtccaag 6240 gccatcgagg cccggcacgc ctccctcatg aagaggtgga gccagcttct ggccaactca 6300 gccgcccgca agaagaagct tctggaggct cagagtcact tccgcaaggt ggaggacctc 6360 ttcctgacct tcgccaaaaa ggcttctgcc ttcaacagct ggtttgaaaa tgcagaggag 6420 gacttaacag accccgtgcg ctgcaactcc ttggaagaaa tcaaagcttt gcgcgaggcc 6480 cacgacgcct tccgctcctc cctcagctct gcccaggctg acttcaacca gctggccgag 6540 ctggaccgcc agatcaagag cttccgcgta gcctccaacc cctacacctg gtttaccatg 6600 gaggccctgg aggagacctg gaggaaccta cagaaaatca tcaaggagag ggagctggag 6660 ctgcagaagg aacagcggcg gcaggaggag aacgacaagc tgcgccagga gtttgcccag 6720 cacgccaacg ccttccacca gtggatccaa gagaccagga catacctcct cgatgggtcc 6780 tgtatggtgg aagagtcggg gaccctcgaa tcccagcttg aagctaccaa acgcaagcac 6840 caggaaatcc gagccatgag aagtcagctc aaaaagatcg aggacctggg ggccgccatg 6900 gaggaggccc tcatcctgga caacaagtac acggagcaca gcaccgtggg cctcgcccag 6960 cagtgggacc agctggacca gctgggcatg cgcatgcagc acaacctgga gcagcagatc 7020 caggccagga acacaacagg tgtgactgag gaggccctca aagaattcag catgatgttt 7080 aaacactttg acaaggacaa gtctggcagg ctgaaccatc aggagttcaa atcttgcctg 7140 cgctccctgg gctatgacct gcccatggtg gaggaagggg aacctgaccc tgagttcgag 7200 gcaatcctgg acacggtgga tccgaacaga gatggccatg tctccttgca agaatacatg 7260 gctttcatga tcagccgcga aactgagaac gtcaagtcca gcgaggagat tgagagcgcc 7320 ttccgggccc tcagctcaga gggaaagcct tacgtgacca aggaggagct ctaccagaac 7380 ctgacccggg aacaagccga ctactgcgtc tcccacatga agccctacgt ggacggcaag 7440 ggccgcgagc tccccaccgc gttcgactac gtggagttca cccgctcgct tttcgtgaac 7500 tgagccactc cctgggtcac ccacccctcg ctgcttgccc tgcgtcgcct tgctgcatgt 7560 ccgctcctct gtgtgctctc actttccact gtaaccttaa gcctgcttag cttggaataa 7620 gacttaggag aaaatggtgc ttcactaacc cgcttccggt ccagtcacaa tc 7672 25 1121 DNA Homo sapiens 25 ggaattccct atagagccgg gtgagagagc gagcgcccgt cggcgggtgt cgagggcggg 60 ttgcctcgcg ctgacccttc ccgccctcct tctcgtcaca caccaggtcc ccgcggaagc 120 cgcggtgtcg gcgccatggc ggagctgacg gctcttgaga gtctcatcga gatgggcttc 180 cccaggggac gcgcggagaa ggctctggcc ctcacaggga accagggcat cgaggctgcg 240 atggactggc tgatggagca cgaagacgac cccgatgtgg acgagccttt agagactccc 300 cttggacata tcctgggacg ggagcccact tcctcagagc aaggcggcct tgaaggatct 360 gcttctgctg ccggagaagg caaacccgct ttgagtgaag aggaaagaca ggaacaaact 420 aagaggatgt tggagctggt ggcccagaag cagcgggagc gtgaagaaag agaggaacgg 480 gaggcattgg aacgggaacg gcagcgcagg agacaagggc aagagttgtc agcagcacga 540 cagcggctac aggaagatga gatgcgccgg gctgctgctg aggagaggcg gagggaaaat 600 gccgaggagt tagcagccag acaaagagtt agagaaaaga tcgagaggga caaagcagag 660 agagccaaga agtatggtgg cagtgtgggc tctcagccac ccccagtggc accagagcca 720 ggtcctgttc cctcttctcc cagccaggag cctcccacca agcgggagta tgaccagtgt 780 cgcatacagg tcaggctgcc agatgggacc tcactgaccc agacgttccg ggcccgggaa 840 cagctggcag ctgtgaggct ctatgtggag ctccaccgtg gggaggaact aggtgggggc 900 caggaccctg tgcaattgct cagtggcttc cccagacggg ccttctcaga agctgacatg 960 gagcggcctc tgcaggagct gggactcgtg ccttctgctg ttctcattgt ggccaagaaa 1020 tgtcccagct gagggccttt gtcccattgt ccctctgtga ccccttcatc tttgataaag 1080 cactgacatc tccttcctaa taaatagacc ctgagttctg t 1121 26 3468 DNA Homo sapiens 26 aatggcgatg cctaccacct agaactggat tgtgcgctgg ccgccaccgc tgccacctgc 60 tcagagtgaa ataatgaagg tggtcaacct gaagcaagcc attttgcaag cctggaagga 120 gcgctggagt tactaccaat gggcaatcaa catgaagaaa ttctttccta aaggagccac 180 ctgggatatt ctcaacctgg cagatgcgtt actagagcag gccatgattg gaccatcccc 240 caatcctctc atcttgtcct acctgaagta tgccattagt tcccagatgg tgtcctactc 300 ttctgtcctc acagccatca gtaagtttga tgacttttct cgggacctgt gtgtccaggc 360 attgctggac atcatggaca tgttttgtga ccgtctgagc tgtcacggca aagcagagga 420 atgcatcgga ctgtgccgag cccttcttag cgccctccac tggctgctgc gctgcacggc 480 agcctctgca gagcggctgc gggaggggct ggaggccggc actccagccg ctggggagaa 540 gcagcttgcc atgtgccttc agcgcctgga gaaaaccctc agcagcacca agaaccgggc 600 cctgctgcac atcgccaaac tagaggaggc ctcttcttgg actgccatcg agcattctct 660 cttgaaactt ggagagatcc tgaccaatct cagcaacccg cagctccgga gtcaggccga 720 gcagtgtggc accctcatta ggagcatccc cacgatgctg tctgtgcatg cggagcagat 780 gcacaagacc ggcttcccca ctgtccacgc cgtgatcctg ctcgagggca ccatgaacct 840 gacaggcgag acgcagtccc tggtggagca gctgacgatg gtgaagcgca tgcagcatat 900 ccccacccca ctttttgtcc tggagatctg gaaagcttgc ttcgtggggc tcattgagtc 960 tcccgagggt acggaggagc tcaagtggac agctttcact ttcctcaaga ttccacaggt 1020 tttggtgaag ttgaagaagt actctcatgg agacaaggac ttcactgagg atgtcaactg 1080 tgcttttgag ttcctgctga agctcacccc cttgttggac aaagctgacc agcgctgcaa 1140 ctgtgactgt acaaacttcc tgctccaaga atgtggcaag caggggcttc tgtctgaggc 1200 cagcgtcaac aaccttatgg ctaagcgcaa agcggaccga gagcacgcac cccagcagaa 1260 atcgggagag aatgccaaca tccagcccaa catccagctg atcctccggg cggagcccac 1320 tgtcacaaac atcctcaaga cgatggatgc agaccactct aagtcaccgg agggactgct 1380 gggagtcctg ggccacatgc tgtccgggaa gagtctggac ttgctgctgg ctgccgccgc 1440 cgccactgga aagctgaaat ccttcgcccg gaaattcatc aatttgaatg aattcacaac 1500 ctatggcagc gaagaaagca ccaaaccggc ctccgtccgg gccctgctgt ttgacatctc 1560 cttcctcatg ctgtgccatg tggcccagac ctatggttca gaggtgattc tgtccgagtc 1620 gcgcacagga gctgaggtgc ccttcttcga gacctggatg cagacctgca tgcctgagga 1680 gggcaagatc ctgaaccctg accacccctg cttccgcccc gactccacca aagtggagtc 1740 cctggtggcc ctgctcaaca actcctcgga gatgaagcta gtgcagatga agtggcatga 1800 ggcctgtctc agcatctcag ccgccatctt ggaaatcctc aatgcctggg agaatggggt 1860 cctggccttc gagtccatcc agaaaatcac tgataacatc aaagggaagg tatgcagtct 1920 ggcggtgtgt gctgtggctt ggcttgtggc ccacgtccgg atgctggggc tggatgagcg 1980 tgagaagtcg ctgcagatga tccgccagct ggcagggcca ctgtttagtg agaacaccct 2040 gcagttctac aatgagaggg tggtgatcat gaactcgatc ctggagcgca tgtgtgccga 2100 cgtgctgcag cagacagcca cgcagatcaa gtttccctcc accggggtgg acacaatgcc 2160 ctactggaac ctgctgcccc ccaagcggcc catcaaagag gtgctgacgg acatttttgc 2220 caaggtgctg gagaagggct gggtggacag ccgctccatc cacatctttg acaccctgct 2280 gcacatgggc ggcgtctact ggttctgcaa caacctgatt aaggagctgc tgaaggagac 2340 gcggaaggag cacacgctgc gggcagtgga gctgctctac tccatcttct gcctggacat 2400 gcagcaagtg accctggtcc tgctgggcca catcctacct ggcctgctca ctgactcctc 2460 caagtggcac agcctcatgg accccccggg cactgctctt gccaagctgg ccgtgtggtg 2520 tgccctcagt tcctactcct cccacaaggg acaggcgtcc acccgccaga agaagagaca 2580 ccgcgaagac attgaggatt atatcagcct cttccccctg gacgatgtgc agccttcgaa 2640 gttgatgcga ctgctgagct ctaatgagga cgatgccaac atcctttcga gccccacaga 2700 ccgatccatg agcagctccc tctcagcctc tcagctccac acggtcaaca tgcgggaccc 2760 tctgaaccga gtcctggcca acctgttcct gctcatctcc tccatcctgg ggtctcgcac 2820 cgctggcccc cacacccagt tcgtgcagtg gttcatggag gagtgtgtgg actgcctgga 2880 gcagggtggc cgtggcagcg tcctgcagtt catgcccttc accaccgtgt cggaactggt 2940 gaaggtgtca gccatgtcca gccccaaggt ggttctggcc atcacggacc tcagcctgcc 3000 cctgggccgc caggtggctg ctaaagccat tgctgcactc tgaggggctt ggcatggccg 3060 cagtgggggc tggggactgg cgcagcccca ggcgcctcca agggaagcag tgaggaaaga 3120 tgaggcatcg tgcctcacat ccgctccaca tggtgcaaga gcctctagcg gcttccagtt 3180 ccccgctcct gactcctgac ctccaggatg tctcccggtt tcttctttca aaatttcctc 3240 tccatctgct ggcacctgag gagagtgagc agcctggacc acaagcccag tggtcacccc 3300 tgtgtgcgcc cgccccagcc caggagtagt cttacctctg aggaactttc tagatgcaaa 3360 gtgtgtatgt gtgtgtgtgt gtgtgtgtgt gtgtttgtgt gtattttgta atatgtgagg 3420 gaaatctacc ttcgttcatg tataaataaa gctcctcgtg gctccctt 3468 27 2704 DNA Homo sapiens 27 gcttagtgta accagcggcg tatatttttt aggcgccttt tcgaaaacct agtagttaat 60 attcatttgt ttaaatctta ttttattttt aagctcaaac tgcttaagaa taccttaatt 120 ccttaaagtg aaataatttt ttgcaaaggg gtttcctcga tttggagctt tttttttctt 180 ccaccgtcat ttctaactct taaaaccaac tcagttccat catggtgatg ttcaagaaga 240 tcaagtcttt tgaggtggtc tttaacgacc ctgaaaaggt gtacggcagt ggcgagaggg 300 tggctggccg ggtgatagtg gaggtgtgtg aagttactcg tgtcaaagcc gttaggatcc 360 tggcttgcgg agtggctaaa gtgctttgga tgcagggatc ccagcagtgc aaacagactt 420 cggagtacct gcgctatgaa gacacgcttc ttctggaaga ccagccaaca ggtgagaatg 480 agatggtgat catgagacct ggaaacaaat atgagtacaa gttcggcttt gagcttcctc 540 aggggcctct gggaacatcc ttcaaaggaa aatatgggtg tgtagactac tgggtgaagg 600 cttttcttga ccgcccgagc cagccaactc aagagacaaa gaaaaacttt gaagtagtgg 660 atctggtgga tgtcaatacc cctgatttaa tggcacctgt gtctgctaaa aaagaaaaga 720 aagtttcctg catgttcatt cctgatgggc gggtgtctgt ctctgctcga attgacagaa 780 aaggattctg tgaaggtgat gagatttcca tccatgctga ctttgagaat acatgttccc 840 gaattgtggt ccccaaagct gccattgtgg cccgccacac ttaccttgcc aatggccaga 900 ccaaggtgct gactcagaag ttgtcatcag tcagaggcaa tcatattatc tcagggacat 960 gcgcatcatg gcgtggcaag agccttcggg ttcagaagat caggccttct atcctgggct 1020 gcaacatcct tcgagttgaa tattccttac tgatctatgt tagcgttcct ggatccaaga 1080 aggtcatcct tgacctgccc ctggtaattg gcagcagatc aggtctaagc agcagaacat 1140 ccagcatggc cagccgaacc agctctgaga tgagttgggt agatctgaac atccctgata 1200 ccccagaagc tcctccctgc tatatggatg tcattcctga agatcaccga ttggagagcc 1260 caacaactcc tctgctagat gacatggatg gctctcaaga cagccctatc tttatgtatg 1320 cccctgagtt caagttcatg ccaccaccga cttatactga ggtggatccc tgcatcctca 1380 acaacaatgt gcagtgagca tgtggaagaa aagaagcagc tttacctact tgtttctttt 1440 tgtctctctt cctggacact cactttttca gagactcaac agtctcgtca atggagtgtg 1500 ggtccacctt agcctctgac ttcctaatgt aggaggtggt cagcaggcaa tctcctgggc 1560 cttaaaggat gcggactcat cctcagccag cgcccatgtt gtgatacagg ggtgtttgtt 1620 ggatgggttt aaaaataact agaaaaactc aggcccatcc attttctcag atctccttga 1680 aaattgaggc cttttcgata gtttcgggtc aggtaaaaat ggcctcctgg cgtaagcttt 1740 tcaaggtttt ttggaggctt tttgtaaatt gtgataggaa ctttggacct tgaacttacg 1800 tatcatgtgg agaagagcca atttaacaaa ctaggaagat gaaaagggaa attgtggcca 1860 aaactttggg aaaaggaggt tcttaaaatc agtgtttccc ctttgtgcac ttgtagaaaa 1920 aaaagaaaaa ccttctagag ctgatttgat ggacaatgga gagagctttc cctgtgatta 1980 taaaaaagga agctagctgc tctacggtca tctttgctta gagtatactt taacctggct 2040 tttaaagcag tagtaactgc cccaccaaag gtcttaaaag ccatttttgg agcctattgc 2100 actgtgttct cctactgcaa atattttcat atgggaggat ggttttctct tcatgtaagt 2160 ccttggaatt gattctaagg tgatgttctt agcactttaa ttcctgtcaa attttttgtt 2220 ctccccttct gccatcttaa atgtaagctg aaactggtct actgtgtctc tagggttaag 2280 ccaaaagaca aaaaaaattt tactactttt gagattgccc caatgtacag aattatataa 2340 ttctaacgct taaatcatgt gaaagggttg ctgctgtcag ccttgcccac tgtgacttca 2400 aacccaagga ggaactcttg atcaagatgc ccaaccctgt gatcagaacc tccaaatact 2460 gccatgagaa actagagggc aggtgttcat aaaagccctt tgaaccccct tcctgccctg 2520 tgttaggaga tagggatatt ggcccctcac tgcagctgcc agcacttggt cagtcactct 2580 cagccatagc actttgttca ctgtcctgtg tcagagcact gagctccacc cttttctgag 2640 agttattaca gccagaaagt gtgggctgaa gatggttggt ttcatgtggg ggtattatgt 2700 accc 2704 28 413 DNA Homo sapiens misc_feature (1)...(413) n = A,T,C or G 28 acaggcacac tgcaccagcg ttcaatagct gaacttgtgc ccaagtgcca tccgctagca 60 gctttgagca gatggaggct gtgaacatcg cacagacacc tgcagagctc tacaatgcca 120 ttctggtgga cacacccctg gcggcttttt tccaggactg catctcagag caggaccttg 180 atgagatgaa catcgagata atccgaaata cgctttacaa ggcctacttg gaagtccttc 240 tacaagttct gtactctgtt gggtgggacc acagctgatg ccatgtgtcc tatcctagag 300 tttgaagcag accgccgcgc tttcatcatc accatcaact ctttccggca cagagctgtc 360 caaggaggac cgtgccaagc tcttcccgca ctgtggccgg ctctancctg agg 413 29 2602 DNA Homo sapiens 29 gccgtgtcgc caccatggct ccgcaccgcc ccgcgcccgc gctgctttgc gcgctgtccc 60 tggcgctgtg cgcgctgtcg ctgcccgtcc gcgcggccac tgcgtcgcgg ggggcgtccc 120 aggcgggggc gccccagggg cgggtgcccg aggcgcggcc caacagcatg gtggtggaac 180 accccgagtt cctcaaggca gggaaggagc ctggcctgca gatctggcgt gtggagaagt 240 tcgatctggt gcccgtgccc accaaccttt atggagactt cttcacgggc gacgcctacg 300 tcatcctgaa gacagtgcag ctgaggaacg gaaatctgca gtatgacctc cactactggc 360 tgggcaatga gtgcagccag gatgagagcg gggcggccgc catctttacc gtgcagctgg 420 atgactacct gaacggccgg gccgtgcagc accgtgaggt ccagggcttc gagtcggcca 480 ccttcctagg ctacttcaag tctggcctga agtacaagaa aggaggtgtg gcatcaggat 540 tcaagcacgt ggtacccaac gaggtggtgg tgcagagact cttccaggtc aaagggcggc 600 gtgtggtccg tgccaccgag gtacctgtgt cctgggagag cttcaacaat ggcgactgct 660 tcatcctgga cctgggcaac aacatccacc agtggtgtgg ttccaacagc aatcggtatg 720 aaagactgaa ggccacacag gtgtccaagg gcatccggga caacgagcgg agtggccggg 780 cccgagtgca cgtgtctgag gagggcactg agcccgaggc gatgctccag gtgctgggcc 840 ccaagccggc tctgcctgca ggtaccgagg acaccgccaa ggaggatgcg gccaaccgca 900 agctggccaa gctctacaag gtctccaatg gtgcagggac catgtccgtc tccctcgtgg 960 ctgatgagaa ccccttcgcc cagggggccc tgaagtcaga ggactgcttc atcctggacc 1020 acggcaaaga tgggaaaatc tttgtctgga aaggcaagca ggcaaacacg gaggagagga 1080 aggctgccct caaaacagcc tctgacttca tcaccaagat ggactacccc aagcagactc 1140 aggtctcggt ccttcctgag ggcggtgaga ccccactgtt caagcagttc ttcaagaact 1200 ggcgggaccc agaccagaca gatggcctgg gcttgtccta cctttccagc catatcgcca 1260 acgtggagcg ggtgcccttc gacgccgcca ccctgcacac ctccactgcc atggccgccc 1320 agcacggcat ggatgacgat ggcacaggcc agaaacagat ctggagaatc gaaggttcca 1380 acaaggtgcc cgtggaccct gccacatatg gacagttcta tggaggcgac agctacatca 1440 ttctgtacaa ctaccgccat ggtggccgcc aggggcagat aatctataac tggcagggtg 1500 cccagtctac ccaggatgag gtcgctgcat ctgccatcct gactgctcag ctggatgagg 1560 agctgggagg tacccctgtc cagagccgtg tggtccaagg caaggagccc gcccacctca 1620 tgagcctgtt tggtgggaag cccatgatca tctacaaggg cggcacctcc cgcgagggcg 1680 ggcagacagc ccctgccagc acccgcctct tccaggtccg cgccaacagc gctggagcca 1740 cccgggctgt tgaggtattg cctaaggctg gtgcactgaa ctccaacgat gcctttgttc 1800 tgaaaacccc ctcagccgcc tacctgtggg tgggtacagg agccagcgag gcagagaaga 1860 cgggggccca ggagctgctc agggtgctgc gggcccaacc tgtgcaggtg gcagaaggca 1920 gcgagccaga tggcttctgg gaggccctgg gcgggaaggc tgcctaccgc acatccccac 1980 ggctgaagga caagaagatg gatgcccatc ctcctcgcct ctttgcctgc tccaacaaga 2040 ttggacgttt tgtgatcgaa gaggttcctg gtgagctcat gcaggaagac ctggcaacgg 2100 atgacgtcat gcttctggac acctgggacc aggtctttgt ctgggttgga aaggattctc 2160 aagaagaaga aaagacagaa gccttgactt ctgctaagcg gtacatcgag acggacccag 2220 ccaatcggga tcggcggacg cccatcaccg tggtgaagca aggctttgag cctccctcct 2280 ttgtgggctg gttccttggc tgggatgatg attactggtc tgtggacccc ttggacaggg 2340 ccatggctga gctggctgcc tgaggagggg cagggcccac ccatgtcacc ggtcagtgcc 2400 ttttggaact gtccttccct caaagaggcc ttagagcgag cagagcagct ctgctatgag 2460 tgtgtgtgtg tgtgtgtgtt gtttcttttt ttttttttta cagtatccaa aaatagccct 2520 gcaaaaattc agagtccttg caaaattgtc taaaatgtca gtgtttggga aattaaatcc 2580 aataaaaaca ttttgaagtg tg 2602 30 14770 DNA Homo sapiens 30 gggacaccat catttgggtt tttaaaagct tcagcttctc cagcatcttt gcattgtgaa 60 tatcttcctg cttctagtca aagctttctc tctagtgatt ggaatgctgc tgtaagccta 120 ttagaggtgc ctgaggatat caccttttac aaggaagccg tgtgtgcttg agaggatctt 180 tttaaatgca ttatggctca tgcagcctca caattaaaga aaaacaggga tttagaaatc 240 aatgctgaag aagagcctga gaaaaaaagg aaacaccgca aacggtcccg ggatcggaag 300 aaaaagtctg atgccaatgc aagttactta agagcagctc gagctggaca ccttgaaaag 360 gccctcgact acataaaaaa tggagttgac atcaacattt gcaatcagaa tgggttgaac 420 gctctccacc ttgcttccaa agaaggccat gtagaggttg tttctgagct gctgcagaga 480 gaagccaatg tggatgcagc tacaaagaaa ggaaacacag cattgcacat cgcatctttg 540 gctgggcaag cagaggtggt aaaagtcttg gttacaaatg gagccaatgt caatgcacaa 600 tctcagaatg gtttcacgcc attgtatatg gcagcccagg aaaatcacct ggaagttgtc 660 aagtttcttc ttgacaatgg tgcaagccag agcctagcca cagaggatgg cttcacacca 720 ttggcagtgg ctttgcaaca aggtcacgac caagtcgttt cgctcctgct agagaatgac 780 accaaaggaa aagtgcgtct cccagctctt catatcgcgg cccgcaaaga cgacacaaaa 840 gccgccgccc tgctgctgca gaatgacaac aatgcagatg tggaatcaaa gagtggcttc 900 actccgctcc acatagctgc tcactatgga aatatcaatg tagccacgtt gctgttaaac 960 cgagcggctg ctgtggattt caccgcaagg aatgacatca ctcctttaca tgttgcatca 1020 aaaagaggaa atgcaaatat ggtaaaacta ttgctcgatc gaggagctaa aatcgatgcc 1080 aaaaccaggg atggtctgac accactgcac tgtggagcaa ggagtggcca cgagcaggtg 1140 gtagaaatgt tgcttgatcg agctgccccc attctttcaa aaaccaagaa tggattatct 1200 ccattgcaca tggccacaca aggggatcat ttaaactgcg tccagcttct cctccagcat 1260 aatgtacccg tggatgatgt caccaatgac tacctgactg ccctacacgt ggctgcccac 1320 tgtggccatt acaaagttgc caaggttctc ttggataaga aagctaaccc caatgccaaa 1380 gccctgaatg gctttacccc tcttcatatc gcctgcaaga agaatcgaat taaagtaatg 1440 gaactccttc tgaaacacgg tgcatccatc caagctgtaa ccgagtcggg ccttacccca 1500 atccatgttg ctgccttcat ggggcatgta aatattgtat cacaactaat gcatcatgga 1560 gcctcaccaa acaccaccaa tgtgagagga gaaacagcac tgcacatggc agctcgctcc 1620 ggccaagctg aagttgtgcg gtatctggta caagacggag ctcaggtaga agctaaagct 1680 aaggatgacc aaacaccact ccacatttca gcccgactgg ggaaagcaga catagtacaa 1740 cagctgttgc agcaaggggc atctccaaat gcagccacaa cttctgggta caccccactt 1800 cacctttccg cccgagaggg gcatgaggat gtggccgcgt tccttttgga tcatggagcg 1860 tctttatcta taacaacaaa gaaaggattt actcctcttc atgtggcagc aaaatatgga 1920 aagcttgaag tcgccaatct cctgctacag aaaagtgcat ctccagatgc tgctgggaag 1980 agcgggctaa caccactgca tgtagctgca cattacgata atcagaaagt ggcccttctg 2040 cttttggacc aaggagcctc acctcacgca gccgcaaaga atggttatac gccactgcac 2100 atcgctgcca aaaagaacca gatggacata gcgacaactc tgctggaata tggtgctgat 2160 gccaacgcag ttacccggca aggaattgct tccgtccatc tcgcagctca ggaagggcac 2220 gtggacatgg tgtcgctgct cctcggtaga aatgcgaatg tgaacctgag caataagagc 2280 ggcctgaccc cactccattt ggctgctcaa gaagatcgag tgaatgtggc agaagtcctc 2340 gtaaaccaag gggctcatgt ggacgcccag acaaagatgg gatacacacc actgcatgtg 2400 ggctgccact atggaaatat caagattgtt aatttcctgc tccagcattc tgcaaaagtt 2460 aatgccaaaa caaagaatgg gtatacgcca ttacatcaag cagcacagca ggggcatacg 2520 catataataa atgtcttact tcagaacaac gcctccccca atgaactcac tgtgaatggg 2580 aatactgccc ttggcattgc ccggcgcctc ggctacatct cagtagtgga caccctgaag 2640 atagtgaccg aagaaaccat gaccacaact actgtcacag agaagcacaa aatgaatgtt 2700 ccagaaacga tgaatgaagt tcttgatatg tctgatgatg aagttcgtaa agccaatgcc 2760 cctgaaatgc tcagtgatgg cgaatatatc tcagatgttg aagaaggtga agatgcaatg 2820 accggggaca cagacaaata tcttgggcca caggacctta aggaattggg tgatgattcc 2880 ctgcctgcag agggttacat gggctttagt ctcggagcgc gttctgccag cctccgctcc 2940 ttcagttcgg ataggtctta caccttgaac agaagctcct atgcacggga cagcatgatg 3000 attgaagaac tccttgtgcc atccaaagag cagcatctaa cattcacaag ggaatttgat 3060 tcagattctc ttagacatta cagctgggct gcagacacct tagacaatgt caatcttgtt 3120 tcaagcccca ttcattctgg gtttctggtt agctttatgg tggacgcgag agggggctcc 3180 atgagaggaa gccgtcatca cgggatgaga atcatcattc ctccacgcaa gtgtacggcc 3240 cccactcgaa tcacctgccg tttggtaaag agacataaac tggccaaccc acccccacat 3300 ggtgaaagga gagggattag cagtaggctg gtagaaatgg gtcctgcagg ggcacaattt 3360 ttaggccctg tcatagtgga aatccctcac tttgggtcca tgagaggaaa agagagagaa 3420 ctcattgttc ttcgaagtga aaatggtgaa acttggaagg agcatcagtt tgacagcaaa 3480 aatgaagatt taaccgagtt acttaatggc atggatgaag aacttgatag cccagaagag 3540 ttagggaaaa agcgtatctg caggattatc acgaaagatt tcccccagta ttttgcagtg 3600 gtttcccgga ttaagcagga aagcaaccag attggtcctg aaggtggaat tctgagcagc 3660 accacagtgc cccttgttca agcatctttc ccagagggtg ccctaactaa aagaattcga 3720 gtgggcctcc aggcccagcc tgttccagat gaaattgtga aaaagatcct tggaaacaaa 3780 gcaactttta gcccaattgt cactgtggaa ccaagaagac ggaaattcca taaaccaatc 3840 acaatgacca ttccggtgcc cccgccctca ggagaaggtg tatccaatgg atacaaaggg 3900 gacactacac ccaatctgcg tcttctctgt agcattacag ggggcacttc gcctgctcag 3960 tgggaagaca tcacaggaac aactcctttg acgtttataa aagattgtgt ctcctttaca 4020 accaatgttt cagccagatt ttggcttgca gactgccatc aagttttaga aactgtgggg 4080 ttagccacgc aactgtacag agaattgata tgtgttccat atatggccaa gtttgttgtt 4140 tttgccaaaa tgaatgatcc cgtagaatct tccttgcgat gtttctgcat gacagatgac 4200 aaagtggaca aaactttaga gcaacaagag aattttgagg aagtcgcaag aagcaaagat 4260 attgaggttc tggaaggaaa acctatttat gttgattgtt atggaaattt ggccccactt 4320 accaaaggag gacagcaact tgtttttaac ttttattctt tcaaagaaaa tagactgcca 4380 ttttccatca agattagaga caccagccaa gagccctgtg gtcgtctgtc ttttctgaaa 4440 gaacgaaaga caacaaaagg actgcctcaa acagcggttt gcaacttaaa tatcactctg 4500 ccagcacata aaaaggagac agagtcagat caagatgatg agattgagaa aacagataga 4560 cgacagagct tcgcatcctt agctttacgt aagcgctaca gctacttgac tgagcctgga 4620 atgattgaac ggagtacagg agcaacaaga tccctcccca ccacttactc atacaagcca 4680 ttcttttcta caagaccata ccagtcctgg acaacagctc cgattacagt gcctgggcca 4740 gccaagtcag gcttcacttc cttatcaagt tcttcctcta atacgccatc agcttctccg 4800 ttaaaatcaa tatggtctgt ttcgacacct tctccaatca aatccacatt aggcgcgtca 4860 actacatctt cagttaaatc cattagtgac gtggcatctc caattagatc cttacggaca 4920 atgtcttcgc cgataaaaac tgtggtgtca caatctccat acaatatcca ggtttcctct 4980 ggtaccctgg ctagagctcc agcagtcacg gaagctacgc ccttaaaagg gctggcatcc 5040 aattctacgt tttcctctcg aacctctcca gtgactacag cagggtctct tttggagagg 5100 tcatcaatta ctatgacacc ccctgcctcc cccaaatcaa acattaatat gtattcctca 5160 agtttgccat ttaagtcaat tattacatca gcagcaccgc taatatcttc acctttaaag 5220 tcagtggtgt ctccagttaa atcacgagtt gatgtcattt catcagccaa aattacaatg 5280 gcatcttctc tctcatcacc tgtgaagcag atgcctggac atgcagaggt agcattagtc 5340 aatggatcta tttcccctct aaaatatgca tcatcctcaa ctttaattaa tggatgcaaa 5400 gccactgcca cgttacagga aaaaatttct tctgctacaa actctgtgag ctctgtggtc 5460 agtgcagcca ctgacacagt tgagaaagtg ttttctacca cgactgcaat gccattttcc 5520 ccactcaggt catatgtttc tgcagcacca tcagcttttc agtctctaag aactccttcc 5580 gcaagtgcac tctatacatc ccttgggtcg tcaatatctg caactacctc atctgtaact 5640 tcatcaatta taacagtgcc agtatactct gtagtcaatg ttttgccaga accagcatta 5700 aagaaacttc cagactctaa ttcatttaca aaatcagcag cagccttgct gtcacccatt 5760 aaaacattga ctacggagac acatcctcag cctcacttca gtcgaacttc atctccagtt 5820 aagtcatctt tgttccttgc accctctgcc cttaagttgt ctacaccatc ttctttatct 5880 tccagtcagg agatactaaa agatgtagct gaaatgaaag aggacctaat gcggatgacc 5940 gcaatactac agacagatgt gcctgaggag aagccattcc aacctgaact cccaaaggaa 6000 gggagaatag atgatgaaga acctttcaaa attgtagaga aagtaaagga agacttagtg 6060 aaagttagtg aaatccttaa aaaggatgta tgtgtagata ataaaggatc acccaaatca 6120 ccaaagagtg acaaaggaca ctctcctgaa gatgactgga tagaatttag ttcggaagaa 6180 atccgggaag ccagacaaca agctgctgcg agccagtctc catctctgcc agagagagtg 6240 caagtaaaag caaaagccgc ctccgaaaag gattataact tgaccaaagt tattgattac 6300 ctaacaaatg atattgggag tagttcactg acaaacttaa aatacaagtt tgaggatgca 6360 aagaaggatg gtgagggagg acagaaaaga gttttaaaac cagcaattgc tttgcaggaa 6420 cacaaactca aaatgcctcc agcctccatg aggacttcca cctctgagaa agaattgtgt 6480 aaaatggctg attccttttt tggaacagat actattttag agtctcctga tgacttttct 6540 caacacgacc aagataaaag tcccttgtct gacagtggct ttgaaacaag aagtgaaaag 6600 acaccttcag ccccacaaag cgctgaaacg actggtccta aaccactttt tcatgaagtt 6660 cccatccctc ctgttattac agaaacaaga actgaagtgg ttcatgttat caggagctat 6720 gatccctcag ctggggatgt tccccagacc caaccagagg agcctgtgtc acctaaacct 6780 tcacctactt ttatggaatt ggaaccaaag cccaccacct ctagtattaa agaaaaggtt 6840 aaagcatttc aaatgaaagc cagtagtgaa gaagatgacc acaatcgggt tttaagcaaa 6900 ggcatgcgtg ttaaagaaga gactcacata accacaacca ccagaatggt ttatcattct 6960 ccaccaggcg gtgaaggtgc atctgaaaga attgaagaaa ccatgtcagt ccatgacatc 7020 atgaaggcct ttcagtccgg gcgggatcct tccaaagaac tggcaggtct gtttgaacat 7080 aagtcggcag tgtctccaga tgttcacaag tctgctgctg aaacctcagc ccagcatgca 7140 gagaaggaca accaaatgaa acccaaactg gagcgtataa tagaagtcca catcgaaaaa 7200 ggtaaccaag ctgagcccac tgaagtcatt attagagaaa ccaaaaagca tccagaaaaa 7260 gaaatgtatg tatatcagaa agacttatcc cggggagata ttaacctaaa agattttctg 7320 ccagaaaaac acgatgcttt tccttgttca gaggaacagg gtcagcaaga agaagaagaa 7380 cttactgctg aagagtcatt gccttcttat ctggagtctt ccagagtaaa cactcctgtg 7440 tcccaagaag aagatagccg ccctagttct gctcaactca tatctgatga ctcttataaa 7500 acattgaagc ttttgagtca acactcaata gaataccatg acgatgagtt gtcagaacta 7560 agaggggagt cttacaggtt tgctgagaaa atgcttctgt cagaaaagct agatgtgtct 7620 cattctgata ctgaggaatc ggttacagac catgcaggac cccctagctc agagttacag 7680 gggtctgata agcggtccag agaaaaaata gccactgccc ccaaaaaaga aattctctcc 7740 aaaatctata aagatgtttc tgaaaatggt gtaggtaaag tgtctaaaga tgagcatttt 7800 gataaagtga cagtgttgca ctattctggc aatgttagta gtccaaaaca tgccatgtgg 7860 atgcgcttta ctgaggacag attagacaga ggtagagaga agttgatata tgaagatagg 7920 gtggacagga ctgtgaagga ggctgaagaa aaactgactg aagtgtcaca gttttttcgt 7980 gacaaaactg aaaagctaaa tgatgaactg cagtccccag agaaaaaggc acgccctaaa 8040 aatggcaaag aatattcttc tcaaagccct accagtagca gccctgagaa agtgctactg 8100 acagaactgc tggcatccaa tgatgagtgg gttaaggcaa gacagcatgg ccctgatgga 8160 caaggcttcc ccaaggccga ggagaaggca cccagtctgc ccagcagccc agagaagatg 8220 gttctctccc aacagactga ggacagcaag tccacagtgg aagccaaagg aagtatttca 8280 cagagcaaag caccagatgg gccccagtct ggattccagc tcaaacaatc taaactcagt 8340 tccattagat taaaatttga acaaggcaca cacgcaaaaa gtaaggacat gtctcaagaa 8400 gacagaaagt cagatggcca gtccagaatc ccagttaaaa aaatacagga gagcaagcta 8460 cccgtctacc aagtttttgc tagagaaaaa cagcagaagg ccatagacct cccagatgaa 8520 agtgtatctg tgcaaaaaga ttttatggta ttaaaaacca aagatgagca tgcccaaagc 8580 aacgaaattg ttgtaaatga ttctggctct gataatgtga aaaaacagag aactgaaatg 8640 tcaagtaaag caatgcctga ctctttttct gagcagcagg ctaaagactt ggcatgtcat 8700 ataacctcag atttagcaac taggggacca tgggacaaaa aggtctttag aacatgggag 8760 agttcgggag ccactaacaa taagtctcag aaagaaaaac tttcgcatgt acttgttcat 8820 gatgtaagag agaatcacat tggtcaccct gagagtaaaa gtgttgatca aaagaatgaa 8880 tttatgtctg tgactgagag agaacgcaaa ttgttaacaa acggctctct ctcagaaatt 8940 aaagaaatga ctgtaaaatc tccctccaaa aaagtcttat atagggaata tgttgtgaaa 9000 gaaggggacc atccaggcgg attgcttgat cagccttcca ggaggagcga gagctcagca 9060 gtgtcacaca ttcccgtcag agttgctgat gagaggagaa tgctgtcttc taatattccc 9120 gatggttttt gtgaacagtc ggcatttcca aaacatgaac tatcacaaaa attgtcccag 9180 tcaagcatga gtaaagagac agttgagaca cagcacttta attctataga agatgaaaaa 9240 gttacctatt cagaaatcag caaagtttcc aaacaccaga gttatgtagg tttatgccca 9300 cctctcgagg aaaccgaaac ctcccccacc aaatctcctg attctttaga gtttagccca 9360 ggaaaggaat ctccctctag tgatgtattc gaccacagtc ccattgatgg attggaaaaa 9420 ctcgcaccac tagcccagac agagggaggg aaagagataa aaactttacc cgtttatgtc 9480 agttttgtac aagtggggaa gcaatatgaa aaggagatac aacaaggagg tgtaaaaaaa 9540 atcataagtc aggaatgtaa gacagtacaa gaaaccaggg ggacctttta tacaactaga 9600 cagcaaaagc aacctccttc tccccaaggt agtccagaag atgatactct agagcaagta 9660 tcctttctag acagctctgg gaaaagccct ttaaccccag aaacacccag ttcagaggaa 9720 gtgagttatg aatttacatc taagacacct gactcgctca tagcttatat accaggcaaa 9780 cccagcccaa ttcccgaggt ttctgaggag tcagaggagg aggaacaggc caagtcaacc 9840 tcccttaagc agactacagt ggaggaaaca gcagttgagc gtgaaatgcc taatgacgtg 9900 agcaaagact ctaaccaaag acccaaaaat aacagagttg cctatattga atttccccct 9960 cctccaccac tggatgcgga ccagattgag tcagataaga agcatcatta tctcccagaa 10020 aaagaggttg acatgattga agtcaatctg caagatgagc atgacaagta ccagctggct 10080 gaacctgtca ttagagtgca gccaccttca ccagttcctc ccggggcaga cgtcagtgat 10140 tcaagcgatg acgaatctat ttatcagcca gtcccagtta aaaaatatac cttcaaatta 10200 aaggaagtgg acgatgaaca aaaagaaaaa cccaaagctt ctgctgaaaa ggcttccaac 10260 cagaaagaac tggaaagtaa tggatctgga aaagataatg aatttggcct tggccttgat 10320 tcacctcaga atgaaattgc ccagaatggg aacaacgacc agtccatcac agagtgttcc 10380 attgccacca cagcagagtt ttctcatgac acggatgcca cagagatcga ctctctggat 10440 ggctatgacc tgcaagatga agatgatggc ttgacagaga gtgattctaa actcccaatt 10500 caagccatgg aaattaagaa agatatctgg aacacagagg gcattctgaa gccagctgac 10560 cgctctttta gccaaagtaa acttgaagtt atcgaggagg agggaaaggt gggaccagat 10620 gaggacaagc caccttctaa aagttcttca tctgaaaaga ctcctgataa gactgatcag 10680 aagtcagggg cccagttctt cacactggaa ggcagacatc ctgacagatc agtgtttcct 10740 gatacttact tcagttacaa agtagatgaa gaatttgcca ctccttttaa aacagtagct 10800 accaaaggtc tagattttga cccttggtct aataaccgag gggatgatga agtttttgac 10860 agtaaatcac gggaagatga aactaagcca tttgggctgg cggtagaaga ccgctctcca 10920 gcaacaaccc ctgatacaac gccagccaga acgccaactg atgaaagtac cccaactagt 10980 gagcctaacc ccttcccatt tcatgaagga aaaatgtttg agatgactcg cagtggtgca 11040 attgacatga gcaagaggga ttttgttgaa gagaggctcc aatttttcca gattggtgag 11100 catacttctg aagggaagtc aggggaccag ggggaagggg ataaaagtat ggtcactgcc 11160 acaccacagc cacagtcagg ggacaccact gtagaaacca atctagagag aaatgtagag 11220 acacctacag tggaacctaa ccccagcatc ccgaccagcg gagagtgtca ggaaggcaca 11280 tccagtagtg gctccctgga gaaatcagca gcagccacta acacctctaa agttgacccc 11340 aagttgcgca cgcctataaa aatgggaatt tctgcatcca ccatgaccat gaagaaagaa 11400 ggccctggag aaataacaga taagatagaa gcggtgatga ccagttgtca gggattagaa 11460 aatgaaacta taacaatgat ttcaaataca gccaatagcc agatgggcgt taggccccat 11520 gaaaaacatg attttcaaaa agataacttt aataacaaca acaatttgga ttcttccact 11580 atacagacag ataacattat gagtaatata gttctgacag aacattctgc acccacttgt 11640 accacagaga aagataaccc agtgaaagtc tcatcaggaa aaaagacagg ggtactacaa 11700 ggacactgtg taagagataa gcagaaagtt cttggagaac agcaaaaaac aaaggaattg 11760 atagggatta ggcaaaaatc caaacttccc ataaaggcca cttcaccaaa agataccttc 11820 ccaccgaacc atatgtcaaa cactaaagca agtaaaatga agcaggttag tcaatccgag 11880 aaaaccaaag cccttactac ttcttcatgt gtagatgtaa agtccagaat tccagtgaaa 11940 aacacaccca gggataacat aattgcagtt agaaaagcat gtgccacaca aaagcaaggg 12000 cagccagaga aaggcaaggc caaacagctt ccatccaagt tgccagtaaa ggtaagatcc 12060 acctgtgtca ctaccaccac caccactgcc accaccacca ccactaccac cactaccacc 12120 accaccagct gcacagttaa agttaggaaa agtcagctca aggaagtatg taaacattcc 12180 attgaatatt ttaagggaat tagtggtgag accttaaagc ttgtggaccg cctctctgaa 12240 gaagaaaaaa agatgcagtc cgagttgtcc gatgaggaag aaagtacctc aagaaacacg 12300 tcgttgtccg agacttcccg gggtggccag ccttcggtta caacgaagtc tgctagagat 12360 aagaaaacag aggcagcacc tttaaaatca aagagtgaaa aggccggcag tgagaaaagg 12420 agcagtagaa ggactggtcc acagagtcca tgtgaacgga cagatatcag gatggcaata 12480 gtagccgatc acctgggact tagttggaca gaactggcaa gggaactgaa tttttcagtg 12540 gatgaaatca atcaaatacg tgtggaaaat ccaaattctt taatttctca gagcttcatg 12600 ttattaaaaa aatgggttac cagagacgga aaaaatgcca caactgatgc cttaacttcg 12660 gtcttgacaa aaattaatcg aatagatata gtgacactgc tagaaggacc aatatttgat 12720 tatggaaata tttcaggcac cagaagtttt gcagatgaga acaatgtttt ccatgaccct 12780 gttgatggtt ggcagaatga gacatcaagt ggaaacctag agtcctgcgc tcaagctcga 12840 agagtaactg gtgggttact agatcgactg gatgacagcc ctgaccagtg tagagattcc 12900 attacctcat atctcaaagg agaagctggc aaatttgaag caaatggaag ccatacagaa 12960 atcactccag aagcaaagac aaaatcttac tttccagaat cccaaaatga tgtaggaaaa 13020 cagagtacca aggaaactct gaaaccaaaa atacatggat ctggtcatgt tgaagaacca 13080 gcatcaccac tagcagcata tcagaaatct ctagaagaaa ccagcaagct tataatagaa 13140 gagactaaac cctgtgtgcc tgtcagtatg aaaaagatga gtaggacttc tccagcagat 13200 ggcaagccaa ggcttagcct ccatgaagaa gaggggtcca gtgggtctga gcaaaagcag 13260 ggagaaggtt ttaaggtgaa aacgaagaaa gaaatccggc atgtggaaaa gaagagccac 13320 tcgtaacagc gaacggtcag tcaaggatca taagttttta ctgccagtat tgagaaattc 13380 gtggaagaaa tgtcagcagg aagtaaaaat tcaccgagaa gtgtgtgtgt gttcgctgct 13440 tccacacatt aatggcatga ttttttttat gcaaaaagaa aagaaaagaa aaccacccac 13500 attttaattt agcatgagcc aatttacaga gcatggaaat cactttcatt tccggattgg 13560 cgcgtgtgca attagcaatg cagtgtatat acaagaagcc atgctgttaa cagtttatct 13620 caagtaattt ggtgtcattt acaaaaggaa gaaattcttg ccatcagaag ggacagaagg 13680 agatggaatg atcaaatcac agagaaacac taaaattact aaatctacaa cagctcgcct 13740 tatttttctt ggacccaaac tgtcagggta taaacactat ttgtttcttt tttaaaacat 13800 cgatagtttt gctgtaaata ataacactgt ataaattcta acagaaaaat agaataaaat 13860 gttgataagg cactgcctct tagaacacaa acagaatatt gcaaatgcat ttaacaaata 13920 ggggtctcaa gtgacttcac cctagaagag gagggaggga ttctgggtgg gggtgactct 13980 tcactgattc ttgtatatta gcaattataa tgtttgtata tgcaaaactg ctagcttgat 14040 tttaaaaaaa aacaaatctt taaaatctgc tgcaaattta aataattccc aaaatgagga 14100 attctgtagt tctgtgaaaa atttttttct tcagaatact aatattttga tgcatgtgta 14160 tcaccttatt ttgattaaat cttttccaat tttgcaaaca ctacagtata ctgcaacaca 14220 aaagatttta tctgtaaaca caaagccctt catctaatat ttgttgctat tgccaatttt 14280 tcaatgaaat gacctaaaaa caacaaaaaa aaataaccta tacggtagtt gctttagggg 14340 gtggggggat gctatctgtt agtgcttaaa agggggtaaa tgcttgccgc tttagaggtg 14400 gatggtgctc ataaaaggcc ccagtcgggg gtatttaaaa aggactgaac agaaatcctt 14460 agctagtaga atggcagcac gctgtaaaat tattactgta ttgtgtactg gctataagat 14520 gtagacacct ttcagtaagc caatcatttg taaccattct agcagtgtca tattaggtta 14580 ataaggctgc tgtgttttaa agggcatttt tatttgggtt ttggtgaaat tctttaattt 14640 gttgattata ttcacataaa atcagcattc attgacacat agctctaatg acatatgtat 14700 gaaaaaccat acactggatg acctagtcga ttatttaagc ataaaataaa ttgtgttaaa 14760 ctcttcacct 14770 31 1194 DNA Homo sapiens 31 ttaattcggc ggccgcggat ccgagccgga cgggcactgg gcgactctgt gcttcgctga 60 ggaaaaataa ctaaacatgg gcaaaggaga tcctaagaag ccgagacgga aaatgtcatc 120 atatgcattt tttgtgcaaa cttgtcggga ggagcataag aagaagcacc cagatgcttc 180 agtcaacttc tcagagtttt ctaagaagtg ctcagagagg tggaagacca tgtctgctaa 240 agagaaagga aaatttgaag atatggcaaa agcggacaag gcccgttatg aaagagaaat 300 gaaaacctat atccctccca aaggggagac aaaaaagaag ttcaaggatc ccaatgcacc 360 caagaggcct ccttcggcct tcttcctctt ctgctctgag tatcgcccaa aaatcaaagg 420 agaacatcct ggcctgtcca ttggtgatgt tgcgaagaaa ctgggagaga tgtggaataa 480 cactgctgca gatgacaagc agccttatga aaagaaggct gaaaagctga aggaaaaata 540 cgaaaaggat attgctgcat atcgagctaa aggaaagcct gatgcagcaa aaaagggagt 600 tgtcaaggct gaaaaaagca agaaaaagaa ggaagaggag gaaggtgagg aagatgaaga 660 ggatgaggag gaggaggaag atgaagaaga tgaagatgaa gaagaagatg atgatgatga 720 ataagttggt tctagcgcag tttttttttt cttgtctata aagcatttaa cccccctgta 780 cacaactcac tccttttaaa gaaaaaaatt gaaatgtaag gctgtgtaag atttgttttt 840 aaactgtaca gtgtcttttt ttgtatagtt aacacactac cgaatgtgtc tttagatagc 900 cctgtcctgg tggtatcttc aatagccact aaccctgcct ggtacagtat gggggttgta 960 aattggcatg gaaatttaaa gcaggttctt gtttgggcac agcacaaatt agttatatat 1020 ggggatggta gttttttcat cttcagttgt ctctgatgca gctatacgaa ataattgttg 1080 ttctgttaac tgaataccac tctgtaattg caaaaaaaaa aaaaaagttg cagctgtttt 1140 gttgacattc tgaatgcttc taagtaaata caattttttt tattaaaaaa aaaa 1194 32 1805 DNA Homo sapiens 32 aagagactga actgtatctg cctctatttc caaaagactc acgttcaact ttcgctcaca 60 caaagccggg aaaattttat tagtcctttt tttaaaaaaa gttaatataa aattatagca 120 aaaaaaaaaa ggaacctgaa ctttagtaac acagctggaa caatcgcagc ggcggcggca 180 gcggcgggag aagaggttta atttagttga ttttctgtgg ttgttggttg ttcgctagtc 240 tcacggtgat ggaagctgca cattttttcg aagggaccga gaagctgctg gaggtttggt 300 tctcccggca gcagcccgac gcaaaccaag gatctgggga tcttcgcact atcccaagat 360 ctgagtggga catacttttg aaggatgtgc aatgttcaat cataagtgtg acaaaaactg 420 acaagcagga agcttatgta ctcagtgaga gtagcatgtt tgtctccaag agacgtttca 480 ttttgaagac atgtggtacc accctcttgc tgaaagcact ggttcccctg ttgaagcttg 540 ctagggatta cagtgggttt gactcaattc aaagcttctt ttattctcgt aagaatttca 600 tgaagccttc tcaccaaggg tacccacacc ggaatttcca ggaagaaata gagtttctta 660 atgcaatttt cccaaatgga gcaggatatt gtatgggacg tatgaattct gactgttggt 720 acttatatac tctggatttc ccagagagtc gggtaatcag tcagccagat caaaccttgg 780 aaattctgat gagtgagctt gacccagcag ttatggacca gttctacatg aaagatggtg 840 ttactgcaaa ggatgtcact cgtgagagtg gaattcgtga cctgatacca ggttctgtca 900 ttgatgccac aatgttcaat ccttgtgggt attcgatgaa tggaatgaaa tcggatggaa 960 cttattggac tattcacatc actccagaac cagaattttc ttatgttagc tttgaaacaa 1020 acttaagtca gacctcctat gatgacctga tcaggaaagt tgtagaagtc ttcaagccag 1080 gaaaatttgt gaccaccttg tttgttaatc agagttctaa atgtcgcaca gtgcttgctt 1140 cgccccagaa gattgaaggt tttaagcgtc ttgattgcca gagtgctatg ttcaatgatt 1200 acaattttgt ttttaccagt tttgctaaga agcagcaaca acagcagagt tgattaagaa 1260 aaatgaagaa aaaacgcaaa aagagaacac atgtagaagg tggtggatgc tttctagatg 1320 tcgatgctgg gggcagtgct ttccataacc accactgtgt agttgcagaa agccctagat 1380 gtaatgatag tgtaatcatt ttgaattgta tgcattatta tatcaaggag ttagatatct 1440 tgcatgaatg ctctcttctg tgtttaggta ttctctgcca ctcttgctgt gaaattgaag 1500 tggatgtaga aaaaaccttt tactatatga aactttacaa cacttgtgaa agcaactcaa 1560 tttggtttat gcacagtgta atatttctcc aagtatcatc caaaattccc cacagacaag 1620 gctttcgtcc tcattaggtg ttggcctcag cctaaccctc taggactgtt ctattaaatt 1680 gctgccagaa ttttacatcc agttacctcc actttctaga acatattctt tactaatgtt 1740 attgaaacca atttctactt catactgatg tttttggaaa cagcaattaa agtttttctt 1800 ccatg 1805 33 3907 DNA Homo sapiens 33 ctactgttgt ttttgagggg cgggcagccg cgccgccgcg gcactttttt aattttttcg 60 ggtgccgcag cagcgacccc tcggcgccga tgtccctgat ccctggagcg acgacggccg 120 ctgcctaagc tgggaagagg aatgccagct cctgagcagg cctcattggt ggaggagggg 180 caaccacaga cccgccagga agctgcctcc actggcccag gcatggaacc cgagaccaca 240 gccaccacta ttctagcatc cgtgaaggag caggagcttc agtttcagcg actcacccga 300 gaactggaag tggaaaggca gattgttgcc agtcagctag aaagatgtag gcttggagca 360 gaatcaccaa gcatcgccag caccagctca actgagaagt catttccttg gagatcaaca 420 gacgtgccaa atactggtgt aagcaaacct agagtttctg acgctgtcca gcccaacaac 480 tatctcatca ggacagagcc agaacaagga accctctatt caccagaaca gacatctctc 540 catgaaagtg agggatcatt gggtaactca agaagttcaa cacaaatgaa ttcttattcc 600 gacagtggat accaggaagc agggagtttc cacaacagcc agaacgtgag caaggcagac 660 aacagacagc agcattcatt cataggatca actaacaacc atgtggtgag gaattcaaga 720 gctgaaggac aaacactggt tcagccatca gtagccaatc gggccatgag aagagttagt 780 tcagttccat ctagagcaca gtctccttct tatgttatca gcacaggcgt gtctccttca 840 agggggtctc tgagaacttc tctgggtagt ggatttggct ctccgtcagt gaccgacccc 900 cgacctctga accccagtgc atattcctcc accacattac ctgctgcacg ggcagcctct 960 ccgtactcac agagacccgc ctccccaaca gctatacggc ggattgggtc agtcacctcc 1020 cggcagacct ccaatcccaa cggaccaacc cctcaatacc aaaccaccgc cagagtgggg 1080 tccccactga ccctgacgga tgcacagact cgagtagctt ccccatccca aggccaggtg 1140 gggtcgtcgt cccccaaacg ctcagggatg accgccgtac cacagcatct gggaccttca 1200 ctgcaaagga ctgttcatga catggagcaa ttcggacagc agcagtatga catttatgag 1260 aggatggttc cacccaggcc agacagcctg acaggcttac ggagttccta tgctagtcag 1320 catagtcagc ttgggcaaga ccttcgttct gccgtgtctc ccgacttgca cattactcct 1380 atatatgagg ggaggaccta ttacagccca gtgtaccgca gcccaaacca tggaactgtg 1440 gagctccaag gatcgcagac ggcgttgtat cgcacaggtg tatcaggtat tggaaatcta 1500 caaaggacat ccagccaacg aagtaccctt acataccaaa gaaataatta tgctctgaac 1560 acaacagcta cctacgcgga gccctacagg cctatacaat accgagtgca agagtgcaat 1620 tataacaggc ttcagcatgc agtgccggct gatgatggca ccacaagatc cccatcaata 1680 gacagcattc agaaggaccc cagggagttt gcctggcgtg atcctgagtt gcctgaggtc 1740 attcacatgc ttgagcacca gttcccatct gttcaggcaa atgcagcggc ctacctgcag 1800 cacctgtgct ttggtgacaa caaagtgaag atggaggtgt gtaggttagg gggaatcaag 1860 catctggttg accttctgga ccacagagtt ttggaagttc agaagaatgc ttgtggtgcc 1920 cttcgaaacc tcgtttttgg caagtctaca gatgaaaata aaatagcaat gaagaatgtt 1980 ggtgggatac ctgccttgtt gcgactgttg agaaaatcta ttgatgcaga agtaagggag 2040 cttgttacag gagttctttg gaatttatcc tcatgtgatg ctgtaaaaat gacaatcatt 2100 cgagatgctc tctcaacctt aacaaacact gtgattgttc cacattctgg atggaataac 2160 tcttcttttg atgatgatca taaaattaaa tttcagactt cactagttct gcgtaacacg 2220 acaggttgcc taaggaacct cacgtccgcg ggggaagaag ctcggaagca aatgcggtcc 2280 tgcgaggggc tggtagactc actgttgtat gtgatccaca cgtgtgtgaa cacatccgat 2340 tacgacagca agacggtgga gaactgcgtg tgcaccctga ggaacctgtc ctatcggctg 2400 gagctggagg tgccccaggc ccggttactg ggactgaacg aattggatga cttactagga 2460 aaagagtctc ccagcaaaga ctctgagcca agttgctggg ggaagaagaa gaaaaagaaa 2520 aagaggactc cgcaagaaga tcaatgggat ggagttggtc ctatcccagg actgtcgaag 2580 tcccccaaag gggttgagat gctgtggcac ccatcggtgg taaaaccata tctgactctt 2640 ctagcagaaa gttccaaccc agccaccttg gaaggctctg cagggtctct ccagaacctc 2700 tctgctagca actggaagtt tgcagcatat atccggggcg gccgtccgaa aagaaaaggg 2760 ctccccatcc ttgtggagct tctgagaatg gataacgata gagttgtttc ttccggtgca 2820 acagccttga ggaatatggc actagatgtt cgcaacaagg agctcatagg caaatacgcc 2880 atgcgagacc tggtcaaccg gctccccggc ggcaatggcc ccagtgtctt gtctgatgag 2940 accatggcag ccatctgctg tgctctgcac gaggtcacca gcaaaaacat ggagaacgca 3000 aaagccctgg ccgactcagg aggcatagag aagctggtga acataaccaa aggcaggggc 3060 gacagatcat ctctgaaagt ggtgaaggca gcagcccagg tcttgaatac attatggcaa 3120 tatcgggacc tccggagcat ttataaaaag gatgggtgga atcagaacca ttttattaca 3180 cctgtgtcga cattggagcg agaccgattc aaatcacatc cttccttgtc taccaccaac 3240 caacagatgt cacccatcat tcagtcagtc ggcagcacct cttcctcacc agcactgtta 3300 ggaatcagag accctcgctc tgaatacgat aggacccagc cacctatgca gtattacaat 3360 agccaagggg atgccacaca taaaggcctg taccctggct ccagcaaacc ttcaccaatt 3420 tacatcagtt cctattcctc accagcaaga gaacaaaata gacggctaca gcatcaacag 3480 ctgtattata gtcaagatga ctccaacaga aagaactttg atgcatacag attgtatttg 3540 cagtctcctc atagctatga agatccttat tttgatgacc gagttcactt tccagcttct 3600 actgattact caacacagta tggactgaaa tcgaccacaa attatgtaga cttttattcc 3660 actaaacgac cttcttatag agcagaacag tacccagggt ccccagactc atgggtgtac 3720 gatcaagatg cccaacagag gaactctttc tttctaacct tgttcagatt gaggtgaaaa 3780 gtccatcttg ctgatttcat gattgaaatg tgaaagtgaa gtggaaggaa tgaatgaagt 3840 gtgttttttt ttcctttttg aggaattatc aggggaattc gatatcaagc ttatcgatac 3900 cgtcgac 3907 34 568 DNA Homo sapiens misc_feature (1)...(568) n = A,T,C or G 34 cagtgaaaat acaactttat attaatcatc tcaataatac agattacaga actgagttta 60 cagattacag aacttttcat actttgtggg tcagaaagga taaccgtaaa ttactgtctc 120 cgctttatgg gtggtaaaac tgagccacag agaaatttct ctaagaaaat ttaaaaggaa 180 ttgatgttca ttaaataaat atcctcactg atttttttaa ggtagaaaag tacaatgcac 240 agtgttaaaa aaattactgt aacagcctca tgttcgagaa gtctaaaatt ttaaggctac 300 tacatgtgtt aattttcagt acatgtccaa cagaaaacat cctttattcc agttacatcc 360 tgaagatacc gaagtcagtc ttctctattg gtgcgttgag ggctgcacta aaactggaga 420 cccaagacca gtctggtgtc tgctgggatc aatgatccca tcatcccata cccctgcgct 480 gggaatagta aggggttccc tcctcttcca acntcctaat ggatggggcc cttttaaagc 540 cgcttcatca gcactggggn actgcttt 568 35 362 DNA Homo sapiens 35 gtcggctctt agagtagtaa ccgccagaaa ggagtcggaa gaggtctcac gaggctgtca 60 tcaccgccat gcccaagaat aaaggtaaag gaggtaaaaa caggcgcagg ggtaaaaatg 120 agaatgaatc tgaaaaaaga gagttggtgt ttaaagagga tggacaagag tatgctcagg 180 taatcaaaat gttgggaaat ggacgattgg aagcattgtg ttttgatggt gtaaagaggt 240 tatgccatat cagagggaaa ttgagaaaaa aggtttggat aaatacatca gacattatat 300 tggttggtct acgggactat caggataaca aagctgatgt aatttttaaa gtacattgca 360 ga 362 36 1661 DNA Homo sapiens 36 tgctgcagcc gctgccgccg attccggatc tcattgccac gcgcccccga cgaccgcccg 60 acgtgcattc ccgattcctt ttggttccaa gtccaatatg gcaactctaa aggatcagct 120 gatttataat cttctaaagg aagaacagac cccccagaat aagattacag ttgttggggt 180 tggtgctgtt ggcatggcct gtgccatcag tatcttaatg aaggacttgg cagatgaact 240 tgctcttgtt gatgtcatcg aagacaaatt gaagggagag atgatggatc tccaacatgg 300 cagccttttc cttagaacac caaagattgt ctctggcaaa gactataatg taactgcaaa 360 ctccaagctg gtcattatca cggctggggc acgtcagcaa gagggagaaa gccgtcttaa 420 tttggtccag cgtaacgtga acatatttaa attcatcatt cctaatgttg taaaatacag 480 cccgaactgc aagttgctta ttgtttcaaa tccagtggat atcttgacct acgtggcttg 540 gaagataagt ggttttccca aaaaccgtgt tattggaagt ggttgcaatc tggattcagc 600 ccgattccgt tacctgatgg gggaaaggct gggagttcac ccattaagct gtcatgggtg 660 ggtccttggg gaacatggag attccagtgt gcctgtatgg agtggaatga atgttgctgg 720 tgtctctctg aagactctgc acccagattt agggactgat aaagataagg aacagtggaa 780 agaggttcac aagcaggtgg ttgagagtgc ttatgaggtg atcaaactca aaggctacac 840 atcctgggct attggactct ctgtagcaga tttggcagag agtataatga agaatcttag 900 gcgggtgcac ccagtttcca ccatgattaa gggtctttac ggaataaagg atgatgtctt 960 ccttagtgtt ccttgcattt tgggacagaa tggaatctca gaccttgtga aggtgactct 1020 gacttctgag gaagaggccc gtttgaagaa gagtgcagat acactttggg ggatccaaaa 1080 ggagctgcaa ttttaaagtc ttctgatgtc atatcatttc actgtctagg ctacaacagg 1140 attctaggtg gaggttgtgc atgttgtcct ttttatctga tctgtgatta aagcagtaat 1200 attttaagat ggactgggaa aaacatcaac tcctgaagtt agaaataaga atggtttgta 1260 aaatccacag ctatatcctg atgctggatg gtattaatct tgtgtagtct tcaactggtt 1320 agtgtgaaat agttctgcca cctctgacgc accactgcca atgctgtacg tactgcattt 1380 gccccttgag ccaggtggat gtttaccgtg tgttatataa cttcctggct ccttcactga 1440 acatgcctag tccaacattt tttcccagtg agtcacatcc tgggatccag tgtataaatc 1500 caatatcatg tcttgtgcat aattcttcca aaggatctta ttttgtgaac tatatcagta 1560 gtgtacatta ccatataatg taaaaagatc tacatacaaa caatgcaacc aactatccaa 1620 gtgttatacc aactaaaacc cccaataaac cttgaacagt g 1661 37 743 DNA Homo sapiens 37 cagccagctc gacggggctg tgtgtgctgg gcctggctcg cggcgaaccg agatggcaga 60 gcagtcggac gaggccgtga agtactacac cctagaggag attcagaagc acaaccacag 120 caagagcacc tggctgatcc tgcaccacaa ggtgtacgat ttgaccaaat ttctggaaga 180 gcatcctggt ggggaagaag ttttaaggga acaagctgga ggtgacgcta ctgagaactt 240 tgaggatgtc gggcactcta cagatgccag ggaaatgtcc aaaacattca tcattgggga 300 gctccatcca gatgacagac caaagttaaa caagcctccg gaaactctta tcactactat 360 tgattctagt tccagttggt ggaccaactg ggtgatccct gccatctctg cagtggccgt 420 cgccttgatg tatcgcctat acatggcaga ggactgaaca cctcctcaga agtcagcgca 480 ggccgagcct gctttggaca cgggagaaaa gaagccattg ctaactactt caactgacag 540 aaaccttcac ttgaaaacaa tgattttaat atatctcttt ctttttcttc cgacattaga 600 aacaaaacaa aaagaactgt cctttctgcg ctcaaatttt tcgagtgtgc ctttttattc 660 atctacttta ttttgatgtt tccttaatgt gtaatttact tattataagc atgatctttt 720 aaaaatatat ttggctttta aag 743 38 7679 DNA Homo sapiens 38 gaagagcaag aggcaggctc agcaaatggt tcagccccag tccccggtgg ctgtcagtca 60 aagcaagccc ggttgttatg acaatggaaa acactatcag ataaatcaac agtgggagcg 120 gacctaccta ggtaatgtgt tggtttgtac ttgttatgga ggaagccgag gttttaactg 180 cgaaagtaaa cctgaagctg aagagacttg ctttgacaag tacactggga acacttaccg 240 agtgggtgac acttatgagc gtcctaaaga ctccatgatc tgggactgta cctgcatcgg 300 ggctgggcga gggagaataa gctgtaccat cgcaaaccgc tgccatgaag ggggtcagtc 360 ctacaagatt ggtgacacct ggaggagacc acatgagact ggtggttaca tgttagagtg 420 tgtgtgtctt ggtaatggaa aaggagaatg gacctgcaag cccatagctg agaagtgttt 480 tgatcatgct gctgggactt cctatgtggt cggagaaacg tgggagaagc cctaccaagg 540 ctggatgatg gtagattgta cttgcctggg agaaggcagc ggacgcatca cttgcacttc 600 tagaaataga tgcaacgatc aggacacaag gacatcctat agaattggag acacctggag 660 caagaaggat aatcgaggaa acctgctcca gtgcatctgc acaggcaacg gccgaggaga 720 gtggaagtgt gagaggcaca cctctgtgca gaccacatcg agcggatctg gccccttcac 780 cgatgttcgt gcagctgttt accaaccgca gcctcacccc cagcctcctc cctatggcca 840 ctgtgtcaca gacagtggtg tggtctactc tgtggggatg cagtggttga agacacaagg 900 aaataagcaa atgctttgca cgtgcctggg caacggagtc agctgccaag agacagctgt 960 aacccagact tacggtggca acttaaatgg agagccatgt gtcttaccat tcacctacaa 1020 tggcaggacg ttctactcct gcaccacgga agggcgacag gacggacatc tttggtgcag 1080 cacaacttcg aattatgagc aggaccagaa atactctttc tgcacagacc acactgtttt 1140 ggttcagact caaggaggaa attccaatgg tgccttgtgc cacttcccct tcctatacaa 1200 caaccacaat tacactgatt gcacttctga gggcagaaga gacaacatga agtggtgtgg 1260 gaccacacag aactatgatg ccgaccagaa gtttgggttc tgccccatgg ctgcccacga 1320 ggaaatctgc acaaccaatg aaggggtcat gtaccgcatt ggagatcagt gggataagca 1380 gcatgacatg ggtcacatga tgaggtgcac gtgtgttggg aatggtcgtg gggaatggac 1440 atgcattgcc tactcgcaac ttcgagatca gtgcattgtt gatgacatca cttacaatgt 1500 gaacgacaca ttccacaagc gtcatgaaga ggggcacatg ctgaactgta catgcttcgg 1560 tcagggtcgg ggcaggtgga agtgtgatcc cgtcgaccaa tgccaggatt cagagactgg 1620 gacgttttat caaattggag attcatggga gaagtatgtg catggtgtca gataccagtg 1680 ctactgctat ggccgtggca ttggggagtg gcattgccaa cctttacaga cctatccaag 1740 ctcaagtggt cctgtcgaag tatttatcac tgagactccg agtcagccca actcccaccc 1800 catccagtgg aatgcaccac agccatctca catttccaag tacattctca ggtggagacc 1860 taaaaattct gtaggccgtt ggaaggaagc taccatacca ggccacttaa actcctacac 1920 catcaaaggc ctgaagcctg gtgtggtata cgagggccag ctcatcagca tccagcagta 1980 cggccaccaa gaagtgactc gctttgactt caccaccacc agcaccagca cacctgtgac 2040 cagcaacacc gtgacaggag agacgactcc cttttctcct cttgtggcca cttctgaatc 2100 tgtgaccgaa atcacagcca gtagctttgt ggtctcctgg gtctcagctt ccgacaccgt 2160 gtcgggattc cgggtggaat atgagctgag tgaggaggga gatgagccac agtacctgga 2220 tcttccaagc acagccactt ctgtgaacat ccctgacctg cttcctggcc gaaaatacat 2280 tgtaaatgtc tatcagatat ctgaggatgg ggagcagagt ttgatcctgt ctacttcaca 2340 aacaacagcg cctgatgccc ctcctgaccc gactgtggac caagttgatg acacctcaat 2400 tgttgttcgc tggagcagac cccaggctcc catcacaggg tacagaatag tctattcgcc 2460 atcagtagaa ggtagcagca cagaactcaa ccttcctgaa actgcaaact ccgtcaccct 2520 cagtgacttg caacctggtg ttcagtataa catcactatc tatgctgtgg aagaaaatca 2580 agaaagtaca cctgttgtca ttcaacaaga aaccactggc accccacgct cagatacagt 2640 gccctctccc agggacctgc agtttgtgga agtgacagac gtgaaggtca ccatcatgtg 2700 gacaccgcct gagagtgcag tgaccggcta ccgtgtggat gtgatccccg tcaacctgcc 2760 tggcgagcac gggcagaggc tgcccatcag caggaacacc tttgcagaag tcaccgggct 2820 gtcccctggg gtcacctatt acttcaaagt ctttgcagtg agccatggga gggagagcaa 2880 gcctctgact gctcaacaga caaccaaact ggatgctccc actaacctcc agtttgtcaa 2940 tgaaactgat tctactgtcc tggtgagatg gactccacct cgggcccaga taacaggata 3000 ccgactgacc gtgggcctta cccgaagagg ccagcccagg cagtacaatg tgggtccctc 3060 tgtctccaag taccccctga ggaatctgca gcctgcatct gagtacaccg tatccctcgt 3120 ggccataaag ggcaaccaag agagccccaa agccactgga gtctttacca cactgcagcc 3180 tgggagctct attccacctt acaacaccga ggtgactgag accaccatcg tgatcacatg 3240 gacgcctgct ccaagaattg gttttaagct gggtgtacga ccaagccagg gaggagaggc 3300 accacgagaa gtgacttcag actcaggaag catcgttgtg tccggcttga ctccaggagt 3360 agaatacgtc tacaccatcc aagtcctgag agatggacag gaaagagatg cgccaattgt 3420 aaacaaagtg gtgacaccat tgtctccacc aacaaacttg catctggagg caaaccctga 3480 cactggagtg ctcacagtct cctgggagag gagcaccacc ccagacatta ctggttatag 3540 aattaccaca acccctacaa acggccagca gggaaattct ttggaagaag tggtccatgc 3600 tgatcagagc tcctgcactt ttgataacct gagtcccggc ctggagtaca atgtcagtgt 3660 ttacactgtc aaggatgaca aggaaagtgt ccctatctct gataccatca tcccagctgt 3720 tcctcctccc actgacctgc gattcaccaa cattggtcca gacaccatgc gtgtcacctg 3780 ggctccaccc ccatccattg atttaaccaa cttcctggtg cgttactcac ctgtgaaaaa 3840 tgaggaagat gttgcagagt tgtcaatttc tccttcagac aatgcagtgg tcttaacaaa 3900 tctcctgcct ggtacagaat atgtagtgag tgtctccagt gtctacgaac aacatgagag 3960 cacacctctt agaggaagac agaaaacagg tcttgattcc ccaactggca ttgacttttc 4020 tgatattact gccaactctt ttactgtgca ctggattgct cctcgagcca ccatcactgg 4080 ctacaggatc cgccatcatc ccgagcactt cagtgggaga cctcgagaag atcgggtgcc 4140 ccactctcgg aattccatca ccctcaccaa cctcactcca ggcacagagt atgtggtcag 4200 catcgttgct cttaatggca gagaggaaag tcccttattg attggccaac aatcaacagt 4260 ttctgatgtt ccgagggacc tggaagttgt tgctgcgacc cccaccagcc tactgatcag 4320 ctgggatgct cctgctgtca cagtgagata ttacaggatc acttacggag aaacaggagg 4380 aaatagccct gtccaggagt tcactgtgcc tgggagcaag tctacagcta ccatcagcgg 4440 ccttaaacct ggagttgatt ataccatcac tgtgtatgct gtcactggcc gtggagacag 4500 ccccgcaagc agcaagccaa tttccattaa ttaccgaaca gaaattgaca aaccatccca 4560 gatgcaagtg accgatgttc aggacaacag cattagtgtc aagtggctgc cttcaagttc 4620 ccctgttact ggttacagag taaccaccac tcccaaaaat ggaccaggac caacaaaaac 4680 taaaactgca ggtccagatc aaacagaaat gactattgaa ggcttgcagc ccacagtgga 4740 gtatgtggtt agtgtctatg ctcagaatcc aagcggagag agtcagcctc tggttcagac 4800 tgcagtaacc aacattgatc gccctaaagg actggcattc actgatgtgg atgtcgattc 4860 catcaaaatt gcttgggaaa gcccacaggg gcaagtttcc aggtacaggg tgacctactc 4920 gagccctgag gatggaatcc atgagctatt ccctgcacct gatggtgaag aagacactgc 4980 agagctgcaa ggcctcagac cgggttctga gtacacagtc agtgtggttg ccttgcacga 5040 tgatatggag agccagcccc tgattggaac ccagtccaca gctattcctg caccaactga 5100 cctgaagttc actcaggtca cacccacaag cctgagcgcc cagtggacac cacccaatgt 5160 tcagctcact ggatatcgag tgcgggtgac ccccaaggag aagaccggac caatgaaaga 5220 aatcaacctt gctcctgaca gctcatccgt ggttgtatca ggacttatgg tggccaccaa 5280 atatgaagtg agtgtctatg ctcttaagga cactttgaca agcagaccag ctcagggtgt 5340 tgtcaccact ctggagaatg tcagcccacc aagaagggct cgtgtgacag atgctactga 5400 gaccaccatc accattagct ggagaaccaa gactgagacg atcactggct tccaagttga 5460 tgccgttcca gccaatggcc agactccaat ccagagaacc atcaagccag atgtcagaag 5520 ctacaccatc acaggtttac aaccaggcac tgactacaag atctacctgt acaccttgaa 5580 tgacaatgct cggagctccc ctgtggtcat cgacgcctcc actgccattg atgcaccatc 5640 caacctgcgt ttcctggcca ccacacccaa ttccttgctg gtatcatggc agccgccacg 5700 tgccaggatt accggctaca tcatcaagta tgagaagcct gggtctcctc ccagagaagt 5760 ggtccctcgg ccccgccctg gtgtcacaga ggctactatt actggcctgg aaccgggaac 5820 cgaatataca atttatgtca ttgccctgaa gaataatcag aagagcgagc ccctgattgg 5880 aaggaaaaag acagacgagc ttccccaact ggtaaccctt ccacacccca atcttcatgg 5940 accagagatc ttggatgttc cttccacagt tcaaaagacc cctttcgtca cccaccctgg 6000 gtatgacact ggaaatggta ttcagcttcc tggcacttct ggtcagcaac ccagtgttgg 6060 gcaacaaatg atctttgagg aacatggttt taggcggacc acaccgccca caacggccac 6120 ccccataagg cataggccaa gaccataccc gccgaatgta ggacaagaag ctctctctca 6180 gacaaccatc tcatgggccc cattccagga cacttctgag tacatcattt catgtcatcc 6240 tgttggcact gatgaagaac ccttacagtt cagggttcct ggaacttcta ccagtgccac 6300 tctgacaggc ctcaccagag gtgccaccta caacatcata gtggaggcac tgaaagacca 6360 gcagaggcat aaggttcggg aagaggttgt taccgtgggc aactctgtca acgaaggctt 6420 gaaccaacct acggatgact cgtgctttga cccctacaca gtttcccatt atgccgttgg 6480 agatgagtgg gaacgaatgt ctgaatcagg ctttaaactg ttgtgccagt gcttaggctt 6540 tggaagtggt catttcagat gtgattcatc tagatggtgc catgacaatg gtgtgaacta 6600 caagattgga gagaagtggg accgtcaggg agaaaatggc cagatgatga gctgcacatg 6660 tcttgggaac ggaaaaggag aattcaagtg tgaccctcat gaggcaacgt gttacgatga 6720 tgggaagaca taccacgtag gagaacagtg gcagaaggaa tatctcggtg ccatttgctc 6780 ctgcacatgc tttggaggcc agcggggctg gcgctgtgac aactgccgca gacctggggg 6840 tgaacccagt cccgaaggca ctactggcca gtcctacaac cagtattctc agagatacca 6900 tcagagaaca aacactaatg ttaattgccc aattgagtgc ttcatgcctt tagatgtaca 6960 ggctgacaga gaagattccc gagagtaaat catctttcca atccagagga acaagcatgt 7020 ctctctgcca agatccatct aaactggagt gatgttagca gacccagctt agagttcttc 7080 tttctttctt aagccctttg ctctggagga agttctccag cttcagctca actcacagct 7140 tctccaagca tcaccctggg agtttcctga gggttttctc ataaatgagg gctgcacatt 7200 gcctgttctg cttcgaagta ttcaataccg ctcagtattt taaatgaagt gattctaaga 7260 tttggtttgg gatcaatagg aaagcatatg cagccaacca agatgcaaat gttttgaaat 7320 gatatgacca aaattttaag taggaaagtc acccaaacac ttctgctttc acttaagtgt 7380 ctggcccgca atactgtagg aacaagcatg atcttgttac tgtgatattt taaatatcca 7440 cagtactcac tttttccaaa tgatcctagt aattgcctag aaatatcttt ctcttacctg 7500 ttatttatca atttttccca gtatttttat acggaaaaaa ttgtattgaa aacacttaga 7560 tgcagttgat aagaggaatt tggtataatt atggtgggtg attatttttt atactgtatg 7620 tgccaaagct ttactactgt ggaaagacaa ctgttttaat aaaagattta cattccaca 7679 39 1441 DNA Homo sapiens 39 caggctggtc aatgtggcaa ccagatcggt gccaagttct gggaggtgat cagtgatgaa 60 catggcatcg accccaccgg cacctaccac ggggacagcg acctgcagct ggaccgcatc 120 tctgtgtact acaatgaagc cacaggtggc aaatatgttc ctcgtgccat cctggtggat 180 ctagaacctg ggaccatgga ctctgttcgc tcaggtcctt ttggccagat ctttagacca 240 gacaactttg tatttggtca gtctggggca ggtaacaact gggccaaagg ccactacaca 300 gagggcgccg agctggttga ttctgtcctg gatgtggtac ggaaggaggc agagagctgt 360 gactgcctgc agggcttcca gctgacccac tcactgggcg ggggcacagg ctctggaatg 420 ggcactctcc ttatcagcaa gatccgagaa gaataccctg atcgcatcat gaataccttc 480 agtgtggtgc cttcacccaa agtgtctgac accgtggtcg agccctacaa tgccaccctc 540 tccgtccatc agttggtaga gaatactgat gagacctatt gcattgacaa cgaggccctc 600 tatgatatct gcttccgcac tctgaggctg accacaccaa cctacgggga tctgaaccac 660 cttgtctcag gcaccatgga gtgtgtcacc acctgcctcc gtttccctgg ccagctcaat 720 gctgacctcc gcaagttggc agtcaacatg gtccccttcc cacgtctcca tttctttatg 780 cctggctttg cccctctcac cagccgtgga agccagcagt atcgagctct cacagtgccg 840 gacctcaccc agcaggtctt cgatgccaag aacatgatgg ctgcctgtga cccccgccac 900 ggccgatacc tcaccgtggc tgctgtcttc cgtggtcgga tgtccatgaa ggaggtcgat 960 gagcagatgc ttaacgtgca gaacaagaac agcagctact ttgtggaatg gatccccaac 1020 aatgtcaaga cagccgtctg tgacatccca cctcgtggcc tcaagatggc agtcaccttc 1080 attggcaata gcacagccat ccaggagctc ttcaagcgca tctcggagca gttcactgcc 1140 atgttccgcc ggaaggcctt cctccactgg tacacaggcg agggcatgga cgagatggag 1200 ttcaccgagg ctgagagcaa catgaacgac ctcgtctctg agtatcagca gtaccaggat 1260 gccaccgcag aagaggagga ggatttcggt gaggaggccg aagaggaggc ctaaggagag 1320 cccccatcac ctcaggcttc tcagttccct tagccgtctt actcaactgc cccctttcct 1380 ctccctcaga atttgtgttt gctgcctcta tcttgttttt tgttttttct tctggggggg 1440 g 1441 40 873 DNA Homo sapiens 40 cagtttgaat cgcggtgcga ccgaaggagt aggtgctggg atcgtcaccg tggcaccgat 60 tagccttttc tctgccttgc ttgcttgagc ttcagcggaa ttcgaaatgg ctggcggtaa 120 ggctggaaag gactccggaa aggccaagac aaaggcggtt tcccgctcgc agagagccgg 180 cttgcagttc ccagtgggcc gtattcatcg acacctaaaa tctaggacga ccagtcatgg 240 acgtgtgggc gcgactgccg ctgtgtacag cgcagccatc ctggagtacc tcaccgcaga 300 ggtacttgaa ctggcaggaa atgcatcaaa agacttaaag gtaaagcgta ttacccctcg 360 tcacttgcaa cttgctattc gtggagatga agaattggat tctctcatca aggctacaat 420 tgctggtggt ggtgtcattc cacacatcca caaatctctg attgggaaga aaggacaaca 480 gaagactgtc taaaggatgc ctggattcct tgttatctca ggactctaaa tactctaaca 540 gctgtccagt gttggtgatt ccagtggact gtatctctgt gaaaaacaca attttgcctt 600 tttgtaattc tatttgagca agttggaagt ttaattagct ttccaaccaa ccaaatttct 660 gcattcgagt cttaaccata tttaagtgtt actgtggctt caaagaagct attgattctg 720 aagtagtggg ttttgattga gttgactgtt tttaaaaaac tgtttggatt ttaattgtga 780 tgcagaagtt atagtaacaa acatttggtt ttgttcagac cttatttcca ctctggtgga 840 taagttcaat aaaggtcata tcccaaacta aaa 873 41 2098 DNA Homo sapiens 41 cctgccgaag tcagttcctt gtggagccgg agctgggcgc ggattcgccg aggcaccgag 60 gcactcagag gaggcgccat gtcagaaccg gctggggatg tccgtcagaa cccatgcggc 120 agcaaggcct gccgccgcct cttcggccca gtggacagcg agcagctgag ccgcgactgt 180 gatgcgctaa tggcgggctg catccaggag gcccgtgagc gatggaactt cgactttgtc 240 accgagacac cactggaggg tgacttcgcc tgggagcgtg tgcggggcct tggcctgccc 300 aagctctacc ttcccacggg gccccggcga ggccgggatg agttgggagg aggcaggcgg 360 cctggcacct cacctgctct gctgcagggg acagcagagg aagaccatgt ggacctgtca 420 ctgtcttgta cccttgtgcc tcgctcaggg gagcaggctg aagggtcccc aggtggacct 480 ggagactctc agggtcgaaa acggcggcag accagcatga cagatttcta ccactccaaa 540 cgccggctga tcttctccaa gaggaagccc taatccgccc acaggaagcc tgcagtcctg 600 gaagcgcgag ggcctcaaag gcccgctcta catcttctgc cttagtctca gtttgtgtgt 660 cttaattatt atttgtgttt taatttaaac acctcctcat gtacataccc tggccgcccc 720 ctgcccccca gcctctggca ttagaattat ttaaacaaaa actaggcggt tgaatgagag 780 gttcctaaga gtgctgggca tttttatttt atgaaatact atttaaagcc tcctcatccc 840 gtgttctcct tttcctctct cccggaggtt gggtgggccg gcttcatgcc agctacttcc 900 tcctccccac ttgtccgctg ggtggtaccc tctggagggg tgtggctcct tcccatcgct 960 gtcacaggcg gttatgaaat tcaccccctt tcctggacac tcagacctga attctttttc 1020 atttgagaag taaacagatg gcactttgaa ggggcctcac cgagtggggg catcatcaaa 1080 aactttggag tcccctcacc tcctctaagg ttgggcaggg tgaccctgaa gtgagcacag 1140 cctagggctg agctggggac ctggtaccct cctggctctt gatacccccc tctgtcttgt 1200 gaaggcaggg ggaaggtggg gtcctggagc agaccacccc gcctgccctc atggcccctc 1260 tgacctgcac tggggagccc gtctcagtgt tgagcctttt ccctctttgg ctcccctgta 1320 ccttttgagg agccccagct acccttcttc tccagctggg ctctgcaatt cccctctgct 1380 gctgtccctc ccccttgtcc tttcccttca gtaccctctc agctccaggt ggctctgagg 1440 tgcctgtccc acccccaccc ccagctcaat ggactggaag gggaagggac acacaagaag 1500 aagggcaccc tagttctacc tcaggcagct caagcagcga ccgccccctc ctctagctgt 1560 gggggtgagg gtcccatgtg gtggcacagg cccccttgag tggggttatc tctgtgttag 1620 gggtatatga tgggggagta gatctttcta ggagggagac actggcccct caaatcgtcc 1680 agcgaccttc ctcatccacc ccatccctcc ccagttcatt gcactttgat tagcagcgga 1740 acaaggagtc agacatttta agatggtggc agtagaggct atggacaggg catgccacgt 1800 gggctcatat ggggctggga gtagttgtct ttcctggcac taacgttgag cccctggagg 1860 cactgaagtg cttagtgtac ttggagtatt ggggtctgac cccaaacacc ttccagctcc 1920 tgtaacatac tggcctggac tgttttctct cggctcccca tgtgtcctgg ttcccgtttc 1980 tccacctaga ctgtaaacct ctcgagggca gggaccacac cctgtactgt tctgtgtctt 2040 tcacagctcc tcccacaatg ctgatataca gcaggtgctc aataaacgat tcttagtg 2098 42 1914 DNA Homo sapiens 42 gcagccaggc gcgcactgca cagctctctt ctctcgccgc cgcccgagcg cacccttcag 60 cccgcgcgcc ggccgtgagt cctcggtgct cgcccgccgg ccagacaaac agcccgcccg 120 accccgtccc gaccctggcc gccccgagcg gagcctggag caaaatgatg cttcaacacc 180 caggccaggt ctctgcctcg gaagtgagtg cttctgccat cgtcccctgc ctgtcccctc 240 ctgggtcact ggtgtttgag gattttgcta acctgacgcc ctttgtcaag gaagagctga 300 ggtttgccat ccagaacaag cacctctgcc accggatgtc ctctgcgctg gaatcagtca 360 ctgtcagcga cagacccctc ggggtgtcca tcacaaaagc cgaggtagcc cctgaagaag 420 atgaaaggaa aaagaggcga cgagaaagaa ataagattgc agctgcaaag tgccgaaaca 480 agaagaagga gaagacggag tgcctgcaga aagagtcgga gaagctggaa agtgtgaatg 540 ctgaactgaa ggctcagatt gaggagctca agaacgagaa gcagcatttg atatacatgc 600 tcaaccttca tcggcccacg tgtattgtcc gggctcagaa tgggaggact ccagaagatg 660 agagaaacct ctttatccaa cagataaaag aaggaacatt gcagagctaa gcagtcgtgg 720 tatgggggcg actggggagt cctcattgaa tcctcatttt atacccaaaa ccctgaagcc 780 attggagagc tgtcttcctg tgtacctcta gaatcccagc agcagagaac catcaaggcg 840 ggagggcctg cagtgattca gcaggccctt cccattctgc cccagagtgg gtcttggacc 900 agggcaagtg catctttgcc tcaactccag gatttaggcc ttaacacact ggccattctt 960 atgttccaga tggcccccag ctggtgtcct gcccgccttt catctggatt ctacaaaaaa 1020 ccaggatgcc caccgttaga ttcaggcagc agtgtctgta cctcgggtgg gagggatggg 1080 gccatctcct tcaccgtggc taccattgtc actcgtaggg gatgtggagt gagaacagca 1140 tttagtgaag ttgtgcaacg gccagggttg tgctttctag caaatatgct gttatgtcca 1200 gaaattgtgt gtgcaagaaa actaggcaat gtactcttcc gatgtttgtg tcacacaaca 1260 ctgatgtgac ttttatatgc tttttctcag atctggtttc taagagtttt ggggggcggg 1320 gctgtcacca cgtgcagtat ctcaagatat tcaggtggcc agaagagctt gtcagcaaga 1380 ggaggaacag aattctccca gcgttaacac aaaatccatg ggcagcatga tggcaggtcc 1440 tctgttgcaa actcagttcc aaagtcacag gaagaaagca gaaagttcaa cttccaaagg 1500 gttaggactc tccactcaat gtcttaggtc aggagttgtg tctaggctgg aagagccaaa 1560 gaaatattcc attttccttt ccttgtggtt gaaaccacag tcagtggaga gatgtttgga 1620 acacagtcag tggagctggt ggtaccaggt ttagcattat tggatgtcaa aagcattttt 1680 tttgtcatgt agctgtttta agaaatctgg cccagggtgt ttgcagctgt gagaagtcac 1740 tcacactggc cacaaggacg ctggctactg tctattaaaa ttctgatgtt tctgtgaaat 1800 tctcagagtg tttaattgta ctcaatggta tcattacaat tttctgtaag agaaaatatt 1860 acttatttat cctagtattc ctaacctgtc agaataataa atattgtggt aaaa 1914 43 699 DNA Homo sapiens 43 catccggtgt ggtcgacggg tcctccaaga gtttggggcg cggaccggag taccttgcgt 60 gcagttatgt cggcgtcggt agtgtctgtc atttcgcggt tcttagaaga gtacttgagc 120 tccactccgc agcgtctgaa gttgctggac gcgtacctgc tgtatatact gctgaccggg 180 gcgctgcagt tcggttactg tctcctcgtg gggaccttcc ccttcaactc ttttctctcg 240 ggcttcatct cttgtgtggg gagtttcatc ctagcggttt gcctgagaat acagatcaac 300 ccacagaaca aagcggattt ccaaggcatc tccccagagc gagcctttgc tgattttctc 360 tttgccagca ccatcctgca ccttgttgtc atgaactttg ttggctgaat cattctcatt 420 tacttaattg aggagtagga gactaaaaga atgttcactc tttgaatttc ctggataaga 480 gttctggaga tggcagctta ttggacacat ggattttctt cagatttgac acttactgct 540 agctctgctt tttatgacag gagaaaagcc cagagttcac tgtgtgtcag aacaactttc 600 taacaaacat ttattaatcc agcctctgcc tttcattaaa tgtaaccttt tgctttccaa 660 attaaagaac tccatgccac tcctcaaaaa aaaaaaaaa 699 44 2049 DNA Homo sapiens 44 gaattcgggg gggtagaaga cagaagtagc tcagggtcct gggggaatgg aggacatcca 60 agcccgtcca ggaactatgg agatgggact ccctatgacc acatgaccag cagggacctt 120 gggtcacatg acaatctctc tccacctttt gtcaattcca gaatacaaag taaaacagaa 180 aggggctcat actcatctta tgggagagaa tcaaacttac agggttgcca ccagcagagt 240 ctccttggag gtgacatgga tatgggcaac ccaggaaccc tttcgcccac caaacctggt 300 tcccagtact atcagtattc tagcaataat ccccgaagga ggcctcttca cagtagtgcc 360 atggaggtac agacaaagaa agttcgaaaa gttcctccag gtttgccatc ttcagtctat 420 gctccatcag caagcactgc cgactacaat agggactcgc caggctatcc ttcctccaaa 480 ccagcaacca gcactttccc tagctccttc ttcatgcaag atggccatca cagcagtgac 540 ccttggagct cctccagtgg gatgaatcag cctggctatg caggaatgtt gggcaactct 600 tctcatattc cacagtccag cagctactgt agcctgcatc cacatgaacg tttgagctat 660 ccatcacact cctcagcaga catcaattcc agtcttcctc cgatgtccac tttccatcgt 720 agtggtacaa accattacag cacctcttcc tgtacgcctc ctgccaacgg gacagacagt 780 ataatggcaa atagaggaag cggggcagcc ggcagctccc agactggaga tgctctgggg 840 aaagcacttg cttcgatcta ttcttcagat cacactaaca acagcttttc atcaaaccct 900 tcaactcctg ttggctctcc tccatctctc tcagcaggca cagctgtttg gtctagaaat 960 ggaggacagg cctcatcgtc tcctaattat gaaggaccct tacactcttt gcaaagccga 1020 attgaagatc gtttagaaag actggatgat gctattcatg ttctccggaa ccatgcagtg 1080 ggcccatcca cagctatgcc tggtggtcat ggggacatgc atggaatcat tggaccttct 1140 cataatggag ccatgggtgg tctgggctca gggtatggaa ccggccttct ttcagccaac 1200 agacattcac tcatggtggg gacccatcgt gaagatggcg tggccctgag aggcagccat 1260 tctcttctgc caaaccaggt tccggttcca cagcttcctg tccagtctgc gacttcccct 1320 gacctgaacc caccccagga cccttacaga ggcatgccac caggactaca ggggcagagt 1380 gtctcctctg gcagctctga gatcaaatcc gatgacgagg gtgatgagaa cctgcaagac 1440 acgaaatctt cggaggacaa gaaattagat gacgacaaga aggatatcaa atcaattact 1500 agcaataatg acgatgagga cctgacacca gagcagaagg cagagcgtga gaaggagcgg 1560 aggatggcca acaatgcccg agagcgtctg cgggtccgtg acatcaacga ggctttcaaa 1620 gagctcggcc gcatggtgca gctccacctc aagagtgaca agccccagac caagctcctg 1680 atcctccacc aggcggtggc cgtcatcctc agtctggagc agcaagtccg agaaaggaat 1740 ctgaatccga aagctgcgtg tctgaaaaga agggaggaag agaaggtgtc ctcggagcct 1800 ccccctctct ccttggccgg cccacaccct ggaatgggag acgcatcgaa tcacatggga 1860 cagatgtaaa agggtccaag ttgccacatt gcttcattaa aacaagagac cacttcctta 1920 acagctgtat tatcttaaac ccacataaac acttctcctt aacccccatt tttgtaatat 1980 aagacaagtc tgagtagtta tgaatcgcag acgcaagagg tttcagcatt cccaattatc 2040 aaaaaacag 2049 45 316 DNA Homo sapiens misc_feature (1)...(316) n = A,T,C or G 45 tctatgtgta cagatgaatg ataaactctc tgcttctccc tctgcccctc tccaggcgcc 60 ggcgggcgcg ccngtcttcg aagttgatgc aatcggttta aacatggctg aacgcgtgtg 120 tacacgggac tgacgcaacc cacgtgtaac tgtcagccgg gccctgagta atcgcttaaa 180 gatgttccta cgggcttgtt gctgttgatg ttttgttttg ttttgttttt tggtcttttt 240 ttgtatnata aaaaataatc tatttctatg agaaaagacg gcgtctgtat atnttgggaa 300 tcttttccgt ttcaag 316 46 3953 DNA Homo sapiens 46 ggggtcacgg gcgaactaga acactgggaa aggggctgca ggttccggac cggaccggcc 60 ctgacccgga ataatgagca aggagggtgt ggtgggttga aagccatcct actttactcc 120 cgagttagag catggattca gttttagtct taagggggaa gtgagattgg agatttttat 180 ttttaatttt gggcagaagc aggttgactc tagggatctc cagagcgaga ggatttaact 240 tcatgttgct cccgtgtttg aaggaggaca ataaaagtcc caccgggcaa aattttcgta 300 acctctgcgg tagaaaacgt caggtatctt ttaaatcgcg atagttttcg ctgtgtcagg 360 ctttcttcgg tggagctccg agggtagcta ggttctaggt ttgaaacaga tgcagaatcc 420 aaaggcagcg caaaaaacag ccaccgattt tgctatgtct ctgagctgcg agataatcag 480 acagctaaat ggagtctgag cagctgttcc atagaggcta ctatagaaac agctacaaca 540 gtataacaag tgcaagtagt gatgaggaac ttttagatgg agcaggtgtt attatggact 600 ttcaaacatc tgaagatgac aatttattag atggtgacac tgcagttgga actcattata 660 caatgacaaa tggaggcagc attaacagtt ctacacattt actggatctt ttggatgaac 720 caattccagg tgttggtaca tatgatgatt tccatactat tgattgggtg cgagaaaaat 780 gtaaagacag agaaaggcat agacggatca acagcaaaaa gaaagaatca gcatgggaaa 840 tgacaaaaag tttgtatgat gcgtggtcag gatggctagt agtaacacta acaggattgg 900 catcaggggc actggccgga ttaatagaca ttgctgccga ttggatgact gacctaaagg 960 agggcatttg ccttagtgcg ttgtggtaca accacgaaca gtgctgttgg ggatctaatg 1020 aaacaacatt tgaagagagg gataaatgtc cacagtggaa aacatgggca gaattaatca 1080 taggtcaagc agagggtcct ggttcttata tcatgaacta cataatgtac atcttctggg 1140 ccttgagttt tgcctttctt gcagtttccc tggtaaaggt atttgctcca tatgcctgtg 1200 gctctggaat tccagagatt aaaactattt taagtggatt catcatcaga ggttacttgg 1260 gaaaatggac tttaatgatt aaaaccatca cattagtcct ggctgtggca tcaggtttga 1320 gtttaggaaa agaaggtccc ctggtacatg ttgcctgttg ctgcggaaat atcttttcct 1380 acctctttcc aaagtatagc acaaacgaag ctaaaaaaag ggaggtgcta tcagctgcct 1440 cagctgcagg ggtttctgta gcttttggtg caccaattgg aggagttctt tttagcctgg 1500 aagaggttag ctattatttt cctctcaaaa ctttatggag atcatttttt gctgctttag 1560 tggctgcatt tgttttgagg tccatcaatc catttggtaa cagccgtctg gtcctttttt 1620 atgtggagta tcatacacca tggtaccttt ttgaactgtt tccttttatt cttctagggg 1680 tatttggagg gctttgggga gcctttttca ttagggcaaa tattgcctgg tgtcgtcgac 1740 gcaagtccac gaaatttgga aagtatcccg ttctggaagt cattattgtt gcagccatta 1800 ctgctgtgat agccttccct aatccataca ctaggctaaa caccagtgaa ctgatcaaag 1860 agctttttac agactgtggt cccctggaat cctcttctct ttgtgactac agaaatgaca 1920 tgaatgccag taaaattgtc gatgacattc ctgatcgtcc agcaggcatt ggagtatatt 1980 cagctatatg gcagttatgc ctggcactca tatttaaaat cataatgaca gtattcactt 2040 ttggcatcaa ggttccatca ggcttgttca tccccagcat ggccattgga gcgatcgcag 2100 gaaggattgt ggggattgcg gtggagcagc ttgcctacta tcaccacgac tggtttatct 2160 ttaaggagtg gtgtgaggtc ggggctgatt gcattacacc tggcctttat gccatggttg 2220 gtgctgctgc atgcttaggt ggtgtgacaa gaatgactgt ctccctggtg gttattgttt 2280 ttgagcttac tggaggcttg gaatatattg ttccccttat ggctgcagtc atgaccagta 2340 aatgggttgg agatgccttt ggcagggaag gcatttatga agcacacatc cgattaaatg 2400 gatacccttt cttggatgca aaagaagaat tcgaattcac tcataccacc ctggctgctg 2460 acgttatgag acctcgaagg aatgatcctc ccttagctgt cctgacacag gacaatatga 2520 cagtggatga tatagaaaac atgattaatg aaaccagcta caatggattt cctgtcataa 2580 tgtcaaaaga atctcagaga ttagtgggat ttgccctcag aagagacctg acaattgcaa 2640 tagaaagtgc caggaaaaaa caagaaggta tcgttggcag ttctcgggtg tgttttgcac 2700 agcacacccc atctcttcca gcagaaagtc ctcggccatt gaagcttcga agcattcttg 2760 acatgagccc ttttacagtg acagaccaca ccccaatgga gattgtggtg gatattttcc 2820 gaaagctggg actgaggcag tgccttgtaa ctcacaatgg gcgcctcctt ggcattataa 2880 caaaaaaaga tatcctccgg catatggccc agacggcaaa ccaagacccc gcttcaataa 2940 tgttcaactg aatctcacag atgaggagag agaagaaacg gaagaggaag tttatttgtt 3000 gaatagcaca actctttaac ctgagggagt catctacttt tttttcctcc tttacaaaaa 3060 aagaaaggaa atataaaagc cgggtttttg caacatggtt tgcaaataat gctggtggaa 3120 tggaggagtt gtttggggag ggaaaggaga gagaaggaaa ggagtgaggt atttcccgtc 3180 taacagaaag cagcgtatca actcctattg ttctgcactg gatgcattca gctgaggatg 3240 tgcctgatag tgcaggcttg cgcctcaaca gagatgacag cagagtcctc gagcacctgg 3300 cctgtttgct cacatgcaag acacatacag ccctattcta gaggatactt gaatggacct 3360 ctataaacgc aaggttcttg ccttttttta atcaaaactg ttctgtttaa ttcatgaatt 3420 gtatagttaa gcattacctt tctacattcc agaagagcct ttatttctct ctctctctct 3480 ctctctctct ctctctctac tgagctgtaa caaagcctct ttaaatcggt gtatcctttt 3540 gaagcagtcc tttctcatat tgagatgtac tgtgatttta ctgaggtttc atcacaagaa 3600 gggagtgttt cttgtgccat taaccatgta gtttgtacca tcactaaatg cttggaacag 3660 tacacatgca ccacaacaaa ggctcatcaa acaggtaaag tctcgaagga agcgagaacg 3720 aaatctctca ttgtgtgccg tgtggctcaa aaccgaaaac aatgaagctt ggttttaaag 3780 gataaagttt tcttttttgt tttcctctca gactttatgg ataatgtgac cgggtcttat 3840 gcaaattttc tatttctaaa actactacta tgatatacaa gtgctgttga gcataattaa 3900 ataaaatgct gctgctttga cagtaaagag aaggaagtat tctgaaaaaa aac 3953 47 2074 DNA Homo sapiens 47 gaattcggca cgaggcgcgg cggctgcgac cgggacggcc cattttccgc cagctcgccg 60 ctcgctatgg cgtcgctcac cgtgaaggcc taccttctgg gcaaggagga cgcggcgcgc 120 gagattcgcc gcttcagctt ctgctgcagc cccgagcctg aggcggaagc cgaggctgcg 180 gcgggtccgg gaccctgcga gcggctgctg agccgggtgg ccgccctgtt ccccgcgctg 240 cggcctggcg gcttccaggc gcactaccgc gatgaggacg gggacttggt tgccttttcc 300 agtgacgagg aattgacaat ggccatgtcc tacgtgaagg atgacatctt ccgaatctac 360 attaaagaga aaaaagagtg ccggcgggac caccgcccac cgtgtgctca ggaggcgccc 420 cgcaacatgg tgcaccccaa tgtgatctgc gatggctgca atgggcctgt ggtaggaacc 480 cgctacaagt gcagcgtctg cccagactac gacttgtgta gcgtctgcga gggaaagggc 540 ttgcaccggg ggcacaccaa gctcgcattc cccagcccct tcgggcacct gtctgagggc 600 ttctcgcaca gccgctggct ccggaaggtg aaacacggac acttcgggtg gccaggatgg 660 gaaatgggtc caccaggaaa ctggagccca cgtcctcctc gtgcagggga ggcccgccct 720 ggccccacgg cagaatcagc ttctggtcca tcggaggatc cgagtgtgaa tttcctgaag 780 aacgttgggg agagtgtggc agctgccctt agccctctgg gcattgaagt tgatatcgat 840 gtggagcacg gagggaaaag aagccgcctg acccccgtct ctccagagag ttccagcaca 900 gaggagaaga gcagctcaca gccaagcagc tgctgctctg accccagcaa gccgggtggg 960 aatgttgagg gcgccacgca gtctctggcg gagcagatga ggaagatcgc cttggagtcc 1020 gaggggcgcc ctgaggaaca gatggagtcg gataactgtt caggaggaga tgatgactgg 1080 acccatctgt cttcaaaaga agtggacccg tctacaggtg aactccagtc cctacagatg 1140 ccagaatccg aagggccaag ctctctggac ccctcccagg agggacccac agggctgaag 1200 gaagctgcct tgtacccaca tctcccgcca gaggctgacc cgcggctgat tgagtccctc 1260 tcccagatgc tgtccatggg cttctctgat gaaggcggct ggctcaccag gctcctgcag 1320 accaagaact atgacatcgg agcggctctg gacaccatcc agtattcaaa gcatcccccg 1380 ccgttgtgac cacttttgcc cacctcttct gcgtgcccct cttctgtctc atagttgtgt 1440 taagcttgcg tagaattgca ggtctctgta cgggccagtt tctctgcctt cttccaggat 1500 caggggttag ggtgcaagaa gccatttagg gcagcaaaac aagtgacatg aagggagggt 1560 ccctgtgtgt gtgtgtgctg atgtttcctg ggtgccctgg ctccttgcag cagggctggg 1620 cctgcgagac ccaaggctca ctgcagcgcg ctcctgaccc ctccctgcag gggctacgtt 1680 agcagcccag cacatagctt gcctaatggc tttcactttc tcttttgttt taaatgactc 1740 ataggtccct gacatttagt tgattatttt ctgctacaga cctggtacac tctgatttta 1800 gataaagtaa gcctaggtgt tgtcagcagg caggctgggg aggccagtgt tgtgggcttc 1860 ctgctgggac tgagaaggct cacgaagggc atccgcaatg ttggtttcac tgagagctgc 1920 ctcctggtct cttcaccact gtagttctct catttccaaa ccatcagctg cttttaaaat 1980 aagatctctt tgtagccatc ctgttaaatt tgtaaacaat ctaattaaat ggcatcagca 2040 ctttaaccaa taaaaaaaaa aaaaaaaaaa aaaa 2074 48 1846 DNA Homo sapiens 48 gcagtgcggc ggtcacaggc tgagtgctgc ggcgcgatcc ttgcttccct gagcgttggc 60 ccgggaggaa agaagatggt gctggatctg gatttgtttc gggtggataa aggaggggac 120 ccagccctca tccgagagac gcaggagaag cgcttcaagg acccgggact agtggaccag 180 ctggtgaagg cagacagcga gtggcgacga tgtagatttc gggcagacaa cttgagcaag 240 ctgaagaacc tatgcagcaa gacaatcgga gagaaaatga agaaaaaaga gccagtggga 300 gatgatgagt ctgtcccaga gaatgtgctg agtttcgatg accttactgc agacgcttta 360 gctaacctga aagtctcaca aatcaaaaaa gtccgactcc tcattgatga agccatcctg 420 aagtgtgacg cggagcggat aaagttggaa gcagagcggt ttgagaacct ccgagagatt 480 gggaaccttc tgcacccttc tgtacccatc agtaacgatg aggatgtgga caacaaagta 540 gagaggattt ggggcgattg tacagtcagg aagaagtact ctcatgtgga cctggtggtg 600 atggtagatg gctttgaagg cgaaaagggg gccgtggtgg ctgggagtcg agggtacttc 660 ttgaaggggg tcctggtgtt cctggaacag gctctcatcc agtatgccct tcgcaccttg 720 ggaagtcggg gctacattcc catttatacc ccctttttca tgaggaagga ggtcatgcag 780 gaggtggcac agctcagcca gtttgatgaa gaactttata aggtgattgg caaaggcagt 840 gaaaagtctg atgacaactc ctatgatgag aagtacctga ttgccacctc agagcagccc 900 attgctgccc tgcaccggga tgagtggctc cggccggagg acctgcccat caagtatgct 960 ggcctgtcta cctgcttccg tcaggaggtg ggctcccatg gccgtgacac ccgtggcatc 1020 ttccgagtcc atcagtttga gaagattgaa cagtttgtgt actcatcacc ccatgacaac 1080 aagtcatggg agatgtttga agagatgatt accaccgcag aggagttcta ccagtccctg 1140 gggattcctt accacattgt gaatattgtc tcaggttctt tgaatcatgc tgccagtaag 1200 aagcttgacc tggaggcctg gtttccgggc tcaggagcct tccgtgagtt ggtctcctgt 1260 tctaattgca cggattacca ggctcgccgg cttcgaatcc gatatgggca aaccaagaag 1320 atgatggaca aggtggagtt tgtccatatg ctcaatgcta ccatgtgcgc cactacccgt 1380 accatctgcg ccatcctgga gaactaccag acagagaagg gcatcactgt gcctgagaaa 1440 ttgaaggagt tcatgccgcc aggactgcaa gaactgatcc cctttgtgaa gcctgcgccc 1500 attgagcagg agccatcaaa gaagcagaag aagcaacatg agggcagcaa aaagaaagca 1560 gcagcaagag acgtcaccct agaaaacagg ctgcagaaca tggaggtcac cgatgcttga 1620 acattcctgc ctccctattt gccaggcttt catttctgtc tgctgagatc tcagagcctg 1680 cccaacagca gggaagccaa gcacccattc atccccctgc ccccatctga ctgcgtagct 1740 gagaggggaa cagtgccatg taccacacag atgttcctgt ctcctcgcat gggcataggg 1800 acccatcatt gatgactgat gaaaccatgt aataaagcat ctctgg 1846 49 1325 DNA Homo sapiens 49 cagaagcggc tagtggcggc tgcctgcgtc cccaaccccc tccgcgcagc gctcgcgaca 60 cgcgtgccag gagtgggagc gagcggcggg gccagctgcg ttctgagcct gggcgcagct 120 gccatctgct ctgggaagca ccagggtgtc cccgccgccc tcagctcgaa gtcagccacc 180 atggaggcgc aggcacaagg tttgttggag actgaaccgt tgcaaggaac agacgaagat 240 gcagtagcca gtgctgactt ctctagcatg ctctctgagg aggaaaagga agagttaaaa 300 gcagagttag ttcagctaga agacgaaatt acaacactac gacaagtttt gtcagcgaaa 360 gaaaggcatc tagttgagat aaaacaaaaa ctcggcatga acctgatgaa tgaattaaaa 420 cagaacttca gcaaaagctg gcatgacatg cagactacca ctgcctacaa gaaaacacat 480 gaaaccctga gtcacgcagg gcaaaaggca actgcagctt tcagcaacgt tggaacggcc 540 atcagcaaga agttcggaga catgagttac tccattcgcc attccataag tatgcctgct 600 atgaggaatt ctcctacttt caaatcattt gaggagaggg ttgagacaac tgtcacaagc 660 ctcaagacga aagtaggcgg tacgaaccct aatggaggca gttttgagga ggtcctcagc 720 tccacggccc atgccagtgc ccagagcttg gcaggaggct cccggcggac caaggaggag 780 gagctgcagt gctaagtcca gccagcgtgc agctgcatcc agaaaccggc cactacccag 840 cccatctctg cctgtgctta tccagataag aagaccaaaa tcccgctggg aaaaacccag 900 gccttgacat tgttattcaa atggcccctc cagaaagttt aatgatttcc atttgtattt 960 gtgttgatga tggaccactt gaccatcaca tttcagtatt catagatgac tgtcacattt 1020 taaaatgttc ccacttgagc aggtacacaa ctggtcataa ttcctgtctg tgtaattcga 1080 tgtatatttt tccaaacatg tagctattgt ttgctttgat ttttgcttgg cctcctttat 1140 gatgtgcatg tccttgaagg ctgaatgaac agtccctttc agttcagcag atcaacagga 1200 tggagctctt catgactgtc tccagcaata ggatgattta ctataaattt catccaacta 1260 cttgtgatct ctctcaccta catcaattat gtatgttaat ttcagcaatt aaaagaattg 1320 atttt 1325 50 1216 DNA Homo sapiens 50 ccacgagtga gccttgaacg cctggacctg gacctcacag ctgacagcca gccacccgtc 60 ttcaaggtct tcccaggcag taccactgag gactacaacc ttattgttat tgaacgtggc 120 gctgccgctg cagctaccgg ccagccaggg actgcgcctg caggaacccc tggtgcccca 180 cccctggctg gcatggccat tgtcaaggag gaggagacgg aggctgccat tggagcccct 240 cctactgcca ctgagggccc tgagaccaaa cctgtgctta tggctcttgc ggagggtcct 300 ggtgctgagg gtccccgcct ggcctcacct agtggcagca ccagctcagg gctggaggtg 360 gtggctcctg agggtacctc agccccaggt ggtggcccgg gaaccctgga tgacagtgcc 420 accatttgcc gtgtctgcca gaagccaggc gatctggtta tgtgcaacca gtgtgagttt 480 tgtttccacc tggactgtca cctgccggcc ctgcaggatg taccagggga ggagtggagc 540 tgctcactct gccatgtgct ccctgacctg aaggaggagg atggcagcct cagcctggat 600 ggtgcagaca gcactggcgt ggtggccaag ctctcaccag ccaaccagcg gaaatgtgag 660 cgtgtactgc tggccctatt ctgtcacgaa ccctgccgcc ccctgcatca gctggctacc 720 gactccacct tctccctgga ccagcccggt ggcaccctgg atctgaccct gatccgtgcc 780 cgcctccagg agaagttgtc acctccctac agctccccac aggagtttgc ccaggatgtg 840 ggccgcatgt tcaagcaatt caacaagtta actgaggaca aggcagacgt gcagtccatc 900 atcggcctgc agcgcttctt cgagacgcgc atgaacgagg ccttcggtga caccaagttc 960 tctgctgtgc tggtggagcc cccgccgatg agcctgcctg gtgctggcct gagttcccag 1020 gagctgtctg gtggccctgg tgatggcccc tgaggctgga gcccccatgg ccagcccagc 1080 ctggctctgt tctctgtcct gtcaccccat ccccactccc ctggtggcct gactcccact 1140 ccctggtggc cccatccccc agttcctcac gatatggttt ttacttctgt ggatttaata 1200 aaaacttcac cagtta 1216 51 3826 DNA Homo sapiens 51 gaattcgggt ggagtcctga aggagggcct gatgtcttca tcattctcaa attcttgtaa 60 gctctgcgtc gggtgaaacc agacaaagcc gcgagcccag ggatgggagc acgcggggga 120 cggcctgccg gcggggacga cagcattgcg cctgggtgca gcagtgtgcg tctcggggaa 180 gggaagatat tttaaggcgt gtctgagcag acggggaggc ttttccaaac ccaggcagct 240 tcgtggcgtg tgcggtttcg acccggtcac acaaagcttc agcatgtcat gtgaggacgg 300 tcgggccctg aaaggaacgc tctcggaatt ggccgcggaa accgatctgc ccgttgtgtt 360 tgtgaaacag agaaagatag gcggccatgg tccaaccttg aaggcttatc aggagggcag 420 acttcaaaag ctactaaaaa tgaacggccc tgaagatctt cccaagtcct atgactatga 480 ccttatcatc attggaggtg gctcaggagg tctggcagct gctaaggagg cagcccaata 540 tggcaagaag gtgatggtcc tggactttgt cactcccacc cctcttggaa ctagatgggg 600 tcttggagga acatgtgtga atgtgggttg catacctaaa aaactgatgc atcaagcagc 660 tttgttagga caagccctgc aagactctcg aaattatgga tggaaagtcg aggagacagt 720 taagcatgat tgggacagaa tgatagaagc tgtacagaat cacattggct ctttgaattg 780 gggctaccga gtagctctgc gggagaaaaa agtcgtctat gagaatgctt atgggcaatt 840 tattggtcct cacaggatta aggcaacaaa taataaaggc aaagaaaaaa tttattcagc 900 agagagtttt ctcattgcca ctggtgaaag accacgttac ttgggcatcc ctggtgacaa 960 agaatactgc atcagcagtg atgatctttt ctccttgcct tactgcccgg gtaagaccct 1020 ggttgttgga gcatcctatg tcgctttgga gtgcgctgga tttcttgctg gtattggttt 1080 aggcgtcact gttatggtta ggtccattct tcttagagga tttgaccagg acatggccaa 1140 caaaattggt gaacacatgg aagaacatgg catcaagttt ataagacagt tcgtaccaat 1200 taaagttgaa caaattgaag cagggacacc aggccgactc agagtagtag ctcagtccac 1260 caatagtgag gaaatcattg aaggagaata taatacggtg atgctggcaa taggaagaga 1320 tgcttgcaca agaaaaattg gcttagaaac cgtaggggtg aagataaatg aaaagactgg 1380 aaaaatacct gtcacagatg aagaacagac caatgtgcct tacatctatg ccattggcga 1440 tatattggag gataaggtgg agctcacccc agttgcaatc caggcaggaa gattgctggc 1500 tcagaggctc tatgcaggtt ccactgtcaa gtgtgactat gaaaatgttc caaccactgt 1560 atttactcct ttggaatatg gtgcttgtgg cctttctgag gagaaagctg tggagaagtt 1620 tggggaagaa aatattgagg tttaccatag ttacttttgg ccattggaat ggacgattcc 1680 gtcaagagat aacaacaaat gttatgcaaa aataatctgt aatactaaag acaatgaacg 1740 tgttgtgggc tttcacgtac tgggtccaaa tgctggagaa gttacacaag gctttgcagc 1800 tgcgctcaaa tgtggactga ccaaaaagca gctggacagc acaattggaa tccaccctgt 1860 ctgtgcagag gtattcacaa cattgtctgt gaccaagcgc tctggggcaa gcatcctcca 1920 ggctggctgc tgaggttaag ccccagtgtg gatgctgttg ccaagactgc aaaccactgg 1980 ctcgtttccg tgcccaaatc caaggcgaag ttttctagag ggttcttggg ctcttggcac 2040 ctgcgtgtcc tgtgcttacc accgcccaag gcccccttgg atctcttgga taggagttgg 2100 tgaatagaag gcaggcagca tcacactggg gtcactgaca gacttgaagc tgacatttgg 2160 cagggcatcg aagggatgca tccatgaagt caccagtctc aagcccatgt ggtaggcggt 2220 gatggaacaa ctgtcaaatc agttttagca tgacctttcc ttgtggattt tcttattctc 2280 gttgtcaagt tttctagggt tgaatttttt tcttttttct ccatggtgtt aatgatatta 2340 gagatgaaaa acgttagcag ttgatttttg tccaaaagca agtcatggct agagtatcca 2400 tgcaaggtgt cttgttgcat ggaagggata gtttggctcc cttggaggct atgtaggctt 2460 gtcccgggaa agagaactgt cctgcagctg aaatggactg ttctttactg acctgctcag 2520 cagtttcttc tctcatatat tcccaaaaca agtacatctg cgatcaactc tagccaaatt 2580 tgcccctgtg tgctacatga tggatgatta ttattttaag gtctgtttag gaagggaaat 2640 ggctacttgg ccagccattg cctggcattt ggtagtatag tatgattctc accattattt 2700 gtcatggagg cagacataca ccagaaatgg gggagaaaca gtacatatct ttctgtcttt 2760 agtttattgt gtgctggtct aagcaagctg agatcatttg caatggaaaa cacgtaactt 2820 gtttaaaagt ttttctggta gctttagctt tatgctaaaa aaaataatga cattgggtat 2880 ctatttcttt ctaagacata cattagtagg aaaataagtc ttttcatgct tatgatttag 2940 ctgttttgtg gtaattgctt tttaaaggaa gttattaata tcataagtta ttattaatat 3000 tttgaacaca ggtggatgtg aaggattttc atttaaaaac caagtggttt tgactttttc 3060 tgttgaatga acaactgtgc cttgtggaat ttttgcagaa gtgtttatgc tttgttagca 3120 tttcaacttg cattattata aagaggtatt aatgcctcag ttatgtgttt gtcaatgtac 3180 tggctgagga ttctatctca gctgtctttt ctaactgtgt aggttgagtt ttgaacacgt 3240 gcttgtggac atcagcctcc tgccagcagt tcttgaagct tctttttcat tcctgctact 3300 ctacctgtat ttctcagttg cagcactgag tggtcaaaat acatttctgg gccacctcag 3360 ggaacccatg catctgcctg gcatttaggc agcagagccc ctgaccgtcc cccacaggct 3420 ctgcctcacg tcctcatctc atttggctgt gtaaagaaat gggaaaaggg aaaaggagag 3480 agcaattgag gcagttgacc atattcagtt ttatttattt atttttaatt tgtttttttc 3540 tccaagtcca ccagtctctg aaattagaac agtaggcggt atgagataat caggcctaat 3600 catgttgtga ttctcttttc ttagtggagt ggaatgttct atccccacaa gaaggattat 3660 atcttataga cttgtcttgt tcagattctg tatttaccca ttttattgaa acatatacta 3720 agttccatgt atttttgtta caaatcttct gaaaaaaaac aaaacaatgt gaaacattaa 3780 aattaaaagg cattaataat aaaaaaaaaa aaaaaaaccc gaattc 3826 52 1959 DNA Homo sapiens 52 cgaaaaaaga ggggaagagt attaaagacc atttctggct gggcagggca ctctcagcag 60 ctcaactgcc cagcgtgacc agtggccacc tctgcagtgt cttccacaac ctggtcttga 120 ctcgtctgct gaacaaatcc tctgacctca ggccggctgt gaacgtagtt cctgagagat 180 agcaaacatg cccaacagtg agcccgcatc tctgctggag ctgttcaaca gcatcgccac 240 acaaggggag ctcgtaaggt ccctcaaagc gggaaatgcg tcaaaggatg aaattgattc 300 tgcagtaaag atgttggtgt cattaaaaat gagctacaaa gctgccgcgg gggaggatta 360 caaggctgac tgtcctccag ggaacccagc acctaccagt aatcatggcc cagatgccac 420 agaagctgaa gaggattttg tggacccatg gacagtacag acaagcagtg caaaaggcat 480 agactacgat aagctcattg ttcggtttgg aagtagtaaa attgacaaag agctaataaa 540 ccgaatagag agagccaccg gccaaagacc acaccacttc ctgcgcagag gcatcttctt 600 ctcacacaga gatatgaatc aggttcttga tgcctatgaa aataagaagc cattttatct 660 gtacacgggc cggggcccct cttctgaagc aatgcatgta ggtcacctca ttccatttat 720 tttcacaaag tggctccagg atgtatttaa cgtgcccttg gtcatccaga tgacggatga 780 cgagaagtat ctgtggaagg acctgaccct ggaccaggcc tatggcgatg ctgttgagaa 840 tgccaaggac atcatcgcct gtggctttga catcaacaag actttcatat tctctgacct 900 ggactacatg gggatgagct caggtttcta caaaaatgtg gtgaagattc aaaagcatgt 960 taccttcaac caagtgaaag gcattttcgg cttcactgac agcgactgca ttgggaagat 1020 cagttttcct gccatccagg ctgctccctc cttcagcaac tcattcccac agatcttccg 1080 agacaggacg gatatccagt gccttatccc atgtgccatt gaccaggatc cttactttag 1140 aatgacaagg gacgtcgccc ccaggatcgg ctatcctaaa ccagccctgt tgcactccac 1200 cttcttccca gccctgcagg gcgcccagac caaaatgagt gccagcgacc caaactcctc 1260 catcttcctc accgacacgg ccaagcagat caaaaccaag gtcaataagc atgcgttttc 1320 tggagggaga gacaccatcg aggagcacag gcagtttggg ggcaactgtg atgtggacgt 1380 gtctttcatg tacctgacct tcttcctcga ggacgacgac aagctcgagc agatcaggaa 1440 ggattacacc agcggagcca tgctcaccgg tgagctcaag aaggcactca tagaggttct 1500 gcagcccttg atcgcagagc accaggcccg gcgcaaggag gtcacggatg agatagtgaa 1560 agagttcatg actccccgga agctgtcctt cgactttcag tagcactcgt tttacatatg 1620 cttataaaag aagtgatgta tcagtaatgt atcaataatc ccagcccagt caaagcaccg 1680 ccacctgtag gcttctgtct catggtaatt actgggcctg gcctctgtaa gcctgtgtat 1740 gttatcaata ctgtttcttc ctgtgagttc cattatttct atctcttatg ggcaaagcat 1800 tgtgggtaat tggtgctggc taacattgca tggtcggata gagaagtcca gctgtgagtc 1860 tctccccaaa gcagccccac agtggagcct tcggctggaa gtccatgggc caccctgttc 1920 ttgtccatgg aggacttccg agggttccaa gtatactct 1959 53 1826 DNA Homo sapiens 53 cacgtcggct gctgggaaga tctggattct cgtttcaggt caccatcaga aaagctaagt 60 ttgctgtata gtgaggatca ggagatctga tcctgattgc agaaccttcc ctgattacag 120 aatcttggat gatttcacaa aagttcatct tcattgcaga tacctgcctt tctttctagg 180 ttgtatctcc cacttcaccc ttctagacca tcccagaaga tctataagat ttcatctggg 240 aaatcactag gagttcttgg aagggaaaga aggaagattg ttggttggaa taaaaacagg 300 gttgaatgag ttccagaaag cagggttctc aacctcgtgg acagcaatct gcagaagaag 360 agaacttcaa aaaaccaact agaagcaaca tgcagagaag taaaatgaga ggggcctcct 420 caggaaagaa gacagctggt ccacagcaga aaaatcttga accagctctc ccaggaagat 480 ggggtggtcg ctctgcagag aacccccctt caggatccgt gaggaagacc agaaagaaca 540 agcagaagac tcctggaaac ggagatggtg gcagtaccag cgaagcacct cagccccctc 600 ggaagaaaag ggcccgggca gaccccactg ttgaaagtga ggaggcgttt aagaatagaa 660 tggaggttaa agtgaagatt cctgaagaat taaaaccatg gcttgttgag gactgggact 720 tagttaccag gcagaagcag ctgtttcaac tccctgccaa gaaaaatgta gatgcaattc 780 tggaggagta tgcaaattgc aagaaatcgc agggaaatgt tgataataag gaatatgcgg 840 ttaatgaagt tgtggcagga ataaaagaat atttcaatgt gatgttgggc actcagctgc 900 tctacaaatt tgagaggccc cagtatgctg aaatcctctt ggctcaccct gatgctccaa 960 tgtcccaggt ttatggagca ccacacctac tgagattatt tgtaagaatt ggagcaatgt 1020 tggcctatac gccccttgat gagaaaagcc ttgcattatt gttgggctat ttgcatgatt 1080 tcctaaaata tctggcaaag aattctgcat ctctctttac tgccagtgat tacaaagtgg 1140 cttctgctga gtaccaccgc aaagccctgt gagcgtctac agacagctca ccatttttgt 1200 cctgtatctg taaacacttt ttgttcttag tctttttctt gtaaaattga tgttctttaa 1260 aatcgttaat gtataacagg gcttatgttt cagtttgttt tccgttctgt tttaaacaga 1320 aaataaaagg agtgtaagct ccttttctca tttcaaagtt gctaccagtg tatgcagtaa 1380 ttagaacaaa gaagaaacat tcagtagaac attttattgc ctagttgaca acattgcttg 1440 aatgctggtg gttcctatcc ctttgacact acacaatttt ctaatatgtg ttaatgctat 1500 gtgacaaaac gccctgattc ctagtgccaa aggttcaact taatgtatat acctgaaaac 1560 ccatgcattt gtgctctttt tttttttatg gtgcttgaag taaaacagcc catcctctgc 1620 aagtccatct atgttgttct taggcattct atctttgctc aaattgttga aggatggtga 1680 tttgtttcat ggtttttgta tttgagtcta atgcacgttc taacatgata gaggcaatgc 1740 attattgtgt agccacggtt ttctggaaaa gttgatattt taggaattgt atttcagatc 1800 ttaaataaaa tttgtttcta aatttc 1826 54 1822 DNA Homo sapiens 54 ttgagccacc atctgaccgc aagctgcgtc gtgtcgccgg ttctgcaggc accatgagcc 60 aggacaccga ggtggatatg aaggaggtgg agctgaatga gttagagccc gagaagcagc 120 cgatgaacgc ggcgtctggg gcggccatgt ccctggcggg agccgagaag aatggtctgg 180 tgaagatcaa ggtggcggaa gacgaggcgg aggcggcagc gccggctaag ttcacgggcc 240 tgtccaagga ggagctgctg aaggtggcag gcagccccgg ctgggtacgc acccgctggg 300 cactgctgct gctcttctgg ctcggctggc tcggcatgct tgctggtgcc gtggtcataa 360 tcgtgcgagc gccgcgttgt cgcgagctac cggcgcagaa gtggtggcac acgggcgccc 420 tctaccgcat cggcgacctt caggccttcc agggccacgg cgcgggcaac ctggcgggtc 480 tgaaggggcg tctcgattac ctgagctctc tgaaggtgaa gggccttgtg ctgggtccaa 540 ttcacaagaa ccagaaggat gatgtcgctc agactgactt gctgcagatc gaccccaatt 600 ttggctccaa ggaagatttt gacagtctct tgcaatcggc taaaaaaaag agcatccgtg 660 tcattctgga ccttactccc aactaccggg gtgagaactc gtggttctcc actcaggttg 720 acactgtggc caccaaggtg aaggatgctc tggagttttg gctgcaagct ggcgtggatg 780 ggttccaggt tcgggacata gagaatctga aggatgcatc ctcattcttg gctgagtggc 840 aaaatatcac caagggcttc agtgaagaca ggctcttgat tgcggggact aactcctccg 900 accttcagca gatcctgagc ctactcgaat ccaacaaaga cttgctgttg actagctcat 960 acctgtctga ttctggttct actggggagc atacaaaatc cctagtcaca cagtatttga 1020 atgccactgg caatcgctgg tgcagctgga gtttgtctca ggcaaggctc ctgacttcct 1080 tcttgccggc tcaacttctc cgactctacc agctgatgct cttcaccctg ccagggaccc 1140 ctgttttcag ctacggggat gagattggcc tggatgcagc tgcccttcct ggacagccta 1200 tggaggctcc agtcatgctg tgggatgagt ccagcttccc tgacatccca ggggctgtaa 1260 gtgccaacat gactgtgaag ggccagagtg aagaccctgg ctccctcctt tccttgttcc 1320 ggcggctgag tgaccagcgg agtaaggagc gctccctact gcatggggac ttccacgcgt 1380 tctccgctgg gcctggactc ttctcctata tccgccactg ggaccagaat gagcgttttc 1440 tggtagtgct taactttggg gatgtgggcc tctcggctgg actgcaggcc tccgacctgc 1500 ctgccagcgc cagcctgcca gccaaggctg acctcctgct cagcacccag ccaggccgtg 1560 aggagggctc ccctcttgag ctggaacgcc tgaaactgga gcctcacgaa gggctgctgc 1620 tccgcttccc ctacgcggcc tgacttcagc ctgacatgga cccactaccc ttctcctttc 1680 cttcccaggc cctttggctt ctgatttttc tcttttttaa aaacaaacaa acaaactgtt 1740 gcagattatg agtgaacccc caaatagggt gttttctgcc ttcaaataaa agtcacccct 1800 gcatggtgaa gtcttccctc tg 1822 55 1992 DNA Homo sapiens 55 aaacttcccg cacgcgttac aggagccagg tcggtataag cgccacgcct cgccgcccgt 60 caagctgtcc acatccctgg cctcagcccg ccacatcacc ctgacctgct tacgcccaga 120 ttttcttcaa tcacatctga ataaatcact tgaagaaagc ttatagcttc attgcaccat 180 gtgtggcatt tgggcgctgt ttggcagtga tgattgcctt tctgttcagt gtctgagtgc 240 tatgaagatt gcacacagag gtccagatgc attccgtttt gagaatgtca atggatacac 300 caactgctgc tttggatttc accggttggc ggtagttgac ccgctgtttg gaatgcagcc 360 aattcgagtg aagaaatatc cgtatttgtg gctctgttac aatggtgaaa tctacaacca 420 taagaagatg caacagcatt ttgaatttga ataccagacc aaagtggatg gtgagataat 480 ccttcatctt tatgacaaag gaggaattga gcaaacaatt tgtatgttgg atggtgtgtt 540 tgcatttgtt ttactggata ctgccaataa gaaagtgttc ctgggtagag atacatatgg 600 agtcagacct ttgtttaaag caatgacaga agatggattt ttggctgtat gttcagaagc 660 taaaggtctt gttacattga agcactccgc gactcccttt ttaaaagtgg agccttttct 720 tcctggacac tatgaagttt tggatttaaa gccaaatggc aaagttgcat ccgtggaaat 780 ggttaaatat catcactgtc gggatgtacc cctgcacgcc ctctatgaca atgtggagaa 840 actctttcca ggttttgaga tagaaactgt gaagaacaac ctcaggatcc tttttaataa 900 tgctgtaaag aaacgtttga tgacagacag aaggattggc tgccttttat cagggggctt 960 ggactccagc ttggttgctg ccactctgtt gaagcagctg aaagaagccc aagtacagta 1020 tcctctccag acatttgcaa ttggcatgga agacagcccc gatttactgg ctgctagaaa 1080 ggtggcagat catattggaa gtgaacatta tgaagtcctt tttaactctg aggaaggcat 1140 tcaggctctg gatgaagtca tattttcctt ggaaacttat gacattacaa cagttcgtgc 1200 ttcagtaggt atgtatttaa tttccaagta tattcggaag aacacagata gcgtggtgat 1260 cttctctgga gaaggatcag atgaacttac gcagggttac atatattttc acaaggctcc 1320 ttctcctgaa aaagccgagg aggagagtga gaggcttctg agggaactct atttgtttga 1380 tgttctccgc gcagatcgaa ctactgctgc ccatggtctt gaactgagag tcccatttct 1440 agatcatcga tttttttcct attacttgtc tctgccacca gaaatgagaa ttccaaagaa 1500 tgggatagaa aaacatctcc tgagagagac gtttgaggat tccaatctga tacccaaaga 1560 gattctctgg cgaccaaaag aagccttcag tgatggaata acttcagtta agaattcctg 1620 gtttaagatt ttacaggaat acgttgaaca tcaggttgat gatgcaatga tggcaaatgc 1680 agcccagaaa tttcccttca atactcctaa aaccaaagaa ggatattact accgtcaagt 1740 ctttgaacgc cattacccag gccgggctga ctggctgagc cattactgga tgcccaagtg 1800 gatcaatgcc actgaccctt ctgcccgcac gctgacccac tacaagtcag ctgtcaaagc 1860 ttaggtggtc tttatgctgt aatgtgaaag caaatatttc ttcgtgttgg atggggactg 1920 tgggtagata ggggaacaat gagagtcaac tcaggctaac ttgggtttga aaaaaataaa 1980 attcctaaat tt 1992 56 4086 DNA Homo sapiens 56 cgcgacctcg tggtgggctg cggtggcttc gtcaagtcgg acgtggagat caactactct 60 ctcatcgaga taaagctgta caccaagcat gggactttga aataccagac agactgtgcc 120 cctaataatg gttactttat gatccctttg tatgataagg gggatttcat tctgaagatt 180 gagcctcccc tagggtggag ttttgagccg acgaccgtgg agctccatgt ggatggagtc 240 agtgacatct gcacaaaggg tggggacatc aactttgtct tcactgggtt ctctgtgaat 300 ggcaaggtcc tcagcaaagg gcagcccctg ggtcctgcgg gagttcaggt gtctctgaga 360 aacactggga ccgaagcaaa gatccagtcc acagttacac agcctggcgg aaagtttgca 420 ttttttaaag ttctgcctgg agattatgaa atcctcgcaa ctcatccaac ctgggcgttg 480 aaagaggcaa gcaccacagt gagtgtaacc aactccaatg ccaatgcggc cagtcccctc 540 atagttgctg gctacaatgt gtctggctct gtccgaagtg atggggagcc catgaaaggc 600 gtgaagtttc ttctcttttc ttctttagta actaaagagg atgtcctggg ctgcaatgtc 660 tcaccagtgc ctgggttcca gccccaagac gagagtctgg tgtatttgtg ctacacggtc 720 tccagagaag atggctcgtt ctctttctat tccttgccaa gtgggggcta cactgtgatt 780 ccgttctatc gaggggagag gattaccttt gatgtggcgc cttccagact tgacttcaca 840 gtggagcatg acagcttgaa aatcgagccc gtgttccacg tcatgggatt ctccgtcacc 900 gggagggtct tgaacggacc cgaaggagat ggtgttccag aagcagtagt caccctgaat 960 aaccaaatca aagttaaaac aaaagctgat ggctcattcc gccttgagaa cataaccaca 1020 gggacataca ccatccatgc tcagaaagag cacctctact ttgaaacggt caccatcaaa 1080 attgcaccga acacacctca gctggctgac attattgcaa cagggttcag tgtctgtggt 1140 cagatatcaa tcattcgctt ccccgacacc gtcaagcaga tgaataaata caaagttgtc 1200 ctgtcatctc aagacaagga caagtctttg gtcaccgtgg agacagatgc tcatggatca 1260 ttttgtttta aagcaaaacc agggacttac aaagtgcagg tgatggttcc tgaggcagaa 1320 accagagcag ggctgacgtt gaaaccccag acatttcctc ttactgtgac caacaggccc 1380 atgatggatg tggcctttgt acagttcttg gcatcagttt ctgggaaagt ctcttgcttg 1440 aacacctgtg gtgacttgct ggtgactcta cagtccctga gccgccaggg tgagaagcgg 1500 agcctccagc tctccggcaa ggtcaacgcc atgactttca cctttgacaa cgtgctccct 1560 ggaaaataca aaataagcat catgcatgag gattggtgct ggaagaacaa gagcctggag 1620 gtggaagtgc tggaggatga catgtctgca gttgagttca ggcagacggg ctacatgctg 1680 agatgttccc tgtctcacgc catcactctg gaattttatc aggatggaaa tgggcgtgag 1740 aatgtgggga tttatagcct cttcaaagga gtcaaccgat tctgcctgtc caagcctggt 1800 gtgtacaaag tgacccctcg ctcctgccac cggtttgagc aagcgttcta tatctatgac 1860 acgtcttcac ctagtatctt tacattgaca gccattcgcc accatgtcct tggaactatc 1920 accaccgaca aaatgatgga tgtcactgtg actatcaagt cttccatcga cagtgaaccc 1980 gccttggtct taggccctct gaagtctgtg caggagctgc ggagggagca gcagctggct 2040 gagatcgagg cccgcaggca ggagagggag aaaaacggca atgaggaagg cgaagaaaga 2100 atgaccaagc ctcccgtgca ggagatggta gatgagttac aaggcccctt ctcgtatgat 2160 ttctcttact gggcgcggtc tggagagaaa atcactgtta caccgtcatc taaagagctg 2220 ctcttttatc ccccttcaat ggaagccgtt gtcagtggag aaagctgccc agggaagctg 2280 atcgagatcc atgggaaggc aggcctgttt ttagaaggcc agatccaccc cgagttggaa 2340 ggagtcgaga ttgtcatcag tgaaaagggg gcaagttcac cgctgatcac agtctttact 2400 gatgacaaag gtgcctacag tgttggcccc ctgcacagtg acctggagta cacggtgacc 2460 tcacagaagg agggctatgt tctgactgcg gtggaaggaa ccatcggaga cttcaaggcc 2520 tatgccctgg caggcgtaag ctttgagata aaagctgagg atgaccagcc cctcccggga 2580 gtcctcttat ccctgagcgg tggcctgttt cgttccaacc tcttgaccca ggacaacggc 2640 attctgacat tctcaaacct gagccctggc cagtattact tcaaacccat gatgaaggag 2700 ttccggtttg agccatcctc acagatgatc gaggtgcagg aaggccagaa cctgaagatc 2760 accatcacgg ggtaccgaac cgcttacagt tgctatggca cagtgtcttc cttaaacgga 2820 gagcccgaac aaggggttgc catggaagcg gtgggccaga acgactgcag catttacgga 2880 gaagacaccg tgacagacga agagggcaag ttcagattac gtggattgct gccgggatgt 2940 gtgtaccacg ttcagctcaa ggcagaaggc aacgaccaca ttgagcgggc gctcccccac 3000 catagggtga ttgaggttgg gaataatgac atcgatgatg taaacatcat agttttccgg 3060 cagattaatc aatttgattt aagtggaaat gtgatcactt cctctgaata ccttcctaca 3120 ttatgggtca agctttacaa aagcgaaaac ctcgacaatc caatccagac agtttccctt 3180 ggccagtccc tgttcttcca tttcccccca ctgctcagag acggcgagaa ctatgttgtg 3240 cttctggact ccacactccc cagatcccag tatgactaca tcttgcctca agtttctttc 3300 accgcagtgg gctaccataa acacaccacc ttgattttta atcccacgag gaagctgcct 3360 gaacaggaca tcgcacaagg atcctacatt gccctgccat tgacgctgct ggttctgctg 3420 gccggttaca accatgacaa gctcattcct ttgctgctgc agttgacaag ccggctacag 3480 ggagtccgcg cgctcggcca ggcagcctct gacaatagcg gcccagaaga tgcaaagaga 3540 caagccaaga aacagaagac aaggcggact tgaggaggaa ggggacagtt gcagtctcac 3600 ttgggacagg ccacagccag gggtccggcc actacccgcc cgtgggataa aagccaaaag 3660 catgcgtcag ctaacttcag cctgtgctgc tgggcccgca ccccatgtcc cttgtcactg 3720 tgacatcctg cacccatcct cacccctccg tagagcccct cgtgcaatgc aatgaatgga 3780 ccctcctgtc actctgctga acagaattta ttttctgagt caaatataat ttattattat 3840 tttcgtcaaa gaagtattta agctgtgctg tggtgtgaga atgtcattct tgatcttcag 3900 ccttcgtttg caaggagagt tccagttgac gtggtgtttg gttccatggc ggggtaccct 3960 ggggattcat ctgttttctt cacttccctt tgcatctgag atcctgttgg aaaccacagc 4020 aacctgtatt cattattagg aaataaaaat cgaaaaaaag gttcattctt ttgtgttgta 4080 gttttg 4086 57 3701 DNA Homo sapiens 57 cggaaatcat cctagtaata aagtgaaatc agacccacaa cgaatgaatg aacagccacg 60 tcagcttttc caaagctcat gaacactgga aaacaacata cgtttgttga aacagagagt 120 gtaagatatg tctaccagcc tatggagaaa ctgtatatgg tactgatcac taccaaaaac 180 agcaacattt tagaagattt ggagacccta aggctcttct caagagtgat ccctgaatat 240 tgccgagcct tagaagagaa tgaaatatct gagcactgtt ttgatttgat ttttgctttt 300 gatgaaattg tcgcactggg ataccgggag aatgttaact tggcacagat cagaaccttc 360 acagaaatgg attctcatga ggagaaggtg ttcagagccg tcagagagac tcaagaacgt 420 gaagctaagg ctgagatgcg tcgtaaagca aaggaattac aacaggcccg aagagatgca 480 gagagacagg gcaaaaaagc accaggattt ggcggatttg gcagctctgc agtatctgga 540 ggcagcacag ctgccatgat cacagagacc atcattgaaa ctgataaacc aaaagtggca 600 cctgcaccag ccaggccttc aggccccagc aaggctttaa aacttggagc caaaggaaag 660 gaagtagata actttgtgga caaattaaaa tctgaaggtg aaaccatcat gtcctctagt 720 atgggcaagc gtacttctga agcaaccaaa atgcatgctc cacccattaa tatggaaagt 780 gtacatatga agattgaaga aaagataaca ttaacctgtg gacgagacgg aggattacag 840 aatatggagt tgcatggcat gatcatgctt aggatctcag atgacaacta tggccgaatt 900 cgtcttcatg tggaaaatga agataagaaa ggggtgcagc tacagaccca tccaaatgtg 960 gataaaaaac ttttcactgc agagtctcta attggcctga agaatccaga gaagtcattt 1020 ccagtcaaca gtgacgtagg ggtgctaaag tggagactac aaaccacaga ggaatctttt 1080 attccactga caattaattg ctggccctcg gagagtggaa atggctgtga tgtcaacata 1140 gaatatgagc tacaagaaga taatttagaa ctgaatgatg tggttatcac catcccactc 1200 ccgtctggtg tcggcgcgcc tgttatcggt gagatcgatg gggagtatcg acatgacagt 1260 cgacgaaata ccctggagtg gtgcctgcct gtgattgatg ccaaaaataa gagtggcagc 1320 ctggagttta gcattgctgg gcagcccaat gacttcttcc ctgttcaagt ttcctttgtc 1380 tccaagaaaa attactgtaa catacaggtt accaaagtga cccaggtaga tggaaacagc 1440 cccgtcaggt tttccacaga gaccactttc ctagtggata agtatgaaat tctgtaatac 1500 caagaagagg gagctgaaaa ggaaaatttt cagattaata aagaagacgc caatgatggc 1560 tgaagagttt ttcccagatt tacaagccac tggagacccc ttttttctga tacaatgcac 1620 gattctctgc gcgcaaggac cctcgactca cccccatgtt tcagtgtcac agagacattc 1680 tttgataagg aaatggcaca aacataaagg gaaaggctgc taattttctt tggcagattg 1740 tattggccag caggaaagca agctctccag agaatgcccc cagttaaata cctcctctac 1800 ctttacctaa gttgctcctt tatttttatt ttattattat tattattatt attatttttt 1860 gagatggagt ctcactttgt aacccaggct ggaatgcaat ggcatgatct cagctcactg 1920 caacctccgc ctcctgggtt caagcaagtc tcctgcctca gcctccgagt agctgggact 1980 acaggtgcac gccaccacgc ctggctaatt ttttgtattt tagtagagac ggggtttcac 2040 cgtgttgccc aggctggtcg cgaactcctg agctcaggca atccgcccac ctcagcctcc 2100 caaagtgttg ggattacagg catgagccac catgcccagc tgctccttta ttttaatccc 2160 taaatataat ccctaaatat agttatattt catacttagt ttgtttttaa aaagttttct 2220 ctgtagaaaa ttttaatcat tcataccctt tacctttagg tttttctttc tatacattca 2280 gtcaggcact gggatcatct gtttacaggc attatattta tttggcactc ctggaacaag 2340 tatatctaac ccattcttga tttttggact attcaggtga actatttgag gggtatgggg 2400 tctagaagtt aaaagatacg catgtcttct rttcttttcc cgtatcaatt cattccttca 2460 tctctttgcc aagttgtttt cctttcaggg cctgtccttc cagtttagaa cagtaccatg 2520 aatcccactt gtgtcaatat taaagatagc tgagaagcac ctttcaaatg gcacagtccc 2580 tcttcaagat gtctaaaaga atggttatgt ctgtccagtt agggatttca catccacatg 2640 taatcatgtc tgctgctgtt gctacccaaa ttttcatttc tccacatttt gggtacttaa 2700 gctaaaacgt aatggccaca gtctgtaatc cattcacatt cctcagtttc accacctccc 2760 tcttccagac tgcactctct gtcatcagtc ccctcctttc taacagaaat ggggttatga 2820 ttttgaaggc tgtgggttca gggagtcttt gccaatcctg ttggccctaa actatcaagg 2880 aggctccatt tcaccatttg attttttgca tttcaggagg caactgattg tttcgatatg 2940 tacatattac tcacgtatac cccatttcct tccagtcagc ccaacatttt ccaccagtct 3000 gtccccatct ctgaaatcct tccttctctt tccccctaag tcttttgagt gtcatcatgt 3060 actggtggtt tctcggttcc atctcatcca tttccttttc aatggagact acagcgtcag 3120 ccagctcagc cttggctttt aactcaatat tccagtccat aggggtggtt aaaagttgct 3180 gcaaggctgc aggcactggc agtgggaaga ggcagacgac tagatgactt ctgcactttt 3240 agctggttga aaagtaccac tcccactctg aacatctggc cgtccctgca aagagtgtac 3300 tgtgcttgaa gcagagcact cacacataaa tggctgtgtg tggaattgct tgccaaagaa 3360 gtttctagcc tttccctttc ccctaactgc atcagggaag aattcttatc tctagcttgg 3420 tttccacatg aggtttttct gagaagggct tgggacaaga agtctgtcat gttagttaag 3480 caggcaagaa atcctactaa tccagttttg tttgaaagtt gtttgtccgt atgatttttt 3540 aaaagtcaag tttaatttca aaaaaccttt tttttctgag attacttttg gggtaatatt 3600 taaaatgaga gacattttgt aaccctgtaa aatacatagg gaatataaca ttccagtgta 3660 tacaaagaag gcaaattcca aaaaaaaaaa aaaaaaaaaa a 3701 58 6608 DNA Homo sapiens 58 ccttctttta aggagtttgc cgcgagcgcg tctccttcat tcgcaggctg ggcgcgttcg 60 cagtcggctg gcggcgaagg aaggcgctct cgggacctca cgggcgcgcg tcttttggct 120 cttgcccctg tccctgcggc ttggggaaag cgtaacccgg cggctaggcg cgggagaagt 180 gcggaggagc catgggcgcc gggagctcca ccgagcagcg cagcccggag cagccgcccg 240 aggggagctc cacgccggct gagcccgagc ccagcggcgg cggcccctcg gccgaggcgg 300 cgccagacac caccgcggac cccgccatcg ctgcctcgga ccccgccacc aagctcctac 360 agaagaatgg tcagctgtcc accatcaatg gcgtagctga gcaagatgag ctcagcctcc 420 aggagggtga cctaaatggc cagaaaggag ccctgaacgg tcaaggagcc ctaaacagcc 480 aggaggaaga agaagtcatt gtcacggagg ttggacagag agactctgaa gatgtgagcg 540 aaagagactc cgataaagag atggctacta agtcagcggt tgttcacgac atcacagatg 600 atgggcagga ggagaaccga aatatcgaac agattccttc ttcagaaagc aatttagaag 660 agctaacaca acccactgag tcccaggcta atgatattgg atttaagaag gtgtttaagt 720 ttgttggctt taaattcact gtgaaaaagg ataagacaga gaagcctgac actgtccagc 780 tactcactgt gaagaaagat gaaggggagg gagcagcagg ggctggcgac caccaggacc 840 ccagccttgg ggctggagaa gcagcatcca aagaaagcga acccaaacaa tctacagaga 900 aacccgaaga gaccctgaag cgtgagcaaa gccacgcaga aatttctccc ccagccgaat 960 ctggccaagc agtggaggaa tgcaaagagg aaggagaaga gaaacaagaa aaagaaccta 1020 gcaagtctgc agaatctccg actagtcccg tgaccagtga aacaggatca accttcaaaa 1080 aattcttcac tcaaggttgg gccggctggc gcaaaaagac cagtttcagg aagccgaagg 1140 aggatgaagt ggaagcttca gagaagaaaa aggaacaaga gccagaaaaa gtagacacag 1200 aagaagacgg aaaggcagag gttgcctccg agaaactgac cgcctccgag caagcccacc 1260 cacaggagcc ggcagaaagt gcccacgagc cccggttatc agctgaatat gagaaagttg 1320 agctgccctc agaggagcaa gtcagtggct cgcagggacc ttctgaagag aaacctgctc 1380 cgttggcgac agaagtgttt gatgagaaaa tagaagtcca ccaagaagag gttgtggccg 1440 aagtccacgt cagcaccgtg gaggagagaa ccgaagagca gaaaacggag gtggaagaaa 1500 cagcagggtc tgtgccagct gaagaattgg ttggaatgga tgcagaacct caggaagccg 1560 aacctgccaa ggagctggtg aagctcaaag aaacgtgtgt ttccggagag gaccctacac 1620 agggagctga cctcagtcct gatgagaagg tgctgtccaa accccccgaa ggcgttgtga 1680 gtgaggtgga aatgctgtca tcacaggaga gaatgaaggt gcagggaagt ccactaaaga 1740 agctttttac cagcactggc ttaaaaaagc tttctggaaa gaaacagaaa gggaaaagag 1800 gaggaggaga cgaggaatca ggggagcaca ctcaggttcc agccgattct ccggacagcc 1860 aggaggagca aaagggcgag agctctgcct catcccctga ggagcccgag gagatcacgt 1920 gtctggaaaa gggcttagcc gaggtgcagc aggatgggga agctgaagaa ggagctactt 1980 ccgatggaga gaaaaaaaga gaaggtgtca ctccctgggc atcattcaaa aagatggtga 2040 cgcccaagaa gcgtgttaga cggccttcgg aaagtgataa agaagatgag ctggacaagg 2100 tcaagagcgc taccttgtct tccaccgaga gcacagcctc tgaaatgcaa gaagaaatga 2160 aagggagcgt ggaagagcca aagccggaag aaccaaagcg caaggtggat acctcagtat 2220 cttgggaagc tttaatttgt gtgggatcat ccaagaaaag agcaaggaga aggtcctctt 2280 ctgatgagga agggggacca aaagcaatgg gaggagacca ccagaaagct gatgaggccg 2340 gaaaagacaa agagacgggg acagacggga tccttgctgg ttcccaagaa catgatccag 2400 ggcagggaag ttcctccccg gagcaagctg gaagccctac cgaaggggag ggcgtttcca 2460 cctgggagtc atttaaaagg ttagtcacgc caagaaaaaa atcaaagtcc aagctggaag 2520 agaaaagcga agactccata gctgggtctg gtgtagaaca ttccactcca gacactgaac 2580 ccggtaaaga agaatcctgg gtctcaatca agaagtttat tcctggacga aggaagaaaa 2640 ggccagatgg gaaacaagaa caagcccctg ttgaagacgc agggccaaca ggggccaacg 2700 aagatgactc tgatgtcccg gccgtggtcc ctctgtctga gtatgatgct gtagaaaggg 2760 agaaaatgga ggcacagcaa gcccaaaaag gcgcagagca gcccgagcag aaggcagcca 2820 ctgaggtgtc caaggagctc agcgagagtc aggttcatat gatggcagca gctgtcgctg 2880 acgggacgag ggcagctacc attattgaag aaaggtctcc ttcttggata tctgcttcag 2940 tgacagaacc tcttgaacaa gtagaagctg aagccgcact gttaactgag gaggtattgg 3000 aaagagaagt aattgcagaa gaagaacccc ccacggttac tgaacctctg ccagagaaca 3060 gagaggcccg gggcgacacg gtcgttagtg aggcggaatt gacccccgaa gctgtgacag 3120 ctgcagaaac tgcagggcca ttgggttccg aagaaggaac cgaagcatct gctgctgaag 3180 agaccacaga aatggtgtca gcagtctccc agttaaccga ctccccagac accacagagg 3240 aggccactcc ggtgcaggag gtggaaggtg gcgtacctga catagaagag caagagaggc 3300 ggactcaaga ggtcctccag gcagtggcag aaaaagtgaa agaggaatcc cagctgcctg 3360 gcaccggtgg gccagaagat gtgcttcagc ctgtgcagag agcagaggca gaaagaccag 3420 aagagcaggc tgaagcgtcg ggtctgaaga aagagacgga tgtagtgttg aaagtagatg 3480 ctcaggaggc aaaaactgag ccttttacac aagggaaggt ggtggggcag accaccccag 3540 aaagctttga aaaagctcct caagtcacag agagcataga gtccagtgag cttgtaacca 3600 cttgtcaagc cgaaacctta gctggggtaa aatcacagga gatggtgatg gaacaggcta 3660 tcccccctga ctcggtggaa acccctacag acagtgagac tgatggaagc acccccgtag 3720 ccgactttga cgcaccaggc acaacccaga aagacgagat tgtggaaatc catgaggaga 3780 atgaggtcgc atctggtacc cagtcagggg gcacagaagc agaggcagtt cctgcacaga 3840 aagagaggcc tccagcacct tccagttttg tgttccagga agaaactaaa gaacaatcaa 3900 agatggaaga cactctagag catacagata aagaggtgtc agtggaaact gtatccattc 3960 tgtcaaagac tgaggggact caagaggctg accagtatgc tgatgagaaa accaaagacg 4020 taccattttt cgaaggactt gaggggtcta tagacacagg cataacagtc agtcgggaaa 4080 aggtcactga agttgccctt aaaggtgaag ggacagaaga agctgaatgt aaaaaggatg 4140 atgctcttga actgcagagt cacgctaagt ctcctccatc ccccgtggag agagagatgg 4200 tagttcaagt cgaaagggag aaaacagaag cagagccaac ccatgtgaat gaagagaagc 4260 ttgagcacga aacagctgtt accgtatctg aagaggtcag taagcagctc ctccagacag 4320 tgaatgtgcc catcatagat ggggcaaagg aagtcagcag tttggaagga agccctcctc 4380 cctgcctagg tcaagaggag gcagtatgca ccaaaattca agttcagagc tctgaggcat 4440 cattcactct aacagcggct gcagaggagg aaaaggtctt aggagaaact gccaacattt 4500 tagaaacagg tgaaacgttg gagcctgcag gtgcacattt agttctggaa gagaaatcct 4560 ctgaaaaaaa tgaagacttt gccgctcatc caggggaaga tgctgtgccc acagggcccg 4620 actgtcaggc aaaatcgaca ccagtgatag tatctgctac taccaagaaa ggcttaagtt 4680 ccgacctgga aggagagaaa accacatcac tgaagtggaa gtcagatgaa gtcgatgagc 4740 aggttgcttg ccaggaggtc aaagtgagtg tagcaattga ggatttagag cctgaaaatg 4800 ggattttgga acttgagacc aaaagcagta aacttgtcca aaacatcatc cagacagccg 4860 ttgaccagtt tgtacgtaca gaagaaacag ccaccgaaat gttgacgtct gagttacaga 4920 cacaagctca cgtgataaaa gctgacagcc aggacgctgg acaggaaacg gagaaagaag 4980 gagaggaacc tcaggcctct gcacaggatg aaacaccaat tacttcagcc aaagaggagt 5040 cagagtcaac cgcagtggga caagcacatt ctgatatttc caaagacatg agtgaagcct 5100 cagaaaagac catgactgtt gaggtagaag gttccactgt aaatgatcag cagctggaag 5160 aggtcgtcct cccatctgag gaagagggag gtggagctgg aacaaagtct gtgccagaag 5220 atgatggtca tgccttgtta gcagaaagaa tagagaagtc actagttgaa ccgaaagaag 5280 atgaaaaagg tgatgatgtt gatgaccctg aaaaccagaa ctcagccctg gctgatactg 5340 atgcctcagg aggcttaacc aaagagtccc cagatacaaa tggaccaaaa caaaaagaga 5400 aggaggatgc ccaggaagta gaattgcagg aaggaaaagt gcacagtgaa tcagataaag 5460 cgatcacacc ccaagcacag gaggagttac agaaacaaga gagagaatct gcaaagtcag 5520 aacttacaga atcttaaaac atcatgcagt taaactcatt gtctgtttgg aagaccagaa 5580 tgtgaagaca agtagtagaa gaaaatgaat gctgctgctg agactgaaga ccagtatttc 5640 agaactttga gaattggaga gcaggcacat caactgatct catttctaga gagcccctga 5700 caatcctgag gcttcatcag gagctagagc catttaacat ttcctctttc caagaccaac 5760 ctacaatttt cccttgataa ccatataaat tctgatttaa ggtcctaaat tcttaacctg 5820 gaactggagt tggcaatacc tagttctgct tctgaaactg gagtatcatt ctttacatat 5880 ttatatgtat gttttaagta gtcctcctgt atctattgta tatttttttc ttaatgttta 5940 aggaaatgtg caggatacta catgcttttt gtatcacaca gtatatgatg gggcatgtgc 6000 catagtgcag gcttggggag ctttaagcct cagttatata acccacaaaa aacagagcct 6060 cctagatgta acattcctga tcaaggtaca attctttaaa attcactaat gattgaggtc 6120 catatttagt ggtactctga aattggtcac tttcctatta cacggagtgt gccaaaacta 6180 aaaagcattt tgaaacatac agaatgttct attgtcattg ggaaattttg ctttctaacc 6240 cagtggaggt tagaaagaag ttatattctg gtagcaaatt aactttacat cctttttcct 6300 acttgttatg gttgtttgga ccgataagtg tgcttaatcc tgaggcaaag tagtgaatat 6360 gttttatatg ttatgaagaa aagaattgtt gtaagttttt gattctactc ttatatgctg 6420 gactgcattc acacatggca tgaaataagt caggttcttt acaaatggta ttttgataga 6480 tactggattg tgtttgtgcc atatttgtgc cattccttta agaacaatgt tgcaacacat 6540 tcatttggat aagttgtgat ttgacgactg atttaaataa aatatttgct tcacttaaaa 6600 aaaaaaaa 6608 59 1703 DNA Homo sapiens 59 aagcttgtgg cttcttctcc ttactcttcc tccttggtgt ctctatgtta gagggccgtt 60 agcatctgct ggggcctggt cgcattcacc ctgctctgcc actcactggc tgtgtgactc 120 tggacaaatt aacttctctg gacctggcag tttctcctct ctacaatgag aatactggag 180 agtccttatc ttatgggttg ctacagaatt aagtgacatc tcacacacaa cacacttcct 240 acagtccctg ttacacgcta aaagtactca actagcttcg gatacgtcat cagcaaccac 300 cccacgggtt actgtgatgc tgcacaatta ttaagccctg gctgctacag agttgtaacc 360 tgtctgcact tccaaccggc gccgcaagca gcattcccag tcccgctttc acccgcgcgc 420 taacggctca ggttcgagta caggacagga gggaggggag ctgtgcacac ggcggaggcg 480 cacggcgtgg gcacccagca cccggtacac tgtgtcctcc cgctgcaccc agccccttca 540 gcccgaggcg tccccgaggc gcaagtgggc cgccttcagg gaactgaccg cccgcggccc 600 gtgtgcagag ccgggtgcgc ccggcccagt gcgcgcggcc gggtgtttcg cttggagccg 660 caagtgactt ctagcgcggg gcgtgtgcag gcacggccgg ggcggggctt ttgcactcgt 720 cccggctctt tctagctata aacactgctt gccgcgctgc actccaccac gcctcctcca 780 agtcccagcg aacccgcgtg caacctgtcc cgactctagc cgcctcttca gcacgccatg 840 gatcccaact gctcctgcgc cgccggtaag aggctgggga tgcccagtgt agactgtagc 900 gctagagaag caatttctga cccctctttc tttctctggt cactcaattt caggcacagg 960 agttgctctt cccaaagagt tttggtatct ttctctccat tctaggttat tcggagcccc 1020 ctttttaccg ttaaggagat ctgagttaat ggcttgctca agttcccagg aatcggttgt 1080 ggactgagga actcggcccc gggtcttagt acgcgtccct tgttcaggta tccagggagt 1140 tctcacctct gtcttttctc cttcaggtga ctcctgcacc tgcgccggct cctgcaaatg 1200 caaagagtgc aaatgcacct cctgcaagaa aagtaagtgg gatcctctct ttcctctacc 1260 ccttccctgt cctccagcct gtcccctctc caccatcctc aggggaatta aagcagtctg 1320 gggatgcccc attgcgcgga aattgttgcc tcctcagtga tcttatcagg gagagcagga 1380 atccttattc ccggtgtcgc tagtactcat ctctgcgcct cctgtctgcc cccaggctgc 1440 tgctcctgct gccctgtggg ctgtgccaag tgtgcccagg gctgcatctg caaaggggcg 1500 tcggacaagt gcagctgctg cgcctgatgc tgggacagcc ccgctcccag atgtaaagaa 1560 cgcgacttcc acaaacctgg attttttatg tacaaccctg accgtgaccg tttgctatat 1620 tcctttttct ataaaataat gtgaatgata ataaaacagc tttgacttga ttctgtctct 1680 ggttttcttt atatgcctta aaa 1703 60 2932 DNA Homo sapiens 60 aggcccggtt cgccgccgct tcctgctgcc gccatgctcg acttcttcac cattttctcc 60 aagggcgggc ttgtgctctg gtgcttccag ggcgttagcg actcatgcac cggacccgtt 120 aacgcgttga ttcgttccgt gctgctgcag gaacggggag gtaacaactc cttcacccat 180 gaggcactga cactcaagta taaactggac aaccagtttg agctggtgtt tgtggttggt 240 tttcagaaga tcctgacact gacatatgta gacagattga tagatgacgt gcatcggctg 300 tttcgggaca agtaccgcac agagatccaa cagcaaagtg ctttaagttt attaaatggc 360 acttttgatt tccaaaatga cttcctgcgg ctccttcgtg aagcagagga gagcagtaag 420 atccgtgctc ccactaccat gaagaaattt gaagattctg aaaaggccaa gaaacctgtg 480 aggtccatga ttgagacacg gggggaaaag cccaaggaaa aagcaaagaa tagcaaaaaa 540 aagggggcca agaaggaagg ttctgatggt cctttggcta ccagcaaacc agtccctgca 600 gaaaagtcag gtcttccagt gggtcctgag aacgaggtag aactttccaa agaggagctg 660 atccgcagga agcgcgagga gttcattcag aagcatggga ggggtatgga gaagtccaac 720 aagtccacga agtcagatgc tccaaaggag aagggcaaaa aagcaccccg ggtgtgggaa 780 ctgggtggct gtgctaacaa agaagtgttg gattacagta ctcccaccac caatggaacc 840 cctgaggctg ccttgtctga ggacatcaac ctgattcgag ggactgggtc tggggggcag 900 cttcaggatc tggactgcag cagctctgat gacgaagggg ctgctcaaac tctcaccaaa 960 cctagtgcga ccaagggaac actgggtggc atgtttggta tgctgaaggg ccttgtgggt 1020 tcaaagagct tgagtcgtga agacatggaa tctgtgctgg acaagatgcg tgatcatctc 1080 attgctaaga acgtggctgc agacattgcc gtccagctct gtgaatctgt tgccaacaag 1140 ttggaaggga aggtgatggg gacgttcagc acggtgactt ccacagtaaa gcaagcccta 1200 caggagtccc tggtgcagat tctgcagcca cagcgtcgtg tagacatgct ccgggacatc 1260 atggatgccc agcgtcgcca gcgcccttat gtcgtcacct tctgcggcgt taatggagtg 1320 gggaaatcta ctaatcttgc caagatttcc ttctggttgt tagagaatgg cttcagtgtc 1380 ctcattgctg cctgtgatac atttcgtgct ggggccgtgg agcagctgcg tacacacacc 1440 cggcgtttga gtgccctaca ccctccagag aagcatggtg gccgcaccat ggtgcagttg 1500 tttgaaaagg gctatggcaa ggatgctgct ggcattgcca tggaagccat tgcttttgca 1560 cgtaaccaag gctttgacgt ggtgctggtg gacacggcag gccgcatgca agacaatgcc 1620 cctctgatga ctgccctggc caaactcatt actgtcaata cacctgattt ggtgctgttt 1680 gtaggagaag ccttagtagg caatgaagcc gtggaccagc tggtcaagtt caacagagcc 1740 ttggctgacc attctatggc tcagacacct cggctcattg atggcattgt tcttaccaaa 1800 tttgatacca ttgatgacaa ggtgggagct gctatttcta tgacgtacat cacaagcaaa 1860 cccatcgtct ttgtgggcac cggccagacc tactgtgacc tacgcagcct caatgccaag 1920 gctgtggtgg ctgccctcat gaaggcttaa cgtggctctt gcccaatacc aaatcgccgc 1980 tttccccaca agcccttctt cctgtatcaa gaatgtgctt tagagtatgt gagcaacctg 2040 tcttaagtgt agtacaaagg cagagtgagg gggcttgtgg ctccttccaa ccccactccc 2100 cgttcagcac agccgccatt tgcaaggaag gcctaatcat gttacaatca ctgcccgact 2160 gaccctctcc cagcggcctc ccccttccta ctcaggcacc cccttcactc tgcctacaga 2220 ctcagtctta ttacagcttt gaccaatggt tggaacccaa caccagagct ttgctaataa 2280 tgagtgtggt caagagccgt ctgagcctaa tgagtcccag ctgcattagg ttaagagact 2340 cttccagagc cagcgccagg tcttgaatgg cacctctccc taggatacac agcctgcagg 2400 tccccaggac ctgatgacac ccgcctcact gtggcagtgt attgcctgtt aattgctgct 2460 aattctaatt ctgatgatga ctcctactcc attgtttacc ccaaagcatc agctaggctg 2520 gagtgatttg ttacaaatga gcaaaagatg agtccttgct tccctcagaa ataaaagtag 2580 cccagctgca gcgttgcatt ggcttcttgg cctcccaact cttccactcc cagaatcaga 2640 agtaagctct gcatgttccc ttcctggagg aaaccaattg tcagaaggtg tatgatgacc 2700 ccctcccctc ccatccttca cctcctaagc agtcctggct tttcctcatc actcccctct 2760 acagtgcctg gtagacaagt gctacattga agaacacaaa cctcttgtta agacttgtcc 2820 tgtagcttga tattacaggt gtgctattag tgcaataagg tgaaggctgt ctgcccagag 2880 aaataagtaa tttatataag aaaataaatt tcataaataa attggaaatt cc 2932 61 2165 DNA Homo sapiens 61 cccgccttcc atacctcccc ggctccgctc ggttcctggc caccccgcag cccctgccca 60 ggtgccatgg ccgcattgta ccgccctggc ctgcggctta actggcatgg gctgagcccc 120 ttgggctggc catcatgccg tagcatccag accctgcgag tgcttagtgg agatctgggc 180 cagcttccca ctggcattcg agattttgta gagcacagtg cccgcctgtg ccaaccagag 240 ggcatccaca tctgtgatgg aactgaggct gagaatactg ccacactgac cctgctggag 300 cagcagggcc tcatccgaaa gctccccaag tacaataact gctggctggc ccgcacagac 360 cccaaggatg tggcacgagt agagagcaag acggtgattg taactccttc tcagcgggac 420 acggtaccac tcccgcctgg tggggcctgt gggcagctgg gcaactggat gtccccagct 480 gatttccagc gagctgtgga tgagaggttt ccaggctgca tgcagggccg caccatgtat 540 gtgcttccat tcagcatggg tcctgtgggc tccccgctgt cccgcatcgg ggtgcagctc 600 actgactcag cctatgtggt ggcaagcatg cgtattatga cccgactggg gacacctgtg 660 cttcaggccc tgggagatgg tgactttgtc aagtgtctgc actccgtggg ccagcccctg 720 acaggacaag gggagccagt gagccagtgg ccgtgcaacc cagagaaaac cctgattggc 780 cacgtgcccg accagcggga gatcatctcc ttcggcagcg gctatggtgg caactccctg 840 ctgggcaaga agtgctttgc cctacgcatc gcctctcggc tggcccggga tgagggctgg 900 ctggcagagc acatgctgat cctgggcatc accagccctg cagggaagaa ggcgctatgt 960 gcagccgcct tccctagtgc ctgtggcaag accaacctgg ctatgatgcg gcctgcactg 1020 ccaggctgga aagtggagtg tgtgggggat gatattgctt ggatgaggtt tgacagtgaa 1080 ggtcgactcc gggccatcaa ccctgagaac ggcttctttg gggttgcccc tggtacctct 1140 gccaccacca atcccaacgc catggctaca atccagagta acactatttt taccaatgtg 1200 gctgagacca gtgatggtgg cgtgtactgg gagggcattg accagcctct tccacctggt 1260 gttactgtga cctcctggct gggcaaaccc tggaaacctg gtgacaagga gccctgtgca 1320 catcccaact ctcgattttg tgccccggct cgccagtgcc ccatcatgga cccagcctgg 1380 gaggccccag agggtgtccc cattgacgcc atcatctttg gtggccgcag acccaaaggg 1440 gtacccctgg tatacgaggc cttcaactgg cgtcatgggg tgtttgtggg cagagccatg 1500 cgctctgagt ccactgctgc agcagaacac aaagggaaga tcatcatgca cgacccattt 1560 gccatgcggc ccttttttgg ctacaacttc gggcactacc tggaacactg gctgagcatg 1620 gaagggcgca agggggccca gctgccccgt atcttccatg tcaactggtt ccggcgtgac 1680 gaggcagggc acttcctgtg gccaggcttt ggggagaatg ctcgggtgct agactggatc 1740 tgccggcggt tagaggggga ggacagtgcc cgagagacac ccattgggct ggtgccaaag 1800 gaaggagcct tggatctcag cggcctcaga gctatagaca ccactcagct gttctccctc 1860 cccaaggact tctgggaaca ggaggttcgt gacattcgga gctacctgac agagcaggtc 1920 aaccaggatc tgcccaaaga ggtgttggct gagcttgagg ccctggagag acgtgtgcac 1980 aaaatgtgac ctgaggccta gtctagcaag aggacatagc accctcatct gggaataggg 2040 aaggcacctt gcagaaaata tgagcaattg atattaacta acatcttcaa tgtgccatag 2100 accttcccac aaagactgtc caataataag agatgcttat ctattttaaa aaaaaaaaaa 2160 aaaaa 2165 62 660 DNA Homo sapiens 62 gccgccgycg aggattcagc agcctccccc ttgagccccc tcgcttcccg acgttccgtt 60 cccccctgcc cgccttctcc cgccaccgcc gccgccgcct tccgcagccg tttccaccga 120 ggaaaaggaa tcgtatcgta tgtccgctat ccagaacctc cactctttcg acccctttgc 180 tgatgcaagt aagggtgatg acctgcttcc tgctggcact gaggattata tccatataag 240 aattcaacag agaaacggca ggaagaccct tactactgtc caagggatcg ctgatgatta 300 cgataaaaag aaactagtga aggcgtttaa gaaaaagttt gcctgcaatg gtactgtaat 360 tgagcatccg gaatatggag aagtaattca gctacagggt gaccaacgca agaacatatg 420 ccagttcctc gtagagattg gactggctaa ggacgatcag ctgaaggttc atgggtttta 480 agtgcttgtg gctcactgaa gcttaagtga ggatttcctt gcaatgagta gaatttccct 540 tctctccctt gtcacaggtt taaaaacctc acagcttgta taatgtaacc atttggggtc 600 cgcttttaac ttggactagt gtaactcctt catgcaataa actgaaaaga gccatgcaaa 660 63 794 DNA Homo sapiens 63 cccccccccc cccccccagc cagtgggttc ccgcgcgtgc cgagactctg aggccttgca 60 cccccacgat cccgtacgat ggccgtcaag aagatcgcga tcttcggcgc cactggccag 120 accgggctca ccaccctggc gcaggcggtg caagcaggtt acgaagtgac agtgctggtg 180 cgggactcct ccaggctgcc atcagagggg ccccggccgg cccacgtggt agtgggagat 240 gttctgcagg cagccgatgt ggacaagacc gtggctgggc aggacgctgt catcgtgctg 300 ctgggcaccc gcaatgacct cagtcccacg acagtgatgt ccgagggcgc ccggaacatt 360 gtggcagcca tgaaggctca tggtgtggac aaggtcgtgg cctgcacctc ggctttcctg 420 ctctgggacc ctaccaaggt gcccccacga ctgcaggctg tgactgatga ccacatccgg 480 atgcacaagg tgctgcggga atcaggcctg aagtacgtgg ctgtgatgcc gccacacata 540 ggagaccagc cactaactgg ggcgtacaca gtgaccctgg atggacgagg gccctcaagg 600 gtcatctcca aacatgacct gggccatttc atgctgcgct gcctcaccac cgatgagtac 660 gacggacaca gcacctaccc ctcccaccag taccagtagc actctgtccc catctgggag 720 ggtggcattc tgggacatga ggagcaaagg aagggggcaa taaatgttga gccaagagct 780 tcaaattact ctag 794 64 851 DNA Homo sapiens 64 cgggaacgca acatgaaggt gctccttgcc gccgccctca tcgcggggtc cgtcttcttc 60 ctgctgctgc cgggaccttc tgcggccgat gagaagaaga aggggcccaa agtcaccgtc 120 aaggtgtatt ttgacctacg aattggagat gaagatgtag gccgggtgat ctttggtctc 180 ttcggaaaga ctgttccaaa aacagtggat aattttgtgg ccttagctac aggagagaaa 240 ggatttggct acaaaaacag caaattccat cgtgtaatca aggacttcat gatccagggc 300 ggagacttca ccaggggaga tggcacagga ggaaagagca tctacggtga gcgcttcccc 360 gatgagaact tcaaactgaa gcactacggg cctggctggg tcagcatggc caacgcaggc 420 aaagacacca acggctccca gttcttcatc acgacagtca agacagcctg gctagatggc 480 aagcatgtgg tgtttggcaa agttctagag ggcatggagg tggtgcggaa ggtggagagc 540 accaagacag acagccggga taaacccctg aaggatgtga tcatcgcaga ctgcggcaag 600 atcgaggtgg agaagccctt tgccatcgcc aaggagtagg gcacagggac atctttcttt 660 gagtgaccgt ctgtgcaggc cctgtagtcc gccacagggc tctgagctgc actggccccg 720 gtgctggcat ctggtggagc ggacccactc ccctcacatt ccacaggccc atggactcac 780 ttttgtaaca aactcctacc aacactgacc aataaaaaaa aatgtgggtt tttttttttt 840 ttaataaaaa a 851 65 1941 DNA Homo sapiens 65 tctcttgatt cctagtctct cgatatggca cctccgtcag tctttgccga ggttccgcag 60 gcccagcctg tcctggtctt caagctcact gccgacttca gggaggatcc ggacccccgc 120 aaggtcaacc tgggagtggg agcatatcgc acggatgact gccatccctg ggttttgcca 180 gtagtgaaga aagtggagca gaagattgct aatgacaata gcctaaatca cgagtatctg 240 ccaatcctgg gcctggctga gttccggagc tgtgcttctc gtcttgccct tggggatgac 300 agcccagcac tcaaggagaa gcgggtagga ggtgtgcaat ctttgggggg aacaggtgca 360 cttcgaattg gagctgattt cttagcgcgt tggtacaatg gaacaaacaa caagaacaca 420 cctgtctatg tgtcctcacc aacctgggag aatcacaatg ctgtgttttc cgctgctggt 480 tttaaagaca ttcggtccta tcgctactgg gatgcagaga agagaggatt ggacctccag 540 ggcttcctga atgatctgga gaatgctcct gagttctcca ttgttgtcct ccacgcctgt 600 gcacacaacc caactgggat tgacccaact ccggagcagt ggaagcagat tgcttctgtc 660 atgaagcacc ggtttctgtt ccccttcttt gactcagcct atcagggctt cgcatctgga 720 aacctggaga gagatgcctg ggccattcgc tattttgtgt ctgaaggctt cgagttcttc 780 tgtgcccagt ccttctccaa gaacttcggg ctctacaatg agagagtcgg gaatctgact 840 gtggttggaa aagaacctga gagcatcctg caagtccttt cccagatgga gaagatcgtg 900 cggattactt ggtccaatcc ccccgcccag ggagcacgaa ttgtggccag caccctctct 960 aaccctgagc tctttgagga atggacaggt aatgtgaaga caatggctga ccggattctg 1020 accatgagat ctgaactcag ggcacgacta gaagccctca aaacccctgg gacctggaac 1080 cacatcactg atcaaattgg catgttcagc ttcactgggt tgaaccccaa gcaggttgag 1140 tatctggtca atgaaaagca catctacctg ctgccaagtg gtcgaatcaa cgtgagtggc 1200 ttaaccacca aaaatctaga ttacgtggcc acctccatcc atgaagcagt caccaaaatc 1260 cagtgaagaa acaccacccg tccagtacca ccaaagtagt tctctgtcat gtgtgttccc 1320 tgcctgcaca aacctacatg tacataccat ggattagaga cacttgcagg actgaaagct 1380 gctctggtga ggcagcctct gtttaaaccg gccccacatg aagagaacat cccttgagac 1440 gaatttggag actgggatta gagcctttgg aggtcaaagc aaattaagat ttttatttaa 1500 gaataaaaga gtactttgat catgagacat aggtatcttg tccctctcac taaaaaggag 1560 tgttgtgtgt ggcggccacg tgcttctatg tggtgtttga ctctgtacaa attctagtcc 1620 caaagatcaa gttgtctgaa ggagccaaag tgtgaatgtg ggtgtcggct gcggcattaa 1680 attcatcatc tcaacccaga gtgtctggtc tccctgctct ttctgcatgg ttgtgtccct 1740 agtcctaagc tttggttctt tagggtgact gtggtaagaa ggatatttaa tcatgacatg 1800 cacggacacg tacatattta actgaaacaa gttttaccaa acagtattta ctcgtgatgt 1860 gcgtagtgca ttctgatatt tttgagccat tctattgtgt tctacttcac ctaaaaaaat 1920 aaaataaaaa tgttgatcaa g 1941 66 2736 DNA Homo sapiens 66 ttgcactctc ccacaccctt ttcttttcgt ccgctcttcg cttatttctc ccgccgtctc 60 ctctgcataa gaaggggaac gaaagatggc ggcggaaacg ctgctgtcca gtttgttagg 120 actgctgctt ctgggactcc tgttacccgc aagtctgacc ggcggtgtcg ggagcctgaa 180 cctggaggag ctgagtgaga tgcgttatgg gatcgagatc ctgccgttgc ctgtcatggg 240 agggcagagc caatcttcgg acgtggtgat tgtctcctct aagtacaaac agcgctatga 300 gtgtcgcctg ccagctggag ctattcactt ccagcgtgaa agggaggagg aaacacctgc 360 ttaccaaggg cctgggatcc ctgagttgtt gagcccaatg agagatgctc cctgcttgct 420 gaagacaaag gactggtgga catatgaatt ctgttatgga cgccacatcc agcaatacca 480 catggaagat tcagagatca aaggtgaagt cctctatctc ggctactacc aatcagcctt 540 cgactgggat gatgaaacag ccaaggcctc caagcagcat cgtcttaaac gctaccacag 600 ccagacctat ggcaatgggt ccaagtgcga ccttaatggg aggccccggg aggccgaggt 660 tcggttcctc tgtgacgagg gtgcaggtat ctctggggac tacatcgatc gcgtggacga 720 gcccttgtcc tgctcttatg tgctgaccat tcgcactcct cggctctgcc cccaccctct 780 cctccggccc ccacccagtg ctgcaccaca ggccatcctc tgtcaccctt ccctacagcc 840 tgaggagtac atggcctacg ttcagaggca agccgactca aagcagtatg gagataaaat 900 catagaggag ctgcaagatc taggccccca agtgtggagt gagaccaagt ctggggtggc 960 accccaaaag atggcaggtg cgagcccgac caaggatgac agtaaggact cagatttctg 1020 gaagatgctt aatgagccag aggaccaggc cccaggaggg gaggaggtgc cggctgagga 1080 gcaggaccca agccctgagg cagcagattc agcttctggt gctcccaatg attttcagaa 1140 caacgtgcag gtcaaagtca ttcgaagccc tgcggatttg attcgattca tagaggagct 1200 gaaaggtgga acaaaaaagg ggaagccaaa tataggccaa gagcagcctg tggatgatgc 1260 tgcagaagtc cctcagaggg aaccagagaa ggaaaggggt gatccagaac ggcagagaga 1320 gatggaagaa gaggaggatg aggatgagga tgaggatgaa gatgaggatg aacggcagtt 1380 actgggagaa tttgagaagg aactggaagg gatcctgctt ccgtcagacc gagaccggct 1440 ccgttcggag gtgaaggctg gcatggagcg ggaactggag aacatcatcc aggagacaga 1500 gaaagagctg gacccagatg ggctgaagaa ggagtcagag cgggatcggg caatgctggc 1560 tctcacatcc actctcaaca aactcatcaa aagactggag gaaaaacaga gtccagagct 1620 ggtgaagaag cacaagaaaa agagggttgt ccccaaaaag cctcccccat caccccaacc 1680 tacagaggag gatcctgagc acagagtccg ggtccgggtc accaagctcc gtctcggagg 1740 ccctaatcag gatctgactg tcctcgagat gaaacgggaa aacccacagc tgaaacaaat 1800 cgaggggctg gtgaaggagc tgctggagag ggagggactc acagctgcag ggaaaattga 1860 gatcaaaatt gtccgcccat gggctgaagg gactgaagag ggtgcacgtt ggctgactga 1920 tgaggacacg agaaacctca aggagatctt cttcaatatc ttggtgccgg gagctgaaga 1980 ggcccagaag gaacgccagc ggcagaaaga gctggagagc aattaccgcc gggtgtgggg 2040 ctctccaggt ggggagggca caggggacct ggacgaattt gacttctgag accaacacta 2100 cacttgaccc ttcacggaat ccagactctt cctggactgg cttgcctcct ccccacctcc 2160 ccaccctgga acccctgagg gccaaacagc agagtggagc tgagctgtgg acctctcggg 2220 caactctgtg ggtgtggggg ccctgggtga atgctgctgc ccctgctggc agccaccttg 2280 agacctcacc gggcctgtga tatttgctct cctgaactct cactcaatcc tcttcctctc 2340 ctctgtggct tttcctgtta ttgtccccta atgataggat attccctgct gcctacctgg 2400 agattcagta ggatcttttg agtggaggtg ggtagagaga gcaaggaggg caggacactt 2460 agcaggcact gagcaagcag gcccccacct gcccttagtg atgtttggag tcgttttacc 2520 ctcttctatt gaattgcctt gggatttcct tctccctttc cctgcccacc ctgtccccta 2580 caatttgtgc ttctgagttg aggagccttc acctctgttg ctgaggaaat ggtagaatgc 2640 tgcctatcac ctccagcaca atcccagcga aaaaggtgtg aagcacccac catgttcttg 2700 aacaatcagg tttctaaata aacaactgga ccatca 2736 67 1860 DNA Homo sapiens 67 cgtgaacggt cgttgcagag attgcgggcg gctgagacgc cgcctgcctg gcacctagga 60 gcgcagcgga gccccgacac cgccgccgcc gccatggagt ccgagaccga acccgagccc 120 gtcacgctcc tggtgaagag ccccaaccag cgccaccgcg acttggagct gagtggcgac 180 cgcggctgga gtgtgggcca cctcaaggcc cacctgagcc gcgtctaccc cgagcgtccg 240 cgtccagagg accagaggtt aatttattct gggaagctgt tgttggatca ccaatgtctc 300 agggacttgc ttccaaagca ggaaaaacgg catgttttgc atctggtgtg caatgtgaag 360 agtccttcaa aaatgccaga aatcaacgcc aaggtggctg aatccacaga ggagcctgct 420 ggttctaatc ggggacagta tcctgaggat tcctcaagtg atggtttaag gcaaagggaa 480 gttcttcgga acctttcttc ccctggatgg gaaaacatct caaggcctga agctgcccag 540 caggcattcc aaggcctggg tcctggtttc tccggttaca caccctatgg gtggcttcag 600 ctttcctggt tccagcagat atatgcacga cagtactaca tgcaatattt agcagccact 660 gctgcatcag gggcttttgt tccaccacca agtgcacaag agatacctgt ggtctctgca 720 cctgctccag cccctattca caaccagttt ccagctgaaa accagcctgc caatcagaat 780 gctgctcctc aagtggttgt taatcctgga gccaatcaaa atttgcggat gaatgcacaa 840 ggtggcccta ttgtggaaga agatgatgaa ataaatcgag attggttgga ttggacctat 900 tcagcagcta cattttctgt ttttctcagt atcctctact tctactcctc cctgagcaga 960 ttcctcatgg tcatgggggc caccgttgtt atgtacctgc atcacgttgg gtggtttcca 1020 tttagaccga ggccggttca gaacttccca aatgatggtc ctcctcctga cgttgtaaat 1080 caggacccca acaataactt acaggaaggc actgatcctg aaactgaaga ccccaaccac 1140 ctccctccag acagggatgt actagatggc gagcagacca gcccctcctt tatgagcaca 1200 gcatggcttg tcttcaagac tttctttgcc tctcttcttc cagaaggccc cccagccatc 1260 gcaaactgat ggtgtttgtg ctgtagctgt tggaggcttt gacaggaatg gactggatca 1320 cctgactcca gctagattgc ctctcctgga catggcaatg atgagttttt aaaaaacagt 1380 gtggatgatg atatgctttt gtgagcaagc aaaagcagaa acgtgaagcc gtgatacaaa 1440 ttggtgaaca aaaaatgccc aaggcttctc atgtgtttat tctgaagagc tttaatatat 1500 actctatgta gtttaataag cactgtacgt agaaggcctt aggtgttgca tgtctatgct 1560 tgaggaactt ttccaaatgt gtgtgtctgc atgtgtgttt gtacatagaa gtcatagatg 1620 cagaagtggt tctgctggta agatttgatt cctgttggaa tgtttaaatt acactaagtg 1680 tactacttta tataatcaat gaaattgcta gacatgtttt agcaggactt ttctaggaaa 1740 gacttatgta taattgcttt ttaaaatgca gtgctttact ttaaactaag gggaactttg 1800 cggaggtgaa aacctttgct gggttttctg ttcaataaag ttttactatg aatgaccctg 1860 68 3082 DNA Homo sapiens 68 agggagtcgt gtcggcgcca ccccggcccc cgagcccgca gattgcccac cgaagctcgt 60 gtgtgcaccc ccgatcccgc cagccactcg cccctggcct cgcgggccgt gtctccggca 120 tcatgtgtgg tatatttgct tacttaaact accatgttcc tcgaacgaga cgagaaatcc 180 tggagaccct aatcaaaggc cttcagagac tggagtacag aggatatgat tctgctggtg 240 tgggatttga tggaggcaat gataaagatt gggaagccaa tgcctgcaaa acccagctta 300 ttaagaagaa aggaaaagtt aaggcactgg atgaagaagt tcacaagcaa caagatatgg 360 atttggatat agaatttgat gtacaccttg gaatagctca tacccgttgg gcaacacatg 420 gagaacccag tcctgtcaat agccaccccc agcgctctga taaaaataat gaatttatcg 480 ttattcacaa tggaatcatc accaactaca aagacttgaa aaagtttttg gaaagcaaag 540 gctatgactt cgaatctgaa acagacacag agacaattgc caagctcgtt aagtatatgt 600 atgacaatcg ggaaagtcaa gataccagct ttactacctt ggtggagaga gttatccaac 660 aattggaagg tgcttttgca cttgtgttta aaagtgttca ttttcccggg caagcagttg 720 gcacaaggcg aggtagccct ctgttgattg gtgtacggag tgaacataaa ctttctactg 780 atcacattcc tatactctac agaacaggca aagacaagaa aggaagctgc aatctctctc 840 gtgtggacag cacaacctgc cttttcccgg tggaagaaaa agcagtggag tattactttg 900 cttctgatgc aagtgctgtc atagaacaca ccaatcgcgt catctttctg gaagatgatg 960 atgttgcagc agtagtggat ggacgtcttt ctatccatcg aattaaacga actgcaggag 1020 atcaccccgg acgagctgtg caaacactcc agatggaact ccagcagatc atgaagggca 1080 acttcagttc atttatgcag aaggaaatat ttgagcagcc agagtctgtc gtgaacacaa 1140 tgagaggaag agtcaacttt gatgactata ctgtgaattt gggtggtttg aaggatcaca 1200 taaaggagat ccagagatgc cggcgtttga ttcttattgc ttgtggaaca agttaccatg 1260 ctggtgtagc aacacgtcaa gttcttgagg agctgactga gttgcctgtg atggtggaac 1320 tagcaagtga cttcctggac agaaacacac cagtctttcg agatgatgtt tgctttttcc 1380 ttagtcaatc aggtgagaca gcagatactt tgatgggtct tcgttactgt aaggagagag 1440 gagctttaac tgtggggatc acaaacacag ttggcagttc catatcacgg gagacagatt 1500 gtggagttca tattaatgct ggtcctgaga ttggtgtggc cagtacaaag gcttatacca 1560 gccagtttgt atcccttgtg atgtttgccc ttatgatgtg tgatgatcgg atctccatgc 1620 aagaaagacg caaagagatc atgcttggat tgaaacggct gcctgatttg attaaggaag 1680 tactgagcat ggatgacgaa attcagaaac tagcaacaga actttatcat cagaagtcag 1740 ttctgataat gggacgaggc tatcattatg ctacttgtct tgaaggggca ctgaaaatca 1800 aagaaattac ttatatgcac tctgaaggca tccttgctgg tgaattgaaa catggccctc 1860 tggctttggt ggataaattg atgcctgtga tcatgatcat catgagagat cacacttatg 1920 ccaagtgtca gaatgctctt cagcaagtgg ttgctcggca ggggcggcct gtggtaattt 1980 gtgataagga ggatactgag accattaaga acacaaaaag aacgatcaag gtgccccact 2040 cagtggactg cttgcagggc attctcagcg tgatcccttt acagttgctg gctttccacc 2100 ttgctgtgct gagaggctat gatgttgatt tcccacggaa tcttgccaaa tctgtgactg 2160 tagagtgagg aatatctata caaaatgtac gaaactgtat gattaagcaa cacaagacac 2220 cttttgtatt taaaaccttg atttaaaata tcaccccttg aagccttttt ttagtaaatc 2280 cttatttata tatcagttat aattattcca ctcaatatgt gatttttgtg aagttacctc 2340 ttacattttc ccagtaattt gtggaggact ttgaataatg gaatctatat tggaatctgt 2400 atcagaaaga ttctagctat tattttcttt aaagaatgct gggtgttgca tttctggacc 2460 ctccacttca atctgagaag acaatatgtt tctaaaaatt ggtacttgtt tcaccatact 2520 tcattcagac cagtgaaaga gtagtgcatt taattggagt atctaaagcc agtggcagtg 2580 tatgctcata cttggacagt tagggaaggg tttgccaagt tttaagagaa gatgtgattt 2640 attttgaaat ttgtttctgt tttgttttta aatcaaactg taaaacttaa aactgaaaaa 2700 ttttattggt aggatttata tctaagtttg gttagcctta gtttctcaga cttgttgtct 2760 attatctgta ggtggaagaa atttaggaag cgaaatatta cagtagtgca ttggtgggtc 2820 tcaatcctta acatatttgc acaattttat agcacaaact ttaaattcaa gctgctttgg 2880 acaactgaca atatgatttt aaatttgaag atgggatgtg tacatgttgg gtatcctact 2940 actttgtgtt ttcatctcct aaaagtgttt tttatttcct tgtatctgta gtcttttatt 3000 ttttaaatga ctgctgaatg acatatttta tcttgttctt taaaatcaca acacagagct 3060 gctattaaat taatattgat at 3082 69 1815 DNA Homo sapiens 69 aaaccaacgc ctggctcgga gcagcagcct ctgaggtgtc cctggccagt gtccttccac 60 ctgtccacaa gcatggggaa catcttcgcc aacctcttca agggcctttt tggcaaaaaa 120 gaaatgcgca tcctcatggt gggcctggat gctgcaggga agaccacgat cctctacaag 180 cttaagctgg gtgagatcgt gaccaccatt cccaccatag gcttcaacgt ggaaaccgtg 240 gagtacaaga acatcagctt cactgtgtgg gacgtgggtg gccaggacaa gatccggccc 300 ctgtggcgcc actacttcca gaacacacaa ggcctgatct tcgtggtgga cagcaatgac 360 agagagcgtg tgaacgaggc ccgtgaggag ctcatgagga tgctggccga ggacgagctc 420 cgggatgctg tcctcctggt gttcgccaac aagcaggacc tccccaacgc catgaatgcg 480 gccgagatca cagacaagct ggggctgcac tcactacgcc acaggaactg gtacattcag 540 gccacctgcg ccaccagcgg cgacgggctc tatgaaggac tggactggct gtccaatcag 600 ctccggaacc agaagtgaac gcgacccccc tccctctcac tcctcttgcc ctctgcttta 660 ctctcatgtg gcaaacgtgc ggctcgtggt gtgagtgcca gaagctgcct ccgtggtttg 720 gtcaccgtgt gcatcgcacc gtgctgtaaa tgtggcagac gcagcctgcg gccaggcttt 780 ttatttaatg taaatagttt ttgtttccaa tgaggcagtt tctggtactc ctatgcaata 840 ttactcagct ttttttattg taaaaagaaa aatcaactca ctgttcagtg ctgagagggg 900 atgtaggccc atgggcacct ggcctccagg agtcgctgtg ttgggagagc cggccacgcc 960 cttggcttta gagctgtgtt gaaatccatt ttggtggttg gtttttaacc caaactcagt 1020 gcatttttta aaatagttaa gaatccaagt cgagaacact tgaacacaca gaagggagac 1080 cccgcctagc atagatttgc agttacggcc tggatgccag tcgccagccc agctgttccc 1140 ctcgggaaca tgaggtggtg gtggcgcagc agactgcgat caattctgca tggtcacagt 1200 agagatcccc gcaactcgct tgtccttggg tcaccctgca ttccatagcc atgtgcttgt 1260 ccctgtgctc ccacggttcc caggggccag gctgggagcc cacagccacc ccactatgcc 1320 gcaggccgcc ctacccacct tcaggcagcc tatgggacgc agggccccat ctgtccctcg 1380 gtcgccgtgt ggccagagtg ggtccgtcgt ccccaacact cgtgctcgct cagacacttt 1440 ggcaggatgt ctggggcctc accagcagga gcgcgtgcaa gccgggcagg cggtccacct 1500 agacccacag cccctcggga gcaccccacc tctgtgtgtg atgtagcttt ctctccctca 1560 gcctgcaagg gtccgatttg ccatcgaaaa agacaacctc tacttttttc ttttgtattt 1620 tgataaacac tgaagctgga gctgttaaat ttatcttggg gaaacctcag aactggtcta 1680 tttggtgtcg tggaacctct tactgctttc aatacacgat tagtaatcaa ctgttttgta 1740 tacttgtttt cagttttcat ttcgacaaac aagcactgta attatagcta ttagaataaa 1800 atctcttaac tattt 1815 70 2462 DNA Homo sapiens 70 gctccccatt gtccttgtca atactgtgag actcatccaa tatcctatcc acctctacgt 60 agtctggatt aaagggctct tcatcctcat ggaagaagtg tctcatctga gccagggggg 120 gcggcgattt catcatgctc cgagccggcg gcgcgcgccg cttccgtcgc caccctctct 180 ggacagccca gggccgcacg tcatgccctc tccgcgtcca gtgctgctta gaggtgctcg 240 cgccgctctg ctgctgctgc tgccgccccg gctcttagcc cgaccctcgc tcctgctccg 300 ccggtccctc agcgcggcct cctgcgcccc gatctccttg cccgccgccg cctcccggag 360 cagcatggac ggcgcggggg ctgaggaggt gctggctcct ctgaggctag cagtgcgcca 420 gcagggagat cttgtgcgaa aactcaaaga agataaagca ccccaagtag acgtagacaa 480 agcagtggct gagctcaaag cccgcaagag ggttctggaa gcaaaggagc tggcgttaca 540 gcccaaagat gatattgtag accgagcaaa aatggaagat accctgaaga ggaggttttt 600 ctatgatcaa gcttttgcta tttatggagg tgttagtggt ctgtatgact ttgggccagt 660 tggctgtgct ttgaagaaca atattattca gacctggagg cagcacttta tccaagagga 720 acagatcctg gagatcgatt gcaccatgct cacccctgag ccagttttaa agacctctgg 780 ccatgtagac aaatttgctg acttcatggt gaaagacgta aaaaatggag aatgttttcg 840 tgctgaccat ctattaaaag ctcatttaca gaaattgatg tctgataaga agtgttctgt 900 cgaaaagaaa tcagaaatgg aaagtgtttt ggcccagctt gataactatg gacagcaaga 960 acttgcggat ctttttgtga actataatgt aaaatctccc attactggaa atgatctatc 1020 ccctccagtg tcttttaact taatgttcaa gactttcatt gggcctggag gaaacatgcc 1080 tgggtacttg agaccagaaa ctgcacaggg gattttcttg aatttcaaac gacttttgga 1140 gttcaaccaa ggaaagttgc cttttgctgc tgcccagatt ggaaattctt ttagaaatga 1200 gatctcccct cgatctggac tgatcagagt cagagaattc acaatggcag aaattgagca 1260 ctttgtagat cccagtgaga aagaccaccc caagttccag aatgtggcag accttcacct 1320 ttatttgtat tcagcaaaag cccaggtcag cggacagtcc gctcggaaaa tgcgcctggg 1380 agatgctgtt gaacagggtg tgattaataa cacagtatta ggctatttca ttggccgcat 1440 ctacctctac ctcacgaagg ttggaatatc tccagataaa ctccgcttcc ggcagcacat 1500 ggagaatgag atggcccatt atgcctgtga ctgttgggat gcagaatcca aaacatccta 1560 cggttggatt gagattgttg gatgtgctga tcgttcctgt tatgacctct cctgtcatgc 1620 acgagccacc aaagtcccac ttgtagctga gaaacctctg aaagaaccca aaacagtcaa 1680 tgttgttcag tttgaaccca gtaagggagc aattggtaag gcatataaga aggatgcaaa 1740 actggtgatg gagtatcttg ccatttgtga tgagtgctac attacagaaa ttgagatgct 1800 gctgaatgag aaaggggaat tcacaattga aactgaaggg aaaacatttc agttaacaaa 1860 agacatgatc aatgtgaaga gattccagaa aacactatat gtggaagaag ttgttccgaa 1920 tgtaattgaa ccttccttcg gcctgggtag gatcatgtat acggtatttg aacatacatt 1980 ccatgtacga gaaggagatg aacagagaac attcttcagt ttccctgctg tagttgctcc 2040 attcaaatgt tccgtcctcc cactgagcca aaaccaggag ttcatgccat ttgtcaagga 2100 attatcggaa gccctgacca ggcatggagt atctcacaaa gtagacgatt cctctgggtc 2160 aatcggaagg cgctatgcca ggactgatga gattggcgtg gcttttggtg tcaccattga 2220 ctttgacaca gtgaacaaga ccccccacac tgcaactctg agggaccgtg actcaatgcg 2280 gcagataaga gcagagatct ctgagctgcc cagcatagtc caagacctag ccaatggcaa 2340 catcacatgg gctgatgtgg aggccaggta tcctctgttt gaagggcaag agactggtaa 2400 aaaagagaca atcgaggaat gaggacaatt ttgacaactt ttgaccactt gcgctaataa 2460 aa 2462 71 2415 DNA Homo sapiens 71 cggcgccgcg agcttctcct ctcctcacga ccgaggcaga gcagtcatta tggcgaacct 60 tggctgctgg atgctggttc tctttgtggc cacatggagt gacctgggcc tctgcaagaa 120 gcgcccgaag cctggaggat ggaacactgg gggcagccga tacccggggc agggcagccc 180 tggaggcaac cgctacccac ctcagggcgg tggtggctgg gggcagcctc atggtggtgg 240 ctgggggcag cctcatggtg gtggctgggg gcagccccat ggtggtggct ggggacagcc 300 tcatggtggt ggctggggtc aaggaggtgg cacccacagt cagtggaaca agccgagtaa 360 gccaaaaacc aacatgaagc acatggctgg tgctgcagca gctggggcag tggtgggggg 420 ccttggcggc tacatgctgg gaagtgccat gagcaggccc atcatacatt tcggcagtga 480 ctatgaggac cgttactatc gtgaaaacat gcaccgttac cccaaccaag tgtactacag 540 gcccatggat gagtacagca accagaacaa ctttgtgcac gactgcgtca atatcacaat 600 caagcagcac acggtcacca caaccaccaa gggggagaac ttcaccgaga ccgacgttaa 660 gatgatggag cgcgtggttg agcagatgtg tatcacccag tacgagaggg aatctcaggc 720 ctattaccag agaggatcga gcatggtcct cttctcctct ccacctgtga tcctcctgat 780 ctctttcctc atcttcctga tagtgggatg aggaaggtct tcctgttttc accatctttc 840 taatcttttt ccagcttgag ggaggcggta tccacctgca gcccttttag tggtggtgtc 900 tcactctttc ttctctcttt gtcccggata ggctaatcaa tacccttggc actgatgggc 960 actggaaaac atagagtaga cctgagatgc tggtcaagcc ccctttgatt gagttcatca 1020 tgagccgttg ctaatgccag gccagtaaaa gtataacagc aaataaccat tggttaatct 1080 ggacttattt ttggacttag tgcaacaggt tgaggctaaa acaaatctca gaacagtctg 1140 aaataccttt gcctggatac ctctggctcc ttcagcagct agagctcagt atactaatgc 1200 cctatcttag tagagatttc atagctattt agagatattt tccattttaa gaaaacccga 1260 caacatttct gccaggtttg ttaggaggcc acatgatact tattcaaaaa aatcctagag 1320 attcttagct cttgggatgc aggctcagcc cgctggagca tgagctctgt gtgtaccgag 1380 aactggggtg atgttttact tttcacagta tgggctacac agcagctgtt caacaagagt 1440 aaatattgtc acaacactga acctctggct agaggacata ttcacagtga acataactgt 1500 aacatatatg aaaggcttct gggacttgaa atcaaatgtt tgggaatggt gcccttggag 1560 gcaacctccc attttagatg tttaaaggac cctatatgtg gcattccttt ctttaaacta 1620 taggtaatta aggcagctga aaagtaaatt gccttctaga cactgaaggc aaatctcctt 1680 tgtccattta cctggaaacc agaatgattt tgacatacag gagagctgca gttgtgaaag 1740 caccatcatc atagaggatg atgtaattaa aaaatggtca gtgtgcaaag aaaagaactg 1800 cttgcatttc tttatttctg tctcataatt gtcaaaaacc agaattaggt caagttcata 1860 gtttctgtaa ttggcttttg aatcaaagaa tagggagaca atctaaaaaa tatcttaggt 1920 tggagatgac agaaatatga ttgatttgaa gtggaaaaag aaattctgtt aatgttaatt 1980 aaagtaaaat tattccctga attgtttgat attgtcacct agcagatatg tattactttt 2040 ctgcaatgtt attattggct tgcactttgt gagtatctat gtaaaaatat atatgtatat 2100 aaaatatata ttgcatagga cagacttagg agttttgttt agagcagtta acatctgaag 2160 tgtctaatgc attaactttt gtaaggtact gaatacttaa tatgtgggaa acccttttgc 2220 gtggtcctta ggcttacaat gtgcactgaa tcgtttcatg taagaatcca aagtggacac 2280 cattaacagg tctttgaaat atgcatgtac tttatatttt ctatatttgt aactttgcat 2340 gttcttgttt tgttatataa aaaaattgta aatgtttaat atctgactga aattaaacga 2400 gcgaagatga gcacc 2415 72 3869 DNA Homo sapiens 72 aagcttggct ccagaactgg cttttgaagg tggaggtggg ggtagtgaga actgaaacag 60 gctggctgga caactggcag cttggtgtgg ccttagaagc atgagtgagg gtggccggga 120 gacgatttgt ctggactgtt gtgatttcac cctgactttt cctgccttca gcctctgcag 180 agatgtgggc agctggtcag gatggccatt cgggctcagc acagcaacgc agcccagact 240 cagactgggg aagcaaacag gggctggaca ggccaggaga gcctgtcgga cagtgatcct 300 gagatgtggg agttgctgca gagggagaag gacaggcagt gtcgtggcct ggagctcatt 360 gcctcagagg tgggactggg gagatgggca ggggttgggc caccatgggt acaggaagta 420 acaaagttat cttaactgat atttctccaa aacccccttt cacactcagg acctttcttt 480 gggctttatc ttcctttctt atctccctca agcaaaggca gtgcaagtcc agtttatggg 540 gttgggacat ttagggagcc tccagggtcc ctacagtttc atctgatccc ttccttcctc 600 ctatgaggaa ggaggagcct agaagcacaa gtttgagtgg gtaggtggca ttgaggggcc 660 actgctcatg gcagatgggt ttctgagaat gctgcctctg gctttgcccc aggcctggtg 720 ctgagtgaat ggagctttct gcagggagta ctcccgcttt cagctctggc tctggcaggg 780 agggactgtg ggagtccagg ggaaggggct caataccttc tgacattgcc ccccaccacc 840 ccagaacttc tgcagccgag ctgcgctgga ggccctgggg tcctgtctga acaacaagta 900 ctcggagggt tatcctggca agaggtgagg gctggagggc agtgtcaggg atggtgctcc 960 cagtggggga acccacctgt accttcccag tgttcattga ggagtgaact tcccagtcct 1020 ttgctgatgg ttgagagtcc tttctctgtg ccctcattac ccctctccca cggcagatac 1080 tatgggggag cagaggtggt ggatgaaatt gagctgctgt gccagcgccg ggccttggaa 1140 gcctttgacc tggatcctgc acagtgggga gtcaatgtcc agccctactc cgggtcccca 1200 gccaacctgg ccgtctacac agcccttctg caacctcacg accggatcat ggggctggac 1260 ctgcccgatg ggggccagtg agtatggatg ggctggctga tggtcttggc ggcaggattg 1320 gtgtgggaaa ggagttattt attgaatacc tactgtggac catacagatg gaacaggcct 1380 tgccctgtcc tgcatgtcac agtggatgag gaagataaga tcccagttat agtgcctacc 1440 acagagtgga cagagcagtg aggcggtgtg tcctaggact ggtgttctgg ggacagagaa 1500 ctgtggagtt gaagggagtg gttaagtccg ggggtccttc cacccaggcc ttcttacttc 1560 ctctcacttc gcagtctcac ccacggctac atgtctgacg tcaagcggat atcagccacg 1620 tccatcttct tcgagtctat gccctataag ctcaacgtga gtgctctagg gtgtggggag 1680 gggctcttgg ccctggtggt ggtcctcccc tggagaagct gagggcctgg agcgccgggc 1740 cgtccttagg gttaaggagg agagtgagct gccctgcttc cttctcaggg ctttagctgt 1800 ttgtgtgtct gtccagccca aaactggcct cattgactac aaccagctgg cactgactgc 1860 tcgacttttc cggccacggc tcatcatagc tggcaccagc gcctatgctc gcctcattga 1920 ctacgcccgc atgagagagg ttggtggggg gggctggaga ctgggcacct ccccaggggg 1980 tggtgaggag gtgtgggagg agggcagcct tgggcaggcc tctccgggcc ctccccaggc 2040 tgaggccttg cctctgtacc tgcccaggtg tgtgatgaag tcaaagcaca cctgctggca 2100 gacatggccc acatcagtgg cctggtggct gccaaggtga ttccctcgcc tttcaagcac 2160 gcggacatcg tcaccaccac tactcacaag actcttcgag gggccaggtc aggtcctgag 2220 gtcgggcttg cctttccctg ccttcaggcc tattcctggg gcactgttgg cctggacctg 2280 agaggaattc attcccacct gcagccctta agactcctgc ccagtctgtg agagttctcc 2340 ttctcttgcc catggtggcc atgccctggc aggggatttg tggatgggat tgaggggctg 2400 attccctcta ccactggaat ccagtgtacc aagcccacgt gagctgtgcc cttggggccc 2460 aggtccgcca gcttcctctg ccttctctgt cccttgtcct tcttttcagc ttagactctg 2520 accatccacc tctcacacag gtcagggctc atcttctacc ggaaaggggt gaaggctgtg 2580 gaccccaaga ctggccggga gatcccttac acatttgagg accgaatcaa ctttgccgtg 2640 ttcccatccc tgcagggggg cccccacaat catgccattg ctgcagtagc tgtggcccta 2700 aagcaggttg gggatcctgt ctttgtaggg tgtggggggg caatggcctg gaggcttaga 2760 ccctgcacct tgctaactga tgctggggct gatggaaggg aaatgccagg atggaaggag 2820 tcaaggctgg ggtcacagag ctatgctgag ggtgcagggc cagagggtag tgcagggctt 2880 gggtccaggc ctagggtgac agctgctact gtctcatctc caggcctgca cccccatgtt 2940 ccgggagtac tccctgcagg ttctgaagaa tgctcgggcc atggcagatg ccctgctaga 3000 gcgaggctac tcactggtat caggtaagcc agcaggtgat gggtgagggc ctctgtagct 3060 tcaggcagag gcccaggact caccactccc catttcttac ccaccttagg tggtactgac 3120 aaccacctgg tgctggtgga cctgcggccc aagggcctgg atggagctcg ggctgagcgg 3180 gtgctagagc ttgtatccat cactgccaac aagaacacct gtcctggaga ccgaagtgcc 3240 atcacaccgg gcggcctgcg gcttggggcc ccagccttaa cttctcgaca gttccgtgag 3300 gatgacttcc ggagagttgt ggactttata gatgaagggg tcaacattgg cttagaggtg 3360 aagagcaaga ctggtgagtg agcaagaagg agccccgggc cagccagttc ccactcactg 3420 tctgctccct cccccagctg atctcactgc cttccctaga gctctgacca cttgtttcct 3480 caccctctct ctctagccaa gctccaggat ttcaaatcct tcctgcttaa ggactcagaa 3540 acaagtcagc gtctggccaa cctcaggcaa cgggtggagc agtttgccag ggccttcccc 3600 atgcctggtt ttgatgagca ttgaaggcac ctgggaaatg aggcccacag actcaaagtt 3660 actctccttc cccctacctg ggccagtgaa atagaaagcc tttctatttt ttggtgcggg 3720 agggaagacc tctcacttag ggcaagagcc aggtatagtc tcccttccca gaatttgtaa 3780 ctgagaagat cttttctttt tccttttttt ggtaacaaga cttagaagga gggcccaggc 3840 actttctgtt tgaacccctg tcatgatca 3869 73 3344 DNA Homo sapiens 73 ggtacagctg cgcgtctgcg ggaataggtg cagcgggccc ttggcggggg actctgaggg 60 aggagctggg gacggcgacc ctaggagagt tctttggggt gactttcaag atggactcta 120 ctctaacagc aagtgaaatc cggcagcgat ttatagattt cttcaagagg aacgagcata 180 cgtatgttca ctcgtctgcc accatcccat tggatgaccc cactttgctc tttgccaatg 240 caggcatgaa ccagtttaaa cccattttcc tgaacacaat tgacccatct caccccatgg 300 caaagctgag cagagctgcc aatacccaga agtgcatccg ggctgggggc aaacaaaatg 360 acctggacga tgtgggcaag gatgtctatc atcacacctt cttcgagatg ctgggctctt 420 ggtcttttgg agattacttt aaggaattgg catgtaagat ggctctggaa ctcctcaccc 480 aagagtttgg cattcccatt gaaagacttt atgttactta ctttggcggg gatgaagcag 540 ctggcttaga agcagatctg gaatgcaaac agatctggca aaatttgggg ctggatgaca 600 ccaaaatcct cccaggcaac atgaaggata acttctggga gatgggtgac acgggcccct 660 gtggtccttg cagtgagatc cactacgacc ggattggtgg tcgggacgcc gcacatcttg 720 tcaaccagga cgaccctaat gtgctggaga tctggaacct tgtgttcatc cagtataaca 780 gggaagctga tggcattctg aaacctcttc ccaagaaaag cattgacaca gggatgggcc 840 tggaacgact ggtatctgtg ctgcagaata agatgtccaa ctatgacact gacctttttg 900 tcccttactt tgaagccatt cagaagggca caggtgcccg accatacact gggaaagttg 960 gtgctgagga tgccgatggg attgacatgg cctaccgggt gctggctgac catgctcgga 1020 ccatcactgt ggcactggct gatggtggcc ggcctgacaa cacagggcgt ggatatgtgt 1080 tgagacggat tctccgccga gctgtccgat acgcccatga aaagctcaat gccagcaggg 1140 gcttctttgc tacgttagtg gatgttgtcg tccagtccct gggagatgca tttcctgagc 1200 tgaagaagga cccagacatg gtgaaggaca tcattaatga agaagaggtg cagtttctca 1260 agactctcag cagagggcgt cgcatcctgg acaggaaaat tcagagcctg ggagacagca 1320 agaccattcc cggagacact gcttggctcc tctatgacac ctatgggttt ccagtggatc 1380 tgactggact gattgctgaa gagaagggcc tggtggtaga catggatggc tttgaagagg 1440 agaggaaact ggcccagctg aaatcacagg gcaagggagc tggtggggaa gacctcatta 1500 tgctggacat ttacgctatc gaagagctcc gggcacgggg tctggaggtc acagatgatt 1560 ccccaaagta caattaccat ttggactcca gtggtagcta tgtatttgag aacacagtgg 1620 ctacggtgat ggctctgcgc agggagaaga tgttcgtgga agaggtgtcc acaggccagg 1680 agtgtggagt ggtgctggac aagacctgtt tctatgctga gcaaggaggc cagatctatg 1740 acgaaggcta cctggtgaag gtggatgaca gcagtgaaga taaaacagag tttacagtga 1800 agaatgctca ggtccgagga gggtatgtgc tacacattgg aaccatctac ggtgacctga 1860 aagtggggga tcaggtctgg ctgtttattg atgagccccg acgaagaccc atcatgagca 1920 accacacagc tacgcacatt ctgaacttcg ccctgcgctc agtgcttggg gaagctgacc 1980 agaaaggctc attggttgct cctgaccgcc tcagatttga ctttactgcc aagggagcca 2040 tgtccaccca acagatcaag aaggctgaag agattgctaa tgagatgatt gaggcagcca 2100 aggccgtcta tacccaggat tgccccctgg cagcagcgaa agccatccag ggcctacggg 2160 ctgtgtttga tgagacctat cctgaccctg tgcgagtcgt ctccattggg gtcccggtgt 2220 ccgagttgct ggatgacccc tctgggcctg ctggctccct gacttctgtt gagttctgtg 2280 ggggaacgca cctgcggaac tcgagtcatg caggagcttt tgtgatcgtg acggaagaag 2340 ccattgccaa gggtatccgg aggattgtgg ctgtcacagg tgccgaggcc cagaaggccc 2400 tcaggaaagc agagagcttg aagaaatgtc tctctgtcat ggaagccaaa gtgaaggctc 2460 agactgctcc aaacaaggat gtgcagaggg agatcgctga ccttggagag gccctggcca 2520 ctgcagtcat cccccagtgg cagaaggatg aattgcggga gactctcaaa tccctaaaga 2580 aggtcatgga tgacttggac cgagccagca aagccgatgt ccagaaacga gtgttagaga 2640 agacgaagca gttcatcgac agcaacccca accagcctct tgtcatcctg gagatggaga 2700 gcggcgcctc agccaaggcc ctgaatgaag ccttgaagct cttcaagatg cactcccctc 2760 agacttctgc catgctcttc acggtggaca atgaggctgg caagatcacg tgcctgtgtc 2820 aagtccccca gaatgcagcc aatcggggct taaaagccag cgagtgggtg cagcaggtgt 2880 caggcttgat ggacggtaaa ggtggtggca aggatgtgtc tgcacaggcc acaggcaaga 2940 acgttggctg cctgcaggag gcgctgcagc tggccacttc cttcgcccag ctgcgcctcg 3000 gggatgtaaa gaactgagtg gggaaggagg aggctcccac tggatccatc cgtccagcca 3060 agagctcttc atctgctaca agaacatttg aatcttggga cctttaaaga gcccctccta 3120 acccagcagt aactggaaca cacttgggag cagtcctatg tctcagtgcc ccttaaattt 3180 ctgccctgag ccctccacgt cagtgccatc ggtctagaac cactaacccc gcattgctgt 3240 tgatcgtcac gctcgcatct atagataacg gctctccaga cctgagcttt ccgcgtcagc 3300 aagtaggaat cgtttttgct gcagagaata aaaggaccac gtgc 3344 74 1902 DNA Homo sapiens 74 gcccctttct ttctcctcgt cggcccgaga gcaggaacac gataacgaag gaggcccaac 60 ttcattcaat aaggagcctg acggatttat cccagacggt agaacaaaag gaagaatatt 120 gatggatttt aaaccagagt ttttaaagag cttgagaata cggggaaatt aatttgttct 180 cctacacaca tagatagggt aaggttgttt ctgatgcagc tgagaaaaat gcagaccgtc 240 aaaaaggagc aggcgtctct tgatgccagt agcaatgtgg acaagatgat ggtccttaat 300 tctgctttaa cggaagtgtc agaagactcc acaacaggtg aggacgtgct tctcagtgaa 360 ggaagtgtgg ggaagaacaa atcttctgca tgtcggagga aacgggaatt cattcctgat 420 gaaaagaaag atgctatgta ttgggaaaaa aggcggaaaa ataatgaagc tgccaaaaga 480 tctcgtgaga agcgtcgact gaatgacctg gttttagaga acaaactaat tgcactggga 540 gaagaaaacg ccactttaaa agctgagctg ctttcactaa aattaaagtt tggtttaatt 600 agctccacag catatgctca agagattcag aaactcagta attctacagc tgtgtacttt 660 caagattacc agacttccaa atccaatgtg agttcatttg tggacgagca cgaaccctcg 720 atggtgtcaa gtagttgtat ttctgtcatt aaacactctc cacaaagctc gctgtccgat 780 gtttcagaag tgtcctcagt agaacacacg caggagagct ctgtgcaggg aagctgcaga 840 agtcctgaaa acaagttcca gattatcaag caagagccga tggaattaga gagctacaca 900 agggagccaa gagatgaccg aggctcttac acagcgtcca tctatcaaaa ctatatgggg 960 aattctttct ctgggtactc acactctccc ccactactgc aagtcaaccg atcctccagc 1020 aactccccgg gaacgtcgga aactgatgat ggtgtggtag gaaagtcatc tgatggagaa 1080 gacgagcaac aggtccccaa gggccccatc cattctccag ttgaactcaa gcatgtgcat 1140 gcaactgtgg ttaaagttcc agaagtgaat tcctctgcct tgccacacaa gctccggatc 1200 aaagccaaag ccatgcagat caaagtagaa gcctttgata atgaatttga ggccacgcaa 1260 aaactttcct cacctattga catgacatct aaaagacatt tcgaactcga aaagcatagt 1320 gccccaagta tggtacattc ttctcttact cctttctcag tgcaagtgac taacattcaa 1380 gattggtctc tcaaatcgga gcactggcat caaaaagaac tgagtggcaa aactcagaat 1440 agtttcaaaa ctggagttgt tgaaatgaaa gacagtggct acaaagtttc tgacccagag 1500 aacttgtatt tgaagcaggg gatagcaaac ttatctgcag aggttgtctc actcaagaga 1560 cttatagcca cacaaccaat ctctgcttca gactctgggt aaattactac tgagtaagag 1620 ctgggcattt agaaagatgt catttgcaat agagcagtcc attttgtatt atgctgaatt 1680 ttcactggac ctgtgatgtc atttcactgt gatgtgcaca tgttgtctgt ttggtgtctt 1740 tttgtgcaca gattatgatg aagattagat tgtgttatca ctctgcctgt gtatagtcag 1800 atagtccatg cgaaggctgt atatattgaa cattattttt gttgttctat tataaagtgt 1860 gtaagttacc agtttcaata aaggattggt gacaaacaca ga 1902 75 1560 DNA Homo sapiens 75 ctccataagg cacaaacttt cagagacagc agagcacaca agcttctagg acaagagcca 60 ggaagaaacc accggaagga accatctcac tgtgtgtaaa catgacttcc aagctggccg 120 tggctctctt ggcagccttc ctgatttctg cagctctgtg tgaaggtgca gttttgccaa 180 ggagtgctaa agaacttaga tgtcagtgca taaagacata ctccaaacct ttccacccca 240 aatttatcaa agaactgaga gtgattgaga gtggaccaca ctgcgccaac acagaaatta 300 ttgtaaagct ttctgatgga agagagctct gtctggaccc caaggaaaac tgggtgcaga 360 gggttgtgga gaagtttttg aagagggctg agaattcata aaaaaattca ttctctgtgg 420 tatccaagaa tcagtgaaga tgccagtgaa acttcaagca aatctacttc aacacttcat 480 gtattgtgtg ggtctgttgt agggttgcca gatgcaatac aagattcctg gttaaatttg 540 aatttcagta aacaatgaat agtttttcat tgtaccatga aatatccaga acatacttat 600 atgtaaagta ttatttattt gaatctacaa aaaacaacaa ataattttta aatataagga 660 ttttcctaga tattgcacgg gagaatatac aaatagcaaa attgggccaa gggccaagag 720 aatatccgaa ctttaatttc aggaattgaa tgggtttgct agaatgtgat atttgaagca 780 tcacataaaa atgatgggac aataaatttt gccataaagt caaatttagc tggaaatcct 840 ggattttttt ctgttaaatc tggcaaccct agtctgctag ccaggatcca caagtccttg 900 ttccactgtg ccttggtttc tcctttattt ctaagtggaa aaagtattag ccaccatctt 960 acctcacagt gatgttgtga ggacatgtgg aagcacttta agttttttca tcataacata 1020 aattattttc aagtgtaact tattaaccta tttattattt atgtatttat ttaagcatca 1080 aatatttgtg caagaatttg gaaaaataga agatgaatca ttgattgaat agttataaag 1140 atgttatagt aaatttattt tattttagat attaaatgat gttttattag ataaatttca 1200 atcagggttt ttagattaaa caaacaaaca attgggtacc cagttaaatt ttcatttcag 1260 atatacaaca aataattttt tagtataagt acattattgt ttatctgaaa ttttaattga 1320 actaacaatc ctagtttgat actcccagtc ttgtcattgc cagctgtgtt ggtagtgctg 1380 tgttgaatta cggaataatg agttagaact attaaaacag ccaaaactcc acagtcaata 1440 ttagtaattt cttgctggtt gaaacttgtt tattatgtac aaatagattc ttataatatt 1500 atttaaatga ctgcattttt aaatacaagg ctttatattt ttaactttaa aaaaaaccgg 1560 76 642 DNA Homo sapiens 76 tcgtgttcat gggagctcgt tttcttttcc tctaggcaga gaagaggcga tggcggcgat 60 ggcatctctc ggcgccctgg cgctgctcct gctgtccagc ctctcccgct gctcagccga 120 ggcctgcctg gagccccaga tcaccccttc ctactacacc acttctgacg ctgtcatttc 180 cactgagacc gtcttcattg tggagatctc cctgacatgc aagaacaggg tccagaacat 240 ggctctctat gctgacgtcg gtggaaaaca attccctgtc actcgaggcc aggatgtggg 300 gcgttatcag gtgtcctgga gcctggacca caagagcgcc cacgcaggca cctatgaggt 360 tagattcttc gacgaggagt cctacagcct cctcaggaag gctcagagga ataacgagga 420 catttccatc atcccgcctc tgtttacagt cagcgtggac catcggggca cttggaacgg 480 gccctgggtg tccactgagg tgctggctgc ggcgatcggc cttgtgatct actacttggc 540 cttcagtgcg aagagccaca tccaggcctg agggcggcac cccagccctg cccttgcttc 600 cttcaataaa catcacagga cctgggactg cacaggaaaa aa 642 77 2647 DNA Homo sapiens 77 gccgcgctgg tggcggcggc gcgtcgttgc agttgcgcca tctgtcagga gcggagccgg 60 cgaggagggg gctgccgcgg gcgaggagga ggggtcgccg cgagccgaag gccttcgaga 120 cccgcccgcc gcccggcggc gagagtagag gcgaggttgt tgtgcgagcg gcgcgtcctc 180 tcccgcccgg gcgcgccgcg cttctcccag cgcaccgagg accgcccggg cgcacacaaa 240 gccgccgccc gcgccgcacc gcccggcggc cgccgcccgc gccagggagg gattcggccg 300 ccgggccggg gacaccccgg cgccgccccc tcggtgctct cggaaggccc accggctccc 360 gggcccgccg gggacccccc ggagccgcct cggccgcgcc ggaggagggc ggggagagga 420 ccatgtgagt gggctccgga gcctcagcgc cgcgcagttt ttttgaagaa gcaggatgct 480 gatctaaacg tggaaaaaga ccagtcctgc ctctgttgta gaagacatgt ggtgtatata 540 aagtttgtga tcgttggcgg aaattttgga atttagataa tgggctgtgt gcaatgtaag 600 gataaagaag caacaaaact gacggaggag agggacggca gcctgaacca gagctctggg 660 taccgctatg gcacagaccc cacccctcag cactacccca gcttcggtgt gacctccatc 720 cccaactaca acaacttcca cgcagccggg ggccaaggac tcaccgtctt tggaggtgtg 780 aactcttcgt ctcatacggg gaccttgcgt acgagaggag gaacaggagt gacactcttt 840 gtggcccttt atgactatga agcacggaca gaagatgacc tgagttttca caaaggagaa 900 aaatttcaaa tattgaacag ctcggaagga gattggtggg aagcccgctc cttgacaact 960 ggagagacag gttacattcc cagcaattat gtggctccag ttgactctat ccaggcagaa 1020 gagtggtact ttggaaaact tggccgaaaa gatgctgagc gacagctatt gtcctttgga 1080 aacccaagag gtacctttct tatccgcgag agtgaaacca ccaaaggtgc ctattcactt 1140 tctatccgtg attgggatga tatgaaagga gaccatgtca aacattataa aattcgcaaa 1200 cttgacaatg gtggatacta cattaccacc cgggcccagt ttgaaacact tcagcagctt 1260 gtacaacatt actcagagag agctgcaggt ctctgctgcc gcctagtagt tccctgtcac 1320 aaagggatgc caaggcttac cgatctgtct gtcaaaacca aagatgtctg ggaaatccct 1380 cgagaatccc tgcagttgat caagagactg ggaaatgggc agtttgggga agtatggatg 1440 ggtacctgga atggaaacac aaaagtagcc ataaagactc ttaaaccagg cacaatgtcc 1500 cccgaatcat tccttgagga agcgcagatc atgaagaagc tgaagcacga caagctggtc 1560 cagctctatg cagtggtgtc tgaggagccc atctacatcg tcaccgagta tatgaacaaa 1620 ggaagtttac tggatttctt aaaagatgga gaaggaagag ctctgaaatt accaaatctt 1680 gtggacatgg cagcacaggt ggctgcagga atggcttaca tcgagcgcat gaattatatc 1740 catagagatc tgcgatcagc aaacattcta gtggggaatg gactcatatg caagattgct 1800 gacttcggat tggcccgatt gatagaagac aatgagtaca cagcaagaca aggtgcaaag 1860 ttccccatca agtggacggc ccccgaggca gccctgtacg ggaggttcac aatcaagtct 1920 gacgtgtggt cttttggaat cttactcaca gagctggtca ccaaaggaag agtgccatac 1980 ccaggcatga acaaccggga ggtgctggag caggtggagc gaggctacag gatgccctgc 2040 ccgcaggact gccccatctc tctgcatgag ctcatgatcc actgctggaa aaaggaccct 2100 gaagaacgcc ccacttttga gtacttgcag agcttcctgg aagactactt taccgcgaca 2160 gagccccagt accaacctgg tgaaaacctg taaggcccgg gtctgcggag agaggccttg 2220 tcccagaggc tgccccaccc ctccccatta gctttcaatt ccgtagccag ctgctcccca 2280 gcagcggaac cgcccaggat cagattgcat gtgactctga agctgacgaa cttccatggc 2340 cctcattaat gacacttgtc cccaaatccg aacctcctct gtgaagcatt cgagacagaa 2400 ccttgttatt tctcagactt tggaaaatgc attgtatcga tgttatgtaa aaggccaaac 2460 ctctgttcag tgtaaatagt tactccagtg ccaacaatcc tagtgctttc cttttttaaa 2520 aatgcaaatc ctatgtgatt ttaactctgt cttcacctga ttcaactaaa aaaaaaaagt 2580 attattttcc aaaagtggcc tctttgtcta aaacaataaa attttttttc atgttttaac 2640 aaaaacc 2647 78 1826 DNA Homo sapiens 78 tacctgaccc cagccatttc ccttctagaa attgttctac agacatatgt aataacatat 60 acaaaaggtt attctttcag cagtgtttgt cagagcgaga acattccaga gagctgttgc 120 gcagccattg gtacctgtat tggggaaaca tagcatacaa tcaagaagct tacagcctca 180 gtggcgaaaa ttttttcatg tcagagaccg agaactcttg cagtcgttta tgtcatccct 240 tcttctccag acagaagata ccaaaaagtt gcaatcaaag atctcttcat cttattgata 300 aagccactaa taagccaaaa tgtctgtcaa tgtcaaccgc agcgtgtcag accagttcta 360 tcgctacaag atgccccgtc tgattgccaa ggttgagggc aaaggcaatg gaatcaagac 420 agttatagtc aacatggttg acgttgcaaa ggcgcttaat cggcctccaa cgtatcccac 480 caaatatttt ggttgtgagc tgggagcaca gacccagttt gatgttaaga atgaccgtta 540 cattgtcaat ggatctcatg aggcgaataa gctgcaagac atgttggatg gattcattaa 600 aaaatttgtt ctctgtcctg aatgtgagaa tcctgaaaca gatttgcatg tcaatccaaa 660 gaagcaaaca ataggtaatt cttgtaaagc ctgtggctat cgaggcatgc ttgacacaca 720 tcataaactc tgcacattca ttctcaaaaa cccacctgag aatagtgaca gtggtacagg 780 aaagaaagaa aaagaaaaga aaaacagaaa gggcaaagac aaggaaaatg gctccgtatc 840 cagcagtgag acaccaccac caccaccacc accaaatgaa attaatcctc ctccacatac 900 aatggaagaa gaggaggatg atgactcggg agaagataca actgaggaag ctcaaaggcg 960 tcgaatggat gaaatcagtg accatgcaaa agttctgaca ctcagtgatg atttggaaag 1020 aacaattgag gagagggtca atatcctctt tgattttgtt aagaaaaaga aagaagaggg 1080 tgttattgat tcatctgaca aagaaatcgt tgctgaagca gaaagactgg atgtaaaagc 1140 catgggccct cttgttctaa ctgaagttct ttttaatgag aagattagag aacagattaa 1200 gaaatacagg cgccatttcc tacgattttg tcacaacaac aaaaaagccc aacggtacct 1260 tcttcatggt ttggagtgtg tggtagcaat gcatcaagct cagcttatct ccaagattcc 1320 acatatcttg aaggagatgt acgatgcaga ccttttagaa gaagaggtca tcatcagctg 1380 gtcggaaaag gcctctaaga aatatgtctc caaagaactt gccaaagaga ttcgtgtcaa 1440 agcagaacca tttataaaat ggttgaagga ggcagaggaa gaatcttctg gtggcgaaga 1500 agaagatgaa gatgagaaca ttgaggtggt gtattcgaag gctgccagtg taccgaaagt 1560 tgagactgta aagtcagaca acaaggatga cgacatcgat attgatgcca tttaaaggga 1620 tggatgcaac ctagcttaac agtataatgc tgcaaatttt cctccattat cagccagaag 1680 tgcaacatgt atgtgcaaaa gctaaaatgg cttaacatca tgctacactt tacactaaaa 1740 atctattact gtgagtgtga aaaactagtg gtggacacat ttggatcaca tttatacagt 1800 tataaaaata aaggtttgat tttggt 1826 79 5857 DNA Homo sapiens 79 cggcgcaggc ggcggcgtcc gaggagattt aatccagaga ctgacttcac tatagaaccc 60 acagttgtat caatggttgg ggaaagatag tggcaacagg caaaggagaa acagctctga 120 catacaaaga aaatgagtat gctaaagcca agtgggctta aggcccccac caagatcctg 180 aagcctggaa gcacagctct gaagacacct acggctgttg tagctccagt agaaaaaacc 240 atatccagtg aaaaagcatc aagcactcca tcatctgaga ctcaggagga atttgtggat 300 gactttcgag ttggggagcg agtttgggtg aatggaaata agcctggatt tatccagttt 360 cttggagaaa cccagtttgc accaggccag tgggctggaa ttgttttaga tgaacccata 420 ggcaagaacg atggttcggt ggcaggagtt cggtatttcc agtgtgaacc tttaaagggc 480 atatttaccc gaccttcaaa gttaacaagg aaggtgcaag cagaagatga agctaatggc 540 ctgcagacaa cgcccgcctc ccgagctact tcaccgctgt gcacttctac ggccagcatg 600 gtgtcttcct ccccctccac cccttcaaac atccctcaga aaccatcaca gccagcagca 660 aaggaacctt cagctacgcc tccgatcagc aaccttacaa aaactgccag tgaatctatc 720 tccaaccttt cagaggctgg ctcaatcaag aaaggagaaa gagagctcaa aatcggagac 780 agagtattgg ttggtggcac taaggctggt gtagtccggt ttcttgggga gaccgacttt 840 gccaaggggg agtggtgtgg cgtggagtta gatgagccac ttgggaagaa tgatggcgct 900 gttgctggaa caaggtattt tcagtgtcaa cccaaatatg gcttgttcgc tcctgtccac 960 aaagttacca agattggctt cccttccact acaccagcca aagccaaggc caacgcagtg 1020 aggcgagtga tggcgaccac gtccgccagc ctgaagcgca gcccttctgc ctcttccctc 1080 agctccatga gctcagtggc ctcctctgtg agcagcaggc ccagtcggac aggactattg 1140 actgaaacct cctcccgtta cgccaggaag atctccggta ccactgccct ccaggaggcc 1200 ctgaaggaga agcagcagca cattgagcag ctgctggcgg aacgggatct ggagagggcg 1260 gaggtggcca aggccacgag ccacgtgggg gagatagagc aggagctagc tctggcccgg 1320 gacggacatg accagcatgt cctggaattg gaagccaaaa tggaccagct gcgaacaatg 1380 gtggaagctg ctgacaggga gaaggtggag cttctcaacc agcttgaaga ggagaaaagg 1440 aaggttgagg accttcagtt ccgggttgaa gaagaatcaa ttaccaaagg tgatcttgag 1500 acgcagacca aactggagca tgcccgcatt aaggagcttg aacagagcct gctctttgaa 1560 aagaccaaag ctgacaaact ccagagggag ttagaagaca ctagggtggc tacagtttca 1620 gaaaagtcac gtataatgga actggagaaa gacctagcat tgagagtaca ggaagtagct 1680 gagctccgaa gaaggctaga gtccaataag cctgctgggg atgtggacat gtcactttcc 1740 cttttgcaag agataagctc tttgcaagaa aagttagaag tcacccgtac tgaccaccag 1800 agagaaataa cttctctgaa ggagcatttt ggagcccggg aagaaactca tcagaaggag 1860 ataaaggctc tgtataccgc cacggaaaag ctttccaaag agaacgagtc attgaaaagc 1920 aagctggagc atgccaacaa agagaactca gatgtgatag ctctatggaa gtccaaactg 1980 gagactgcca tcgcatccca ccagcaggcg atggaagaac tgaaggtatc tttcagcaaa 2040 gggcttggaa cagagacggc agaatttgct gaactaaaaa cacaaataga gaaaatgaga 2100 ctagattacc aacacgaaat agaaaatttg cagaatcaac aagactctga acgggctgcc 2160 catgctaaag agatggaagc cttgagggct aaactgatga aagttattaa agaaaaggaa 2220 aacagtctgg aagccatcag gtcgaaactg gacaaagcag aagaccagca tctcgtagaa 2280 atggaagaca cgttaaacaa attacaggaa gctgaaataa aggtaaagga gctagaggta 2340 ctgcaagcca aatgcaatga acaaaccaag gttattgata attttacatc acagctcaag 2400 gctactgaag aaaagctctt ggatcttgat gcacttcgga aagccagttc cgaaggtaaa 2460 tcggaaatga agaaacttag acagcagctt gaggcagctg agaaacagat taaacattta 2520 gagattgaaa agaatgctga aagtagcaag gctagtagca ttaccagaga gctccagggg 2580 agagagctaa agcttactaa ccttcaggaa aatttgagtg aagtcagtca agtgaaagag 2640 actttggaaa aagaacttca gattttgaaa gaaaagtttg ctgaagcttc agaggaggca 2700 gtctctgttc agagaagtat gcaagaaact gtaaataagt tacaccaaaa ggaggaacag 2760 tttaacatgc tgtcttctga cttggagaag ctgagagaaa acttagcaga tatggaggca 2820 aaatttagag agaaagatga gagagaagag cagctgataa aggcaaagga aaaactggaa 2880 aatgacattg cagaaataat gaagatgtca ggagataact cttctcagct gacaaaaatg 2940 aacgatgaat tacgtctgaa agaaagagat gtagaagaat tacagctaaa acttacaaag 3000 gctaatgaaa atgcaagttt tctgcaaaaa agtattgagg acatgactgt caaagctgaa 3060 cagagccagc aagaagcagc taaaaagcat gaggaagaaa agaaagaatt ggagaggaaa 3120 ttgtcggacc tggaaaagaa aatggaaaca agccacaacc agtgtcagga gctgaaagcc 3180 aggtatgaga gagccacttc tgagacaaaa accaagcatg aagaaatcct acagaacctc 3240 cagaagacgc tgctggacac agaggacaag ctgaagggcg cacgggagga gaacagtggc 3300 ttgctgcagg agctggagga gctgagaaag caagccgaca aagccaaagc tgctcaaaca 3360 gcggaagatg ccatgcagat aatggaacag atgaccaaag agaagactga gactctggcc 3420 tccttggagg acaccaagca aacaaatgca aaactacaga atgaattgga cacacttaaa 3480 gaaaacaact tgaaaaatgt ggaagagctg aacaaatcaa aagaactcct gactgtagag 3540 aatcaaaaaa tggaagaatt taggaaagaa atagaaaccc taaagcaggc agcagctcag 3600 aagtcccagc agctttcagc gttgcaagaa gagaacgtta aacttgctga ggagctgggg 3660 agaagcaggg acgaagtcac aagtcatcaa aagctggaag aagaaagatc tgtgctcaat 3720 aatcagttgt tagaaatgaa aaaaagagaa tccaagttca taaaagacgc agatgaagag 3780 aaagcttcct tgcagaaatc catcagtata actagtgcct tactcacaga aaaggatgcc 3840 gagctggaga aactgagaaa tgaggtcaca gtgctcaggg gagaaaacgc ctctgccaag 3900 tccttgcatt cagttgttca gactctagag tctgataagg tgaagctcga gctcaaggta 3960 aagaacttgg agcttcaact caaagaaaac aagaggcagc tcagcagctc ctcaggtaat 4020 acagacactc aggcagacga ggatgaaaga gcccaggaga gtcagattga tttcctaaat 4080 tcagtaatag tggaccttca aaggaagaat caagacctca agatgaaggt ggagatgatg 4140 tcagaagcag ccctgaatgg gaacggggat gacctaaaca attatgacag tgatgatcag 4200 gagaaacagt ccaagaagaa acctcgcctc ttctgtgaca tttgtgactg ctttgatctc 4260 cacgacacag aggattgtcc tacccaggca cagatgtcag aggaccctcc ccattccaca 4320 caccatggca gtcggggtga ggaacgccca tactgtgaaa tctgtgagat gtttggacac 4380 tgggccacca actgcaatga cgacgaaacc ttctgatgaa gcctccagtg gagaactggg 4440 cttgctcaga cgcactcgca ttgacacaac gtaacaccag cattgtgtgt gcagacttca 4500 ggagaactca tgttattttt taaccccgtc aacaaatcta ggaaaatatt ttgatcttca 4560 acaaattgcc ctttagtctc cccgtatgag ttagaataat aaatatttag taggtgagtt 4620 ttcacctcga attttgtttt cttgattttt acgtttgaag acattgcacc agatgccatt 4680 acatttattg gccccccgac cttgtagaaa aacccctacc ctcacaatac cttatttaag 4740 taactttaaa ttatgccgtt acttttcata tttgcaccta agatatttcc aggctgcatt 4800 tgtatattta gattttttgg ttaagctttg acactggaat gagttgaaaa aatgtgccat 4860 tttgcatttt catctactca tttaaagtat tttattctta ttcaaagaaa tatctgagct 4920 ctttgcacta cctgttatca gtagtgcctt tacttcaggc ttgataatac ttaggtgtga 4980 ttataaaatc atgaagcagg taaagggagg ggcaagcccc aaactgctgt ggggacattt 5040 tataatctat atgctgcacc cacttaatct actgtggtgt tttgtttatt agttttgcat 5100 aatttcagct tctatatatt gtatgtatat attttttaaa aatctatatt ttgggaaaaa 5160 aacatacaca atgtgtcttt ctttttggac atttaccttt ttgaaaaaga aaacacttaa 5220 aatgatcatt aggacataac agactaggcc agacatagca tcttgtggct ttgcaaccat 5280 tttcatttgt ttgttttcct tttatttctt caccagattt aaataaaagg aggaattttc 5340 tccaattttt ttttccttct ctggcaggta tccccagcag tcaattaaca ataagccagt 5400 ataaaacacc taaataacca atctacaatc tcccttcaca agttttttta ctgtttttag 5460 atgaatgtac gatgagaaat tcaacgttaa taattctgga ttttcttatc acaaaaaaga 5520 aaatgaagga cctcaaagca cctgaacagt ttatcgacca gtttgaatct atttatcttc 5580 atttgaatgt cttctagata tgtaaaaagt cataaaatgt atcttccatg ctacatgtac 5640 aataagaact tctataattg tatatatgcc tttgatgtat tttcccctca agattatcaa 5700 ctgtgtgttc gacagtgaat attcaatctg gtaccagttg aaatttttgg ttataaatgt 5760 aatacgaatt gtttcacaaa cagaaaacat gtaaagcagt attaaaattt ggccaaacaa 5820 gtgttctgta tctactttta ataaatggtt attcttt 5857 80 2634 DNA Homo sapiens 80 gccgccgccg ccgccgccgc cgcgggcttc gttcgtaagg aagggggcct aggccgggcc 60 tgcggtggtg ggggttgctg cgcgccgggg gtcgctcctg ctgtgtcttc cgctccagct 120 tcgcccactt ccccttacca gcggggtggg cgcggagaag acctgccgga gccatggagg 180 acgaagtggt ccgctttgcc aagaagatgg acaagatggt gcagaagaag aacgcggctg 240 gagcattgga tttgctaaag gagcttaaga atattcctat gaccctggaa ttactgcagt 300 ccacaagaat cggaatgtca gttaatgcta ttcgcaagca gagtacagat gaggaagtta 360 catctttggc aaagtctctc atcaaatcct ggaaaaaatt attagatggg ccatcaactg 420 agaaagacct tgacgaaaag aagaaagaac ctgcaattac atcgcagaac agccctgagg 480 caagagaaga aagtacttcc agcggcaatg taagcaacag aaaggatgag acaaatgctc 540 gagatactta tctttcatcc tttcctcggg caccaagcac ttctgattct gtgcggttga 600 agtgtaggga gatgcttgct gcagctcttc gaacagggga tgactacatt gcaattggag 660 ctgatgagga agaattagga tctcaaattg aagaagctat atatcaagaa ataaggaata 720 cagacatgaa atacaaaaat agagtacgaa gtaggatatc aaatcttaaa gatgcaaaaa 780 atccaaattt aaggaaaaat gtcctctgtg ggaatattcc tcctgactta tttgctagaa 840 tgacagcaga ggaaatggct agtgatgagc tgaaagagat gcggaaaaac ttgaccaaag 900 aagccatcag agagcatcag atggccaaga ctggtgggac ccagactgac ttgttcacat 960 gtggcaaatg taaaaagaag aattgcactt acacacaggt acaaacccgt agtgctgatg 1020 aaccaatgac aacatttgtt gtctgtaatg aatgtggaaa tcgatggaag ttctgttgag 1080 ttggaagaat tggcaaaata tctggaccat taagaaaacg gattttgtaa ctagctttaa 1140 actaggccaa gcaactagtt ttcctgcaaa tcaaattttt aaagcaactt gggttagact 1200 ttgtttttga cctaacatcc cttccttaaa tgccttctgt agtttcagat cagtagggag 1260 accatataat aattgtatgg tacctgtttc aaaacatatt ttttctgttt ttataagtaa 1320 gttgatatta attaaactct tggcaatatt tcttctttct taaaggaaaa tataccttaa 1380 ctttttttct tttacactgt gaaacataca cagtagaaat tctgttactc tctgttatta 1440 atacataaat gaaaatacat ttttttccat attggcatgt agctacaaat attaaaggag 1500 gagaaaaggt aatataattt taggtttacc aaatatggtg tgtattcaaa taatacttga 1560 ccagcttatc taaaatgtac ataattttga ggtagcttat gaatttgatt ttaattatta 1620 tgttcacaag cttggaatat tagatattat tttgcatctg taactaaccg tgatcatcat 1680 ttcttgtaat ttcttgtaca tgtatattac ttgttcttaa tagatttttg gaaacaagac 1740 tttattgaga tcagtttggt tttcctgtta atttacctgt ttgactttat aatgtgtttt 1800 agttttgcag aagaacactg ttgtagttta gaaggctttt cataaatccc ctcataggca 1860 aagatgaaaa cttcccacta tttttttccc ctcttaggaa gacatactgg aaagaaaatg 1920 tttagcatct tagtgtagta tagctattgt aaacagttca tgactagatt ttgattcgga 1980 aatctatact gaccaaggat taatcttaag gattgtataa ttcattaaag ctgtggtctt 2040 tccatgtgga gactgataga aaataatttt gtcccaagtc ttatttgctg actttttctg 2100 tcatgagtga gattgttgaa caaactgaat atatgggcta tagcaagtag ctttacagta 2160 cagatcttac aattaagttt tgcttttgtt aaagtgtgta ccattttttc tgtttggagt 2220 aagacaaaaa ttgttttgac ataggttccc tagggtacac ttgctctagc atactttaaa 2280 ggccactgtt gcaaagtcta cattttatgc tgaatctgca ttctgtcagg cacccataga 2340 aagacctcag tacatgcttt gcactctcct ttgctccctt tttccaattt cttattgcat 2400 atcattttgt tgtaatacag aaagcagcat ttttaaatgt ccgtgttaag aattggcccg 2460 ctggtaccaa ctcacctcta ttttgtcagt tcatagttga agattttgtt ttatttcaaa 2520 aagaaagtac atttttgaaa taatgtttca gaataaaata atctcacttt taagtgatcc 2580 attttaaaat ttgtaattca ataaagtttt ttttgttgtt aaacataaaa aaaa 2634 81 351 DNA Homo sapiens misc_feature (1)...(351) n = A,T,C or G 81 caatctgctt ccnctaatat anccccagtc taaggcattt aaaattaaac agctcttcaa 60 cgccccaagt tattncatca ggctaagaac ttctccgaga aacgcacaag anggcaggca 120 aacaggtggg taggtgagag gtcacggggc tccatctgca agctccatct acaaggcatc 180 aatctgcgtt gtggcatcaa cgttaaaatg ttctacagct tagggatctt cttgaagcaa 240 ggttccaagc acaaaactag gtatgaccgg aggcttcaat ttagaagatg cagcatctga 300 aaacctttac cccgggnaag gaggggtgcc tgctggcatt tcatggggct c 351 82 1682 DNA Homo sapiens 82 atgctcagtc ctccaggcgt cggtgctcag cggtgttgga acttcgttgc ttgcttgcct 60 gtgcgcgcgt gcgcggacat ggcctcaaac gattataccc aacaagcaac ccaaagctat 120 ggggcctacc ccacccagcc cgggcagggc tattcccagc agagcagtca gccctacgga 180 cagcagagtt acagtggtta tagccagtcc acggacactt caggctatgg ccagagcagc 240 tattcttctt atggccagag ccagaacaca ggctatggaa ctcagtcaac tccccaggga 300 tatggctcga ctggcggcta tggcagtagc cagagctccc aatcgtctta cgggcagcag 360 tcctcctacc ctggctatgg ccagcagcca gctcccagca gcacctcggg aagttacggt 420 agcagttctc agagcagcag ctatgggcag ccccagagtg ggagctacag ccagcagcct 480 agctatggtg gacagcagca aagctatgga cagcagcaaa gctataatcc ccctcagggc 540 tatggacagc agaaccagta caacagcagc agtggtggtg gaggtggagg tggaggtgga 600 ggtaactatg gccaagatca atcctccatg agtagtggtg gtggcagtgg tggcggttat 660 ggcaatcaag accagagtgg tggaggtggc agcggtggct atggacagca ggaccgtgga 720 ggccgcggca ggggtggcag tggtggcggc ggcggcggcg gcggtggtgg ttacaaccgc 780 agcagtggtg gctatgaacc cagaggtcgt ggaggtggcc gtggaggcag aggtggcatg 840 ggcggaagtg accgtggtgg cttcaataaa tttggtgtgt tcaagaagga agtgtatctt 900 catacatcac cacacctgaa agcagatgtg cttttccaga ctgatccaac tgcagagatg 960 gcagctgagt cattgccttt ctccttcggg acactgtcca gctgggagct ggaagcctgg 1020 tatgaggacc tgcaagaggt cctgtcttca gatgaaaatg ggggtaccta tgtttcacct 1080 cctggaaatg aagaggaaga atcaaaaatc ttcaccactc ttgaccctgc ttctctggct 1140 tggctgactg aggaggagcc agaaccagca gaggtcacaa gcacctccca gagccctcac 1200 tctccagatt ccagtcagag ctccctggct caggaggaag aggaggaaga ccaagggaga 1260 accaggaaac ggaaacagag tggtcattcc ccagcccggg ctggaaagca gcgcatgaag 1320 gagaaagaac aggagaatga aaggaaagtg gcacagctag ctgaagagaa tgaacggctc 1380 aagcaggaaa tcgagcgcct gaccagggaa gtagaggcga ctcgccgagc tctgattgac 1440 cgaatggtga atctgcacca agcatgaaca attgggagca tcagtccccc acttgggcca 1500 cactacccac ctttcccaga agtggctact gactaccctc tcactagtgc caatgatgtg 1560 accctcaatc ccacatacgc agggggaagg cttggagtag acaaaaggaa aggtctcagc 1620 ttgtatatag agattgtaca tttatttatt actgtcccta tctattaaag tgactttcta 1680 tg 1682 83 1791 DNA Homo sapiens 83 ggcggacgga gcgagccctg ggcgagtgaa ttgtggctgt gggttgacgg tggagacacc 60 ccccggagag gcggagggaa gggaggcgag gctgcacctg catgcttccc gcctcccact 120 ccccagcgcc cccggaccgt gcagttctct gcaggaccag gccatggagc tcgaagtccg 180 gcgggtccga caggcgttcc tgtccggccg gtcgcgacct ctgcggtttc ggctgcagca 240 gctggaggcc ctgcggagga tggtgcagga gcgcgagaag gatatcctga cggccatcgc 300 cgccgacctg tgcaagagtg aattcaatgt gtacagtcag gaagtcatta ctgtccttgg 360 ggaaattgat tttatgcttg agaatcttcc tgaatgggtt actgctaaac cagttaagaa 420 gaacgtgctc accatgctgg atgaggccta tattcagcca cagcctctgg gagtggtgct 480 gataatcgga gcttggaatt accccttcgt tctcaccatt cagccactga taggagccat 540 cgctgcagga aatgctgtga ttataaagcc ttctgaactg agtgaaaata cagccaagat 600 cttggcaaag cttctccctc agtatttaga ccaggatctc tatattgtta ttaatggtgg 660 tgttgaggaa accacggagc tcctgaagca gcgatttgac cacattttct atacgggaaa 720 cactgcggtt ggcaaaattg tcatggaagc tgctgccaag catctgaccc ctgtgactct 780 tgaactggga gggaaaagtc catgttatat tgataaagat tgtgacctgg acattgtttg 840 cagacgcata acctggggaa aatacatgaa ttgtggccaa acctgcattg cacccgacta 900 tattctctgt gaagcatccc tccaaaatca aattgtatgg aagattaagg aaacagtgaa 960 ggaattttat ggagaaaata taaaagagtc tcctgattat gaaaggatca tcaatcttcg 1020 tcattttaag aggatactaa gtttgcttga aggacaaaag atagcttttg gtggggagac 1080 tgatgaggcc acacgctaca tagccccaac agtacttacc gatgttgatc ctaaaaccaa 1140 ggtgatgcaa gaagaaattt ttggaccaat tcttccaata gtgcctgtga aaaatgtaga 1200 tgaggccata aatttcataa atgaacgtga aaagcctctg gctctttatg tattttcgca 1260 taaccataag ctcatcaaac ggatgattga tgagacatcc agtggaggtg tcacaggcaa 1320 tgacgtcatt atgcacttca cgctcaactc tttcccattt ggaggagtgg gttccagtgg 1380 gatgggagct tatcacggaa aacatagttt tgatactttt tctcatcagc gtccctgttt 1440 attaaaaagt ttaaagagag aaggtgctaa caaactcaga tatcctccca acagccagtc 1500 aaaggtggat tgggggaaat tttttctctt gaaacggttc aacaaagaaa aactcggtct 1560 cctgttgctc actttcctgg gtattgtagc cgctgtgctt gtcaaggcag aatattactg 1620 aagaatgatc ctgttcaacc tcctagtgcc tctactgaat tattcctctt ttaaatggtt 1680 aatgaaccaa taatttttaa atcataccaa aaatagtaag aaaatatgca aacactctgt 1740 gatcaaactt aaaagtcatt gccattcatc attaataaaa gttgccattt c 1791 84 3520 DNA Homo sapiens 84 tctagagaag ccaatcagtg tcgccggggt cccagttcta aagtccccac gcacccaccc 60 ggactcagaa tctcctcaga cgccgagatg cgggtcacgg cgccccgaac cgtcctcctg 120 ctgctctggg gggcagtggc cctgaccgag acctgggccg gtgagtgcgg ggtcgggagg 180 gaaatggcct ctgtggggag gagcgagggg accgcaggcg ggggcgcagg acctgaggag 240 ccgcgccggg aggagggtcg ggcgggtctc agcccctcct cgcccccagg ctcccactcc 300 atgaggtatt tctacaccgc catgtcccgg cccggccgcg gggagccccg cttcatcgca 360 gtgggctacg tggacgacac ccagttcgtg aggttcgaca gcgacgccgc gagtccgagg 420 acggagcccc gggcgccatg gatagagcag gaggggccgg agtattggga cggggagaca 480 cggaacatga aggcctccgc gcagacttac cgagagaacc tgcggatcgc gctccgctac 540 tacaaccaga gcgaggccgg tgagtgaccc cggcccgggg cgcaggtcac gactccccat 600 cccccacgta cggcccgggg tcgccccgag tctccgggtc cgagatccgc ctccctgagg 660 ccgcgggacc cgcccagacc ctcgaccggc gagagcccca ggcgcgttta cccggtttca 720 ttttcagttg aggccaaaat ccccgcgggt tggtcggggc ggggcggggc tcgggggacg 780 gggctgaccg cggggccggg gccagggtct cacatcatcc agaggatgta tggctgcgac 840 ctggggcccg acgggcgcct cctccgcggg catgaccagt ccgcctacga cggcaaggat 900 tacatcgccc tgaacgagga cctgagctcc tggaccgcgg cggacaccgc ggctcagatc 960 acccagcgca agtgggaggc ggcccgtgtg gcggagcagc tgagagccta cctggagggc 1020 ctgtgcgtgg agtggctccg cagatacctg gagaacggga aggagacgct gcagcgcgcg 1080 ggtaccaggg gcagtgggga gccttcccca tctcctatag gtcgccgggg atggcctccc 1140 acgagaagag gaggaaaatg ggatcagcgc tagaatgtcg ccctcccttg aatggagaat 1200 ggcatgagtt ttcctgagtt tcctctgagg gccccctctt ctctctagga caattaaggg 1260 atgacgtctc tgaggaaatg gaggggaaga cagtccctag aatactgatc aggggtcccc 1320 tttgacccct gcagcagcct tgggaaccgt gacttttcct ctcaggcctt gttctctgcc 1380 tcacactcag tgtgtttggg gctctgattc cagcacttct gagtcacttt acctccactc 1440 agatcaggag cagaagtccc tgttccccgc tcagagactc gaactttcca atgaatagga 1500 gattatccca ggtgcctgcg tccaggctgg tgtctgggtt ctgtgcccct tccccacacc 1560 aggtgtcctg tccattctca ggctggtcac atgggtggtc ctagggtgtc ccatgagaga 1620 tgcaaagcgc ctgaattttc tgactcttcc catcagaccc cccaaagaca cacgtgaccc 1680 accaccccgt ctctgaccat gaggccaccc tgaggtgctg ggccctgggc ttctaccctg 1740 cggagatcac actgacctgg cagcgggatg gcgaggacca aactcaggac actgagcttg 1800 tggagaccag accagcagga gatagaacct tccagaagtg ggcagctgtg gtggtgcctt 1860 ctggagaaga gcagagatac acatgccatg tacagcatga ggggctgccg aagcccctca 1920 ccctgagatg gggtaaggag ggggatgagg ggtcatatct cttctcaggg aaagcaggag 1980 cccttctgga gcccttcagc agggtcaggg cccctcgtct tcccctcctt tcccagagcc 2040 atcttcccag tccaccatcc ccatcgtggg cattgttgct ggcctggctg tcctagcagt 2100 tgtggtcatc ggagctgtgg tcgctactgt gatgtgtagg aggaagagct caggtaggga 2160 aggggtgagg ggtggggtct gggttttctt gtcccactgg gggtttcaag ccccaggtag 2220 aagtgttccc tccctcatta ctgggaagca gcatccacac aggggctaac gcagcctggg 2280 accctgtgtg ccagcactta ctcttttgtg cagcacatgt gacaatgaag gacggatgta 2340 tcaccttgat ggttgtggtg ttggggtcct gatttcagca ttcatgagtc aggggaaggt 2400 ccctgctaag gacagacctt aggagggcag ttggtccagg acccacactt gctttcctcg 2460 tgtttcctga tcctgccttg ggtctgtagt catacttctg gaaattcctt ttgggtccaa 2520 gacgaggagg ttcctctaag atcttaaggc cctgcttcct cccagtcccc tcacaggaca 2580 ttttcttccc acaggtggaa aaggagggag ctactctcag gctgcgtgta agtggtgggg 2640 gtgggagtgt ggaggagctc acccacccca taattcctcc tgtcccacgt ctcctgcggg 2700 ctctgaccag gtcctgtttt tgttctactc cagccagcga cagtgcccag ggctctgatg 2760 tgtctctcac agcttgaaaa ggtgagattc ttggggtcta gagtgggtcg ggtggcgggt 2820 ctgggggtgg gtggggcaga ggggaaaggc ctgggtaatg gggattcttt gattgggatg 2880 tttcgcgtgt gtggtgggct gtttacagtg tcatcgctta ccatgactaa ccagaatttg 2940 ttcatgactg ttgttttctg tagcctgaga cagctgtctt gtgagggact gagatgcagg 3000 atttcttcac gcctcccctt tgtgacttca agagcctctg gcatctcttt ctgcaaaggc 3060 acctgaatgt gtctgcgtcc ctgttagcat aatgtgagga ggtggagaca cagcccaccc 3120 ttgtgtccac tgtgacccct gttcccatgc tgacctgtgt ttcctcccca gtcatctttc 3180 ctgttccaga gaggtggggc tggatgtctc catctctgtc tcaactttac gtgcactgag 3240 ctgcaacttc ttacttccct actgaaaata agaatctgaa tataaatttg ttttctcaaa 3300 tatttgctat gagaggttga tggattaatt aaataagtca attcctggaa tttgagagag 3360 caaataaaga cctgagaacc ttccagaatc tgcatgttcg ctgtgctgag tctgttgcag 3420 gtggggtgtg gagaaggctg tggggggccg agtgtggacg gggcctgtgc ccatttggtg 3480 ttgagtccat catgggcttt atgtggttag tcctcagctg 3520 85 1923 DNA Homo sapiens 85 gctgagcatc gccagggcgg gcggcagggc gcggcctctc cgccgggtgt acctcctgtc 60 gcggcgcgag acctctggtg aaagaaaaga tgttgtcccg gttaagagta gtttccacca 120 cttgtacttt ggcatgtcga catttgcaca taaaagaaaa aggcaagcca cttatgctga 180 acccaagaac aaacaaggga atggcattta ctttacaaga acgacaaatg cttggtcttc 240 aaggacttct acctcccaaa atagagacac aagatattca agccttacga tttcatagaa 300 acttgaagaa aatgactagc cctttggaaa aatatatcta cataatggga atacaagaaa 360 gaaatgagaa attgttttat agaatactgc aagatgacat tgagagttta atgccaattg 420 tatatacacc gacggttggt cttgcctgct cccagtatgg acacatcttt agaagaccta 480 agggattatt tatttcgatc tcagacagag gtcatgttag atcaattgtg gataactggc 540 cagaaaatca tgttaaggct gttgtagtga ctgatggaga gagaattctg ggtcttggag 600 atctgggtgt ctatggaatg ggaattccag taggaaaact ttgtttgtat acagcttgtg 660 caggaatacg gcctgataga tgcctgccag tgtgtattga tgtgggaact gataatatcg 720 cactcttaaa agacccattt tacatgggct tgtaccagaa acgagatcgc acacaacagt 780 atgatgacct gattgatgag tttatgaaag ctattactga cagatatggc cggaacacac 840 tcattcagtt cgaagacttt ggaaatcata atgcattcag gttcttgaga aagtaccgag 900 aaaaatattg tactttcaat gatgatattc aagggacagc tgcagtagct ctagcaggtc 960 ttcttgcagc acaaaaagtt attagtaaac caatctccga acacaaaatc ttattccttg 1020 gagcaggaga ggctgctctt ggaattgcaa atcttatagt tatgtctatg gtagaaaatg 1080 gcctgtcaga acaagaggca caaaagaaaa tctggatgtt tgacaagtat ggtttattag 1140 ttaagggacg gaaagcaaaa atagatagtt atcaggaacc atttactcac tcagccccag 1200 agagcatacc tgatactttt gaagatgcag tgaatatact gaagccttca actattattg 1260 gagttgcagg tgctggccgt cttttcactc ctgatgtaat cagagccatg gcctctatca 1320 atgaaaggcc tgtaatattt gcattaagta atcctacagc acaggcagag tgcacggctg 1380 aagaagcata tacacttaca gagggcaggt gtttgtttgc cagtggcagt ccatttgggc 1440 cagtgaaact tacagatggg cgagtcttta caccaggtca aggaaacaat gtttatattt 1500 ttccaggtgt ggctttagct gttattctct gtaacacccg gcatattagt gacagtgttt 1560 tcctagaagc tgcaaaggcc ctgacaagcc aattgacaga tgaagagcta gcccaaggga 1620 gactttaccc accgcttgct aatattcagg aagtttctat taacattgct attaaagtta 1680 cagaatacct atatgctaat aaaatggctt tccgataccc agaacctgaa gacaaggcca 1740 aatatgttaa agaaagaaca tggcggagtg aatatgattc cctgctgcca gatgtgtatg 1800 aatggccaga atctgcatca agccctcctg tgataacaga atagaagcac tcccctgata 1860 aatactttct gtgctccagg gaaccccttt tttcagacaa gaagagataa tgtcttcagt 1920 ttt 1923 86 286 DNA Homo sapiens misc_feature (1)...(286) n = A,T,C or G 86 ctcttttctg aaaaccagtt gcaaatagtt ttactcaact tttcacactc aaaaacactt 60 taaattttaa aagctaaaaa ctattnacaa attatccatt ttaattttaa aaatgtttgt 120 tgttggtttc attgttccat gttaaaaaaa aaaaatcggc ctcgtccaac aaccatacct 180 cagctgctac caccattaac ttctggctgc cgtgaagagt acttagaatt ggccccttac 240 aacttttcag aggtccaaca tatattctgt tccacggccc atgata 286 87 1029 DNA Homo sapiens 87 gaattcggca cgaggaaata aaccaagaaa ctcctgggtc tgaaaaatat tcacctgaaa 60 cgtatcaaga aatacctggg cttgaagaat attcacctga aatataccaa gaaacatccc 120 agcttgaaga atattcacct gaaatatacc aagaaacacc ggggcctgaa gacctctcta 180 ctgagacata taaaaataag gatgtgccta aagaatgctt tccagaacca caccaagaaa 240 caggtgggcc ccaaggccag gatcctaaag cacaccagga agatgctaaa gatgcttata 300 cttttcctca agaaatgaaa gaaaaaccca aagaagagcc aggaatacca gcaattctga 360 atgagagtca tccagaaaat gatgtctata gttatgtttt gttttaacaa tgctcaacca 420 taaagttgtg gtccaatgga acatacagct taatagttta tgcgtgattt tctcaaaata 480 ttgtaaaact tttgacaatg ctcattaata ttattttttc tatttgtaga ccatatctga 540 aagaaataac attttttaag gctctaccac atagacaata tcatgctaga atgtgtgtgt 600 gtgtgtgtgt gtgtgtgtgt gtatgtatgt ataggtcggg gagaggatag tggtgggaac 660 agacaaataa ggaagcgggg aggactggat aattggtttt cccccctaag aacatttatt 720 tacgtcttaa gagcagataa gtgactaaga ctgaacacat acattttgtg gagtatatag 780 ttttcttgta aatgctgttc aattattaat gtaacagtag catcaaaatt ttattcaggc 840 tttagttgac tcttttggtc agttttaaca attctcctta aaagatattt tggagtgatg 900 aatgtagttt acttttgtat ttgaattttg attttctatt tttatttttt aaatattgta 960 tttgtgcaca atgtacatta aatcattatt acatgcttaa aaaaaaaaaa aaaaaaaaga 1020 tgcggccgc 1029 88 268 DNA Homo sapiens 88 ttaaattcaa gtggaaaagc gtatcgaaat cttactgcta aaagttctag gtcctcaaat 60 gtgtattcat taatcataag atgatatcat ttgggaatca ttttattcct ttatgttttc 120 aataaatacc tgtggttggt gccaaacact actcttgaca ataggcattc aagcagttaa 180 taatgtcagt accattttta gatatcttag ttttggattt gagcagaaac ttatgaactt 240 ttttaaacag tcattaatcc atattgca 268 89 930 DNA Homo sapiens 89 gaattcggca cgagctgtct tcggccttct cttcccaaaa taatggatga cttttttttt 60 tccactatta gaggctgtta gcactcagac ttcatcctga acctggatta gtgatcggtt 120 ttgttttaag atcctaagag cacaaacaat gagacagaaa caggctccat tcgctaatgc 180 actgctcatt gaggaatgtc agtgatgaca tacatgtgga aaatttgggg ctaccagacc 240 tctccccagt ctcatctcag tctcaggccc agaatgaggt gaaaattgga gagagggccc 300 tggagcagag aaagggggat tcctgggaca tgtagggcca tgtcactgag gcaacttcca 360 gcaatgattt acaggaagcg tttagctcat gcatatattg gggccaatct gaaaaggaat 420 caagggttat gaaactctca actgtgacat tttatagggt atggcgcaac cagagttagc 480 taagtacaga tatcattagc tatatgttca tttgattgct attacatatt ctctctctct 540 gacacacaca tacacacaca cacacacacg cacacacaca cgactgaatt atattcagca 600 gtattttatg ctctttggaa actgttactt attcagatac agggtgtttt gtttttgctt 660 tttgctgatt ctctactaat tttattattc ccaatactct ctttcatttt gaattatgga 720 gtttattgca gtattgtatt ttttgagatg taaaaactat tataattaga actaaatttt 780 tcaaaaatgg aaacatgcag gttaaatgat aaaaatagtg tatttgtgaa atttgggttc 840 cgttttgttt tgtcatcata gcaaatagaa aaaaaatgag ttgattacag aaaaaaaaaa 900 aaaaaaaaag atctttaatt aagcggccgc 930 90 410 DNA Homo sapiens misc_feature (1)...(410) n = A,T,C or G 90 cctttttttt ttttttttac taagaggtct ttgctttaag ntcactgcga tgataccagn 60 ganaattaac tttnagtctt ttaagtanna ctgcaccctc gcgcaggcca ccagccanaa 120 tnctgataag tcgaagtatg gcagntgtgc tgatatanga tgaagtacaa ctgatcagaa 180 atgaaaagcg tgtctttttc cancatgcat naggccgaan tccttttgct ctcgntccgc 240 ccacatctnc ngctacacac atacacacac acacacacac acacacacac acatacacac 300 actcctagcg ctcagtctct ctctctctcc tcttctctca tgataaatca agcaagtggc 360 cctaggcagc ccttcaggag gagaagcctt taagtgcaga acaaaatcag 410 91 1568 DNA Homo sapiens 91 aagcttggca cgagggtaga tttctaggaa tgaagtgggg cagatcttat ctttgtggat 60 tacaggcact gtactaaaaa caggtttcct atttaatata aaaagaaagt gaatcttctt 120 ttggatagaa tcatccattc ccatcgccgc accccctacc ccccaaacac acacacacac 180 acacacacac acacacacac acacacacgc cctactcttc atttgctagg ggaaggtcac 240 agcacaacta aatccaggac aggacattgt gaccatgacc cagccacagt caataccaga 300 aagatgattc agagtctgaa gtggtgcccc aggtgccaac aggataacct ctaccccccg 360 actttgtctc tggggtcctg ttccttcctg caaagcccaa tccaagactg gcatggctca 420 gaggttgtga gaaaggcatg gactggaaca atcatgtcca gaggggtctg gagctttgtt 480 tcctgttcac cagcaaaaaa tgtctctccc atttttctga aagtggctga tgtaagaaca 540 ggcagaagga aaaccctttt tgtcaataac tctgtcctta aggaatggtc ctctgggagg 600 gctgtgctgc tagtgggtac ctcagtcaca cacccccaac cccaggcagc ctctagagcc 660 ttcttgcttt cattttcctt gaatgtacat aggaacaagg gggaaagtct cttactgaag 720 tgcctgaaac ccaaagctag agcttctaga gacgccgttc ttcctgtctc agcttggcca 780 gcctttcaac aatgttctct agtttcaagc tccagcttct cagaaagaat taaagaactt 840 gctgttccaa attaagtaga aagtgagact caataataac tgaactacag caaaaggcag 900 agaattacag ggagaaaaaa cttgtactta ccagcccaat tctactctcc tcaaactgac 960 acacacacac acacacacac acacacacac acacactctc ttttagggga ctaagagaga 1020 gaagcatgtt attacatttt actcatccaa acagtaatgc aaaaataaaa cggtagaata 1080 tgaaaagctc aggatctctc ccaaggctac ctactgcagg agggccaaca ggtgagatgg 1140 gaagaatgga aacagggacc gattttgtag ctcatacaat taggacacct taggaatagc 1200 attgtagtaa tggtgatgaa tatgctctgc caaattcatc cagtctgcac catcttatag 1260 ctgcccagca cactcgactg ttcatgtggt ctctttgtag tgtgagtttg gagtgtccta 1320 ttagcctgtt ctggttagga atgagttaac ggctctttcc ctcaacctta gtctagtccc 1380 agggctgagg attcagctgg atccacatgg tcttgagggt tggcatgagg agggggaagc 1440 ttttttgaat cgctttttga tcacataatc tgccatttta agagtaagat ttgctttatg 1500 gaaatcaatt cattaataaa aaatgatatt caagttgcaa aaaaaaaaaa aaaaaaattc 1560 ctgcggcc 1568 92 747 DNA Homo sapiens 92 agaattcggc acgagggaga cccagctggc ctggggtctg ctttccgaca ttttgcctct 60 ctcactggtc atgtatttat tccatattta tatggtctac ttcctgtggc tgggagcagc 120 agctcctgaa ggttccgtgg gggtgcgggg ggttggacag gacactcctt cttggaaggc 180 accaattttc ccagccccac tcccattaca cacacacaca cacacacaca cacacacaca 240 cacacacaca cacacacaca cactgattca ggccttgaga gtcaagccca agagctccct 300 tggccctgtt ccccactccc tccactggcc tctgctgttc ctgtctttgc tcacaccctc 360 acagctgctc tctggcagag gttggcatag cctaggagca gctgcaattg cacctgaggg 420 acaggcccta gagtttggtg gcccaagtcc tgaacccctc ttagaccagg tgaggtgcag 480 aggtggttgc tgcttccagt ttcccttcag acttagctgt gtgaacccca ctcctatcct 540 ttggccttag ttttcccatc tgtaaaactc agaaacgcag ttggaaagtc cttattcatt 600 tagtaagcga atatattata atatgtatag agcgcctttt gtgtaagtca ctggtcagaa 660 tcctcactga gctcccagtc cagagagaag ccagacaatt aaaacagtaa tgacaatgaa 720 aaaaaaaaaa aaaaaaagtg cggccgc 747 93 1820 DNA Homo sapiens 93 gaattcggcc gagttttttt gttagaccct tgaagctgtt tttgagaata cagattccaa 60 tacaaccaca aaaaccttac cacatctaag aaaattaata ctgattctat cttatgtaat 120 atctgttctt tatttaagtt tcccgaaata tccccaaaat atcttttata gctttcattt 180 ttttccaaac caggcaaggt ttatacattc attgcatgcg gttatgtctc tttcatctct 240 ttcaatctag aatagcccac cccatcatct tttcttctgt tggacagtta tactaatatg 300 cagagatgat gtcatatttt tcactacaga aaaagcactc ataaatatgt ataaatgtat 360 atcgatcata atgcttgaga aggaatgggc attggaccca tacctctgca ctctggcttg 420 aaggaagatg aaaagtttct agatacaaca gaggaaatga taatatagag aagtccagga 480 ggtacaaagt ctgtgtgaca aagatagaaa gtagaggaat gtgatacaaa gggagaaata 540 aaacctttga atcttggagc tatataataa atgttaagat tcttcatact gaggttgtga 600 agcaggacaa tagtgaagag gaatactgaa gaaattatag gagttttaaa aatgattaca 660 agatatatcc tatatagaga gaatattaca atttctggtg aaaactatca aatataaggg 720 gatattctcc agaacgaaaa ggtgaaagaa aacacctcat tggcactatg tagaagaaat 780 gggttgtaat tatccaccac tgcacctgcc agccacgaat ggctgtttaa acttcagtta 840 aactagttaa aattacataa aataaaaaat ctagtccctc agtcacactg accacatttc 900 aagtgctcaa tagctataca tagctagtgg ctccatatta gagtgttttc atcatcgaaa 960 aaagtttaac tggccatcac tgcaatagat tcaatataaa ggtatgctgg cttttagggt 1020 acacattcaa ggtttggtag ggagcctatt aaaactgatc aaaatccttg attgttattt 1080 agtctggatg aatcacatag gggataatga cagtgaggaa gagaacacgg aagcatattt 1140 agagtcctca caaaaaatct ggatgtgctg ggaataatag gttgtgtgtg tgtgtgtgtg 1200 tgtgtgtgtg tgtgtgtgtg tgtgactcct tattgttgat tgacacagtg gaacaatgaa 1260 ggaagatagt agaagacaag taatctagtt ttacctgtgc tcttctctct tgcaaggtag 1320 aaggctaagc ctttgatcca ggctggaggc cctgaaactg ggattgatag gatgggctta 1380 ttactgtggc cctgaactga agcccagttg agggcggcct gggaagcaag gcatgaacac 1440 agccttgata aacaaaatga gtaaaggatg cacagttaag agccaaaaag agaatagcct 1500 gaacgtgtag aaggaaacta aagctacaag ggagttaaaa gctggttgaa gtgagtgttt 1560 tgggggtttt ctgtgaatta ataattttga agaggaaaca gccctggtgc gtggggcaca 1620 ttttcgtaga gaacacaaag aaaagaaaac ctctttggta catattttct ttcagtattt 1680 ttgggcaagg agaatgatgt actttttact gacaagagta taactaaagt tgccattaac 1740 agaaataaag cccagttatc ataaaggaac tgaagtccaa gattaaagaa aaaaaaaaaa 1800 agatctttaa ttaagcggcc 1820 94 1497 DNA Homo sapiens misc_feature (1)...(1497) n = A,T,C or G 94 gaattcggca cgagctgtta tatgaacaca cacacacaca cacacacaca cacacacaca 60 cacacgcaca cacataccac atttcaataa gtcttcattg ttctgggtcc ttacctttcc 120 tgtcctcctg ttatatgaac acacacacac acacacacac acacacacgc acaccacatt 180 tcaatgtctg catggttctg ggggtaacaa aggcaagaag ttaaagtaag accacatttg 240 ragtattact tactctgtmg mayywwramm kmrtwkwkaa mmccmmwtww ksmaamywmy 300 tttttttttc mgsmwraarg ggrarsykrm mwkrwymaaa wycmwkgktt tymaaawkgr 360 amykgraaar rgsmwtyccr smmmmwytww wammmmawtt wawtttymar ktycmrggsy 420 tkrmmrgscc ykggggsmwt yywarsmarg rwtgsmwwaa wtkggymawy ytgkkgraar 480 rktkggkwmy tttkgytyma wttttwawtw mccmawyytt yyyykgattg taattacctc 540 caytactttc atgatccccc tacaaatatt tttttaaatg atatatttat tcactgaatc 600 aaatgtcatt aatgagttat cttcttgtgg aggatgactg ttctctttgt taatgttcac 660 aatcaagatc ttgggctgag aagaggccct tcacccaagg agtttgaagt atcacagcgt 720 gtggggaagg tgggaaccag ggatacccat tcatttccma ccgagacaca ggaggaagtg 780 gagtcacaga attttgagcc cgctctcttt gactgcccag ccagagacac ttgattyykg 840 taacctcttc acttggatcc tgcctyttna agcwttaaaa ccattctcct taaacctctg 900 agtgttttgt gggttctggg tgttttgtac attttagcca agctaaccac ttgtctgcaa 960 gtacttgact ttcctatgaa ttctttgaag attattgagt cagaaaggaa aaatatagcc 1020 ccaaattccc aggcttttaa tgcattacat taactgccta ttgaaatgag aagttcttca 1080 caaacttgta tacccactaa caagattgca cataaacatg caktaaagta tatactraga 1140 wrccmtctgt ccaacggctc atgcatatgn aastccswwc atgggagytt gccaattgca 1200 ttcatcaagt cgttttgcgg agtcagatcc ctgatggaag agctcacagg ctctgccttc 1260 caagtcctgg gttcctaact ggtgacctta gcctggggtc tgtggggaga ccaaccctgg 1320 cttccaagaa aaccacattc catggactat cagaaataga cacagatttg ggtgacaaag 1380 ctggctctgt atttgcattt tatttttgtg twmwatgtca gtttgggaat gattaatatt 1440 aaacatttat ttgagaaaca aaaaaaaaaa aaaaaaaaga tctttaatta agcggcc 1497 95 583 DNA Homo sapiens misc_feature (1)...(583) n = A,T,C or G 95 cccacgaggg tgcaatcctc gtaggctgat cggtcccatt tcaacactgt gagactgagg 60 gtacattaga ggaaatggtg tatatgatcc ctatgaaacg attctttggc ttttgtttaa 120 aaacaaaacg ggtttgttct cataatctat agaactatga agattactgg atcatatttt 180 tttctcttaa ccaggagtgc ctcagagatt ctgctatgac tttggacttc tctgagtctg 240 tgcaatcatt ttctggagaa gcatggggaa aggtggtaga ctgctgcact ttttcattaa 300 aatgagggta gctctttctc caccccccca tctcctttat cccgaagaca taaatgttca 360 attacggagg catttaaatc aagttgtgac cacctccatt ggagggcagg actcttgatt 420 gtgtaattga taatgcactt tctcaatggg ctgtatagtc attattaacg tgtcttccct 480 cttccccaca aggacatata aggncatttc tgccttcaag tttggccaac taacaaatca 540 gaatctgagg ggcatgttct atttcccagg aatgattgac act 583 96 943 DNA Homo sapiens 96 gaattcggca cgaggggatt ttttaaagct tttctgttca ccctcctgcc aggaaaatcc 60 cagaaagctt aatgataccc caaaatgatt acacccaggg aggaaaaaaa ggagcgcttt 120 ctagggtcag aatcgtggag agaatactca gaaatgaacc tctttaaagc cttgcaggaa 180 tgagtcactc ttacttaatg aaatgttaaa gccaattaaa aagcatgctg tgatgcccag 240 cttccctttc cacagggtgc atgcgtctcc tgctggtgaa tcacatgcgg caagaggcaa 300 ctggctccac agcctgggat gctgccgtac caagaggaaa gaagcagcaa aatgccttta 360 cgttgttcta aacccccgac gcataaagtg tagaggaggg atggccaagg gtgggtggta 420 gaaagtgtgt tcaggctgac actggcaatg agtacagata atttcacttt cctcttctag 480 gggcaaaggc tgatggcctc tacctttgta tccaggagaa actgcagagc agccctgtga 540 ctttacaaaa tatgctacct caaagtgcta ccgataaacc tttctaattg taagtgccct 600 tactaagggc acatgtctta atcaaagtta gttttttgtt ttctggtttg tttttttttt 660 ttgtatattg atgaatgaga tcttacctat taaatatatt attggattat ggttcctgaa 720 ggtcattaga gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt tttatgactt aaatatcttt 780 acgtgtgttt tttagagctt ggttctttaa agatttggag aagatatgta aattaccaag 840 gcacttggtt tttctgtttt atatactaat aatcagggcc taagttaaat aaaaatatgt 900 gtgcatgtat tttaaaaaaa aaaaaaaaaa aaattgcggc cgc 943 97 566 DNA Homo sapiens misc_feature (1)...(566) n = A,T,C or G 97 agggantaag cttgcggccg cttaattaaa naanatttag cgtaaaatta cacttaaaca 60 ttatcagctg ctgctgggaa aaaatggaca aattgcccag gcagccacat tagaagaaga 120 aagtcattng aatacagnta tatacttatt tttattgaga cacatcttgc tgngtcaccc 180 agggttttgc tctgttgcca cagcttactg cagccgtgac ccaggctcaa gtgatccctc 240 ccacctcagg cccctctccc cgaccagtag ccgagactac aggcaggcac agactggcac 300 caccacactc ggctaatttt ttttttttga ggcagggtct cactatgttg tccaggctgg 360 tcttgaactc ctgagctcaa gtgatcctct naccttggct tccaaagtgc tgggattaca 420 gacaagtcat ggcanctggc tgagtacagt tattcancat aagcataaca aatacagaat 480 ggcagcccag ttcctttgnt aatgaaatng taaggggtgt actagggcaa gctggccctg 540 attatgtcac atgagtttgg tttaga 566 98 454 DNA Homo sapiens 98 gttcatcacc atggactgga cctggaggtt cctctttgtg gtggcagcag ctacaggtgt 60 ccagtcccag gtgcagctgg tgcagtctgg ggctgaggtg aagaagcctg ggtcctcggt 120 gaaggtctcc tgcaaggctt ctggaggcac cttcagcagc tatgctatca gctgggtgcg 180 acaggcccct ggacaagggc ttgagtggat gggagggatc atccctatct ttggtacagc 240 aaactacgca cagaagttcc agggcagagt cacgattacc gcggacgaat ccacgagcac 300 agcctacatg gagctgagca gcctgagatc tgaggacacg gccgtgtatt actgtgcgag 360 ggggccaaga ctattagccg acgtattact atggttcggg gagttatccg agtttgacta 420 ctggggccag ggaaccctgg tcaccgtctc ctca 454 99 122 DNA Homo sapiens misc_feature (1)...(122) n = A,T,C or G 99 agggcgaatt gggccctcta tatggatcgc actttttttt ttnttttttt ccattcacta 60 attgtaatta atttagcata agcaaagaaa tgaccttagg aacataccca ggttttaaga 120 ta 122 100 967 DNA Homo sapiens 100 gaattcggca cgaggctgga agtggcagaa ctgagatttg cgttccaacg tccattccca 60 tccttccata tcaccctgat tttctcgggt tcagagtcct ggttcatttc ctggctgttc 120 cgcagacatg tcacaaactc cagaaccttc atttctccat ctgcaaatgg caattgtaat 180 tcttgctctg tcaacctcac agatttctct cgaaggcata cacacacaca cacacacaca 240 cacacacaca cacacacaca ctagaaaact gtaaagagat gtaaacctta ccgaataatt 300 acagggtatt ttgattggta tttttactat gattattttt gctaatcaaa gaaaccagac 360 aggtagtgtc agggaattgt ctaaagcaat gagacattct tgaaaagtct gtatcagatc 420 tccacttctt gccagagaaa atcgccttaa ggtgtccata ggtgtcctgg cttccagtga 480 ggcaacctag caattaggaa agaaatgcat ggtgagtgct tcgtatgggc actcatcaaa 540 tgagcctttc agagctcaat agaaaaccct atcccagtga atcttctgtt gtgctgaaga 600 ttgcagctga agattgttgt cccacacagc acagtgatgt tagaattggt tgagctccta 660 atgtggcaag accccacaca tttctagatc cacccagaat gaggtaaacc cttccaaaga 720 aaaagagaaa tatcgaatgc tgtattttga gtcttcttac tctgtgggat tgatagagca 780 agaattacaa gaattctttt gagtctaaga caccactgat tttaaattac acttaaagtc 840 ataccagtga tttttggaga ggaggaaaga aaataccaca tttaacaagt atatcaattg 900 ttagaagtag cctaatttca aaaatgttaa aaatgtaaaa aaaaaaaaaa aaaattcctg 960 cggccgc 967 101 588 DNA Homo sapiens misc_feature (1)...(588) n = A,T,C or G 101 tttttttcag agtaaacngc atgtttattt tgaacattca agtttacaaa aacaaaaagg 60 tntttnaacc atgacacann tcacacacat acacacacac acacacgcac acacacgcac 120 acatgttgca gctcatgtca atttatgtac aaaacaggga gaggagaaag gggcaaggct 180 ggggaggggt tgtcagtagg gtgcactaat gtcacagtgt cagacaactt gacatgctca 240 ctcacactca gcctgggccc atgtgagccc cttccccacc caggggtcgg gggtcagggt 300 gggaggtggg ggtctggggt ggcaggcagt ggaataaagg ggtgaagaga gtagtccctt 360 ctctgggagg gagccccttt ccaagtttac tcaggccaag ggtgctggga cacacaaagg 420 aggggggact caatgctggg gagaggctgg ctgcgtccta naagagggct gaatgcagtc 480 agaaggctgg gcttaagttt nccgtgtcag ctgggtggcc ttgaggtcgc tcccctcccg 540 gcttnacttc ctcatctgta aaatganggc tttggccttt tttaaaac 588 102 553 DNA Homo sapiens misc_feature (1)...(553) n = A,T,C or G 102 ntcctttttt ttttttttaa tagtatcatt catttgtaca gagaaatcat ttggatggat 60 ctatttacag tcttttctga ttatcatttc cactggccaa atatttcaca gaatagtcaa 120 cactgacttg aattgatcac cattataatc gggcttttac tcctcctccc ccctttcaaa 180 gatgatgatc ccattttaac agaaacattt tgtaataaaa gattcaccag tctttttcca 240 tcttatgact aaatccacca aaatttatct aatatggtca aatttttaac acatttcatt 300 gtttcttttc aaactcatta tttgcaggta ttgcaaacca aggcaaataa gtccacgtcc 360 cctcgagcct tctacaactt actacacgcc ctcaagttga gcttctccta tctcctttca 420 cacttgtgaa atgtctggca caaccagaca ttttacttga agacaaaact actctctttt 480 cctctctttt tcttttaact cactaccaat caccttccct cttgcatttc agacaacact 540 aaaactttca aca 553 103 1650 DNA Homo sapiens 103 aagcttggca cgaggtggat ccactagcta cactggctga gaatgctctc accccaggat 60 ttcattttta ttttaccaca tcattgttgg tatcttaaga tcaatgtact ggagcagcgg 120 ggtctcacaa agaggatacc tggtgacacg cccaggcttt cagaatgcac tatagggctt 180 tagtgacttg tccaggttca gctgaaatgt gccatctggg acctactaat gcttgttgaa 240 ctttactgga tctcagaagc tgggtctcag aagctcagat gttcctcaga gctacgatat 300 caacaacctg tgatgacaga gagaaggttg ctccatgatg gatttggaaa cttactggct 360 agctaaacct gactgaatgg gaaggaatgt ggatagcttt ggaactctag tttcactaga 420 tgagctggaa tttgtatttt gacaaattgc acgttatgat tattaagtaa tgcaactgat 480 ttttttttcc cttaaaacaa acaatctaga atctgtgtaa tcaaaataat ttctctaaaa 540 ggctgcaagt atatgcttaa agtgttgggg cattcagagc atttggaaca ttacattctt 600 ttgaatgtca attggtagat gaaaatacca gcttttaagt catacatttg attttttgaa 660 acaatatgca tttagagttt gtaagtcaag tgaataactg ataaggtaaa aaaaaggggg 720 agttcattgt tgagtatgaa tttaaagtaa ccagactgcc ttttgtccag tggctgtcag 780 taatttactt cagcaggcat tttttttttt ttgaggctgt tctatgatat catgaccctt 840 cttgtaggga tgagcttcca gtggtgaggc agtctgagaa tgtgtgaagc agtataatga 900 agccagacca agatggaagc ttggcctggg atttgagcat caggaaaact gttgaagggt 960 tatgtataca tcacacacac acacacacac acacacacac acacacacac actctcttcc 1020 atactcctat aacaacgtat agtatttact atacctggtg acaggtattt actatacatt 1080 gttgaagatc tataacatgg aatgcctagt gctaagtgca gtgtccttag tgaaattgta 1140 ttggtttgga attatttatg agtttgggat tatttgtcac tacccttaaa tgatcttgac 1200 actcacctat ttgaaaagat attgaggatt tgccatttga tattgaccag ggtgtattgt 1260 gcacaaatat tgtgaatata catctgtctg tccttaaatc actgtaagtt ttaactggaa 1320 tagatttgct ccacattact cggtagggct gatatttcat gcctcatgga tgagaaaaga 1380 ataggcaaaa attatatctc gggctgcctc acacatcttt taacaggata agggaaaaat 1440 aaatataaga cctatgagtt atggcatcag gcttgaactt taatttatga attaaaccaa 1500 caatattatt gattattgca attatctatc ttaatttcat ttgttctcct tttaaaaatt 1560 aattatgttt attttaccta ttgtgaataa agtcactcct cccatgtgct taaaaaaaaa 1620 aaaaaaaaaa aaaaaaattc ctgcggccgc 1650 104 590 DNA Homo sapiens 104 ggaatccttt tttttttttt ggaattataa aacaaggctg agtctgaagt taaatgtgtg 60 attatgctag aaatattttg ctagactctt tgcatctctc cctgattgcc tactttctct 120 ccattctgta cttgcacagg agaaatgaaa acacaattct tgtggcacgt ttggtggaaa 180 aatttctttg aatgtatttg ctaaaccaag agatcttaca aaacatggta aaatactttg 240 gctatatttc catcagccca ctgaagtgag ggcttgagaa gcttagtgca ccttgttttg 300 tgagggagga ggcaatgccc ttttatgaca atattcttga attcaatgtt tgtttattcc 360 cttacttcta aatatgcatg tatctacgtg tgtatatatc tgtatgtaca tgtatatacc 420 acacacacac acacacacac atgcatgcac gtgcacacac acacatacac acacacacac 480 acacagtgat tccttgcaag agttccttaa ctgatttcaa atttttattt acttatgtct 540 ttattttgta gaaggtggtg tgggtagatg acagggtgtg agaggcgaaa 590 105 541 DNA Homo sapiens misc_feature (1)...(541) n = A,T,C or G 105 tccagggaat aagcttgcgg ccgcttaatt aaacgatctt tttttttttt ttttttttcc 60 tctcatttag tctcagagcc taaaaagaaa tgcctccagt ctctgttagc cccgatgttt 120 ggaatgaaat taacaagatt ctaccttaaa agagaaaact tatgtgggct tttcaaattg 180 tgaaaatttg ttccctctta taaaatataa tctttcccct gctgctggtt tataaatatg 240 ggcatatagc ccagagccat tataaagaaa aaacaaccaa ccacaataaa ctaaggagcc 300 tcatctgatg gctaaggttc tcaggaaaaa atgagaagag caccttgatc aggaaaggaa 360 aaaaggatag aggataaaaa cagtaacctt taacttctat gccctnactc agccagtaac 420 ttacggcagg tgttgctggc aaggccttag ctgnatttct tcattaagtt gaacatcctg 480 tctgccactc ctaccaaccc agctgctnat aagctgccct gagcacccan gaaaagaagg 540 g 541 106 776 DNA Homo sapiens 106 gaattcggca cgagcactac tgaatcttga aactataaat atattattga tatggaccac 60 aattgctgtt ttggaaatca gtgttcacac atcatgttca agcagttaca aagattttat 120 gtagataatc agtcagctga tatattttca tgagtcatta attttaagat actctatgag 180 tcacatctgt gattttcagc aagctatatt tatgataaat gatggacaga ttttgagtag 240 tacagattga aaatttttga ttaactcaaa gtgaagtatg ctgagagatc aaggacacag 300 acatactctt tctctagcat gtgcgcgcgc gcgcacacac acacacacac acacacacac 360 cactcattgt atttgaggtg aagcagttgt taatgtgtgc tttgtacctc acctaggaaa 420 atcctaaact ttctttttaa ctattttaca aaattggggc acatacttaa gacatttcat 480 taggtggtgg tgataatcat tatataaaaa tctaaagcct gaagtgaggt tttaggcttt 540 gcatagatta taatatgggg aaatgtttgc aatgtgataa catatacatg atgtccacta 600 ctcacctgta attagtctga ggtagtgggt tgatgttaag ttctctattc aggcttcaag 660 atactgtttg ggggctggcg gggagggaag gtgcagccca cttttcaaaa gaggaagaat 720 tggttgtaat gttggaaaaa aaaaaaaaaa aaaaagatct ttaattaagc ggccgc 776 107 468 DNA Homo sapiens misc_feature (1)...(468) n = A,T,C or G 107 attaaccctc actaaaggga ataagcttgc ggccgcttaa ttaaagatct tttttttttt 60 ttttttttga gggttttctg ttatttcttt attggggtgg gggtggggtg catcattcag 120 atctttgtgc tggtgcctac gtgcatacaa gtacacacac acacacacac acaggcatgt 180 gttcacgtat gtatacatat acacacaagg ccagagctct agtgtgctgg aggaggggca 240 agctcttttt ccaagagggt attagaaaga ggttgattcc agaggatgag tggtctctga 300 ggctatagcc ccccactggg tgggcagcca gctctgtgag aatgccaggg tgcagctgac 360 agcgctggag gcctggggac tggactctga gaggagcttg ggcagacaca gcagcctccg 420 gccccaanac tgccctgggt tggcaggccc aaccctggtc ctgacagg 468 108 515 DNA Homo sapiens misc_feature (1)...(515) n = A,T,C or G 108 tccttttttt ttttttttaa attgaattta tactttatta aaatcaaaca atacaagcct 60 taaaatttga ttttntaaca ttataaaact atgcatcctt tatgaagttt cagttgatat 120 ctgattaaaa aacactttgt ttcataagtg ttcagtgatt tatgaaactt ttaaaacaaa 180 ttaagatggg atttattaca tcttatagcc attattggac ccattctaca ttttgaaaga 240 ctaagagaat agggttagct atgggaaatg ctggctcact ggaagaatcc tgcattttcc 300 aacttcccca ctcctagaag ttttgctaac aggaattgca actaggaatg cctcacctga 360 aaaactaatt tcatacaact ttcattaagt agtttgacaa tctgtgaccc acaaatactt 420 ccatagaatg gtagaattat ttataatcag aaatggatgg tgggggtata aagggaatca 480 agagaggana gaaganggct aatggtggtt cttca 515 109 1179 DNA Homo sapiens misc_feature (1)...(1179) n = A,T,C or G 109 aagcttggca cgaggaattt cttaaagcaa acaacaaaaa tgtacatttc tgtttttcct 60 tttaataaac aggtgtactc tttatcatgg ttggtatgat ggaccattct ttggggcgga 120 ggattgatta tgttactctc tttaaaatct gttcccatat tgaacaggca gattggaaaa 180 gctatggttc gatttctcag aagaaatgtt taggtcttag tcaatagttt taactatgcc 240 atttgtttaa atgagtgcat ttgcttcgag ggtagtgtct tactaaaagt taggaacaga 300 gacctagtgg gtgtgtccaa ggccgtgtca ctttcccctt cagcacaccc cagcttctga 360 cctcagagcc caggagctgc gtggacagtg tggggtgcca ggaggagggg cggtggctgg 420 tcctcaggca cgctgcactc ccagccagac atggtctttc cgtttcttaa gtagcaagtg 480 taggtttcag ctggcagttc cacctgcatg ttctctgctt cgctgccttg gaaggggcca 540 cattccccat tcctcttctc cttacagcgc ctgcctcctt tttcaagcag gcggaaagct 600 gctgtttctc acgtttcagg gagaggggtg agcggaggga gacctgtgtc cgtgccgtcc 660 ggctccctgg gtgggaacag gcaagggatc agatgcccct gacaccacgc ctctggccac 720 accagatgcc tctgcagtcc tcgacagcct cttcagtgtc cctcctgcgg tgatgtcctt 780 actgtcccca gccagggccg gggaccggtg tttcactgag gacctgcatt agaaacattt 840 tttaaattgt tgtacaggaa gagatgtgtc taaaacagca tcttaaagct gagtgtattt 900 ctttgcacaa ggggtcatgc tgatgaattc ttctttcatt ctgatctttg ttcagccaac 960 aggagcgtcc ttttctaatg tcttccattc ctacccccca cccaaaaaca aaagaaatat 1020 ttgtagcttg ctatctgtat ttgaattttt agcaatttta tatttagata ctttgaaaaa 1080 tgtaaatgac taatttggtc attaaatctt gtgacatatt cgatattaaa atgatattaa 1140 aataaaagtc atataaatca aaaaaaaaaa aaaaaannc 1179 110 510 DNA Homo sapiens misc_feature (1)...(510) n = A,T,C or G 110 ccngggaata agcttgcggc cgcttaatta aagatctttt tttttttttt tttttgagga 60 gataaaccaa ttttatgtct atcatgttat acaaaaatct agaaataata gatttgtaca 120 gaaaaaaatg ataataaatg agaacacaaa acatataatt taaatttggt attttttccc 180 ccatgatatt aggatgataa tcatttcaaa gcacatgtct agcttcagag taggatttgt 240 tcactggcca aagcctgcca tgaaactatg gctttcagca tctgtctgct ctactggctc 300 ttgacaaaac tcttgaggtc ttcaagaaaa gtaatgtact cctggtgctc cagggctgtg 360 ctgagctcca ccagctcatc tgcaaaagtg ttgtccaccc ctnggtcggc aaggaaatcc 420 attaggtggt catataaggc ccagtccaag gaatctgtgt tgagtgtata attagtattc 480 ttccattcag actcgccagt ggactaaaag 510 111 1634 DNA Homo sapiens 111 aagcttggca cgagggcctt tgtaacaata aatagtgata gtgttgtttt cattcatctc 60 atccatttat aagtctaggt attagatcta agagaagata ccctctgcat ccaactgcta 120 aagcagggaa ctgggcaagg agctacatcc ttcatcaact atccagtcaa atgcaaggga 180 aagggctgaa gcagcaagca aatgaactca gaagaggtga aatcaatgaa tttcatgttc 240 tttccattac catttgctag gtcagcctag ctatcctcat ggtcaaagat taataaacag 300 aaataaaaac aaattcacca ttgctaggca ctacaggaag ctaaaaagga aatacttgaa 360 gattcagaaa aaaataaaag gaacacttac agtgatttac taccaaaata aaaacatttg 420 tgtttctcga taagtattgt attcccggct cctaaaatct ttgtatgaca gatggtcagc 480 attcaataaa tatacattga attagtgaat aatcttttag aaaatgattc catatcctca 540 gtgggtggca agaagtcttt gaatccataa agcatgaatg taaggctata gaaagaataa 600 actgagacca aaaaatatat agagagagaa agagagaaaa gaaaagaaag caagaaggca 660 agcaagaaag aaaaaaacag aaacaaaaga gaaagaaatg aaaacaatgt acaaagtaag 720 aaaatatgaa aaatgaaagt gcaattgagg gattaataga tgcgtgtaaa taaaattttc 780 cacatatata agaatttttc catagataga tagatagata gatagataga cagacagata 840 gatagataga tagatagatc ctactctagg tctataattt gtcttttgat gtcatgttat 900 tttttaataa acaggaatat ttattatata aaaaaatctc tctctccccc catggcccct 960 tcttcctggt ttctagtttt tatgtctgac ttagaaaaac ccttatcaaa ctaaaattat 1020 ctttctgatt ttccctaatt ttatatcata tttttaattt taatcttttt aacctaactg 1080 aaatttttta ttatgtctga tgagcaattt gtgtttaata aatgatatta aagaaagaaa 1140 ctttggaaga agtcactgat ggtggcttgt aattacagac taagtaattt ggatcatgat 1200 tccttccaaa gacatcttaa aagctgaaaa attataaaaa taatctcttt gtaggctttg 1260 gagaattaag aagatggtga gaaaatagtg ggcaatgatc cataagaaga taaacatctc 1320 aggccgggag cggtggctca cacctgtaat gtcagcactt tgggaggccg aggtgggcag 1380 atgcttgagc tcagaagttc aagatcaccc tggctaacat ggtgaaaccc tgtctctact 1440 aaaaatacaa aaattagcca ggtatggtgg caggtgcctg taattccatc tacttgagag 1500 gcttaggtag gagaagtgct tgaactgggg aggcagaggt tgtagtgagc caagattgtg 1560 ccattgcact ccagcctggg caacagagtg agactccatc tcaaaaaaaa aaaaaaaaaa 1620 tttcctgcgg ccgc 1634 112 426 DNA Homo sapiens misc_feature (1)...(426) n = A,T,C or G 112 nntttttttt ttttcctatg gatgtttagt tctaaaaagc accatttctc aaaaaaacta 60 tccttcctcc attgaactgc ttttgcacct ctgtcaaaaa tcaattgggc atatttgtgt 120 gagtctattt ctgggttctt tattctgttc cattgatcta cgtgtctatc cctctgtcaa 180 taccacagtc ttgattactg tcactaaaaa gaaagtctta aaatagggta gacagactac 240 ttccaattca ttcttctttt ttaaaattgt tttatctatt ttggtttctg tgcctttata 300 tataantttt agaacaagct tgtctgtatc tataagaaat cttgctgtga ttctaatagg 360 aattgcatta nacctataat cactttgggg agaattgaca tctttacgat gttgattntt 420 ccaacc 426 113 727 DNA Homo sapiens 113 agaattcggc acgaggcact aagatgtgtc ttaagaatca cagtgcgtgc ttcatccctt 60 tattgaagaa cagaaaatta tgactactct acaaggtgga taatattttg gtacctgtgc 120 ttgccacagc cctgttcctc aaagctgaat tgatagattt ctctttgact tccaagacct 180 agcagttata aggcaccttg aaataaattg tttgtgcctg gaaatgcagg gagggcaata 240 gctttgtaaa ttggtttaca tttttctcct tgaatttttc tagggtccta gtgcttccga 300 atcatttaat ggcattgtcg gatatctttt acatttcaat tgcaatccat gaaattacat 360 ttagaagatt cttagtactt aactgtagtc ttctccatga attacacgtt agaatagact 420 ggcagcaact gaatatgcag caagtaagcc tctagcttat agtttcatcc ctacccctca 480 tgcctgcgtg agtctgtaca gggatatgtg tgtgtgtgtg tgtgtgtgtg tgttagagag 540 gaagaggaag agcagaatgt ctgtatacta catgctgcta aggtagtgaa taaatcagta 600 atgcaatatt gtgggtccaa actactcttt gcactacttt atttacagta gtaaataaaa 660 ttatttttat acaattgact accaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaagatg 720 cggccgc 727 114 2291 DNA Homo sapiens 114 gaacaatgaa gaaagcccca cagccactgt tgctgagcag ggagaggata ttacctccaa 60 aaaagacagg ggagtattaa agattgtcaa aagagtgggg aatggtgagg aaacgccgat 120 gattggagac aaagtttatg tccattacaa aggaaaattg tcaaatggaa agaagtttga 180 ttccagtcat gatagaaatg aaccatttgt ctttagtctt ggcaaaggcc aagtcatcaa 240 ggcatgggac attggggtgg ctaccatgaa gaaaggagag atatgccatt tactgtgcaa 300 accagaatat gcatatggct cggctggcag tctccctaaa attccctcga atgcaactct 360 cttttttgag attgagctcc ttgatttcaa aggagaggat ttatttgaag atggaggcat 420 tatccggaga accaaacgga aaggagaggg atattcaaat ccaaacgaag gagcaacagt 480 agaaatccac ctggaaggcc gctgtggtgg aaggatgttt gactgcagag atgtggcatt 540 cactgtgggc gaaggagaag accacgacat tccaattgga attgacaaag ctctggagaa 600 aatgcagcgg gaagaacaat gtattttata tcttggacca agatatggtt ttggagaggc 660 agggaagcct aaatttggca ttgaacctaa tgctgagctt atatatgaag ttacacttaa 720 gagcttcgaa aaggccaaag aatcctggga gatggatacc aaagaaaaat tggagcaggc 780 tgccattgtc aaagagaagg gaaccgtata cttcaaggga ggcaaataca tgcaggcggt 840 gattcagtat gggaagatag tgtcctggtt agagatggaa tatggtttat cagaaaagga 900 atcgaaagct tctgaatcat ttctccttgc tgcctttctg aacctggcca tgtgctacct 960 gaagcttaga gaatacacca aagctgttga atgctgtgac aaggcccttg gactggacag 1020 tgccaatgag aaaggcttgt ataggagggg tgaagcccag ctgctcatga acgagtttga 1080 gtcagccaag ggtgactttg agaaagtgct ggaagtaaac ccccagaata aggctgcaag 1140 actgcagatc tccatgtgcc agaaaaaggc caaggagcac aacgagcggg accgcaggat 1200 atacgccaac atgttcaaga agtttgcaga gcaggatgcc aaggaagagg ccaataaagc 1260 aatgggcaag aagacttcag aaggggtcac taatgaaaaa ggaacagaca gtcaagcaat 1320 ggaagaagag aaacctgagg gccacgtatg acgccacgcc aaggagggaa gagtcccagt 1380 gaactcggcc cctcctcaat gggctttccc ccaactcagg acagaacagt gtttaatgta 1440 aagtttgtta tagtctatgt gattctggaa gcaaatggca aaaccagtag cttcccaaaa 1500 acagcccccc tgctgctgcc cggagggttc actgaggggt ggcacgggac cactccaggt 1560 ggaacaaaca gaaatgactg tggtgtggag ggagtgagcc agcagcttaa gtccagctca 1620 tttcagtttc tatcaacctt caagtatcca attcagggtc cctggagatc atcctaacaa 1680 tgtggggctg ttaggtttta cctttgaact ttcatagcac tgcagaaacc ttttaaaaaa 1740 aaatgcttca tgaatttctc ctttcctaca gttgggtagg gtaggggaag gaggataagc 1800 ttttgttttt taaatgactg aagtgctata aatgtagtct gttgcatttt taaccaacag 1860 aacccacagt agaggggtct catgtctccc cagttccaca gcagtgtcac agacgtgaaa 1920 gccagaacct cagaggccac ttgcttgctg acttagcctc ctcccaaagt ccccctcctc 1980 agccagcctc cttgtgagag tggctttcta ccacacacag cctgtccctg ggggagtaat 2040 tctgtcattc ctaaaacacc cttcagcaat gataatgagc agatgagagt ttctggatta 2100 gcttttccta ttttcgatga agttctgaga tactgaaatg tgaaaagagc aatcagaatt 2160 gtgctttttc tcccctcctc tattcctttt agggaataat attcaataca cagtacttcc 2220 tcccagaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 2280 aaaaaaaaaa a 2291 115 637 DNA Homo sapiens 115 gcggccgcct tttttttttt ttttttttag tttgtaaaag tcttttattg tatccgtgcc 60 acacatagtg aaaaataaca ctcctaaaaa aagaatgcta ccttttccac aacattttat 120 tttaaataaa acttcaagta ctcttacgta ggtacaaaaa aaatctgatc tatttgcctc 180 caacaggcca ccacaacaca cagtagataa aacacagtgg ttacaaacgt cttttaaatt 240 tatttctgag gcaaggcaaa tgggagggaa atgtttctat gaaaaaatac tgtgtgcgta 300 ggaaattgtc acaattttat tccacatgga tacaaatgat tatactttaa tttaggccct 360 ggtggcttaa aattatataa caaaatagaa aaatggaaaa ctaatatccc ctacaccctg 420 tttcaaaggc aggcactacc aagattaagg agacgccaca gtgttggtag aggataatta 480 ctgtacagac tgtatagcta tcattacctt cagacgaaaa taaaatgcta caatcctcta 540 aggcatgaac aataatgtct gcaaacaata tatacacata atacatattt taaaacaaga 600 cttaatataa acaagaatga accctcgtgc cgaattc 637 116 664 DNA Homo sapiens 116 gaattcggca cgagggcaga cacaactcag ctcccttact gtcctcaggc ccggctattt 60 caagaattcc agaaaaagag tgcaccggcg tgtgcgggcc ggtgctgccc ggaaaacccg 120 tgaagcaggc acgcacggcc cggatgcaag cacatctgtc ccctccccca aaggtctccc 180 cagctttatt gatcgcgtgg gtgcgggtag ggatctaaat ttgtctccca gattttctct 240 gaaatcgagt ctcttgggag tgaaggtcca tatgattaca ccacgtcctt agcagtcgcg 300 ttgtgttcaa aatgggcatg ggtgctcgcg gcgcggatac tgagttcccc agagacgcgg 360 agtcttttgc cccaggggct tattcttgtt ttctcaatgg aacaggtctt ctaatctccc 420 caggaacatc tcagtaagta ggggtgtgcg tgtttgtgtg tgtgtcagtg tgtgtgtgta 480 aatggttcct atgagctgac agtttggtat ttaaagaaca aatggacata agcacagaag 540 tcatgacttt tctatggata agattgagat ttctgagatt tccaagacaa ggttgacctg 600 tcacgggata gtattttcaa tccttctcat ttaaaaaaaa aaaaaaaaaa attcctgcgg 660 ccgc 664 117 515 DNA Homo sapiens misc_feature (1)...(515) n = A,T,C or G 117 tccttttttt ttttttttaa attgaattta tactttatta aaatcaaaca atacaagcct 60 taaaatttga ttttntaaca ttataaaact atgcatcctt tatgaagttt cagttgatat 120 ctgattaaaa aacactttgt ttcataagtg ttcagtgatt tatgaaactt ttaaaacaaa 180 ttaagatggg atttattaca tcttatagcc attattggac ccattctaca ttttgaaaga 240 ctaagagaat agggttagct atgggaaatg ctggctcact ggaagaatcc tgcattttcc 300 aacttcccca ctcctagaag ttttgctaac aggaattgca actaggaatg cctcacctga 360 aaaactaatt tcatacaact ttcattaagt agtttgacaa tctgtgaccc acaaatactt 420 ccatagaatg gtagaattat ttataatcag aaatggatgg tgggggtata aagggaatca 480 agagaggana gaaganggct aatggtggtt cttca 515 118 580 DNA Homo sapiens 118 tttttttttt gcaacttgaa tatcattttt tattaatgaa ttgatttcca taaagcaaat 60 ctttctctta aaatggcaga ttatgtgatc aaaaagcgat tcaaaaaagc ttccccctcc 120 tcatgccaac cctcaagacc atgtgggatc cagctgaatc ctcagccctg ggactagact 180 aaggttgagg gaaagagccg ttaactcatt cctaaccaga acaggctaat aggacactcc 240 aaactcacac tacaaagaga ccacatgaac agtcgagtgt gctgggcagc tataagatgg 300 tgcagactgg atgaatttgg cagagcatat tcatcaccat tactacaatg ctattcctaa 360 ggtgtcctaa ttgtatgagc tacaaaatcg gtccctgttt ccattcttcc catctcacct 420 gttggccctc ctgcagtagg tagccttggg agaagatcct gagcttttca tattctaccg 480 ttttattttt gcattactgt ttggatgagt aaaatgtaat aacatgcttc tctctcttaa 540 gtcccctaaa gagagtgtgt gtgtgtgtgt gtgtgtgtgt 580 119 928 DNA Homo sapiens 119 gcggccgcag gaattttttt tttttttttt ttcttttcca taaattggtt tatttaaaca 60 ttacccgaaa tcgtgaagga aaaaatattg gaaattacca aatgccctta aacaggcgaa 120 tgattaggta acattttgtg catatgtatt aggttacgtt aataaagaaa ttttaaggat 180 ataaagaaaa tgcttattga taaaggtaaa ggcaaaatag agaaagcaaa attatgtgaa 240 cagtgtgaac tcaattccat aaaatgtata tgcatagaat atgaaaagaa attatagcaa 300 aatatttatt attggttatc tcctggtctt aagattatac accatttttc cttttcttct 360 tacttttttt ctgtgttata aatatgtaaa ataactaaag acatcctaag tagtaaaaat 420 aatttgacct aaattgtgta tgtgtgtgtg tgtgtgtgtg tgtgtgtgta tcaatgaaga 480 attttttttt gtttttattt atgttttctt taggaaaata aaacatgtct agtaagaaag 540 atgaaacaaa gaaagagttg gggtaagttc acatttttca aaccaacttg tgcttctaaa 600 ataaaattct gcctctccac acactgggtt cctggaagct aaccaaaatc tgctcagtaa 660 tattaactcc acttaaaaaa aggaagagaa catattgaac tgcattcact tatggtctgg 720 gtgcttggaa gaaatcagct ggtgagtacc aaagtgatga ctgcatgttt ctatttgcat 780 tttgaaaatt gacagataat tgaaaggaat cagcatatga aatttctcca aggaagccag 840 ctgagaagcc cgaggaaccc tgcctacgga ggcctcctgg tgcctgaagt ctggttgcag 900 aatgttctag aaccctcgtt ccgaattc 928 120 1853 DNA Homo sapiens 120 gcggccgcag gaattttttt tttttttttt ttttttatgt tacaaatatt ttattgcaat 60 tttttccctt taacaatgtc tggatatttt ggaattaata tctcggactt ctttctaatc 120 cacattggtt catcttgttc attatgaaca gaggattcta ctttacaatg tactaaaatg 180 ttgttatgta tttcaggacc attgaacatt caagttgttt atcattttct ttgaccacca 240 acattgctgt aatgaatagg gatttaagag caaaagtaac gagaatactt gcttaaccac 300 ttatgaaaac atatcataaa agtagaacaa tcaaaatggt ggatgccata gagaaagcaa 360 ggtaacaaaa taggaagcct agggaccaat aaagtatata tacaaggatt tcctatatca 420 caaaagtaac acttcaggta catggaaaaa gaatttcagt accaaaaggc acctcagtct 480 cacatccaca cattcaaaaa taattaaaat tttacatgaa aagttggaaa cacaaaatga 540 actagaaaaa caatatataa attaggacaa acactgcttt gcaatgggag gacctttgta 600 aatctgacag taaaagtgaa gaaggagttt actagggatc tgtttgacat tacagaagca 660 ttcatattca tacaccataa aacctcatat acaacattat aagacaaaca acagatttgg 720 gggaaaaaca ctccaccatc tgtgaaagac tgtatgtcaa tagtcaaaaa gacttaatca 780 gaaaatgata gcacccaaca gaagaaagac cttaatgggc ttggcccagt taaaaaatac 840 caatcgatgc ctaagatacc tataaaaata tgtgcaaact ggataactaa aataatgcaa 900 attaaagcaa tttaatgcca ttatttttcc tgtatctgaa aggcaaagat ttaaaagaac 960 cataatccct ggtgcaggcc caggcataga tcagcagccc ctcatctgtg gccggtggga 1020 gggagagttg cctggtctat ctggaagagt ggccacccgg gccatttgga ccaaaggccc 1080 taaagcatat atgcctttgg ggcattttcc tttgtttggc agtttcccct gacttttccg 1140 cagtagacgt gggctctgga ctcctctcct gatgttcccc aggtcccgcc agcctgccca 1200 ccacttgggc cgttaacttc tctacatgac gtggggtctc aagggactgg aggtcccaca 1260 gacatcactg agacaactag cagggctccc cagaagctcc caaacagtct ctcatgtgcg 1320 tcccttgcac cgcccccccg acccccaata ccatgcccat ttctcggagt gacaatcgag 1380 gctagtctga attccctgag cctcactgag cgtgcccagt cctgtgccac tcttccaagc 1440 cctaaccccc acgggtgccc acctggtgcc tcccacctct gcacccagat gagaatcatg 1500 tcatgtgcat cagcgactgc cggggacagg cagcccacac aagtcctcaa cacaaccagc 1560 cgaatctcag tctgataagg ctcagctcag acctcagccc cactctcata ataaatcagt 1620 gaaaaaagaa ggaagaaaaa tggcaaaagc aaggaaacct gattaaaaaa atgaggggga 1680 gatggaatga gtatatctag aaagttctaa taatgcagaa cctacaaata agttaacctg 1740 acaggaaaaa tgtgtgcatg tacgtgtgtg tgtgtgtgtc tgtgtgagcg cagggagaga 1800 agtgatttgc tgaaggtcaa gggggccgga gcaaggctcc tcgtgccgaa ttc 1853 121 709 DNA Homo sapiens 121 gtttggagac tgtgtccaag gcgactggtg ccccatctct gggggactat gctcggcccg 60 cctacatcgt cacgccctac tggccacctg tccagagcat caggtcacct gggaccccat 120 cgatggacgc gttatcggct cagctctaca attccttatc cctcgactcc cttccttccc 180 cacccagaga acctctaaga ccctcaaagt cctcaccccg ccgaccactc atacaacccc 240 caacattcca ccctccttct tccaagccat gcgaaaccat tcccccttcc gcaacggata 300 tatggagccc accctcgggc agcagctccc agccttgtct ttccccgacc ccggcctccg 360 gccccaaaac ttatacaccc tctggggaag ctccgttgtc tgcatgtacc tctatcagct 420 ctcccccccc atcacctggc ccctcctgcc ccatgtaatc ttctgccacc ctggtcagct 480 cggggccttc ctcactaagg tcccctataa gcgaatggag gagcttctct ataaaatctt 540 ccttaatacc ggggccctta taatactacc tgaagattgc ctgcccacca cccttttcca 600 gcccacaagg gcgcccgcca cgttaacagc ctggcaaaat ggcctccttc ctttccaagc 660 tgcaatcacc accccaggcc ttatttggac atttaccgat ggtacaccc 709 122 241 DNA Homo sapiens misc_feature (1)...(241) n = A,T,C or G 122 agggaggctg gggccaggtg tcagccctag gcctccatcc aacaccgtgg aaatgttgct 60 gccctcttct tggcgctgac cccaagattg gggtttcctt tctgccgctc cctccactgt 120 tgtttatcta actgggcccc cactccaggt ccagagggac tgtgctcact gcacagacat 180 cactcagctt ccgctcccca gtcctgcaga gctgttgcca ggtgccagtg ggggagngga 240 g 241 123 448 DNA Homo sapiens 123 ctcgaggcca agaattcggc acgaggtttc ttctacctct gttatctaag cagagggaag 60 taaacttctc accgcccccc acccctcact gcccccgatt acactagaat tgctttcgcc 120 aaattgtagt tgaagctaag gaaggggaat ctggcccctg ctgggagagg gaactggaat 180 gccacacaag gcaaggcctg cttccttcct tcccctctgc tgctgctgcc tcggaacgct 240 gcagcccagg cttcctccca cagtggccct tggaagcagg ccgcagagta gacagctgct 300 ccttttggaa gagtcagtcc cctgtgtttt ctgaactgtt tttcctagca tgtatgtggg 360 tagagctttc atgcatctct agtaataata agctgaaatt agtttttttt ttaattctcc 420 aatttaaaac ttttaattaa gcggccgc 448 124 1821 DNA Homo sapiens 124 gaattcggaa cgagggaggc attttgtggc cttaaaacgg ggtgttcagg gtcagccctc 60 agggtgctgg ggcccttcca tcccttgtcc ccttcaggtt ggtgaaaagg actccggggg 120 ccaggtgctg tatagcagct tatggaagtc tcagctgggc tatcctgccc ttgggagcac 180 agacaggctc ctagggtgct gagtgaagcc tgaagaccaa gccccctcct cctggaatgc 240 tccttccacc cctacctctc agagatgggc ctgacacctc tttctcattc attctccttt 300 tccctgtgct ctgggaaagc ccctggctca ggctgtcaga gtgaggatgg acctcaaaag 360 tttgatcccc tcgtgcagat gaagaagctg aagcccagag tgcggaaggg gagtggccca 420 aggtcacaca gctagtttga gtagagccag tcttgggaga gccaagtact acagccctgg 480 gggtgtcaca ccgcttgtca ctgcccctga ggtctcctgc caaacaactg cagggagttt 540 ggctaacagt cctgtgtcca gggtgccggt ggggatgtta tagatgttgc tgggatcctg 600 ccctcggctc caaattctgg cctctcatcc caggctgcag acccttctgc cccatgacag 660 gcctgggtgc cacacagagg tggccaccct cccaccacag tgtctgcagc tgctgccctt 720 ctcccaggcc cccagacaga agagaccctg tttcccctcc tctcccctgt gacttcacaa 780 gagcttgggc ttggagtgaa ggtcagcatg ttctcatgtg ctcatcctct tggtttcccc 840 aaagaccggg agggtcacgg atggggcgtg cagaatcctt gtgttttttc tcgctgggca 900 gcttgagggg ctggggagta ttcccagggt ctttgctctg gagagtccct gcagagccac 960 tggctgaggt tgggttcagg gttcagcgga gtcctccatg cttccaaagg ccgggaagca 1020 cccgcctctc tatcgagtca gtgctgtgcg tgtgtgtctg agaatgtgtg tgatgtgtgg 1080 agtgtgcgtg tgtttgtgtg tgtgtgtgtg tgtgttgggg cagaaggacc actctttcct 1140 ggggatccct tgacccttat aactagaagg gaccttaggg agcatctaag ctggtgcccc 1200 cattgtacag gcgaggtcca gagggatggc atctgcccac cccacccctt gccctcttgt 1260 tgcctgcact catttcccag ggaccctcct aggataggaa tgccctcctt cctggccccc 1320 tcccgccatc ctcccagcca cccacataat caccatctca gcccaactct ggtggccctc 1380 taggtctcca tgcattcttc ctgccctaga gtagccagct caccaaggcc tttatcccca 1440 gcccaggaga agggtcaggg agggaagggg ctgcaccagc cctgagacct caaagacttg 1500 ggagaaaagc caaaactcct catgcccagg cccacatgtc tgaccacccc agcccacccc 1560 gccaccaagg taaaagcaca acaggagacc cccttattaa tgggtgaaat gattggggtt 1620 gtttttttag tcacacagcc ccatcctcac ccctttgcct tgctgtctgt ctccacccca 1680 gcctctgttc cccatttgcc tctctttcac ctccaagccc ccaaatgtaa cctctagttg 1740 cggacgcggt tgttctatca ataaagctgc agtgttctag caaaaaaaaa aaaaaaaaaa 1800 aaaaaaaaaa agcgcggccg c 1821 125 540 DNA Homo sapiens misc_feature (1)...(540) n = A,T,C or G 125 tttttttttt tcnttcataa ttgtaattaa tttagcataa gcaaagaaat gaccttagga 60 acatatttag gttttaagat agatttctat ntaatgggcc tgaaaggcat tttgatctga 120 atttattttc caacgatttc aaatataatt tgtcatctgt gtgtagacat atacgggcat 180 gaacacacat tcacccacac atacaaaaac acttgctttc tatcagatca gggtaatttt 240 tttattgcag gtctctttta atattggcta gcagaaaacc tatccccaac ctaacagatt 300 acacacacac acacacacac acacacacac acacagagct atttttccac acttcctcac 360 agtgaaaagc tctctaacaa gataccagaa ggtcgagaga gacaatgctt ttatggctgg 420 gccttgagga caattctggt tgcatttaaa tctcagtgcc aaatgcacta ggttccctgc 480 cgttataatt tttggatcag tctcttctga aatcangtca cagagaaaac aggatgattt 540 126 2490 DNA Homo sapiens 126 gttcgtagtt cggctctggg gtcttttgtg tccgggtctg gcttggcttt gtgtccgcga 60 gtttttgttc cgctccgcag cgctcttccc gggcaggagc cgtgaggctc ggaggcggca 120 gcgcggtccc cggccaggag caagcgcgcc ggcgtgagcg gcggcggcaa aggctgtggg 180 gagggggctt cgcagatccc cgagatgccg gagttcctgg aagacccctc ggtcctgaca 240 aaagacaagt tgaagagtga gttggtcgcc aacaatgtga cgctgccggc cggggagcag 300 cgcaaagacg tgtacgtcca gctctacctg cagcacctca cggctcgcaa ccggccgccg 360 ctccccgccg gcaccaacag caaggggccc ccggacttct ccagtgacga agagcgcgag 420 cccaccccgg tcctcggctc tggggccgcc gccgcgggcc ggagccgagc agccgtcggc 480 aggaaagcca caaaaaaaac tgataaaccc agacaagaag ataaagatga tctagatgta 540 acagagctca ctaatgaaga tcttttggat cagcttgtga aatacggagt gaatcctggt 600 cctattgtgg gaacaaccag gaagctatat gagaaaaagc ttttgaaact gagggaacaa 660 ggaacagaat caagatcttc tactcctctg ccaacaattt cttcttcagc agaaaataca 720 aggcagaatg gaagtaatga ttctgacaga tacagtgaca atgaagaagg aaagaagaaa 780 gaacacaaga aagtgaagtc cactagggat attgttcctt tttctgaact tggaactact 840 ccctctggtg gtggattttt tcagggtatt tcttttcctg aaatctccac ccgtcctcct 900 ttgggcagta ccgaactaca ggcagctaag aaagtacata cttctaaggg agacctacct 960 agggagcctc ttgttgccac aaacttgcct ggcaggggac agttgcagaa gttagcctct 1020 gaaaggaatt tgtttatttc atgcaagtct agccatgata ggtgtttaga gaaaagttct 1080 tcgtcatctt ctcagcctga acacagtgcc atgttggtct ctactgcagc ttctccttca 1140 ctgattaaag aaaccaccac tggttactat aaagacatag tagaaaatat ttgcggtaga 1200 gagaaaagtg gaattcaacc attatgtcct gagaggtccc atatttcaga tcaatcgcct 1260 ctctccagta aaaggaaagc actagaagag tctgagagct cacaactaat ttctccgcca 1320 cttgcccagg caatcagaga ttatgtcaat tctctgttgg tccagggtgg ggtaggtagt 1380 ttgcctggaa cttctaactc tatgccccca ctggatgtag aaaacataca gaagagaatt 1440 gatcagtcta agtttcaaga aactgaattc ctgtctcctc caagaaaagt ccctagactg 1500 agtgagaagt cagtggagga aagggattca ggttcctttg tggcatttca gaacatacct 1560 ggatccgaac tgatgtcttc ttttgccaaa actgttgtct ctcattcact cactacctta 1620 ggtctagaag tggctaagca atcacagcat gataaaatag atgcctcaga actatctttt 1680 cccttccatg aatctatttt aaaagtaatt gaagaagaat ggcagcaagt tgacaggcag 1740 ctgccttcac tggcatgcaa atatccagtt tcttccaggg aggcaacaca gatattatca 1800 gttccaaaag tagatgatga aatcctaggg tttatttctg aagccactcc actaggaggt 1860 attcaagcag cctccactga gtcttgcaat cagcagttgg acttagcact ctgtagagca 1920 tatgaagctg cagcatcagc attgcagatt gcaactcaca ctgcctttgt agctaaggct 1980 atgcaggcag acattagtca agctgcacag attcttagct cagatcctag tcgtacccac 2040 caagcgcttg ggattctgag caaaacatat gatgcagcct catatatttg tgaagctgca 2100 tttgatgaag tgaagatggc tgcccatacc atgggaaatg ccactgtagg tcgtcgatac 2160 ctctggctga aggattgcaa aattaattta gcttctaaga ataagctggc ttccactccc 2220 tttaaaggtg gaacattatt tggaggagaa gtatgcaaag taattaaaaa gcgtggaaat 2280 aaacactagt aaaattaagg acaaaaagac atctatctta tctttcaggt actttatgcc 2340 aacattttct tttctgttaa ggttgtttta gtttccagat agggctaatt acaaaatgtt 2400 aagcttctac ccatcaaatt acagtataaa agtaattgcc tgtgtagaac tacttgtctt 2460 ttctaaagat ttgcgtagat aggaagcctg 2490 127 1478 DNA Homo sapiens 127 aagcttggca cgaggataac ttctacattt tgaaaatttt atgtcaatta tttaatagaa 60 tatctctaaa tttaggtttg tctcattttt caatgtaatt ggattcaggt tacgcatttt 120 tgatagatta gagtggtgct gtgttattct tattgcacag gtctgttggg ttgagtgggg 180 tgagttaaat cattcctttt tggcctctca taatactgaa tcaagtgaaa gttggcctga 240 gtcatcagaa gacttgtctc ggctgaatgt acaaggtgct cactgacata cagatccaaa 300 gttgagtcgg actggtctga ctgttggctg aaagctcacc tggggctgcc agaggtcttc 360 aacctagcgt ctccacgtaa cttaagcttc ttatatcatg tgcctaaatt ctgagacaga 420 ggaatagaga agagagaaag gaagagcaag agagagaagg ggagttccga gtgtccattc 480 caagaaactg aggtggaaac tgcaaggctt cttataccag agcattactt tttgtaccag 540 aacattactt ccagtgtatt ctatctgtaa agcaagttat atttagttca catcttgatg 600 tgagaaatag cattgtgtac agggaaaaag aacttgatag ctatttttgt agactatctg 660 ataaagatgt ttctgggctg agttaataat gctatgttgg ctatttattt ctgattttct 720 agttctgtca tttcttctac atttattagt tagtctttgt gtcagttggg gttccctagg 780 gaaacagaac caataggata tatctatatc tttacctatg tcccatacag atacacacac 840 acacacacac acacacacac acatccaatc cacacacaca tgtacattca atctgttgat 900 agcctgacta gaacaatagg caaaggcaag gggaaattcg tatctctacc tgactgcttc 960 agctgaaata tcaatcagtc tcttcctgcc ctacactggg accaacatca tgagccctct 1020 ggttcccaga actgtaacac tggctttcct ctttccgggg tctccagctt tcagacagta 1080 gaatcatgag acttctcagc ctccttaacc atgtgagcca atgccttata acaaatatcc 1140 tacaaacata tatatataaa tgtatacata caaatataat aatatcatac aaatatatat 1200 atttatatgt atacatgtaa ttacatttaa gaacatttaa ggctatttac atgtaaagaa 1260 aggaaaaata atgtaaatat ttgttttcac ctgaaataaa tgtcagacac tgtctttgtt 1320 taaagaaata gtcctcttaa actttgggca atgctgccaa ttacattaac ttacaatgtt 1380 atttcaattg catcaccaga gtaaaatctt agagtattat ttttatctaa taaattaata 1440 acatccaaaa aaaaaaaaaa aaaaattcct gcggccgc 1478 128 376 DNA Homo sapiens misc_feature (1)...(376) n = A,T,C or G 128 catcactata gggcgaattg gcgtaccggg ccccccctcg agtttttttt tttttttttt 60 ttttttaacc aagctaaggc actaccagaa atttcaagga taatgattct ggccactaga 120 gaatgaaaac agcattggca atacttattt ttaatcatat ctagttgaca tagaaacaaa 180 caatcttttt ctagggaaaa aaaagccaat tctgtgttac atccttgtta gaacattgtg 240 caattcaaat aagcgagtct gcctcatctt taatagaaat tctctcaaaa agggtttagt 300 gaccactaca gtcaatttta aaaacaaatt agctgaattc cctcttactc tgaagtgnta 360 tttcaagtct gggggt 376 129 903 DNA Homo sapiens 129 gaattcggca cgaggtgtca gctcagtgca tcccaggcag ctcttagtgt ggagcagtga 60 actgtctgtg gttccttcta cttggggatc atgcagagag cttcacgtct gaagagagag 120 ctgcacatgt tagccacaga gccaccccca ggcatcacat gttggcaaga taaagaccaa 180 atggatgacc tgcgagctca aatattaggt ggagccaaca caccttatga gaaaggtgtt 240 tttaagctag aagttatcat tcctgagagg tacccatttg aacctcctca gatccgattt 300 ctcactccaa tttatcatcc aaacattgat tctgctggaa ggatttgtct ggatgttctc 360 aaattgccac caaaaggtgc ttggagacca tccctcaaca tcgcaactgt gttgacctct 420 attcagctga tcatgtcaga acccaaccct gatgacccgc tcatggctga catatcctca 480 gaatttaaat ataataagcc agccttcctc aagaatgcca gacagtggac agagaagcat 540 gcaagacaga aacaaaaggc tgatgaggaa gagatgcttg ataatctacc agaggctggt 600 gactccagag tacacaactc aacacagaaa aggaaggcca gtcagctagt aggcatagaa 660 aagaaatttc atcctgatgt ttaggggact tgtcctggtt catcttagtt aatgtgttct 720 ttgccaaggt gatctaagtt gcctaccttg aatttttttt taaatatatt tgatgacata 780 atttttgtgt agtttattta tcttgtacat atgtattttg aaatctttta aacctgaaaa 840 ataaatagtc atttaatgtt gaaaaaaaaa aaaaaaaaaa aagatcttta attaagcggc 900 cgc 903 130 1140 DNA Homo sapiens misc_feature (1)...(1140) n = A,T,C or G 130 ctggcgctgc tggggctcgg cgncggcctt tgtctgcggg cacggccgct gcggtgctca 60 ggaacagccc atggaagaat catatgaaga ggtggtgact gaggtcgtaa gcaggagtgg 120 acatgtttgg atttccaaca gctaccctgc tggactgtca tggaagatat gcccagaatg 180 tagcgttctt caatgtgatg actgaagccc accacaaata tgaccactct gaggctacag 240 gatcctcaag ctgggatatc caaaattctt tcagaagaga gaagctggaa caaaaatccc 300 cagattcgaa gacactacag gaagattcac ctggagtgag acaaagggtc tatgagtgcc 360 aggagtgtgg aaaatccttc cggcaaaaag gtagtctaac gttacatgag agaatccaca 420 ctggtcaaaa gccttttgag tgcacccact gtggaaaaag cttcagggcc aaaggcaatc 480 ttgttacaca tcaacggata cacacgggag agaagcctta tcagtgcaag gagtgtggga 540 aaagcttcag tcaacgaggt agtctcgctg tccacgagag actccacact ggacagaaac 600 cctacgagtg tgctatttgt cagagaagct tcaggaatca gagtaacctt gctgttcaca 660 ggagagttca cagtggtgag aagccctata gatgtgatca gtgtggaaaa gccttcagtc 720 agaaaggaag cttaattgtt cacatcagag tccacacagg cctgaagccc tatgcctgta 780 cccagtgcag gaagagtttc cacaccaggg ggaattgtat tctgcatggc aaaatccaca 840 caggagagac accctatctg tgcggccagt gtggaaaaag cttcacccag agagggagtc 900 tggctgtgca ccagcgaagc tgctcacaga ggctcaccct ttgaccactt tcctgaagag 960 aagttctctt tatgaattaa gagtacaaaa tcctctgaga tgaagcaacc tatccagttc 1020 tatggaatga atggagaatc tttcagaaag accatcattg ggtagggcaa actgattttt 1080 ttcctttccc ccaaaagagt atgaaaaata aaggtcttgt ttattatcat taaaaaaaaa 1140 131 1337 DNA Homo sapiens 131 aagcttggca cgagggcagt ctcatgataa tccaagtaac tctctgtgtg aagcaccttt 60 gaacatttca cgtgatactt tgtgttcaga tgaatacttt gctggtggct tacactcatc 120 ttttgatgat ctttgtggaa actcaggatg tggaaatcag gaaaggaagt tggaaggatc 180 cattaatgac attaaaagtg atgtgtgtat ttcttcactt gtattgaaag caaataatat 240 tcattcatca ccatctttca ctcacctcga taaatcaagt cctcagaaat ttctgagtaa 300 tctttcaaag gaagaaataa acttgcaaag aaatattgca ggtaaagtag tcacccctca 360 ccaaaagcag gctgcaggta tgtctcagga gacgtttgaa gagaagtatc gtttgtctcc 420 taccttatct tcaacaaaag gccacctttt gatacattca agacccagga gttcctcagt 480 aaagagaaaa agagtatcac atggctccca ttcacctccg aaggaaaaat gcaagagaaa 540 gaggagcacc aggagatcta tcatgccgag gctgcagctg tgcaggtcgg aaggcaggct 600 gcagcacgtg gcgggacctg ccctggaggc tcttagctgt ggggagtctt catatgatga 660 ctatttttca cctgataatc ttaaggaaag gtattcagag aatcttcctc ctgaatctca 720 gctgccatca agccctgctc agttgagctg cagaagtctt tctaagaagg agagaacaag 780 catatttgaa atgtctgatt tttcctgcgt tggcaaaaaa accagaacag ttgacattac 840 caatttcaca gcaaaaacca tctccagtcc tcggaaaact ggaaatggtg aaggccgtgc 900 aacttcgagt tgcgtgactt ctgcccctga agaagcccta aggtgttgta gacaggctgg 960 gaaagaagac gcatgcccag agggaaatgg cttttcttac accattgagg accctgctct 1020 tccaaaagga catgatgatg atttaactcc tttggaagga agccttgaag aaatgaaaga 1080 agcggttggt ctgaaaagca cacagaacaa aggtaccact tccaaaatat caaactcctc 1140 tgaaggcgaa gcccagagtg aacatgagcc atgttttata gttgactgta acatggagac 1200 atctacagaa gagaaggaaa acttacccgg aggatacagt ggaagtatgt gaatctcctt 1260 ttccaagtca ccttcgctaa ataaacatgt aacagtgcat ccataaaaaa aaaaaaaaaa 1320 aaaattcctg cggccgc 1337 132 492 DNA Homo sapiens misc_feature (1)...(492) n = A,T,C or G 132 aataagcttg cggccgcgan nccggagcct gcccgcgcgc ccccggaacc cgcgcccccg 60 gccgaggcca ccggggaccc ggcnccgtcc cgcccctgct gcccccgagc cggcggcctc 120 ncccgngggg ccggagganc ctggagagcc cgcggggctg ggggagctcg gggagcctgc 180 gggaccgggg gagcccgaag ggccanggga tcccgcggng gngccagcgg aggcggagga 240 gcaggcggtg gaggcgaggc aggaagagga gcaggacttg gatggtgaga aggggccatc 300 atcggaaggg cctgacgagg angacngaga aggcttctcc ttnaaataca gccccggnaa 360 gctnanggga aaccagtacn ngaagatgat gaccaaagag ganctggang aggagcagat 420 gatnganctg acctntgacc tcacttccct gtagcaagtt ccttangtcc tgagccacaa 480 atattcttgc aa 492 133 693 DNA Homo sapiens 133 ctcgaggcca agaattcggc acgaggctga gagggtgggt ctgagtcccc acaatgtctg 60 aagctgcccc tgggattctc aggccaacct gccaacagca agcggatttt cttgcaagat 120 cagggacccc atttctgcag ccagtgtctc ctgggtgcct tctgaggact cccaccccca 180 tcccagtatc tcatctgtcc cctctcctgg ggcttaagtg ggttgcttcc aggcagaagc 240 agccaaggac cgattccagg cactttctgt agcaaatgac tgtgaattac gacttctctt 300 gcccttcttc tagcagtctg tgcctcctct ctgaccagtt tggagggcac tgaagaaagg 360 caagggccgt gctgctgctg ggcggggcag gagaggagcc tggccagtgt gccacattaa 420 atacccgtgc aggcgcggag aagcaaccgg cacccccttc cggcctgaaa gccctccctg 480 caagaaggtg tgcaggagag aagaggcccc ggcatgggga tctgggttct agagggcatg 540 tgatgactgt aaatgttcac tgggtgggta gggagtggta tccagtgttc aagtgcagaa 600 atctttggct ttgctaccag ttccatatga tgagaaataa acgttcgctg aggttttgtt 660 tcaaaaaaaa aaaaaaaaaa aaaaggcggc cgc 693 134 1855 DNA Homo sapiens 134 cctcaggccg gctgtgaacg tagttcctga gagatagcaa acatgcccaa cagtgagccc 60 gcatctctgc tggagctgtt caacagcatc gccacacaag gggagctcgt aaggtccctc 120 aaagcgggaa atgcgtcaaa ggatgaaatt gattctgcag taaagatgtt ggtgtcatta 180 aaaatgagct acaaagctgc cgcgggggag gattacaagg ctgactgtcc tccagggaac 240 ccagcaccta ccagtaatca tggcccagat gccacagaag ctgaagagga ttttgtggac 300 ccatggacag tacagacaag cagtgcaaaa ggcatagact acgataagct cattgttcgg 360 tttggaagta gtaaaattga caaagagcta ataaaccgaa tagagagagc caccggccaa 420 agaccacacc acttcctgcg cagaggcatc ttcttctcac acagagatat gaatcaggtt 480 cttgatgcct atgaaaataa gaagccattt tatctgtaca cgggccgggg cccctcttct 540 gaagcaatgc atgtaggtca cctcattcca tttattttca caaagtggct ccaggatgta 600 tttaacgtgc ccttggtgat ccagatgacg gatgacgaga agtatctgtg gaaggacctg 660 accctggacc aggcctatag ctatgctgtg gagaatgcca aggacatcat cgcctgtggc 720 tttgacatca acaagacttt catattctct gacctggact acatggggat gagctcaggt 780 ttctacaaaa atgtggtgaa gattcaaaag catgttacct tcaaccaagt gaaaggcatt 840 ttcggcttca ctgacagcga ctgcattggg aagatcagtt ttcctgccat ccaggctgct 900 ccctccttca gcaactcatt cccacagatc ttccgagaca ggacggatat ccagtgcctt 960 atcccatgtg ccattgacca ggatccttac tttagaatga caagggacgt cgcccccagg 1020 atcggctatc ctaaaccagc cctgttgcac tccaccttct tcccagccct gcagggcgcc 1080 cagaccaaaa tgagtgccag cgaccccaac tcctccatct tcctcaccga cacggccaag 1140 cagatcaaaa ccaaggtcaa taagcatgcg ttttctggag ggagagacac catcgaggag 1200 cacaggcagt ttgggggcaa ctgtgatgtg gacgtgtctt tcatgtacct gaccttcttc 1260 ctcgaggacg acgacaagct cgagcagatc aggaaggatt acaccagcgg agccatgctc 1320 accggtgagc tcaagaaggc actcatagag gttctgcagc ccttgatcgc agagcaccag 1380 gcccggcgca aggaggtcac ggatgagata gtgaaagagt tcatgactcc ccggaagctg 1440 tccttcgact ttcagtagca ctcgttttac atatgcttat aaaagaagtg atgtatcagt 1500 aatgtatcaa taatcccagc ccagtcaaag caccgccacc tgtaggcttc tgtctcatgg 1560 taattactgg gcctggcctc tgtaagcctg tgtatgttat caatactgtt tcttcctgtg 1620 agttccatta tttctatctc ttatgggcaa agcattgtgg gtaattggtg ctggctaaca 1680 ttgcatggtc ggatagagaa gtccagctgt gagtctctcc ccaaagcagc cccacagtgg 1740 agcctttggc tggaagtcca tgggccaccc tgttcttgtc catggaggac tccgagggtt 1800 ccaagtatac tcttaagacc cactctgttt aaaaatatat attctatgta tgcgt 1855 135 2559 DNA Homo sapiens 135 ggaattccgg aattccgaat gcgtcggaaa gagcgggagt gtgcgccgcg cgagagtggg 60 aggcgaaggg ggcaggccag ggagaggcgc aggagccttt gcagccacgc gcgcgcgctt 120 ccctgtcttg tgtgcttcgc gaggtagagc gggcgccggc agcggcgggg attactttgc 180 tgctagtttc ggttgccggc agcggcgggt gtagtctcgg cggcagcggc ggagacacta 240 gcactatgtc ggaggagcag ttcggcggga cggggcggcg gcacgcgaac ggcggcggta 300 ggcgctcggc gggcgacgag gagggagcca tggtggcggc gacacagggg gcagcggcgg 360 cgcgggaagc ggacgcggga ccgggggcgg aaccgcgtct ggaggcaccg aagggcagcg 420 ccgagtcgga gggggcgaag attgacgcca gtaagaacga ggaggatgaa gggaaaatgt 480 ttataggagg ccttagctgg gacactacaa agaaagatct gaaggactac ttttccaaat 540 ttggtgaagt tgtagactgc actctgaagt tagatcctat cacagggcga tcaaggggtt 600 ttggctttgt gctatttaaa gaatcggaga gtgtagataa ggtcatggat caaaaagaac 660 ataaattgaa tgggaaggtg attgatccta aaagggccaa agccatgaaa acaaaagagc 720 cggttaaaaa aatttttgtt ggtggccttt ctccagatac acctgaagag aaaataaggg 780 agtactttgg tggttttggt gaggtggaat ccatagagct ccccatggac aacaagacca 840 ataagaggcg tgggttctgc tttattacct ttaaggaaga agaaccagtg aagaagataa 900 tggaaaagaa ataccacaat gttggtctta gtaaatgtga aataaaagta gccatgtcga 960 aggaacaata tcagcaacag caacagtggg gatctagagg aggatttgca ggaagagctc 1020 gtggggaatt ccggaattcc tcagaggcag gagaaggctt ggagctaccc ccaaactcaa 1080 tccactgttg gcagctgagc gtgtagtagg gtggtcctag ccatacagaa ccacttctct 1140 gtctccctcc tcttccctgg ttcgtccagc cccagtccat cagggaccac ctgggcagcc 1200 tcccagagat gggatcgggt tggggctaag ggcatcgggt ctgtcgcagc caggggtgca 1260 ggaggatcgc tgtgctgtga gccgttcagc tggctcccga cgaaggaggc acggaaccag 1320 acagcgcggc gagggcgaga gcgctgcagg caaggcgtag gccccgcggc ggatcttgcc 1380 gaagagcagg acaggctccg agtcctggaa ggggtagtgg ccggccagca tggtgaagag 1440 cgccacgccc aggctccaga catcggctgc cttgcccgag tatgaggccc gtgagctgag 1500 tatctcaggt cccacgtagg ctggcgacgc gtgcttgtcc acagggaatc atctggccca 1560 gtcagcacgc aggagtcctc caggttctcc agcaccagct tcttcctggg acatggggag 1620 aaacagaagg gtcaggtcct acccagaacc cccatgctat cacccttgtg gcacccactt 1680 tccaagtcgc tgctggcctt tgacagacac aagccagtcc tgtgatgtct gatcctgttt 1740 tacagatacc caagcccagg ctcagagagg ttaagtcatt taaggccaca gagcaattaa 1800 atttaaacta aaattctgaa aggaatacat ttttcaacag agtccttggg gagggggctg 1860 atggggctga gagggttaag cctctcttaa accagctaca aacttagggt ccaggcaggt 1920 aataagatga gagaaacagg aagtgtgcct gacatctcag cacaagcgct acctaaaaag 1980 ggtacacaac gcattctagg gtttaccaag tgcctgctgt gttcctggcc cttgacccag 2040 ctcattacct ggctcacctc attctatcta gctacagcct gcaaggaaga caccatttta 2100 cagctgtaga gcatgggcct gggatgggaa cgctggctgg cagatactca gagccagtgc 2160 tgtgacccac cctctcagtt cccaagatgg ccccacattc ccattgtttt ccccaagaga 2220 agccaggaat tgtattttaa tgaaaaggtc cccatttaaa aaatattggc aaaccagttt 2280 atataaaaaa cacaaacagg taagcagggc aaaaaaaaaa gtgtgtaagg ctgggcgcgg 2340 tgctcatgcc cggtaatcct agcactttgg gagcgcgagg cagggggatc acttgagttc 2400 aggagttcaa gaccagcctg ggcaacacgg taaaaaccta tctctacaaa aaatacgaaa 2460 attagcaggc atggtgattc gcacctgtag tcccagctac ttgggaggct gatcttgaac 2520 tcctgaactc aagtgatccc cctgcctcgg ccggaattc 2559 136 895 DNA Homo sapiens 136 agagacttaa gtctaaggca ctgagcgtat catgttaaag atgagcgggt ggcagcgaca 60 gagccaaaat cagagctgga acctgaggag agagtgttca agaaggaagt gtatcttcat 120 acatcaccac acctgaaagc agatgtgctt ttccagactg atccaactgc agagatggca 180 gctgagtcat tgcctttctc ttcggacact gtcagctggg agctggaagc ctggtatgag 240 gacctgcaag aggtcctgtc ttcagatgaa aatgggggta cctatgtttc acctcctgga 300 aatgaagagg aagaatcaaa aatcttcacc actcttgacc ctgcttctct ggcttggctg 360 actgaggagg agccagaacc agcagaggtc acaagcacct cccagagccc tcactctcca 420 gattccagtc agagctccct ggctcaggag gaagaggagg aagaccaagg gagaaccagg 480 aaacggaaac agagtggtca ttccccagcc cgggctggaa agcagcgcat gaaggagaaa 540 gaacaggaga atgaaaggaa agtggcacag ctagctgaag agaatgaacg gctcaagcag 600 gaaatcgagc gcctgaccag ggaagtagag gcgactcgcc gagctctgat tgaccgaatg 660 gtgaatctgc accaagcatg aacaattggg agcatcagtc ccccacttgg gccacactac 720 ccacctttcc cagaagtggc tactgactac cctctcacta gtgccaatga tgtgaccctc 780 aatcccacat acgcaggggg aaggcttgga gtagacaaaa ggaaaggtct cagcttgtat 840 atagagattg tacatttatt tattactgtc cctatctatt aaagtgactt tctat 895 137 1860 DNA Homo sapiens 137 cgtgaacggt cgttgcagag attgcgggcg gctgagacgc cgcctgcctg gcacctagga 60 gcgcagcgga gccccgacac cgccgccgcc gccatggagt ccgagaccga acccgagccc 120 gtcacgctcc tggtgaagag ccccaaccag cgccaccgcg acttggagct gagtggcgac 180 cgcggctgga gtgtgggcca cctcaaggcc cacctgagcc gcgtctaccc cgagcgtccg 240 cgtccagagg accagaggtt aatttattct gggaagctgt tgttggatca ccaatgtctc 300 agggacttgc ttccaaagca ggaaaaacgg catgttttgc atctggtgtg caatgtgaag 360 agtccttcaa aaatgccaga aatcaacgcc aaggtggctg aatccacaga ggagcctgct 420 ggttctaatc ggggacagta tcctgaggat tcctcaagtg atggtttaag gcaaagggaa 480 gttcttcgga acctttcttc ccctggatgg gaaaacatct caaggcctga agctgcccag 540 caggcattcc aaggcctggg tcctggtttc tccggttaca caccctatgg gtggcttcag 600 ctttcctggt tccagcagat atatgcacga cagtactaca tgcaatattt agcagccact 660 gctgcatcag gggcttttgt tccaccacca agtgcacaag agatacctgt ggtctctgca 720 cctgctccag cccctattca caaccagttt ccagctgaaa accagcctgc caatcagaat 780 gctgctcctc aagtggttgt taatcctgga gccaatcaaa atttgcggat gaatgcacaa 840 ggtggcccta ttgtggaaga agatgatgaa ataaatcgag attggttgga ttggacctat 900 tcagcagcta cattttctgt ttttctcagt atcctctact tctactcctc cctgagcaga 960 ttcctcatgg tcatgggggc caccgttgtt atgtacctgc atcacgttgg gtggtttcca 1020 tttagaccga ggccggttca gaacttccca aatgatggtc ctcctcctga cgttgtaaat 1080 caggacccca acaataactt acaggaaggc actgatcctg aaactgaaga ccccaaccac 1140 ctccctccag acagggatgt actagatggc gagcagacca gcccctcctt tatgagcaca 1200 gcatggcttg tcttcaagac tttctttgcc tctcttcttc cagaaggccc cccagccatc 1260 gcaaactgat ggtgtttgtg ctgtagctgt tggaggcttt gacaggaatg gactggatca 1320 cctgactcca gctagattgc ctctcctgga catggcaatg atgagttttt aaaaaacagt 1380 gtggatgatg atatgctttt gtgagcaagc aaaagcagaa acgtgaagcc gtgatacaaa 1440 ttggtgaaca aaaaatgccc aaggcttctc atgtgtttat tctgaagagc tttaatatat 1500 actctatgta gtttaataag cactgtacgt agaaggcctt aggtgttgca tgtctatgct 1560 tgaggaactt ttccaaatgt gtgtgtctgc atgtgtgttt gtacatagaa gtcatagatg 1620 cagaagtggt tctgctggta agatttgatt cctgttggaa tgtttaaatt acactaagtg 1680 tactacttta tataatcaat gaaattgcta gacatgtttt agcaggactt ttctaggaaa 1740 gacttatgta taattgcttt ttaaaatgca gtgctttact ttaaactaag gggaactttg 1800 cggaggtgaa aacctttgct gggttttctg ttcaataaag ttttactatg aatgaccctg 1860 138 2074 DNA Homo sapiens 138 gaattcggca cgaggcgcgg cggctgcgac cgggacggcc cattttccgc cagctcgccg 60 ctcgctatgg cgtcgctcac cgtgaaggcc taccttctgg gcaaggagga cgcggcgcgc 120 gagattcgcc gcttcagctt ctgctgcagc cccgagcctg aggcggaagc cgaggctgcg 180 gcgggtccgg gaccctgcga gcggctgctg agccgggtgg ccgccctgtt ccccgcgctg 240 cggcctggcg gcttccaggc gcactaccgc gatgaggacg gggacttggt tgccttttcc 300 agtgacgagg aattgacaat ggccatgtcc tacgtgaagg atgacatctt ccgaatctac 360 attaaagaga aaaaagagtg ccggcgggac caccgcccac cgtgtgctca ggaggcgccc 420 cgcaacatgg tgcaccccaa tgtgatctgc gatggctgca atgggcctgt ggtaggaacc 480 cgctacaagt gcagcgtctg cccagactac gacttgtgta gcgtctgcga gggaaagggc 540 ttgcaccggg ggcacaccaa gctcgcattc cccagcccct tcgggcacct gtctgagggc 600 ttctcgcaca gccgctggct ccggaaggtg aaacacggac acttcgggtg gccaggatgg 660 gaaatgggtc caccaggaaa ctggagccca cgtcctcctc gtgcagggga ggcccgccct 720 ggccccacgg cagaatcagc ttctggtcca tcggaggatc cgagtgtgaa tttcctgaag 780 aacgttgggg agagtgtggc agctgccctt agccctctgg gcattgaagt tgatatcgat 840 gtggagcacg gagggaaaag aagccgcctg acccccgtct ctccagagag ttccagcaca 900 gaggagaaga gcagctcaca gccaagcagc tgctgctctg accccagcaa gccgggtggg 960 aatgttgagg gcgccacgca gtctctggcg gagcagatga ggaagatcgc cttggagtcc 1020 gaggggcgcc ctgaggaaca gatggagtcg gataactgtt caggaggaga tgatgactgg 1080 acccatctgt cttcaaaaga agtggacccg tctacaggtg aactccagtc cctacagatg 1140 ccagaatccg aagggccaag ctctctggac ccctcccagg agggacccac agggctgaag 1200 gaagctgcct tgtacccaca tctcccgcca gaggctgacc cgcggctgat tgagtccctc 1260 tcccagatgc tgtccatggg cttctctgat gaaggcggct ggctcaccag gctcctgcag 1320 accaagaact atgacatcgg agcggctctg gacaccatcc agtattcaaa gcatcccccg 1380 ccgttgtgac cacttttgcc cacctcttct gcgtgcccct cttctgtctc atagttgtgt 1440 taagcttgcg tagaattgca ggtctctgta cgggccagtt tctctgcctt cttccaggat 1500 caggggttag ggtgcaagaa gccatttagg gcagcaaaac aagtgacatg aagggagggt 1560 ccctgtgtgt gtgtgtgctg atgtttcctg ggtgccctgg ctccttgcag cagggctggg 1620 cctgcgagac ccaaggctca ctgcagcgcg ctcctgaccc ctccctgcag gggctacgtt 1680 agcagcccag cacatagctt gcctaatggc tttcactttc tcttttgttt taaatgactc 1740 ataggtccct gacatttagt tgattatttt ctgctacaga cctggtacac tctgatttta 1800 gataaagtaa gcctaggtgt tgtcagcagg caggctgggg aggccagtgt tgtgggcttc 1860 ctgctgggac tgagaaggct cacgaagggc atccgcaatg ttggtttcac tgagagctgc 1920 ctcctggtct cttcaccact gtagttctct catttccaaa ccatcagctg cttttaaaat 1980 aagatctctt tgtagccatc ctgttaaatt tgtaaacaat ctaattaaat ggcatcagca 2040 ctttaaccaa taaaaaaaaa aaaaaaaaaa aaaa 2074 139 3500 DNA Homo sapiens 139 ttgtgaaggg cgcgggtggg gggcgctgcc ggcctcgtgg gtacgttcgt gccgcgtctg 60 tcccagagct ggggccgcag gagcggaggc aagaggggca ctatggcaga caaagttagg 120 aggcagaggc cgaggaggcg agtctgttgg gccttggtgg ctgtgctctt ggcagacctg 180 ttggcactga gtgatacact ggcagtgatg tctgtggacc tgggcagtga gtccatgaag 240 gtggccattg tcaaacctgg agtgcccatg gaaattgtct tgaataagga atctcggagg 300 aaaacaccgg tgatcgtgac cctgaaagaa aatgaaagat tctttggaga cagtgcagca 360 agcatggcga ttaagaatcc aaaggctacg ctacgttact tccagcacct cctggggaag 420 caggcagata acccccatgt agctctttac caggcccgct tcccggagca cgagctgact 480 ttcgacccac agaggcagac tgtgcacttt cagatcagct cgcagctgca gttctcacct 540 gaggaagtgt tgggcatggt tctcaattat tctcgttctc tagctgaaga ttttgcagag 600 cagcccatca aggatgcagt gatcaccgtg ccagtcttct tcaaccaggc cgagcgccga 660 gctgtgctgc aggctgctcg tatggctggc ctcaaagtgc tgcagctcat caatgacaac 720 accgccactg ccctcagcta tggtgtcttc cgccggaaag atattaacac cactgcccag 780 aatatcatgt tctatgacat gggctcaggc agcaccgtat gcaccattgt gacctaccag 840 atggtgaaga ctaaggaagc tgggatgcag ccacagctgc agatccgggg agtaggattt 900 gaccgtaccc tggggggcct ggagatggag ctccggcttc gagaacgcct ggctgggctt 960 ttcaatgagc agcgcaaggg tcagagagca aaggatgtgc gggagaaccc gcgtgccatg 1020 gccaagctgc tgcgtgaggc taatcggctc aaaaccgtcc tcagtgccaa cgctgaccac 1080 atggcacaga ttgaaggcct gatggatgat gtggacttca aggcaaaagt gactcgtgtg 1140 gaatttgagg agttgtgtgc agacttgttt gagcgggtgc ctgggcctgt acagcaggcc 1200 ctccagagtg ccgaaatgag tctggatgag attgagcagg tgatcctggt gggtggggcc 1260 actcgggtcc ccagagttca ggaggtgctg ctgaaggccg tgggcaagga ggagctgggg 1320 aagaacatca atgcagatga agcagccgcc atgggggcag tgtaccaggc agctgcgctc 1380 agcaaagcct ttaaagtgaa gccatttgtc gtccgagatg cagtggtcta ccccatcctg 1440 gtggagttca cgagggaggt ggaggaggag cctgggattc acagcctgaa gcacaataaa 1500 cgggtactct tctctcggat ggggccctac cctcaacgca aagtcatcac ctttaaccgc 1560 tacagccatg atttcaactt ccacatcaac tacggcgacc tgggcttcct ggggcctgaa 1620 gatcttcggg tatttggctc ccagaatctg accacagtga agctaaaagg ggtgggtgac 1680 agcttcaaga agtatcctga ctacgagtcc aagggcatca aggctcactt caacctggat 1740 gagagtggcg tgctcagtct agacagggtg gagtctgtat ttgagacact ggtagaggac 1800 agcgcagaag aggaatctac tctcaccaaa cttggcaaca ccatttccag cctgtttgga 1860 ggcggtacca caccagatgc caaggagaat ggtactgata ctgtccagga ggaagaggag 1920 agccctgcag aggggagcaa ggacgagcct ggggagcagg tggagctcaa ggaggaagct 1980 gaggccccag tggaggatgg ctctcagccc ccaccccctg aacctaaggg agatgcaacc 2040 cctgagggag aaaaggccac agaaaaagaa aatggggaca agtctgaggc ccagaaacca 2100 agtgagaagg cagaggcagg gcctgagggc gtcgctccag ccccagaggg agagaagaag 2160 cagaagcccg ccaggaagcg gcgaatggta gaggagatcg gggtggagct ggttgttctg 2220 gacctgcctg acttgccaga ggataagctg gctcagtcgg tgcagaaact tcaggacttg 2280 acactccgag acctggagaa gcaggaacgg gaaaaagctg ccaacagctt ggaagcgttc 2340 atatttgaga cccaggacaa gctgtaccag cccgagtacc aggaagtgtc cacagaggag 2400 cagcgtgagg agatctctgg gaagctcagc gccgcatcca cctggctgga ggatgagggt 2460 gttggagcca ccacagtgat gttgaaggag aagctggctg agctgaggaa gctgtgccaa 2520 gggctgtttt ttcgggtaga ggagcgcaag aagtggcccg aacggctgtc tgccctcgat 2580 aatctcctca accattccag catgttcctc aagggggccc ggctcatccc agagatggac 2640 cagatcttca ctgaggtgga gatgacaacg ttagagaaag tcatcaatga gacctgggcc 2700 tggaagaatg caactctggc cgagcaggct aagctgcccg ccacagagaa gcctgtgttg 2760 ctctcaaaag acattgaagc taagatgatg gccctggacc gagaggtgca gtatctgctc 2820 aataaggcca agtttaccaa gccccggccc cggcctaagg acaagaatgg gacccgggca 2880 gagccacccc tcaatgccag tgccagtgac cagggggaga aggtcatccc tccagcaggc 2940 cagactgaag atgcagagcc catttcagaa cctgagaaag tagagactgg atccgagcca 3000 ggagacactg agcctttgga gttaggaggt cctggagcag aacctgaaca gaaagaacaa 3060 tcgacaggac agaagcggcc tttgaagaac gacgaactat aacccccacc tctgttttcc 3120 ccattcatct ccaccccctt cccccaccac ttctatttat ttaacatcga gggttggggg 3180 aggggttggt cctgccctcg gctggagttc ctttctcacc cctgtgattt ggaggtgtgg 3240 agaaggggaa gggagggaca gctcactggt tccttctgca gtacctctgt ggttaaaaat 3300 ggaaactgtt ctcctcccca gccccactcc ctgttcccta cccatatagg ccctaaattt 3360 gggaaaaatc actattaatt tctgaatcct ttgcctgtgg gtaggaagag aatggctgcc 3420 agtggctgat gggtcccggt gatgggaagg gtatcaggtt gctggggagt ttccactctt 3480 ctctggtgat tgttccttcc 3500 140 5468 DNA Homo sapiens 140 cccggggtca ctcctgctgg acctactccg accccctagg ccgggagtga aggcgggact 60 tgtgcggtta ccagcggaaa tgcctcgggg tcagaagtcg caggagagat agacagctgc 120 tgaaccaatg ggaccagcgg atggggcgga tgttatctac cattggtgaa cgttagaaac 180 gaatagcagc catgaatcag ctgggggggc ggagcagtga cgtttattgc ggagggggcc 240 gcttcgaatc ggcggcggcc agcttggtgg cctgggccaa tgaacggcct ccaacgagca 300 gggccttcac caatcggcgg cctccacgac ggggctgggg gagggtatat aagccgagta 360 ggcgacggtg aggtcgacgc cggccaagac agcacagaca gattgaccta ttggggtgtt 420 tcgcgagtgt gagagggaag cgccgcggcc tgtatttcta gacctgccct tcgcctggtt 480 cgtggcgcct tgtgaccccg ggcccctgcc gcctgcaagt cgaaattgcg ctgtgctcct 540 gtgctacggc ctgtggctgg actgcctgct gctgcccaac tggctggcaa gatgaagctc 600 tccctggtgg ccgcgatgct gctgctgctc agcgcggcgc gggccgagga ggaggacaag 660 aaggaggacg tgggcacggt ggtcggcatc gacttgggga ccacctactc ctggtaagtg 720 gggttgcgga tgagggggac ggggcgtggc gctggctggc gtgagaagtg cggtgctgat 780 gtccctctgt cgggtttttg cagcgtcggc gtgttcaaga acggccgcgt ggagatcatc 840 gccaacgatc agggcaaccg catcacgccg tcctatgtcg ccttcactcc tgaaggggaa 900 cgtctgattg gcgatgccgc caagaaccag ctcacctcca accccgagaa cacggtcttt 960 gacgccaagc ggctcatcgg ccgcacgtgg aatgacccgt ctgtgcagca ggacatcaag 1020 ttcttgccgt tcaaggttcg accggttttc ctcatccagt tagagaacgg gtgggtggtg 1080 ggagtattta gagttataag tctctggaaa agtgttgaga caacagttga aggttataga 1140 catgatgtat gtaataactt taatactatt agtatgttac aaaacttaag acagttgctg 1200 tcgtactgtc tacgatagtt taggaataaa agaccgatta aaactgaact ttgtaagaca 1260 cctatactcc ctgaagtatt tctagtcaat ttgcagcccc aagggaccaa aataaaccaa 1320 attgtgggga tggtagtggg tcttttaaac tttgagatgt cattgtatct gtgtctgaaa 1380 acaataattc tttaaaatag gtggttgaaa agaaaactaa accatacatt caagttgata 1440 ttggaggtgg gcaaacaaag acatttgctc ctgaagaaat ttctgccatg gttctcacta 1500 aaatgaaaga aaccgctgag gcttatttgg gaaagaaggt aaatatttct agaacaatgt 1560 taagtatttt ttgatcatta gtattctcgg ttggctgtta tgtatagaag ccttcgtgaa 1620 gggtttcaaa aattttaatc agaatggtat tcatgcttgt cacggtttaa ttattgagtc 1680 cctttactat aagccaaaca aaaatagact tttcatgtat tatttaatgc ttacattcca 1740 ggaacaataa aattttatat gttgtattca tcaataattg gcttaaaaac taaagtgatg 1800 gtttgactgt aatttttttt ttttgagatg gagtcttgct ctgttgccca ggctggactg 1860 cagtggcacg atctcagctc actgcaacct ctgcctcccg ggttaagcag ctctcctgcc 1920 tcagcctcca agtaatggaa cgacaggcac accaccacag ctggctaatt tttttttttt 1980 tttttaattt tcagtagaga cagggtttct ccacattgcc aggctggtct tgaaatcctg 2040 ccctcaggtt gatcctcctg cctagcctcc caaagtgctg gattataggc agaagccacc 2100 gcctggccag actgtaattt aaataagggt taaactatgt gacaatacac ttaattatct 2160 ttatcctttt aggttaccca tgcagttgtt actgtaccag cctattttaa tgatgcccaa 2220 cgccaagcaa ccaaagacgc tggaactatt gctggcctaa atgttatgag gatcatcaac 2280 gagccgtaag tatgaaattc agggatacgg catatttgcc aaatagtgga aatgtgaagt 2340 actgacaaaa cttttccctt tttcaatcta atagtacggc agctgctatt gcttatggcc 2400 tggataagag ggagggggag aagaacatcc tggtgtttga cctgggtggc ggaaccttcg 2460 atgtgtctct tctcaccatt gacaatggtg tcttcgaagt tgtggccact aatggagata 2520 ctcatctggg tggagaagac tttgaccagc gtgtcatgga acacttcatc aaactgtaca 2580 aaaagaagac gggcaaagat gtcaggaagg acaatagagc tgtgcagaaa ctccggcgcg 2640 aggtagaaaa ggccaaggcc ctgtcttctc agcatcaagc aagaattgaa attgagtcct 2700 tctatgaagg agaagacttt tctgagaccc tgactcgggc caaatttgaa gagctcaaca 2760 tggtatgttc cttgttttct gctttgctaa tgagatctcc ttagactctg aattcaggac 2820 attgcatcta gatacttaga taacagacat cacagtaacc atgtcttttt tctaggatct 2880 gttccggtct actatgaagc ccgtccagaa agtgttggaa gattctgatt tgaagaagtc 2940 tgatattgat gaaattgttc ttgttggtgg ctcgactcga attccaaaga ttcagcaact 3000 ggttaaagag ttcttcaatg gcaaggaacc atcccgtggc ataaacccag atgaagctgt 3060 agcgtatggt gctgctgtcc aggctggtgt gctctctggt gatcaagata caggtaggtc 3120 atcatcgcag catctttctt agtgattcag tagcttgatg gaagagctcg gtacccctat 3180 tgctttagaa aataccagaa tatgagcaac aaggtcacac agctagtaaa gggtataagt 3240 gaagacaaga ctggggtagt ctccaagatc attagcaact gtttaattca ctgcctttaa 3300 aatgtgtgtg ttagaaccta accaaatgtt agagagataa actttacata gctcataggg 3360 agaacttgaa ttaaaagtta aataacttat ccttacaggt gacctggtac tgcttcatgt 3420 atgtcccctt acacttggta ttgaaactgt aggaggtgtc atgaccaaac tgattccaag 3480 taatacagtg gtgcctacca agaactctca gatcttttct acagcttctg ataatcaacc 3540 aactgttaca atcaaggtct atgaaggtaa ttaccttaag tttggttaat atcatggctt 3600 tttttttgag atgaagtctt gctctgttgc ccaggctgga ctgcagtggc acgatctcgg 3660 ctcactgcaa attctgtctc ccgggttcaa gtgattctcc tgcctcagcc tccagagtag 3720 ctggattaca gcctgaccac cacacctggc taatttctgt atttttagta gaggatgggc 3780 tttcaccatg tttcccaggc tggtctccaa ctcctgacct caggtcatct gcctgcctcc 3840 accgtcccga aagtactggg attatagcgt gagccaccac gccagatcta tctatcatgg 3900 catattttaa aagaacatga cttaatatgt cctattgaaa tggctaggga actaagtaac 3960 tgctgttttc agatggaggt cttaatttga ataatgttga tattagatat ttagcattct 4020 tttttttttt tttttaatgg agtcttgctc tgtcgcctag gctggggtgc agtggcatga 4080 cttgcaacct ctgcctcccg aatagctggg attacaggtg cccaccatca cgcccggcta 4140 agttttgtat ttttagtaga ggcgagtttc gccatgttgg ccaggctggt cttgaacccc 4200 taacctcagt gatcccacgg tcaccgacct ggcctcccaa aagtactgta cccagccaat 4260 gattagcatt ctcactaata atagcatctg agctggctcc tagagtacaa gaaaaaggag 4320 ttcacagtac tttaaaatag ataaaattca gttgagttag taacctaact cattgttagt 4380 actagttgct gctccttgta gaccaatatg aaattacttt tagctcgata aaaccaaaag 4440 tgtcacttta tgcttcagac tgaaatgcgg ggatctagat gtgctaatgc ttgtcagtaa 4500 caactaacaa gtttttctgt atgtaacttc taggtgaaag acccctgaca aaagacaatc 4560 atcttctggg tacatttgat ctgactggaa ttcctcctgc tcctcgtggg gtcccacaga 4620 ttgaagtcac ctttgagata gatgtgaatg gtattcttcg agtgacagct gaagacaagg 4680 gtacagggaa caaaaataag atcacaatca ccaatgacca gaatcgcctg acacctgaag 4740 aaatcgaaag gatggttaat gatgctgaga agtttgctga ggaagacaaa aagctgaagg 4800 agcgcattga tactagaaat gagttggaaa gctatgccta ttctctaaag aatcagattg 4860 gagataaaga aaagctggga ggtaaacttt cctctgaaga taaggagacc atggaaaaag 4920 ctgtagaaga aaagattgaa tggctggaaa gccaccaaga tgctgacatt gaagacttca 4980 aagctaagaa gaaggaactg gaagaaattg ttcaaccaat tatcagcaaa ctctatggaa 5040 gtgcaggccc tcccccaact ggtgaagagg atacagcaga aaaagatgag ttgtagacac 5100 tgatctgcta gtgctgtaat attgtaaata ctggactcag gaacttttgt taggaaaaaa 5160 ttgaaagaac ttaagtctcg aatgtaattg gaatcttcac ctcagagtgg agttgaaact 5220 gctatagcct aagcggctgt ttactgcttt tcattagcag ttgctcacat gtctttgggt 5280 gggggggaga agaagaattg gccatcttaa aaagcgggta aaaaacctgg gttagggtgt 5340 gtgttcacct tcaaaatgtt ctatttaaca actgggtcat gtgcatctgg tgtaggaggt 5400 tttttctacc ataagtgaca ccaataaatg tttgttattt acactggtct aatgtttgtg 5460 agaagctt 5468 141 1990 DNA Homo sapiens 141 gaattccggg ggtattggca gctgaggagt ggaggctggg cagctccgac tccctgacgc 60 cagcgcgacc agatcaatcc aggctccagg agaaagcagg cgggcgggcg gagaaaggag 120 aggccgagcg gctcaacccg ggccgaggct cggggagcgg agagtggcgc accgcccggc 180 cgtccggacc cgggccgcga gaccccgctc gcccggccac tcgtgctccc gcacggacgg 240 gcgcgccgcc aacccggtgc tgactgggtt acttttttaa acactaggaa tggtaatttc 300 tactcttctg gacttcaaac taagaagtta aagagacttc tctgtaaata aacaaatctc 360 ttctgctgtc cttttgcatt tggagacagc tttatttcac catatccaag gagtataact 420 agtgctgtca ttatgaatgt gacaagttta ttttccttta caagtccagc tgtgaagaga 480 cttcttgggt ggaaacaggg cgatgaagaa gaaaaatggg cagagaaagc tgttgatgct 540 ttggtgaaaa aactgaagaa aaagaaaggt gccatggagg aactggaaaa ggccttgagc 600 tgcccagggc aaccgagtaa ctgtgtcacc attccccgct ctctggatgg caggctgcaa 660 gtctcccacc ggaagggact gcctcatgtc atttactgcc gtgtgtggcg ctggcccgat 720 cttcagagcc accatgaact aaaaccactg gaatgctgtg agtttccttt tggttccaag 780 cagaaggagg tctgcatcaa tccctaccac tataagagag tagaaagccc tgtacttcct 840 cctgtgctgg ttccaagaca cagcgaatat aatcctcagc acagcctctt agctcagttc 900 cgtaacttag gacaaaatga gcctcacatg ccactcaacg ccacttttcc agattctttc 960 cagcaaccca acagccaccc gtttcctcac tctcccaata gcagttaccc aaactctcct 1020 gggagcagca gcagcaccta ccctcactct cccaccagct cagacccagg aagccctttc 1080 cagatgccag ctgatacgcc cccacctgct tacctgcctc ctgaagaccc catgacccag 1140 gatggctctc agccgatgga cacaaacatg atggcgcctc ccctgccctc agaaatcaac 1200 agaggagatg ttcaggcggt tgcttatgag gaaccaaaac actggtgctc tattgtctac 1260 tatgagctca acaatcgtgt gggtgaagcg ttccatgcct cctccacaag tgtgttggtg 1320 gatggtttca ctgatccttc caacaataag aaccgtttct gccttgggct gctctccaat 1380 gttaaccgga attccactat tgaaaacacc aggcggcata ttggaaaagg agttcatctt 1440 tattatgttg gaggggaggt gtatgccgaa tgccttagtg acagtagcat ctttgtgcaa 1500 agtcggaact gcaactacca tcatggattt catcctacta ctgtttgcaa gatccctagt 1560 gggtgtagtc tgaaaatttt taacaaccaa gaatttgctc agttattggc acagtctgtg 1620 aaccatggat ttgagacagt ctatgagctt acaaaaatgt gtactatacg tatgagcttt 1680 gtgaagggct ggggagcaga ataccaccgc caggatgtta ctagcacccc ctgctggatt 1740 gagatacatc tgcacggccc cctccagtgg ctggataaag ttcttactca aatgggttca 1800 cctcataatc ctatttcatc tgtatcttaa atggccccag catctgcctc tggaaaacta 1860 ttgagccttg catgtacttg aaggatggat gagtcagaca cgattgagaa ctgacaaagg 1920 agccttgata atacttgacc tctgtgacca actgttggat tcagaaattt aaacaaaaaa 1980 aaaaaaaaaa 1990 142 576 DNA Homo sapiens 142 tgggggagat tgggactggg gaaatggccc ttgagtgaag gaaagggaga taaagctgag 60 gaagaggcct caggactcag cacagggtgg caacactacc attcactgtc cctgtgccat 120 ttcttcagac tctgggccgc caccaccacc agatggccaa gagcagataa ccttttgtcc 180 acagccaggt agagatgggc aacttacatg gccttgagaa gaggtataga aaaaggagtg 240 cttttgaggg ctaccccctg ttgtgaccat tcctgaagtg cagagaccac accagcaaaa 300 catgcccagt cttagtagtg gggacgaaga attgatgagt ggatccagtc agctccggca 360 gacaggccac agggttgcca ggtttgatga gccaaccagg tgagcacaca gcttcggagc 420 actgccctga atcctgtctt ctccctcagg actgcccttt cctggccaca ccaagtttgg 480 cacctctcca gaaagttggc agggagcaag tggcagacag cacccctctc tccctagcct 540 attaacacac agagccgcca atggcagggc agagcg 576 143 1932 DNA Homo sapiens 143 gcggccgcac caattttttt ttttttattt tttttttttt tttttttttt ttcaaatatt 60 cagggaactt tatttttaaa gaataaatca agtaagacac agctttcgtt tacctaaaca 120 tgcataatcc aacctgaata taaactgcac ttaattggtg aattacacat gaaatacaaa 180 gggaatgcaa ttttacatat gtaaaatgat tgctagctat agcaatttaa cagtcaaatt 240 tatcagaaca ttgtacatta aaaaacacaa acaacaactt aaagccaaat atctatagta 300 aaccaaggaa aattctgata tggaatggtt tgactaaaag caaagaataa ggcacctgct 360 atgaatttag cacaaccata aaacagaatt agttaaccaa gacacttgtt tcaaaaaggg 420 aaacaagtac agagactgat taactgggtg agaaaggcaa gtaacaattt agttaaaaac 480 ctgctggccc aaggtcagtt gattcattcc ttattccaga atagttaagt tcctgaaagt 540 ccttaaccac tctgctccct tactgttctc catgtttgag ggtatcagaa gccccctgtg 600 aggttcacgc tgtgtataga ctaggtagca gatttccctt ctgttcctct taaaacagct 660 tattttaaaa gaaatatcct gaggcaatta acaaagcaaa cacaagcagc tttctttcca 720 acgcattaat acatagacac tgctcaggtt ttttttcacc aagttatggc taagtataca 780 aatagccaat acttgcagtt ttcaacagta ctagaaaacc caaaacctgc cctatgaccc 840 tcacccttac cattagtaaa acgtaaattt gatcaatcat aacctataaa gtcatataac 900 aaagggaaga ctaaagactg atcattatca gtaaatccat tcaattccag atgccacttt 960 aggctgatgt gtctagtacc ctaatgattg aaaaatcatt aatctagaaa aagcatttgc 1020 aaactaagga taacttcgca gttgatgtgc ctttttttgc tattaaaagt gctatttaac 1080 atgctaaaat gtcttatggc acattggact caacagcatg ttctgatgag gcatccattt 1140 ttagcagtat ttttccctag aattttgttt ggcatagtaa acccctttga tatattaaaa 1200 tagttctggt gaaataaatg taacataaac aaaccttccc tgactgactt cactccacca 1260 cggtagcttt tagtgaaacc acagtaactg attaagtcag aaaacgatca agtttttttt 1320 ttatggcatc ttgggttact atactcactc atgcaaaatc caaggtagtg taatggaaac 1380 aatattggta aaatagatgt tgtggctata agcatctccc tttatattag acatttagaa 1440 gcttttaaaa ctttttagat gctaaaggtt gtggcaaaac taggctgtgt agttgttcca 1500 tttataagca ccttattaca ggacagttac atgaacctat aagggagtgt gctttcagtt 1560 caaaagagta ataaagtgcc tagctatata aaaaccacaa gacttcaaat tgtaatttaa 1620 gctaactgca gttatacatt tgggttaaca aaatctagac cctgtctatg cagagttaga 1680 ctaattgttc atactgtttt aataaccaca taaaaaaact tactcttaat tgactgaata 1740 agtagggtcc actactgtat cttaacaatc aaattttatt gctttattca tgtggtgttt 1800 tttgcaaggc actgtggtat ggactagaaa acttggaatg actcatgaag aaaccttgga 1860 atgacacatg aagcatgata ggaaagtcat tctgaggcag gatgctttac tgaattgcct 1920 cgtgccgaat tc 1932 144 1846 DNA Homo sapiens 144 gcagtgcggc ggtcacaggc tgagtgctgc ggcgcgatcc ttgcttccct gagcgttggc 60 ccgggaggaa agaagatggt gctggatctg gatttgtttc gggtggataa aggaggggac 120 ccagccctca tccgagagac gcaggagaag cgcttcaagg acccgggact agtggaccag 180 ctggtgaagg cagacagcga gtggcgacga tgtagatttc gggcagacaa cttgagcaag 240 ctgaagaacc tatgcagcaa gacaatcgga gagaaaatga agaaaaaaga gccagtggga 300 gatgatgagt ctgtcccaga gaatgtgctg agtttcgatg accttactgc agacgcttta 360 gctaacctga aagtctcaca aatcaaaaaa gtccgactcc tcattgatga agccatcctg 420 aagtgtgacg cggagcggat aaagttggaa gcagagcggt ttgagaacct ccgagagatt 480 gggaaccttc tgcacccttc tgtacccatc agtaacgatg aggatgtgga caacaaagta 540 gagaggattt ggggcgattg tacagtcagg aagaagtact ctcatgtgga cctggtggtg 600 atggtagatg gctttgaagg cgaaaagggg gccgtggtgg ctgggagtcg agggtacttc 660 ttgaaggggg tcctggtgtt cctggaacag gctctcatcc agtatgccct tcgcaccttg 720 ggaagtcggg gctacattcc catttatacc ccctttttca tgaggaagga ggtcatgcag 780 gaggtggcac agctcagcca gtttgatgaa gaactttata aggtgattgg caaaggcagt 840 gaaaagtctg atgacaactc ctatgatgag aagtacctga ttgccacctc agagcagccc 900 attgctgccc tgcaccggga tgagtggctc cggccggagg acctgcccat caagtatgct 960 ggcctgtcta cctgcttccg tcaggaggtg ggctcccatg gccgtgacac ccgtggcatc 1020 ttccgagtcc atcagtttga gaagattgaa cagtttgtgt actcatcacc ccatgacaac 1080 aagtcatggg agatgtttga agagatgatt accaccgcag aggagttcta ccagtccctg 1140 gggattcctt accacattgt gaatattgtc tcaggttctt tgaatcatgc tgccagtaag 1200 aagcttgacc tggaggcctg gtttccgggc tcaggagcct tccgtgagtt ggtctcctgt 1260 tctaattgca cggattacca ggctcgccgg cttcgaatcc gatatgggca aaccaagaag 1320 atgatggaca aggtggagtt tgtccatatg ctcaatgcta ccatgtgcgc cactacccgt 1380 accatctgcg ccatcctgga gaactaccag acagagaagg gcatcactgt gcctgagaaa 1440 ttgaaggagt tcatgccgcc aggactgcaa gaactgatcc cctttgtgaa gcctgcgccc 1500 attgagcagg agccatcaaa gaagcagaag aagcaacatg agggcagcaa aaagaaagca 1560 gcagcaagag acgtcaccct agaaaacagg ctgcagaaca tggaggtcac cgatgcttga 1620 acattcctgc ctccctattt gccaggcttt catttctgtc tgctgagatc tcagagcctg 1680 cccaacagca gggaagccaa gcacccattc atccccctgc ccccatctga ctgcgtagct 1740 gagaggggaa cagtgccatg taccacacag atgttcctgt ctcctcgcat gggcataggg 1800 acccatcatt gatgactgat gaaaccatgt aataaagcat ctctgg 1846 145 2131 DNA Homo sapiens 145 ctctttataa tttagtttcc atagaagtta tatgtgcatt taaaaaaatt caatgctgga 60 gcgaccgtgt ctggggagcc gagccccgct tctcgctgcg gtgagcccgg actggggcac 120 gcactgcgca gactccccgc tgcagtgggc ggagtcccac aggccccgcc cctcctccca 180 ccctcgttca gcctgtccag acagaagctg gggcccagcg gaggtagcag cagacgcctg 240 agagcgaggc cgaggccctc agggtttgga gaccctgaca cacccacctt ctcacctggg 300 ctctgcgtat cccccagcct tgagggaaga tgaagcctaa actgatgtac caggagctga 360 aggtgcctgc agaggagccc gccaatgagc tgcccatgaa tgagattgag gcgtggaagg 420 ctgcggaaaa gaaagcccgc tgggtcctgc tggtcctcat tctggcggtt gtgggcttcg 480 gagcctgatg actcagctgt ttctatggga atacggcgac ttgcatctct ttgggcccaa 540 ccagcgccca gccccctgct atgacccttg cgaagcagtg ctggtggaaa gcattcctga 600 gggcctggac ttccccaatg cctccacggg gaacccttcc accagccagg cctggctggg 660 cctgctcgcc ggtgcgcaca gcagcctgga catcgcctcc ttctactgga ccctcaccaa 720 caatgacacc cacacgcagg agccctctgc ccagcagggt gaggaggtcc tccggcagct 780 gcagaccctg gcaccaaagg gcgtgaacgt ccgcatcgct gtgagcaagc ccagcgggcc 840 ccagccacag gcggacctgc aggctctgct gcagagcggt gcccaggtcc gcatggtgga 900 catgcagaag ctgacccatg gcgtcctgca taccaagttc tgggtggtgg accagaccca 960 cttctacctg ggcagtgcca acatggactg gcgttcactg acccaggtca aggagctggg 1020 cgtggtcatg tacaactgca gctgcctggc tcgagacctg accaagatct ttgaggccta 1080 ctggttcctg ggccaggcag gcagctccat cccatcaact tggccccggt tctatgacac 1140 ccgctacaac caagagacac caatggagat ctgcctcaat ggaacccctg ctctggccta 1200 cctggcgagt gcgcccccac ccctgtgtcc aagtggccgc actccagacc tgaaggctct 1260 actcaacgtg gtggacaatg cccggagttt catctacgtc gctgtcatga actacctgcc 1320 cactctggag ttctcccacc ctcacaggtt ctggcctgcc attgacgatg ggctgcggcg 1380 ggccacctac gagcgtggcg tcaaggtgcg cctgctcatc agctgctggg gacactcgga 1440 gccatccatg cgggccttcc tgctctctct ggctgccctg cgtgacaacc atacccactc 1500 tgacatccag gtgaaactct ttgtggtccc cgcggatgag gcccaggctc gaatcccata 1560 tgcccgtgtc aaccacaaca agtacatggt gactgaacgc gccacctaca tcggaacctc 1620 caactggtct ggcaactact tcacggagac ggcgggcacc tcgctgctgg tgacgcagaa 1680 tgggaggggc ggcctgcgga gccagctgga ggccattttc ctgagggact gggactcccc 1740 ttacattcat gaccttgaca cctcagctga cagcgtgggc aacgcctgcc gcctgctctg 1800 aggcccgatc cagtgggcag gccaaggcct gctgggcccc cgcggaccca ggtgctctgg 1860 gtcacggtcc ctgtccccgc acccccgctt ctgtctgccc cattgtggct cctcaggctc 1920 tctcccctgc tctcccacct ctacctccac ccccaccggc ctgacgctgt ggccccggga 1980 cccagcagag ctgggggagg gatcagcccc caaagaaatg ggggtgcatg ctggcctgcc 2040 ccctggccca cccccacttt ccagggcaaa aagggcccag ggttataata agtaaataac 2100 ttgtctgtaa aaaaaaaaaa aaaaaaaaaa a 2131 146 1044 DNA Homo sapiens 146 ttaattaaag atcttttttt tttttttttt tgccagtgcc aggataaaaa gcaaaatttt 60 aaattggaaa atgtctagca ctttacacag tggaatgaaa gaatacgaaa ttcaaaaaca 120 ttattaaaag tccatatgcc gcagcagcac gcgccatgat gagagctccc cttccgaggc 180 gcttctggag cagcttcctc aacctgtccg ggagacgggc tcagaagagc agggccccca 240 tgctgccaac ctcgctttgc tccttaacga agatctcaaa gtactggtag atgattgtga 300 ctgcgagcag gatcccggtt ccagacccaa tggcgcctag gaagtcagcc aggaccgaga 360 gggccccgat gcacagccca ccaaaggccg cggctgtggg gatgtaccgg ttgagttcat 420 ggaccatggg aggtctctcg gtggcctctc atcaccatct gctgctcctt cagctgcttt 480 gcaacatctt tggcagagga acctgagacc tcaatccacg ttttggagaa gaatgcacag 540 gagcccagca tgaacactat gtatacaact gcatggaccg ggtcttctaa cacggagcca 600 aaagattctg gaggggacag gtaatagcaa aggccaccaa ctggataagc acgtgctgac 660 cagcaagttg ccactgaagc gagctgagag catttgggag atgacataaa ggttggacac 720 cagggcagac tgcaggatga tggggatgtt ggacgtatag aagagcttga tgggataggt 780 gttgtactgg ccacggtagc gggccgactt gattggcagg tccactcgga agccctggaa 840 atagatgacc actgcaaaga caaagatggt ggcgatgaga ttcatgaggt tgggaagatt 900 ctggcggtag aacgcctccc gaagggctcg gaccttgtct gtgcgtgtgg ccagcagatg 960 gaaaagtgcg atgatagcac cttcaaattc cattcctcgg ccagtgttga cagtagtggg 1020 gctgaatgcc ctcgtgccga attc 1044 147 526 DNA Homo sapiens misc_feature (1)...(526) n = A,T,C or G 147 aacnaagatc tttttttttt tttttttttt gcttgatttt attttattaa aaaagactgg 60 aactcagtcc nttnttccta ttaagtccat tttcccaaga gatgtcactg tttgagataa 120 taacttaaat attcttgatg tggaggtagt ctctctcttc ctagtgggat gtcttcttag 180 ctcctttccc aaacttggca tcaagaccaa gacccaggaa cacaagcaca gtgcccaccc 240 actgcatggg gctgatggga ttggcgaaga ggatcacaga ggccaaaatt gtgaagaact 300 ttcgagttgt agtgatgatg gagcaggtca ggggaccaaa atacacaacc gtcataaaga 360 tgaagctctg acccagggca ctggtcagcc caaagagcag ggatgttata gatgatggca 420 gggtaccttt cagcaaagct caagaactcc cagagctccc cagtgaacag gattcccatt 480 cccagcagca aatgtcgcca aaaggtttga tgttcagcat catggt 526 148 1923 DNA Homo sapiens 148 gccgggcagg aggaaggagc ctccctcagg gtttcgggaa ccagatctct caccaggaaa 60 gactgataca gaacgatcga tacagaaacc acgctgccgc caccacacca tcaccatcga 120 cagaacagtc cttaatccag aaacctgaaa tgaaggaaga ggagactctg cgcagagcac 180 tttgggtccg gagggcgaga ctccggcgga agcattcccg ggcgggtgac ccagcacggt 240 ccctcttgga attggattcg ccattttatt tttcttgctg ctaaatcacc gagcccggaa 300 gattagagag ttttatttct gggattcctg tagacacacc cacccacata catacattta 360 tatatatata tattatatat atataaaaat aaatatctct attttatata tataaaatat 420 atatattctt tttttaaatt aacagtgcta atgttattgg tgtcttcact ggatgtattt 480 gactgctgtg gacttgagtt gggaggggaa tgttcccact cagatcctga cagggaagag 540 gaggagatga gagactctgg catgatcttt tttttgtccc acttggtggg gccagggtcc 600 tctcccctgc ccaggaatgt gcaaggccag ggcatggggg caaatatgac ccagttttgg 660 gaacaccgac aaacccagcc ctggcgctga gcctctctac cccaggtcag acggacagaa 720 agacagatca caggtacagg gatgaggaca ccggctctga ccaggagttt ggggagcttc 780 aggacattgc tgtgctttgg ggattccctc cacatgctgc acgcgcatct cgcccccagg 840 ggcactgcct ggaagattca ggagcctggg cggccttcgc ttactctcac ctgcttctga 900 gttgcccagg aggccactgg cagatgtccc ggcgaagaga agagacacat tgttggaaga 960 agcagcccat gacagctccc cttcctggga ctcgccctca tcctcttcct gctccccttc 1020 ctggggtgca gcctaaaagg acctatgtcc tcacaccatt gaaaccacta gttctgtccc 1080 cccaggagac ctggttgtgt gtgtgtgagt ggttgacctt cctccatccc ctggtccttc 1140 ccttcccttc ccgaggcaca gagagacagg gcaggatcca cgtgcccatt gtggaggcag 1200 agaaaagaga aagtgtttta tatacggtac ttatttaata tcccttttta attagaaatt 1260 aaaacagtta atttaattaa agagtagggt tttttttcag tattcttggt taatatttaa 1320 tttcaactat ttatgagatg tatcttttgc tctctcttgc tctcttattt gtaccggttt 1380 ttgtatataa aattcatgtt tccaatctct ctctccctga tcggtgacag tcactagctt 1440 atcttgaaca gatatttaat tttgctaaca ctcagctctg ccctccccga tcccctggct 1500 ccccagcaca cattcctttg aaataaggtt tcaatataca tctacatact atatatatat 1560 ttggcaactt gtatttgtgt gtatatatat atatatatgt ttatgtatat atgtgattct 1620 gataaaatag acattgctat tctgtttttt atatgtaaaa acaaaacaag aaaaaataga 1680 gaattctaca tactaaatct ctctcctttt ttaattttaa tatttgttat catttattta 1740 ttggtgctac tgtttatccg taataattgt ggggaaaaga tattaacatc acgtctttgt 1800 ctctagtgca gtttttcgag atattccgta gtacatattt atttttaaac aacgacaaag 1860 aaatacagat atatcttaaa aaaaaaaaaa gcattttgta ttaaagaatt taattctgat 1920 ctc 1923 149 157 DNA Homo sapiens misc_feature (1)...(157) n = A,T,C or G 149 tttttttcnt gatcaaangt actcttttat tcttaaataa aaatcttaat tngctttgac 60 ctccaaaggc tctaatccca ntctccaaat tcnnntnaag ggatgntctn ttcatgtggg 120 gccggtttaa acagaggctg cctcaccaga gcagcct 157 150 1220 DNA Homo sapiens 150 ctcgaggcca agaattcggc acgaggcaat cagcatacag tacagactga aaatagattt 60 catggatcta gcaagcactg caggactgtc actcaacgaa gaggaaatat ggttactaca 120 tacactgact gttcaggaca gtagttctta ttctattctc actaaatcca actggttgac 180 tcttcctcat tatctttgat gctaaacaat tttctgtgaa ctattttgac aagtgcatga 240 tttcacttta aacaatttga tatagctatt aagtatattt aagggttttt ttttttgaca 300 aattcaacat tcaacgagta gacaaaatgc taattatttc cctgattagg aaagtttctt 360 taaaaaacac gtaattttgc ctagtgcttt ttctctacct gcccttgggc tcactaatat 420 caccagtatt attaccaaga aaatattgag tttacctgat taaactttaa aagttaattg 480 tagatttaaa ttgtgtgaac ctaatgattt ttgcagtgaa acctttacta attcaaagtt 540 gcatgttcta tgacatctgt gacttgcgtt gcagagtgta catgaaactg tataattgag 600 tcattcagta aaggagaaca gtatcttggt taattgctac tgaaaggttg agaaaggaat 660 ggtttgatat ttaccacagc gctgtgcctt tctacagtag aactggggta aaggaaatgg 720 ttttattgcc catagtcatt taggctggaa aaaagttgaa aacttaacga aatattgcca 780 agagattgtt atgtgtttgg ttccagccta aaaatgattt tgtagtgttg aaatcatagc 840 tacttacata gctttttcat atttctttct tagttgttgg cactcttagg tcttagtatg 900 gatttatgtg tttgtgtgtg tgtagtttat cctctctctc atctttatct agagattgac 960 tgatacctca ttctgtttgt aaaaccagcc agtaatttct gtgcaacctt actatgtgca 1020 atatttttaa atcctgagaa atgtgtgctt ttgttttcgg atagacttat ttctttagtt 1080 ctgcactttt ccacattata ctccatatga gtattaatcc tatggataca tattaaaaca 1140 agtgtctcat acaacattgt atgtgagaga aatataaata tttacaacct gaaaaaaaaa 1200 aaaaaaaaaa tggcggccgc 1220 151 546 DNA Homo sapiens misc_feature (1)...(546) n = A,T,C or G 151 cttttttttt tttttaaaaa acaaactgca aaatggtatt tatttacatt aaaacatgaa 60 ttgcctgtat tnacacaaat ataagaggaa caatctgtta tgcacaataa ctgtaatatt 120 tagtacatgt tatacacagc agtatctgtt aagtcagtgg tttgagtgaa aacacagtac 180 caaaacattc ctgatacaaa ataagttact cattcacata ttctaatcat acaagacact 240 taatatttta aaagttacat acttcaaata acactggcta aatgtacaac taaagtttat 300 taattttttt tatgaaaaga cttcagattg ttattcataa atgatccctt tcaggatgca 360 ttatctttta aataaataaa ctaaattgac ttcaagacta tttataaata gcccactaaa 420 atatgattga agacattcct tcattttatt aaaggtgtag ctatatacta gagaatatgc 480 tcaactactg cctccaaatt ccaacactgt cattctaatt tgcaaatagg aattatttaa 540 attcca 546 152 543 DNA Homo sapiens misc_feature (1)...(543) n = A,T,C or G 152 tttttttttt tttcaaatct anatacttat tttacttcat cagttccaat cacntttctc 60 atcatacatc caatgacaat atacatatct tcatgggtnc taccattttg canaggcatc 120 atttactaat gcaattatcc aattgattta atgatnctag ctttattctg ggttattata 180 ttccatatta tacaatgata ggatatttga agagacatat aattttgtaa gacaagactc 240 attacatgat tgtattattt tctatgacat atttaaagag tttaataaca tgtataagta 300 aaancaaatt taggagaaga gtcaagatat ttcatgtatt ccaaagaact gatnctagta 360 ttgaggaagc taatagccta aaattatatc caaggcatgg ccacatnttt ttcccaaaat 420 gtctgaatga tcagggcaac ttcttatggt tcccttaggc tgtcagtctt gnccttctct 480 tctgggagct ntggggtaaa agtttggtct acagcagaag tgaaacatng gttgggctgg 540 gtt 543 153 516 DNA Homo sapiens misc_feature (1)...(516) n = A,T,C or G 153 tttttttttt gacngttttt aattgtgcct ttattcaact tagttcatta aaaatgtttt 60 aaagatcntt taaataaagt gaccactnac atgggatata ggtcacccct cagcatgtta 120 ttttttttct taaaaagcag tatttcttac aggaatctta ctgatcacac ggtagttaca 180 ataatgtcag atatgatgta tacagtctaa acgagacagt ccagttaaga atatacataa 240 tgtaaaaata cacatattaa aagttagcca agtggacaga cgcatgcggg ggtgggggga 300 gcaggtgaca ggaactcctt taacaatcag tagagggccc agatgcaaag aatctggttt 360 tccccgttac agtaaacagc tttcactaac gtatacaggt atttcataca catctaaaca 420 cacaaggggt aagttgtgac ctgctacaca tagggtctaa agtggtgtaa ttgtgatttt 480 cccctcgtgc cgaattcttg gcctcgaggg ccaaat 516 154 985 DNA Homo sapiens 154 gaattcggca cgaggctgtt caggggatcc ttctgtttct cacggggtga aacatgtctt 60 tagttcctca tgttaacacg aagccagagc ccacatgaac tgttggatgt cttccttaga 120 aagggtaggc atggaaaatt ccacgaggct cattctcagt atctcattaa ctcattgaaa 180 gattccagtt gtatttgtca cctggggtga caagaccaga caggctttcc caggcctggg 240 tatccaggga ggctctgcag ccctgctgaa gggccctaac tagagttcta gagtttctga 300 ttctgtttct cagtagtcct tttagaggct tgctatactt ggtctgcttc aaggaggtcg 360 accttctaat gtatgaagaa tgggatgcat ttgatctcaa gaccaaagac agatgtcagt 420 gggctgctct ggccctggtg tgcacggctg tggcagctgt tgatgccagt gtcctctaac 480 tcatgctgtc cttgtgatta aacacctcta tctcccttgg gaataagcac atacaggctt 540 aagctctaag atagataggt gtttgtcctt ttaccatcga gctacttccc ataataacca 600 ctttgcatcc aacactcttc acccacctcc catacgcaag gggatgtgga tacttggccc 660 aaagtaactg gtggtaggaa tcttagaaac aagaccactt atactgtctg tctgaggcag 720 aagataacag cagcatctcg accagcctct gccttaaagg aaatctttat taatcacgta 780 aggttcacag ataattcttt ttttaaaaaa acccaacctc ctagagaagc acaactgtca 840 agagtcttgt acacacaact tcagctttgc atcacgagtc ttgtattcca agaaaatcaa 900 agtggtacaa tttgtttgtt tacactatga tactttctaa ataaactctt tttttttaaa 960 aaaaaaaaaa aaaaaaggcg gccgc 985 155 1280 DNA Homo sapiens 155 ctcgaggcca agaattcggc acgagggaaa ggagaagatg aaaaagagga agaagacaga 60 aaagaaacag gagatggaaa agagaatgaa gatggaaaag agaagggaga taaaaaagag 120 gggaaagatg taaaagtcaa agaagatgaa aaagagagag aagatggaaa agaagatgaa 180 ggtggaaatg aggaagaagc tggaaaagag aaagaagatt taaaagaaga ggaagaagga 240 aaagaggaag atgagatcaa agaagatgat ggaaaaaaag aggagccaca gagtattgtt 300 taaaactgcc ctatgtagtt tcataatttg gtaacatgta ccttcatgtt gtaaagttaa 360 tagagataaa tatttttatc aaaaatttta taaacacagc ctttctttag cattgattta 420 atttcagaac atcttcatat tgattattag ccataaagtt tctaacatga aacatttatc 480 tataaatttt gtgattatag tagtggaata catagaaaaa aatatgcttt caactttgtg 540 agtgaatttc gtgttgtgta agttatatgt caaatctttg aattttaatt ttactctttt 600 atacatgtga taatttcata aagtgaggga tcccaaaaaa agagtttcat ccaacattct 660 tgttctgcag gttgctttta taaagaaggt gaactatttt catgtaatgt taagagttaa 720 acttatcttt cccaaatata actttattat tagcttggga aaaatgaaat tgtattccca 780 tttttaaaat aaatacaaat gtttatttca gaagggcagt tttgattata tgtgaataca 840 caaattttac tggatttatc ttaataaaaa gactctgacg atgattgtgt tttgttatat 900 cttcaaaaat atagctagtg aaatattgtg cttaattttt ttctattgtg ttattcatga 960 aaatatttaa tattcactga cataaaatta atataaagta aaattcacca ttttaattat 1020 aataaaaata aagtatataa ttcaatggtt gtcagtatat tcacaatgtt gtgtccactg 1080 tttaattcca gagaattttt atcacccaaa taagaaacaa agcaccaatt agcagtctct 1140 tcccattttc gcccaactta tcccccacct ccatcccttg gcaaccacta atctgccttc 1200 tatctctatg gatttgccta ttctgaacat ttattataaa tggaatcaca taaaaaaaaa 1260 aaaaaaaaaa aggcggccgc 1280 156 604 DNA Homo sapiens misc_feature (1)...(604) n = A,T,C or G 156 gnnttgtang nactnctnng gnaatccaga tctttttttt ttttttttta cgttacctct 60 gnggtgattn atattctacc agtnaggata caaaatttac annancatct acnagtncca 120 aaccattnat gaccttataa ttttatcgng catgaaaang gncnangaca ggantncaaa 180 tggantntat gtntaaagag ttacntagta atnngtnctt gantatggtg ataaaatctg 240 ctanacangt aacaggaatg tnatnaagcc tanctagaca ttatgaacac aatctgacac 300 cgaagcattt ccnggttgta tcctnagctt aacaggcact ggagacngnc aggttcntca 360 aatggtccat gaacacctgc aggctaacan catcnnttag gatgggtgct ncnnttgtcc 420 tgtccnnaag catacaggtg attggcntgt ctgagatggg ttgactcttg gacaccggaa 480 tccagcctga ctgcctacat gctccgtgtt gatgtaacga ggcatcgcga agcgagcttg 540 cagaatgnnt ngagcntcat ccaatggngc ntgcngaagg ngcttgaggt tagcatnctn 600 ggcc 604 157 476 DNA Homo sapiens misc_feature (1)...(476) n = A,T,C or G 157 taatccaaga tctttttttt tttttttttt ttttcttggt tccaatattt attattctga 60 caggttagga atactntgat aaataagtaa tattttctct tacagaaaat tgtaatgata 120 ccattgagta caattaaaca ctctgagaat ttcacagaaa catcagaatt ttaatagaca 180 gtagccagcg tccttgtggc cagtgtgagt gacttctcac agctgcaaac accctgggcc 240 agatttctta aaacagctac atgacaaaaa caatgctatt gacatccaat aatgctaaag 300 cctgggtacc acccaggctc cactgactgg tggtttccaa acatctctcc actgactggt 360 ggttttcaac cacaaggaaa ggaaaatgga atattctttg gctcttccag cctagacaca 420 actcctgacc taagactttg agtggagagt cctaaccctt gggaagttga actttc 476 158 1782 DNA Homo sapiens 158 cggtgagccg gccgtattcc cgctctcgct tagggggcac aggcgcaggc atcggcccgg 60 ccactccaag ccttcggtgc gcgggcgcgt ctgggatacg ggcccgggag gcgccgccct 120 ccgtccgccc ggtgcctctc aggaacagcg aaccggagag agcgccggag agttgggctc 180 agtgcggagc tcggcgccgg ggcccatgcc cgtgcgcccc cgcaggccgg cgccatggcc 240 tccgggagtg tggccgagtg cctgcagcag gagaccacct gccccgtgtg cctgcagtac 300 ttcgcagagc ccatgatgct cgactgcggc cataacatct gttgcgcgtg cctcgcccgc 360 tgctggggca cggcagagac taacgtgtcg tgcccgcagt gccgggagac cttcccgcag 420 aggcacatgc ggcccaaccg gcacctggcc aacgtgaccc aactggtaaa gcagctgcgc 480 accgagcggc cgtcggggcc cggcggcgag atgggcgtgt gcgagaagca ccgcgagccc 540 ctgaagctgt actgcgagga ggaccagatg cccatctgcg tggtgtgcga ccgctcccgc 600 gagcaccgcg gccacagcgt gctgccgctc gaggaggcgg tggagggctt caaggagcaa 660 atccagaacc agctcgacca tttaaaaaga gtgaaagatt taaagaagag acgtcgggcc 720 cagggggaac aggcacgagc tgaactcttg agcctaaccc agatggagag ggagaagatt 780 gtttgggagt ttgagcagct gtatcactcc ttaaaggagc atgagtatcg cctcctggcc 840 cgccttgagg agctagactt ggccatctac aatagcatca atggtgccat cacccagttc 900 tcttgcaaca tctcccacct cagcagcctg atcgctcagc tagaagagaa gcagcagcag 960 cccaccaggg agctcctgca ggacattggg gacacattga gcagggctga aagaatcagg 1020 attcctgaac cttggatcac acctccagat ttgcaagaga aaatccacat ttttgcccaa 1080 aaatgtctat tcttgacgga gagtctaaag cagttcacag aaaaaatgca gtcagatatg 1140 gagaaaatcc aagaattaag agaggctcag ttatactcag tggacgtgac tctggaccca 1200 gacacggcct accccagcct gatcctctct gataatctgc ggcaagtgcg gtacagttac 1260 ctccaacagg acctgcctga caaccccgag aggttcaatc tgtttccctg tgtcttgggc 1320 tctccatgct tcatcgccgg gagacattat tgggaggtag aggtgggaga taaagccaag 1380 tggaccatag gtgtctgtga agactcagtg tgcagaaaag gtggagtaac ctcagccccc 1440 cagaatggat tctgggcagt gtctttgtgg tatgggaaag aatattgggc tcttacctcc 1500 ccaatgactg ccctacccct gcggaccccg ctccagcggg tggggatttt cttggactat 1560 gatgctggtg aggtctcctt ctacaacgtg acagagaggt gtcacacctt cactttctct 1620 catgctacct tttgtgggcc tgtccggccc tacttcagtc tgagttactc gggagggaaa 1680 agtgcagctc ctctgatcat ctgccccatg agtgggatag atgggttttc tggccatgtt 1740 gggaatcatg gtcattccat ggagacctcc ccttgaggag gt 1782 159 1465 DNA Homo sapiens 159 gaattcggca cgagggtgcc ttttaggaga aataaagagg aagatttgca atcaactaaa 60 gaagagagat ttccagcgat ccacaagtcg attgctattg gctctcagcc agtgctcact 120 gttgggacaa cccacatatc caaattgaca gatgaccaac tcataaaaga gtttcttagt 180 ggttcttact gctttcgtgg gggtgtcggt tggtggaaat atgaattctg ctatggcaaa 240 catgtacatc aataccatga ggacaaggat agtgggaaaa cctctgtggt tgtcgggaca 300 tggaaccaag aagagcatat tgaatgggct aagaagaata ctgctagagc ttatcatctt 360 caagacgatg gtacccagac agtcaggatg gtgtcacatt tttatggaaa tggagatatt 420 tgtgatataa ctgacaaacc aagacaggtg actgtaaaac taaagtgcaa agaatcagat 480 tcacctcatg ctgttactgt atatatgcta gagcctcact cctgtcaata tattcttggg 540 gttgaatctc cagtgatctg taaaatctta gatacagcag atgaaaatgg acttctttct 600 ctccccaact aaaggatatt aaagttaggg gaaagaaaag atcattgaaa gtcatgataa 660 tttctgtccc actgtgtctc attatagagt tctcagccat tggacctctt ctaaaggatg 720 gtataaaatg actctcaacc actttgtgaa tacatatgtg tatataagag gttattgata 780 aacttctgag gcagacattt gtctcgcttt ttttcatttt tgttgtgtct tataaactga 840 ctgtttttct ttgcttggat actgtgattc caaaataaat ctcatccaag caagttagag 900 tccagcctaa tcaaatgtca taattgttgt acctattgaa agtttttaaa taatagattt 960 attatgtaaa ttatagtata tgtaagtagc taatgaagta aagatcatga agaaagaaat 1020 tgataggtgt aaatgagaga ccatgtaaaa tatgtaaatt ctagtacctg aaatcctttc 1080 aacagatttt tatatagcaa ctgctctctg caagtagtta aactagaaac tgggcacatg 1140 gtagaggctc acatgggagt tgtcctcacc cttgttaatc tcaagaaact cttatttata 1200 ataggttgct tctctctcag aacttttatc tattactttt ttcttcttat gagtatgttt 1260 actctcagag tatctatctg atgtagacag ttggtgatgc ttctgagact cagaatggtt 1320 tactctaaca aaacactgtg ctgtctatcc cttgtacttg cctactgtaa tatggatttc 1380 acttctgaac agtttacagc acaatattta ttttaaagtg aataaaatgt ccacaagcaa 1440 aaaaaaaaaa aaaaaaggcg gccgc 1465 160 657 DNA Homo sapiens 160 cgcggggtaa cgcggagtag cacgccatga aggcctcggg cacgctacga gagtacaagg 60 tagtgggtcg ctgcctgccc acccccaaat gccacacgcc gcccctctac cgcatgcgaa 120 tctttgcgcc taatcatgtc gtcgccaagt cccgcttctg gtactttgtg tctcagttaa 180 agaagatgaa gaagtcttca ggggagattg tctactgtgg caggtgtttg agaagtcccc 240 cctgcgggtg aagaacttcg ggatctggct gagctatgac tcccggagcg gcacccacaa 300 catgtaccgg gaataccggg acctgaccac cgcaggcgct gtcacccagt gctaccgaga 360 catgggtgcc cggcaccgcg cccgagccca ctccattcag atcatgaagg tggaggagat 420 cgcggtcagc aagtgccgcc ggccggctgt caagcagttc cacgactcca agatcaagtt 480 cccgctgccc caccgggtcc tgcgccgtca gcacaagcca cgcttcacca ccaagaggcc 540 caacaccttc ttctaggtgc agggccctcg tccggggtgt gccccaaata aactcaggaa 600 cgcccggtga aaaaaaaaaa aaaaaaacat aaaaaaaaac catcaaaaaa aataaaa 657 161 483 DNA Homo sapiens misc_feature (1)...(483) n = A,T,C or G 161 nntttttttt tgtttttaaa aagaattgtt tatttaccga acctggggca tattagatac 60 aaccaatttt aaatttacat cttttaaatc agttttgaag tgtttcacac acacaaaaaa 120 cttggcatgc aacagttgtc ctaaggtgaa agtcacctca ttaataaact gttgcaagtg 180 ttctcaccca aggtggaagt atggtttatc ctgaacatga aaacctgtaa caaatttaaa 240 ttaattatat aaaactcgtt acttgtagtt ttgcccttgc aaagatccaa aaaaaaaaaa 300 aaaaagcaca agtaactaat atgtatcagt cacaacataa tcctggatca tncccatacc 360 aaaaccggat gctcttttaa ttttaaaccc atcatcagag aacaagagaa agtaatttca 420 ttttacacaa aacaagattn acatgtgcca aaaaagaaat accccaaaag aaacaaaaac 480 caa 483 162 956 DNA Homo sapiens misc_feature (1)...(956) n = A,T,C or G 162 gacgggagct gcatgaaagc cgaagttatg gaccgctagc atctgtcact ggccaccggt 60 ttccgggagt aagcggcnta ccttacagcc ctgacacgag ccgggtgctc tctcttctca 120 ccgcggccca cgtctcctcg ntggctccgg tggcctcgct gggtcgcgag gaggcngagg 180 actgtactct gaggccaaaa gccagagtcg gccctgaacg cccacgactc tcagggtcca 240 gaggccgtga gaccggccgc ggctgaaagg taaagaaacc aagtggaaga gtgtttcctc 300 ctctggccgt aaagcatgct gtcnccgccc tactcnggac cgccccaaag actcnatggg 360 atggacctga gtcagccgaa tccttagccc cttccctttg gggcctgctg tggtgctcga 420 catcagtgac agacggaagc agcagaccat caaggctaag gggaggnccg gggngttttt 480 ttttaccagt catctacaac acatttattt gtacaatcca gaaactagca ggaccaaaat 540 tagcagcaat gtgagacatt tactggcagc tttgccttct acccnaaggt caaagtactt 600 gagacattgc ctgtgtgcct aaggaggcat cacacaagga aagccccacc ccctacttcc 660 ttcatctgag caaaggaacc tgtttacatg cacagtgctt agtgggtggg actctccaaa 720 gcagtggaaa ttcatcttta acctaattta tacaggtctg cgtcacgatg gcaaattgaa 780 ggtgccatga tttagctggt ttcnctggaa cattcctttc aggngcccan actttgtcac 840 actttcatgc cccaaaggga ttcaggtgct ctgggatgtc taccctggaa tacanccttg 900 cctccttttc cngaggtatt gggctccagt aanccaccgg ggggttttgg aaatca 956 163 560 DNA Homo sapiens misc_feature (1)...(560) n = A,T,C or G 163 tttttttttt ctgaaaacaa gttttattta aataagggtt taaatacatt acacataaca 60 ttaaaacttt aggggaaaaa aaaaccaaaa accagtttgt tacttcacat ggcattgggc 120 agctgctgct attaagttgc aagctctaca gctagctaca tgactgatgg atcagtttga 180 gatttgttcc cttgtcaaaa gtttaactct gatagaaggt tggcctcaca ttctgatgtt 240 tggacatccc ttagctagga tatgtctggt cgaacagacc tttgtggcaa gccagatgtc 300 ctatcacctc gctagcggta agagggcctc tttgagctct gtccacctag tcaggttgga 360 gacaccaggg gatctaccac caaaagctcc cttctagtag tacagctggt gcttctgcct 420 taccccatcc tctcctctca gattcaccga ggactgttca gggtggtaac attctcttag 480 ggtagggaac tctgcagagg gagagctgan gaggttccgg cctagttgtt tgtaatctta 540 gggctctggg cttggctgaa 560 164 526 DNA Homo sapiens misc_feature (1)...(526) n = A,T,C or G 164 tttttttttt ttggaagaat acacgaaata tgtttaatac ttagtatcaa actaaaaagt 60 aatataaaat ttnaaaactt cttttttttc atgcacaggc tttttctggt aaggaccgct 120 gggattgaac agaagcttcc ggtaaataag ggccccgtcg gcaagacagc atactgctgt 180 cacaagtgca aacacccctc caccaactgt caatgttgtg gtttctggta tcagtgccaa 240 cacagatacg atgagcatga atactgttgt taccagtgag ttgataatat ccagccgcag 300 catcttcacg tggcctttca cactgaagca gaaggggccg atgttttatt ttcggctgca 360 cgttatccat cgcgtctgca gacccagcag cagcactttc cctcaactct tctcagctgg 420 ctgcctgagt aggttctgcg aagcgatagc aaccgccacc gcggcggagc accgccctcc 480 cctacttctc ggcctcgtgc cgaattcttg gcctcgaggg ccaaat 526 165 3205 DNA Homo sapiens 165 cgactcgtcg ccattcccgg agcaggtcgg cctcggccca ggggcgagta tccgttgctg 60 tgtcggagac actagtcccc gacaccgaga cagccagccc tctcccctgc ctcgcggcgg 120 gagagcgtgt ccggccggcc ggccggcggg gctcgcgcaa cctccctcgc ctccccttcc 180 cccgcagcct ccgccccgcc aggcccggcc cggactcccg agccccggcc tcctcgtcct 240 cggtcgccgc tgccgccggg cttaacagcc ccgtccgccg cttctcttcc tagtttgaga 300 agccaaggaa ggaaacaggg aaaaatgtcg ccatgaaggc cgagaaccgc tgccgccgcc 360 gacccccgcc ggccctgaac gccatgagcc tgggtccccg ccgcgcccgc tccgctccga 420 ctgccgtcgc cgccgaggcc cccgttgatg ccgctgagct cccccaacgc cgccgccacc 480 gcctccgaca tggacaagaa cagcggctcc aacagctcct ccgcctcttc gggcagcagc 540 aaagggcaac agccgccccg ctccgcctcg gcggggccag ccggcgagtc taaacccaag 600 agcgaattac taatttcagc tggattcaat ttgttgtcag ttgattctgt agtaaggcca 660 tatgttgccc ctctggaggt gcttgtcaac tactctggat gatggatgga aagaactcca 720 gtggatccaa gcgttataat cgcaaacgtg aactttccta ccccaaaaat gaaagtttta 780 acaaccagtc ccgtcgctcc agttcacaga aaagcaagac ttttaacaag atgcctcctc 840 aaaggggcgg cggcagcagc aaactcttta gctcttcttt taatggtgga agacgagatg 900 aggtagcaga ggctcaacgg gcagagttta gccctgccca gttctctggt cctaagaaga 960 tcaacctgaa ccacttgttg aatttcactt ttgaaccccg tggccagacg ggtcactttg 1020 aaggcagtgg acatggtagc tggggaaaga ggaacaagtg gggacataag ccttttaaca 1080 aggaactctt tttacaggcc aactgccaat ttgtggtgtc tgaagaccaa gactacacag 1140 ctcattttgc tgatcctgat acattagtta actgggactt tgtggaacaa gtgcgcattt 1200 gtagccatga agtgccatct tgcccaatat gcctctatcc acctactgca gccaagataa 1260 cccgttgtgg acacatcttc tgctgggcat gcatcctgca ctatctttca ctgagtgaga 1320 agacgtggag taaatgtccc atctgttaca gttctgtgca taagaaggat ctcaagagtg 1380 ttgttgccac agagtcacat cagtatgttg ttggtgatac cattacgatg cagctgatga 1440 agagggagaa aggggtgttg gtggctttgc ccaaatccaa atggatgaat gtagaccatc 1500 ccattcatct aggagatgaa cagcacagcc agtactccaa gttgctgctg gcctctaagg 1560 agcaggtgct gcaccgggta gttctggagg agaaagtagc actagagcag cagctggcag 1620 aggagaagca cactcccgag tcctgcttta ttgaggcagc tatccaggag ctcaagactc 1680 gggaagaggc tctgtcggga ttggccggaa gcagaaggga ggtcactggt gttgtggctg 1740 ctctggaaca actggtgctg atggctccct tggcgaagga gtctgttttt caacccagga 1800 agggtgtgct ggagtatctg tctgccttcg atgaagaaac cacggaagtt tgttctctgg 1860 acactccttc tagacctctt gctctccctc tggtagaaga ggaggaagca gtgtctgaac 1920 cagagcctga ggggttgcca gaggcctgtg atgacttgga gttagcagat gacaatctta 1980 aagaggggac catttgcact gagtccagcc agcaggaacc catcaccaag tcaggcttca 2040 cacgcctcag cagctctcct tgttactact tttaccaagc ggaagatgga cagcatatgt 2100 tcctgcaccc tgtgaatgtg cgctgcctcg tgcgggagta cggcagcctg gagaggagcc 2160 ccgagaagat ctcagcaact gtggtggaga ttgctggcta ctccatgtct gaggatgttc 2220 gacagcgtca cagatatctc tctcacttgc cactcacctg tgagttcagc atctgtgaac 2280 tggctttgca acctcctgtg gtctctaagg aaaccctaga gatgttctca gatgacattg 2340 agaagaggaa acgtcagcgc caaaagaagg ctcgggagga acgccgccga gagcgcagga 2400 ttgagataga ggagaacaag aaacagggca agtacccaga agtccacatt cccctcgaga 2460 atctacagca gtttcctgcc ttcaattctt atacctgctc ctctgattct gctttgggtc 2520 ccaccagcac cgagggccat ggggccctct ccatttctcc tctcagcaga agtccaggtt 2580 cccatgcaga ctttctgctg acccctctgt cacccactgc cagtcagggc agtccctcat 2640 tctgcgttgg gagtctggaa gaagactctc ccttcccttc ctttgcccag atgctgaggg 2700 ttggaaaagc aaaagcagat gtgtggccca aaactgctcc aaagaaagat gagaacagct 2760 tagttcctcc tgcccctgtg gacagcgacg gggagagtga taattcagac cgtgttcctg 2820 tgcccagttt tcaaaattcc ttcagccaag ctattgaagc agccttcatg aaactggaca 2880 caccagctac ttcagatccc ctctctgaag agaaaggagg aaagaaaaga aaaaaacaga 2940 aacagaagct cctgttcagc acctcagtcg tccacaccaa gtgacactac tggcccaggc 3000 taccttctcc atctggtttt tgtttttgtt tttttttccc ccatgctttt gtttggctgc 3060 tgtaattttt aagtatttga gtttgaacag attagctctg gggggagggg gtttccacaa 3120 tgtgaggggg aaccaagaaa attttaaata cagtgtattt tccagcttcc tgtctttaca 3180 ccaaaataaa gtattgacac aagag 3205 166 1143 DNA Homo sapiens 166 ctcgaggcca agaattcggc acgagggctc caaacagcag tctgaggagg acctgctcct 60 gcaggatttc agccgcaatc tctcggccaa gtcctccgcg ctcttcttcg gaaacgcgtt 120 catcgtgtct gccatcccca tctggttata ctggcgaata tggcatatgg atcttattca 180 gtctgctgtt ttgtatagtg tgatgaccct agtaagcaca tatttggtag cctttgcata 240 caagaatgtg aaatttgttc tcaagcacaa agtagcacag aagagggaag atgctgtttc 300 caaagaagtg actcgaaaac tttctgaagc tgataataga aagatgtctc ggaaggagaa 360 agatgaaaga atcttgtgga agaagaatga agttgctgat tatgaagcta caacattttc 420 catcttctat aacaacactc tgttcctggt cgtggtcatt gttgcttcct tcttcatatt 480 gaagaacttc aaccccacag tgaactacat attgtccata agtgcttcat caggactcat 540 cgccctcctg tctactggct ccaaatagac catgtcagct tcaccccctg gctttgtgtc 600 tatgggtggc ctgtggtata tggaaaagta gcagggtggt cagggtggga gacacaagat 660 gtttttatag tctagagcct ttaaaaaaac ccagcagaat gtaattcagt atttgtttat 720 tggctgtttt ttgacagatt gttgaaatta aatgaattga aagggaaact cagagtacta 780 ggacgtttat taaaaggaaa aaaatgtctt gcaatgtgct gtaatcacaa gaggagaaaa 840 taacttgttt ccttgatctg tcagaggtca cagtaacctg ggccgagctg ttattattta 900 ttatataata gtagtaggaa gttaataact ggttctctgt gttccaagca caatattaca 960 acttcctttg aaccgtaaat atcagaatga atcctcttcc caggggattg aacagaagct 1020 taatgtttac aagtgtttga atttgtgatc tgaaataaca caaaattaaa aacatgattt 1080 ctctaatttt ccaactagag gaagagaaaa aaaaaaaaaa aaaaaaaaaa aaactgcggc 1140 cgc 1143 167 560 DNA Homo sapiens misc_feature (1)...(560) n = A,T,C or G 167 ttcctttttt tttttttttt tgccgttgac tgctaatcaa aaataagcct tacctagaaa 60 acagaaactg aattttcaaa cacagagaca gannaaaaaa aaaaaaccca ccaatgctac 120 ctctgtaaaa taaaactaga agcaaaatga atagtttcaa gacagtcggc taaccaacaa 180 accaaatgca caagagaata ctaaacaggg ttttactgtc atcaagttcg aaggcaggaa 240 gacagactag aaaaggtctt aggagagatg ggctaccatg gacaaatgaa gccacactct 300 atctgttaaa tctaaattct aacattaaaa ctcctgaatc ctggagttag tttaatgtca 360 ctgacattaa ctagctttag ttattgtcat tttattcaaa tggatgccat ttgattaggt 420 aagtattgag cattatttta ggagaaaaac caaacccaac tcctatttgc ttaggtacca 480 tgtcccatga acaaaaaaga agaagagagc aaagtatttt tgagacagtc tttaagtgaa 540 gccataagaa ctaagttatt 560 168 9573 DNA Homo sapiens 168 ggatcctaca tgatggctac agatacagct gttgttcaag gttttagcct ggaatctctg 60 ccaattcaat aacggaggca ataaaaatag acactagtat tataaagaca gaattcattt 120 attttgaaag ttttgaaagc tatgaatatc taccaagaat aaaataaatt gtactgaaaa 180 tatattagaa tgaattaaaa aatgccaaat tcacaactaa taaaatttat tataaagtta 240 aaaattctta tatttttctg tctcagtata aaaaataaac atttaatgta tctattagaa 300 aataattagc aattttgtaa atgatatcaa agaaaatttg aacaaatggt gaaatatttt 360 cttatctgcg gacaccaaat taaaaaaatt caggccaggt gcagtggctc acacctgtaa 420 tcccaactac tttgggaggc caaggcagga ggatctcttg atccaaggag tttaagacca 480 gcctgggcag ggacgggtgc agtggctcat gcctgtaatc ccagcatttt gggaggctga 540 gacggcagat catgaggtca agagatcaag accatcctgg ccaacatggt gaaaccctgt 600 ctctactaaa aatacaaaaa ttagctgtac atggtgacgc atgcactcct gtagtcccag 660 ctacttggga ggctgaggca ggagaatcac ttgaaccggg gaggcggagg ttgcagtgag 720 ccagatcgca ccactgcact ccagcctggt gacagagcga gaccccatct caaaaaaaaa 780 ttagccaggc atggcttcat gtgcctatag tcctagctac tagggaggct gaggtcggag 840 gattgcttga gcctgggagg tcgaggctgc tgtgaaccga gattgtgcta ctggactcca 900 gcctgggtga caaagtgaga ccctgtctca aacaaacaaa caaacaaaaa accaaaaaaa 960 ccccaaaata aaacaaaaat tcaacagcat gtagattagt aatgttagtg ctttattttt 1020 aaaaattatt gttaacttat atgggttttc ctctgagaag gtgcactgga aggtgtcagc 1080 agagcagata gcacaaactc ctcagatttc agaagcaggg gtttatggta aatgaaaaat 1140 gccagtcact tgtcagcatg cacaggtggc tatgcccgcc ctgtgtcagg ctctgtgtca 1200 gtagtagggt gctccatgcg tccttttcag agtcctacat gccatctatg ctcactcagc 1260 caggcctgtc acctggaagt aacaggcaac tcctcctgca ctggaattag cagcagagtc 1320 aggtgaataa tgtggcctgg ccacaccacc tctcagcaaa tgtccccagt ggtgatgccc 1380 gatagttccc aatcctcctt aagtaattaa ttcacttcaa ttgaattaaa aaaatcaatc 1440 acttccctat gacacacaag gacattcact ctctggcttt aactatcctt gcctgccttg 1500 ttattatcat tccatgtgcc caatactgtc aaaagatgta tttttgccat accctccaca 1560 tgcatttcat atgtgtgatt tttattttca aattctatat ctcttctagg aatatggtgt 1620 gttttatttg tcctgctgca ggactcccct ctccactcag attaaattat taaattccag 1680 ataaaaaatt aacttggaat actgttgaat caatagtaga agtaaccaaa ataataaaga 1740 tatttcaaaa tgaagattga tttttaaaag taaaaatgtc acatactcca cctagaagat 1800 aagagactgt actacaaatt cattagaaca tccccttcat gtcatgggcc agtcatgtcc 1860 ctgaacttaa cctctgtctt ctcgggtgat gttacaggcc aatgcagcat cagctgccca 1920 cactcctagt ggtggaatct gggagcacag gcaggagtct gcgcctgtgg ccttggctgg 1980 gtgaaagatg acatttccaa gacttcttgc ttggcagcca tcctcacgtg caggtggtct 2040 ggcagcagca ctgcaaaacc caggcaaggg atgccccact gcaaggccca gtggtaactg 2100 tggtggccat tggcattggg ggcagatgca gccatgtgag ttggtgggct gtggcagcca 2160 ccctaatgat ggtttccacc cctcccagct ggtggtggct aaaaccaccc ggtaggagtt 2220 tcaaaagcag tggcaccatt aagcggagct cctggaggag gactggaagc aactgcttgc 2280 attgaaggaa tgtagctata gtggaattat tgaaccacat catatttgca aagatgcaga 2340 atgtattaca gattacgaga tatggaagtt gaggttaatc tggtagagag cagtgaatat 2400 gaggaggaag ctctctattg ggcgggtgct atcatagctg cagaaggtga tggtgcaatg 2460 cttctgccag tgagtaaagt cttgtacaaa cttaaaccag ttacggggta aaatctgatc 2520 caggactacc tgagggtcac ttatgttggc ctgttcaata cacacatttc tttccaggag 2580 ccttaccaaa ggtctatagt agtgagttca gtatggaggc agtaatcaga tcatatctgg 2640 aaggaactgg cataaactcc aatcctgtgg gacatcatgg acagcaacta aattcgaatc 2700 aacagagtag agcccttgac attggacaag ttcgtggtga aagatctgag gctttaggac 2760 tccgacattt gtgaatgaca gcactaaatg aagtctttac tggtgaacgt ctatccagaa 2820 taccttatgc ttgggctgtg gcagtggata atttaagtag acccactcta tttatttatt 2880 tattttgaga cggagtcttg ctctgttgcc caggctggag tgcagtggcg tgatctaggt 2940 tcactgcaag ctccgcctcc caggttcacg ccattctcct gcctcagcct cccaagtagg 3000 tgggactata ggcacccatc accacacctg gctaattttt tgtattttta gtagagacag 3060 ggtttcaccg tgttagccag gatggtctcg atctcctgac ctggtgatcc atccgccttg 3120 gtctcccaaa gtgctgggat tacaggtgtg agcctctgcg cctggctaag tagacccact 3180 ctaaaagact ggtttcttac tgtgagattt cagttggtaa tggtccatgg gaaaaatgga 3240 agacttcagg gctcaatttg tgaactggag caagatcaaa ggcaacaggg ttgcaagtca 3300 ggctgtggag catgattaaa atattgcaaa tgacaaggac gttggagtct tgcattcaac 3360 tgtaaaatga cagaataaca aataaatata atgaatcatt gttctagagt ccaaaaaggg 3420 ccaaaagtaa ttttcagtat tcaagaacta aaaagcaagc agttttctcg agcacccatg 3480 agcattgttt ctcctgagag atttgtcctc gttttcattg ctggaacacc tgcatggttg 3540 tagatggagg aatgtctttt gatgttccta tttttatatc agacaagctt taaagcaaca 3600 acagttataa aagacaaaga aggaaatttt ataatgataa aaggatcggt ccaacagaac 3660 aatatcacaa tcctaaatat atatgcacct aatactggag ctcccaaatt tataaaacaa 3720 ttattactag acctaagaaa tgggatagat ggcaccacaa taatagtagg ggacttcaat 3780 actccatgga cagcactaga caggacatca aggcagaaag tcaataaaga aaaaattgac 3840 tttaattata tcctagaaca aatagattta gcagatattt acctaacatt ctacccaaca 3900 acttcagaat ataccatatt ttaatcagca catagaacgt tctccaagat aaatcataag 3960 ataggccaca aaacaagtct caacaaattt aagaaaattg aaattatgtc aagtaccttt 4020 tcagaccaca atggaataaa actggaaatt aactccaaaa agaaccctta aaactataca 4080 aatacatgaa aattaaataa tctgctcctg aatgaccttt gggttaacaa tgaaatcaag 4140 aaggaaattt aaaaattgct tgaactgaac aataatagtg acacaaccta ttaaaacctc 4200 tgagatacag caaaactaag aggacagttc atagcattaa atagtctgaa acagcatgaa 4260 cagacaatct aaggtgacac ctcaaggaac tcaagaaaca agaaccaacc aaactcaaac 4320 ccagaagaaa agaaataaca aagatcagag cagaactaaa taaaattgaa acaaaaaata 4380 caaaagataa atgaaacaaa aactggttat ttgaagagat aaacaaaatt gacagaccgt 4440 tagtgagatt aaccaagaaa aaaagggaga cgatccaaat aagctcaatt agaaatgaaa 4500 tgggaaatat tacaaccaat accacagaaa tatgaaagat attcaaggct actatgaaca 4560 cccttatgca cacagactag aaaatctaga agagatggat aaattcctgg aaaataagtt 4620 attatttgaa aaagacactt gtatggccgg gcacggtggc tcatgcctgt aatcccagca 4680 ctttgggagg ataagcgggc ggatcatctg aggttaggag ttcaagacca gcctggccaa 4740 catgttgaaa ctccatctct actaaaaata caaaattagc tggacatggt ggtgcatgcc 4800 tgtaatcccc gctactctgg aggctgaggc aggagaatcg cttgaaccca ggaggtggag 4860 gttgcagtga gccaagattg caccattgca ctccagcctg ggcaacaaga gcgaaattct 4920 gtctcaaaaa aaaaaaaaaa aaaaaaaaga agaaaagaaa aagacacttg cacacatgtt 4980 tatagcagta caatttgcaa ttgcaaaaat atgcaaacag tataaatata catcaaccaa 5040 tgagtgaata aagaaaacgt tattttttta tttttagacg gaatttcgct tttgttgccc 5100 aggctggagt gcaatggtat gatctaggtt taccgcaacc tctgcctcct gggttcaagt 5160 gattctcttg cctcagcttc ccgagtagct gggattacag gcatgtacca ccacgtccag 5220 ctaattttgt atttttagta gagacagggt ttctccatgt tggtcaggct ggtctcgaac 5280 tcctgacctc agatgatctg cctaccttgg cctcccaaag tgctgggatt atgggcatca 5340 gccactgcac ccagccaaaa atgtgatttt atatatatat atataatata caccatgaaa 5400 tactactcag acctaaaaag gaataaaata atggaatttg cagcaacctg gatggagttg 5460 gcctcgttta ctactctggg tttctgtctg aggatgaggg tgatgattgc tgatcaggat 5520 gcggaaggaa cccagtgcta acccacagca tctgccccac agggaaataa ggcacaagtc 5580 tcttgtttga tcccacgcta tgacctctag acctactctt ccctcttgtc accaaaacca 5640 caatcaggaa aaatttctgc aggcatttca ccatcctgga acaaggatct gagactcttc 5700 actgaatttg tgaccttcta tccagccaat atttatactg agctattaag attaacatct 5760 tagcctggtc attgccacac aggcaggcaa ggcagctcag gtggaaaata cttttggtca 5820 tcccatgtgt ctgggcatat ggccttgatg tgagtttatg ttcatgctca ggacaagtta 5880 tgggtcaggg gactagtcag cttatgggcc aggaaaaggt gctaaggttt gtggagtcaa 5940 agagggaatt cacacatatt aatgctcctt gtttccacct aaggcagttt gtgaagtctg 6000 tgggttctgt gactgtccac aaatggagca ggaacattcc ttagaacgga tgattgggac 6060 cccacaaagg aaaagacaag aggaagcaca ggctacacaa tgaaaataca cttggtcatg 6120 ccaaaggcta ggtcatgcca aaggctaatg aaagagcttt gagtataatt cagtgccttt 6180 ggggttgagt ggaaaataca aaaaccatct ttgccctgct ctcacaccac aacaatcaac 6240 acgtttccat gaccaaatgt gtaggatttc tccccacccc ctagaaagca agccattggt 6300 tttgcagcgg acaccacaca ggtgccctct cattgaatgc aattctgaca ctatccacat 6360 ggagacaggg tcagatctta cagtttgagg gctacttccc caagactgtg ccccactact 6420 tacgccaatc ccaagcctca gattgcttta cctgtgcttc tgtccaaata gctgtaagtt 6480 gaagatttca caacatctcc ttggcttcta ttaatttgct agaatggctc acagagctca 6540 gtagacactt acaggtttat taaaaaggat acaaccaagc atatagatga agacatgcat 6600 agcacaaggt atgggaagtg gtgcaccacc gtccagtaat cttcatgtgt tcagccttcc 6660 agaagttctc ccagcctagc tccatttggg ttattttatg gacgcttcct caccgaggct 6720 ttatggagta aaccactgcc cattggtgaa taatcggcag cccctctccc ctccacagag 6780 gttgggagat gaggctgaaa gtcccatccc tctaacactg ccttggtctt tcttgtgacc 6840 tgcccccatc ctgaagttac ctagggactg tcagccaaca gtcatctcat tagcatacaa 6900 aaagactctg gtgattttaa gtattttagg agttgtataa caagaaatgg ggtcaaagac 6960 caaaaccata atttataata acacagggat gaaaaagaaa gtagaggttg atgatttcaa 7020 gcccacacta gtcctcatta tgacagatgt ggatttccaa cccataagag gcaggaggct 7080 gaagagctga gacgaaacct gtgaaaagca gggacagggg acatttctca atttcttgtt 7140 actgaagtga tagagctcca ccaggcctca cttggattga caaactaaat taaaagatac 7200 actctttaaa taaaaagcac ttctgagcat acatccaaaa gaatgaaaat caggatattg 7260 cagaaatatt tgcacatttt tattcatgca gcattaatca caatttcaaa gacatggaga 7320 cagcataagg tccactaatc attgaatgtt tacagaaaat gtggtgtata gctgcaatgg 7380 atgctgttca aattcaagaa gaattaggcc gggcacggtg gctcccgcct gtaatcccgg 7440 cactttggga ggccaaggcg ggcggatcac aaggtcagga gttcaagacc agcctgacca 7500 atatggtgaa accccgcccc tactaaaaat accaaaatta actgggtgtg gtggcagaag 7560 cctgtaattc tagatactca ggaggctgag gcaggagaat ctcttgaatc cgggaggcag 7620 aggttgcagt gagctgagat tgcgccactg cactccagcc tgggtgacag agtgagactc 7680 tgtctctcaa aaaaaaaaga ataattaaat tttgccatat gcagcaacag ggaaaaccct 7740 ggaggatatt acactgagtg aaataagcca atcttagaag gggaaatgct gcacggcctc 7800 atttatatga ggtatctaat tttttttttt cgagacagag ttttgctctt gtcacccagg 7860 ttggagtgca atggcgcgat ctcagctcat tgcaacctcc gcctcccggg ttcaagcgat 7920 tctcctgcct cagcctcctg agtagctggt attacaagtg cctgccacca cacctggcta 7980 atttttgtat ttttagtaga gacacagttt caccatgttg gccaagctgg tctcgaactc 8040 ctgacctcag gtgatccgcc tgcctcgacc tcccaaagtg ctgggattac aggcatgagc 8100 caccacgtcc ggcctatagg aggtgtctaa tatactcaac cgagcagaaa tggagtagaa 8160 tgctggttgc caggggtagg gagagaagga aatggggagt cactgctcaa gggctatgaa 8220 gctttaggtt tgcaaaatga acaagttcta gagatgtgct gtacaacact gtgcttacag 8280 ctgacaacac tgtattatgt acttaaaatt ttattcagag ggtatatcac acattaaacg 8340 ttcttattaa catgaaaaag ggatagaaaa taccatgaaa ccacttacag aaagcaagta 8400 tggcaatcct ctgtcctttg tcttgggaga aagttttggc caagagacaa tttaggcaaa 8460 aaagagaatt tactgaagaa aaacagagag caaatagttt atttagagag acagtgtact 8520 ctggaagata aggcagagcg ggctgctgat agagaatgag ccagcggccc gagaaatgtg 8580 cactgagttt ttatgatatt gcactttttc ttggagttcc cacctctgtt ttaagtctcc 8640 accttttttt ctttctctag tttttctgct tcagccttaa gtccctgcct tttccccaca 8700 tagtttccag cccaggctgt gggaccctcc cttaacacac acatgggccc agtgtttgat 8760 aggaattcta cctaatggct gcattgctca ttactgccac cccaggaagg ttgtatggtg 8820 gtcaaatcta tacttactgt acctgcatct ctcttagaaa tttctccttt gctctcaccc 8880 ctattatcag catgcagcta gctacattct gacaggttaa cttcagagtg agtgaatact 8940 gggtgtctta aggggctttg ttctggcata ggtatttacc ctaatctctg ttcgtatcta 9000 gcatgtgtgc tttgggtggt ctctggggtg tgagattttc cagaactccc ttttctcagg 9060 ggctgcccct cctgcttctg tctagctatc tgcctactct aaagttagta ttagtatgaa 9120 agcttttatg aaaaacattt ttttccaaga aaagggaggc attttatact ggtgaaataa 9180 ggtgttcaat gacaacacat aacaactgta aattgtatgc acctaataaa atagctttaa 9240 agtatttgaa gcaaaactgt ctcttttagc agaattaaaa agagaaataa tcaatccata 9300 atcatataca cagatattaa tacaactctc ttattaactg agtgaatgac atggagaaaa 9360 aagagtatac atacaaatac gtgaaaacca tgattaacaa aatcaatcca gtgacaccag 9420 gaacccaagc ctgaagggta gttgcttgag tatgcattca tggatgaacg catccaatga 9480 atcatcacag gaacaaacaa ttgaggcctt cgtttatgta tttctaactg atgttaagtt 9540 tttccttcct attctgtgag tagaggtgga tcc 9573 169 1180 DNA Homo sapiens 169 ggagcggcgg cccctgagag gaagcggcga agatggccat gaacattttc cggctgactg 60 gggacctgtc ccacctggcg gccatcgtca tcctgctgct gaagatctgg aagacgcgct 120 cctgcgccgg tatttctggg aaaagccagc ttctgtttgc actggtcttc acaactcgtt 180 acctggatct ttttacttca tttatttcat tgtataacac atctatgaag gttatctacc 240 ttgcctgctc ctatgccaca gtgtacctga tctacctgaa atttaaggca acctacgatg 300 gaaatcatga taccttccga gtggagtttc tggtggtccc tgtgggaggc ctctcatttt 360 tagttaatca cgatttctct cctcttgaga tcctctggac cttctccatc tacctggagt 420 ccgtggctat ccttccgcag ctgtttatga tcagcaagac tggggaggcc gagaccatca 480 ccacccacta cctgttcttc ctgggcctct atcgtgcttt gtatcttgtc aactggatct 540 ggcgcttcta ctttgagggc ttctttgacc tcattgctgt ggtggccggc gtagtccaga 600 ccatcctata ctgtgacttc ttctacttgt acattacaaa agtactcaag ggaaagaagc 660 tcagtttgcc agcataagtt gccaaagacc atcaccagca tctgtccttc agggtgctcg 720 gacagaattc ttaccacagc aaaggcataa gatgcttgat acggaaaatc agaaacttaa 780 ctcttttgtt gcagatagtc atcagtggct ctgtaaaaac gcagaggaaa agagccagaa 840 ggtttctgtt taatgcatct tgccttatct ttttttatta ctgtgtacaa agattttttt 900 acacaaagaa acttaatgct gtattaataa attcagtgtg tagcttcaat tgggatagtt 960 ccaaaagtga agattttgtg aggaataagt gcaaattttt tttttatttt aaaaaattct 1020 ttgaaactct taagtctttg tgtctgcaat gaaattgtac tccttgacag ttgatagatt 1080 atgtattctt ccatccctca aacttgcatt ccactatatt tattttttgg caaaagatga 1140 gctgtatttg tttgaaatct gagacactat gttcaattgg 1180 170 1267 DNA Homo sapiens 170 cagcgagcgg ctgcagcggg gccgtgacca gcagccagcg ggaggcggcg gcgagtcggt 60 gagcagctgg gaagagcaga accggggcgg agcacctgca ggcgcgggcg gcggccccac 120 catggcgatt cgcaagaaaa gcaccaagag ccccccagtg ctgagccacg aattcgtcct 180 gcagaatcac gcggacatcg tctcctgtgt ggcgatggtc ttcctgctgg ggctcatgtt 240 tgagataacg gcaaaagctt ctatcatttt tgttactctt cagtacaatg tcaccctccc 300 agcaacagaa gaacaagcta ctgaatcagt gtccctttat tactatggca tcaaagattt 360 ggctactgtt ttcttctaca tgctagtggc gataattatt catgccgtaa ttcaagagta 420 tatgttggat aaaattaaca ggcgaatgca cttctccaaa acaaaacaca gcaagtttaa 480 tgaatctggt cagcttagtg cgttctacct ttttgcctgt gtttggggca cattcattct 540 catctctgaa aactacatct cagacccaac tatcttatgg agggcttatc cccataacct 600 gatgacattt caaatgaagt ttttctacat atcacagctg gcttactggc ttcatgcttt 660 tcctgaactc tacttccaga aaaccaaaaa agaagatatt cctcgtcagc ttgtctacat 720 tggtctttac ctcttccaca ttgctggagc ttaccttttg aacttgaatc atctaggact 780 tgttcttctg gtgctacatt attttgttga atttcttttc cacatttccc gcctgtttta 840 ttttagcaat gaaaagtatc agaaaggatt ttctctgtgg gcagttcttt ttgttttggg 900 aagacttctg actttaattc tttcagtact gactgttggt tttggccttg caagagcaga 960 aaatcagaaa ctggatttca gtactggaaa cttcaatgtg ttagctgtta gaatcgctgt 1020 tctggcatcc atttgcgtta ctcaggcatt tatgatgtgg aagttcatta attttcagct 1080 tcgaaggtgg agggaacatt ctgcttttca ggcaccagct gtgaagaaga aaccaacagt 1140 aactaaaggc agatcttcta aaaaaggaac agaaaatggt gtgaatggaa cattaacttc 1200 aaatgtagca gactctcccc ggaataaaaa agagaaatct tcataatgaa ttataaacta 1260 attgatt 1267 171 520 DNA Homo sapiens misc_feature (1)...(520) n = A,T,C or G 171 aatccaagat cttttttttt tttttttttt tttttttttt tttttcagtt acacttttcc 60 ttgctttaat attttttgtc tttttctgct tttgaaatga gctctcaatt acaaaatacc 120 aaactacact caaaagaggg tgtanaaaaa gccagccatt ggcncagcat gganaagccc 180 acaagtaagg acagatagca gcagcaggng gcaagaggtg ggaggtgact gaagcagngg 240 ttacaaatgt tcacaggaag ctaaaactat ccaacaggtt gngccctaat gttagcncag 300 gttanactag ttactacctt gctaggnggc ctcagngngt tcanattnta cgcagcaata 360 caatttnttc cagttaanag ttcttgactt gcaccgatca cagcatggtt gaagggtact 420 ggaccagtct tgttagtttt tcaaaatgct gtcgtaaacc tgatanatgt attgagagac 480 ttcaggagct ntacncttca gtgacagcgt gtaattgggg 520 172 1653 DNA Homo sapiens 172 gcggccgcag tttttttttt tttttttttt tttttttagc caaacagatt ggtcattatt 60 gtacacatag ctggaaggga ggggtggtcc cggggtaagg acagggctgc ccaatatttg 120 gggggaggaa gggactcttc ttccaaatgg gcttgtccgg gaaccggggt cccggggagc 180 tgggcgcctg gtccacatgg accccctcca cctccccaca tacgctgtgg aagaagggca 240 ggagtgagaa atgctggggg aggacgaccc tttggtctga gatgtggagg tgatcataac 300 agttcccgcc cgctggctgt tttgttgact ttggagaggc cttcccggaa cccagagtcc 360 gtcattactt gctccatctg aacatcctcc tcgtcctcct ggggcagctg caggtacggg 420 ttgttccctg tgggctggaa cttgtagccc gtgagcacga agaaggccag ggtggagccc 480 tccaccaaga gctggtacag ccactgccac tgaaagggca cagccacctg cagcaggatg 540 gcgatgatgc gggtgaagta gacgtagcag atgaccatga catagtaatg ccggaacagc 600 ttcagcttgg ccaggttcac tgccaccttc ccgtctgtgc cagacgcatc ctggagatgc 660 cggatggacc agactacggg gaacaggatg gcaccacagc agatgaggtc caccaggaac 720 aaaatctcct tccacagcac gtagtcgctg gcgccttcct cgcgggactc gatgatgatg 780 taggccacgt tggccaggac ctgcatgggg atcacgatcc caaagacctt cttctcctta 840 tccgacagga cgtacttgat gaaggcccag cctgagccaa tcagggcgat ggtgatgaag 900 aggagggcgc ccttcagcag gtgtgcgatg tagtacatga cggcaaggcc ttcgatgggg 960 tggccctggc tgttgatgaa gtagtagttg atgctgtgga agaggagaga gatgctcttg 1020 gtgaaggcca aggccgccat gagccagtgg atcttgaaga cgctgtacgt gttcctgcag 1080 aggatggaca cccagaagat gccagcggcc aggaagcagg cggacatgac catgtagagc 1140 ttgaaaaggg gcatctccgc tgccgacagg aagccatcgg ggttcttctc ccggatcatc 1200 accgtgatgt cgaatggatg ctcctttcct ggcactgaat tgttgcagtt gtggaagttc 1260 aggctgtact ggccttcttc cgcctgagag ccgatcacca cgtggaaact gaagttgtag 1320 gagttgttga ggtggctcag gcccaacacc aggtccttgt ccttcccact aggaccctga 1380 atcactgcgg gtgttgactt gggcttgctg gctgcagagg tccctccgcc atccaccttg 1440 cgggggactg tggcctgtgg cttcgggagc cctggtttgg agggtgcttc cgggaggagc 1500 ccgggaaaga taaacaacgt cttctgctct ccatacttcc gcacctggac ctgcagatcc 1560 ttggtgttga tgaggaacag gaccaggaaa ctgctactgt ttttctggag agggcagtcc 1620 tggaaatccc gggttggcct cgtgcccgaa ttc 1653 173 532 DNA Homo sapiens misc_feature (1)...(532) n = A,T,C or G 173 aggcccaaaa cgagaacatn naananccgt tttttccnca naaaagccnt tttnanaaag 60 cacagcaaga cnngnctgcg gacacacagg aggcacacgg acagcccgcc aaccagagag 120 ggagacgaag gccagcgagg ctctcacagg ccagcgnggc tcncacaggg cagcgcatcn 180 canaacccct ggcccccctc gngccaaggc tggccngagn caggccacgc ccacgccgcc 240 ntangacaaa tagaggccgg agccaaggag gnggcaacag agcaggggca aggaaggnan 300 ccncaggttc ngataangac ccngcaaatc ccaccccacc ctcaggcacc nccggcnaag 360 gggaccggan accccaggna aggaggnacc caggagggcc gnggnaaccc tagggctgac 420 gaaacnagct ccgacaagcc aggccacngg gaggnacctc aggatggaaa agatgctgga 480 ggcnnagntg gcatcangaa gccgggagcc ccacgggggc aaaaggggag gg 532 174 1246 DNA Homo sapiens 174 ctcgaggcca agaattcggc acgagagact tgctaggaag aaatgcagag ccagcctgtg 60 ctgcccactt tcagagttga actctttaag cccttgtgag tgggcttcac cagctactgc 120 agaggcattt tgcatttgtc tgtgtcaaga agttcacctt ctcaagccag tgaaatacag 180 acttaattcg tcatgactga acgaatttgt ttatttccca ttaggtttag tggagctaca 240 cattaatatg tatcgcctta gagcaagagc tgtgttccag gaaccagatc acgattttta 300 gccatggaac aatatatccc atgggagaag acctttcagt gtgaactgtt ctatttttgt 360 gttataattt aaacttcgat ttcctcatag tcctttaagt tgacatttct gcttactgct 420 actggatttt tgctgcagaa atatatcagt ggcccacatt aaacatacca gttggatcat 480 gataagcaaa atgaaagaaa taatgattaa gggaaaatta agtgactgtg ttacactgct 540 tctcccatgc cagagaataa actctttcaa gcatcatctt tgaagagtcg tgtggtgtga 600 attggtttgt gtacattaga atgtatgcac acatccatgg acactcagga tatagttggc 660 ctaataatcg gggcatgggt aaaacttatg aaaatttcct catgctgaat tgtaattttt 720 tcttacctgt aaagtaaaat ttagatcaat tccatgtctt tgttaagtac agggatttaa 780 tatattttga atataatggg tatgttctaa atttgaactt tgagaggcaa tactgttgga 840 attatgtgga ttctaactca ttttaacaag gtagcctgac ctgcataaga tcacttgaat 900 gttaggtttc atagaactat actaatcttc tcacaaaagg tctataaaat acagtcgttg 960 aaaaaaattt tgtatcaaaa tgtttggaaa attagaagct tctccttaac ctgtattgat 1020 actgacttga attattttct aaaattaaga gccgtatacc tacctgtaag tcttttcaca 1080 tatcatttaa acttttgttt gtattattac tgatttacag cttagttatt aatttttctt 1140 tataagaatg ccgtcgatgt gcatactttt atgtttttca gaaaagggtg tgtttggatg 1200 aaagtaaaaa aaaaaaaaaa aaaaagatct ttaattaagc ggccgc 1246 175 1223 DNA Homo sapiens 175 ctcgaggcca agaattcggc acgaggccag caagtgtttt acaggtgcct tggattaaaa 60 caaaattgat tttaaaattt ttatgtaagt cattgtgtct atgatgccac ttttaaaagg 120 aaaatgcaat tgcgtaatgg cttatatcct tatttaatgt acctatttgt gttctaataa 180 ttgtttgaat gttttattca gcttaaaact ttaccatgaa gtcataaaca gtaaacaatg 240 ttttgttatg tattaagggg atatcagtgt ttctcaaagt atgatccatg gaccatctgg 300 gtcatggcgc ctggtttcag acaacctgaa tcaaatctta ggggtggggc tttgggatgt 360 cattgttcaa taggcacctc aggagattct gagcacacca atgtttgaga accactaaaa 420 tgaggagtgg gaaaaaaaaa ataggtgttt tgttaattta gagctgagct gagaagataa 480 tatattttta ttgtcaatga cattaacaga tatgcactga ttcttttata cctacaattt 540 acttaatgtt ccttttatta aaacgcgtgg ttcatgagca actacagact gaatccagat 600 tattacctgt tgctttcagt attttcgtga tggcttttaa tcttatgaaa tcatcttgag 660 atcattcatg gtcaagccat gaaaactccc atcttcaagc ctgcctgcta aagcttcttt 720 gccttcctga ttgtgattat ggtaacaatt tatatcagac agttgtactt tttgataact 780 tagggaaaac agaaatgact tgaacaaggg attgcctgcc tcactgcatt gcagagatac 840 aatttctgta aagaacacaa atagcagttg tgaatattaa ggtgtgatta tctttccctg 900 tccatgtgct tattgaaaga agatagtgaa caaatgatta tattgaggat ttttttaatt 960 tataagatct aatgtgaaat ccacacttgg aactttttag atctgtctgt tgcttgttta 1020 atatatttct tttatgacat tacttaaagt ttaaaagggt tttctatcca ctgtcaattt 1080 caattggata acattttgtc aagttttttt tttcctgatt atttgatgct agctggaatt 1140 caagaaatgg cattgacctt attcaaataa agaaatattt tagtaaaaaa aaaaaaaaaa 1200 aaaaaaaaaa aaaaggcggc cgc 1223 176 2780 DNA Homo sapiens 176 gtgggcggac cgcgcggctg gaggtgtgag gatccgaacc caggggtggg gggtggaggc 60 ggctcctgcg atcgaagggg acttgagact caccggccgc acgccatgag ggccctgtgg 120 gtgctgggcc tctgctgcgt cctgctgacc ttcgggtcgg tcagagctga cgatgaagtt 180 gatgtggatg gtacagtaga agaggatctg ggtaaaagta gagaaggatc aaggacggat 240 gatgaagtag tacagagaga ggaagaagct attcagttgg atggattaaa tgcatcacaa 300 ataagagaac ttagagagaa gtcggaaaag tttgccttcc aagccgaagt taacagaatg 360 atgaaactta tcatcaattc attgtataaa aataaagaga ttttcctgag agaactgatt 420 tcaaatgctt ctgatgcttt agataagata aggctaatat cactgactga tgaaaatgct 480 ctttctggaa atgaggaact aacagtcaaa attaagtgtg ataaggagaa gaacctgctg 540 catgtcacag acaccggtgt aggaatgacc agagaagagt tggttaaaaa ccttggtacc 600 atagccaaat ctgggacaag cgagttttta aacaaaatga ctgaagcaca ggaagatggc 660 cagtcaactt ctgaattgat tggccagttt ggtgtcggtt tctattccgc cttccttgta 720 gcagataagg ttattgtcac ttcaaaacac aacaacgata cccagcacat ctgggagtct 780 gactccaatg aattttctgt aattgctgac ccaagaggaa acactctagg acggggaacg 840 acaattaccc ttgtcttaaa agaagaagca tctgattacc ttgaattgga tacaattaaa 900 aatctcgtca aaaaatattc acagttcata aactttccta tttatgtatg gagcagcaag 960 actgaaactg ttgaggagcc catggaggaa gaagaagcag ccaaagaaga gaaagaagaa 1020 tctgatgatg aagctgcagt agaggaagaa gaagaagaaa agaaaccaaa gactaaaaaa 1080 gttgaaaaaa ctgtctggga ctgggaactt atgaatgata tcaaaccaat atggcagaga 1140 ccatcaaaag aagtagaaga agatgaatac aaagctttct acaaatcatt ttcaaaggaa 1200 agtgatgacc ccatggctta tattcacttt actgctgaag gggaagttac cttcaaatca 1260 attttatttg tacccacatc tgctccacgt ggtctgtttg acgaatatgg atctaaaaag 1320 agcgattaca ttaagctcta tgtgcgccgt gtattcatca cagacgactt ccatgatatg 1380 atgcctaaat acctcaattt tgtcaagggt gtggtggact cagatgatct ccccttgaat 1440 gtttcccgcg agactcttca gcaacataaa ctgcttaagg tgattaggaa gaagcttgtt 1500 cgtaaaacgc tggacatgat caagaagatt gctgatgata aatacaatga tactttttgg 1560 aaagaatttg gtaccaacat caagcttggt gtgattgaag accactcgaa tcgaacacgt 1620 cttgctaaac ttcttaggtt ccagtcttct catcatccaa ctgacattac tagcctagac 1680 cagtatgtgg aaagaatgaa ggaaaaacaa gacaaaatct acttcatggc tgggtccagc 1740 agaaaagagg ctgaatcttc tccatttgtt gagcgacttc tgaaaaaggg ctatgaagtt 1800 atttacctca cagaacctgt ggatgaatac tgtattcagg cccttcccga atttgatggg 1860 aagaggttcc agaatgttgc caaggaagga gtgaagttcg atgaaagtga gaaaactaag 1920 gagagtcgtg aagcagttga gaaagaattt gagcctctgc tgaattggat gaaagataaa 1980 gcccttaagg acaagattga aaaggctgtg gtgtctcagc gcctgacaga atctccgtgt 2040 gctttggtgg ccagccagta cggatggtct ggcaacatgg agagaatcat gaaagcacaa 2100 gcgtaccaaa cgggcaagga catctctaca aattactatg cgagtcagaa gaaaacattt 2160 gaaattaatc ccagacaccc gctgatcaga gacatgcttc gacgaattaa ggaagatgaa 2220 gatgataaaa cagttttgga tcttgctgtg gttttgtttg aaacagcaac gcttcggtca 2280 gggtatcttt taccagacac taaagcatat ggagatagaa tagaaagaat gcttcgcctc 2340 agtttgaaca ttgaccctga tgcaaaggtg gaagaagagc ccgaagaaga acctgaagag 2400 acagcagaag acacaacaga agacacagag caagacgaag atgaagaaat ggatgtggga 2460 acagatgaag aagaagaaac agcaaaggaa tctacagctg aaaaagatga attgtaaatt 2520 atactctcac catttggatc ctgtgtggag agggaatgtg aaatttacat catttctttt 2580 tgggagagac ttgttttgga tgccccctaa tccccttctc ccctgcactg taaaatgtgg 2640 gattatgggt cacaggaaaa agtgggtttt ttagttgaat tttttttaac attcctcatg 2700 aatgtaaatt tgtactattt aactgactat tcttgatgta aaatcttgtc atgtgtataa 2760 aaataaaaaa gatcccaaat 2780 177 998 DNA Homo sapiens misc_feature (1)...(998) n = A,T,C or G 177 gataacccca tcttgtatac ctgtggtgac caacatggag gccttctcat cagaacattt 60 caacttagag atctatcgcc aaaatctgca gaccaagcag ttggggaaag taattttgtt 120 tgccgaagtg acccccacaa cgatgcgtct cctggatggg ctgatgtttc agacaccgca 180 ggaaatgggc ttaatagtga tcgcggcccg gcagaccgag ggcaaaggac ggggagggaa 240 tgtgtggctg agccctgtgg gatgtgctct ttctactctg ctcatctcca ttccactgag 300 atcccagctg ggacagagga tcccgtttgt ccagcatctg atgtccgtgg ctgtngtggg 360 aagcagtgag gtccattccc gagtattcag gatattcaac tttacggagt gnaagtgggc 420 ccaacggtna tttatttaca gtggacctca tgaagatcng gcggattctg ggttaactca 480 acantcatgg ggaggaaaca tttatatact tatttgggtg ttggatttaa tgtggantaa 540 cagttaacct taccatttgc atcaacgacc ttatnacaag tgtcacaaga atgttcttac 600 agttcagtac ctccccagat gcttacaaac agtgatagca tacctctaac tcaccactgg 660 cctgggcgca agagcatatt ttggtttgtt ttttcataga ctaggggtaa aggtctgcac 720 tactaagaaa atatctgaat tttcccattg tcatttccat gtaaaaactc cccttgacaa 780 taaacgtaag tccaagccac agaggggaga gcaatttccc acctgtggga gggctttccc 840 taaactaaat tttctacttc ttaaccatct atcccagagc ctcttcaaac accaaagaaa 900 acgacaacaa aacaaaccta aaaacaaaca ggaaacacag ganaaaggaa caaaggnctt 960 taaccaaatg anttgggagg gaaaggaaaa tttcacct 998 178 2780 DNA Homo sapiens 178 gtgggcggac cgcgcggctg gaggtgtgag gatccgaacc caggggtggg gggtggaggc 60 ggctcctgcg atcgaagggg acttgagact caccggccgc acgccatgag ggccctgtgg 120 gtgctgggcc tctgctgcgt cctgctgacc ttcgggtcgg tcagagctga cgatgaagtt 180 gatgtggatg gtacagtaga agaggatctg ggtaaaagta gagaaggatc aaggacggat 240 gatgaagtag tacagagaga ggaagaagct attcagttgg atggattaaa tgcatcacaa 300 ataagagaac ttagagagaa gtcggaaaag tttgccttcc aagccgaagt taacagaatg 360 atgaaactta tcatcaattc attgtataaa aataaagaga ttttcctgag agaactgatt 420 tcaaatgctt ctgatgcttt agataagata aggctaatat cactgactga tgaaaatgct 480 ctttctggaa atgaggaact aacagtcaaa attaagtgtg ataaggagaa gaacctgctg 540 catgtcacag acaccggtgt aggaatgacc agagaagagt tggttaaaaa ccttggtacc 600 atagccaaat ctgggacaag cgagttttta aacaaaatga ctgaagcaca ggaagatggc 660 cagtcaactt ctgaattgat tggccagttt ggtgtcggtt tctattccgc cttccttgta 720 gcagataagg ttattgtcac ttcaaaacac aacaacgata cccagcacat ctgggagtct 780 gactccaatg aattttctgt aattgctgac ccaagaggaa acactctagg acggggaacg 840 acaattaccc ttgtcttaaa agaagaagca tctgattacc ttgaattgga tacaattaaa 900 aatctcgtca aaaaatattc acagttcata aactttccta tttatgtatg gagcagcaag 960 actgaaactg ttgaggagcc catggaggaa gaagaagcag ccaaagaaga gaaagaagaa 1020 tctgatgatg aagctgcagt agaggaagaa gaagaagaaa agaaaccaaa gactaaaaaa 1080 gttgaaaaaa ctgtctggga ctgggaactt atgaatgata tcaaaccaat atggcagaga 1140 ccatcaaaag aagtagaaga agatgaatac aaagctttct acaaatcatt ttcaaaggaa 1200 agtgatgacc ccatggctta tattcacttt actgctgaag gggaagttac cttcaaatca 1260 attttatttg tacccacatc tgctccacgt ggtctgtttg acgaatatgg atctaaaaag 1320 agcgattaca ttaagctcta tgtgcgccgt gtattcatca cagacgactt ccatgatatg 1380 atgcctaaat acctcaattt tgtcaagggt gtggtggact cagatgatct ccccttgaat 1440 gtttcccgcg agactcttca gcaacataaa ctgcttaagg tgattaggaa gaagcttgtt 1500 cgtaaaacgc tggacatgat caagaagatt gctgatgata aatacaatga tactttttgg 1560 aaagaatttg gtaccaacat caagcttggt gtgattgaag accactcgaa tcgaacacgt 1620 cttgctaaac ttcttaggtt ccagtcttct catcatccaa ctgacattac tagcctagac 1680 cagtatgtgg aaagaatgaa ggaaaaacaa gacaaaatct acttcatggc tgggtccagc 1740 agaaaagagg ctgaatcttc tccatttgtt gagcgacttc tgaaaaaggg ctatgaagtt 1800 atttacctca cagaacctgt ggatgaatac tgtattcagg cccttcccga atttgatggg 1860 aagaggttcc agaatgttgc caaggaagga gtgaagttcg atgaaagtga gaaaactaag 1920 gagagtcgtg aagcagttga gaaagaattt gagcctctgc tgaattggat gaaagataaa 1980 gcccttaagg acaagattga aaaggctgtg gtgtctcagc gcctgacaga atctccgtgt 2040 gctttggtgg ccagccagta cggatggtct ggcaacatgg agagaatcat gaaagcacaa 2100 gcgtaccaaa cgggcaagga catctctaca aattactatg cgagtcagaa gaaaacattt 2160 gaaattaatc ccagacaccc gctgatcaga gacatgcttc gacgaattaa ggaagatgaa 2220 gatgataaaa cagttttgga tcttgctgtg gttttgtttg aaacagcaac gcttcggtca 2280 gggtatcttt taccagacac taaagcatat ggagatagaa tagaaagaat gcttcgcctc 2340 agtttgaaca ttgaccctga tgcaaaggtg gaagaagagc ccgaagaaga acctgaagag 2400 acagcagaag acacaacaga agacacagag caagacgaag atgaagaaat ggatgtggga 2460 acagatgaag aagaagaaac agcaaaggaa tctacagctg aaaaagatga attgtaaatt 2520 atactctcac catttggatc ctgtgtggag agggaatgtg aaatttacat catttctttt 2580 tgggagagac ttgttttgga tgccccctaa tccccttctc ccctgcactg taaaatgtgg 2640 gattatgggt cacaggaaaa agtgggtttt ttagttgaat tttttttaac attcctcatg 2700 aatgtaaatt tgtactattt aactgactat tcttgatgta aaatcttgtc atgtgtataa 2760 aaataaaaaa gatcccaaat 2780 179 2475 DNA Homo sapiens 179 ccggaggagt ccgagaggaa gcggaggcgc gagctggagg cggcggctcc cgtcggcctc 60 cggcaggact gagcgctggg aggccggaag gcgggcgcgc acggcggaga ggcgggcggg 120 aggccggagc atattaatga aaagtgccat aaactgaaaa accaaacatg agggtagcag 180 gtgctgcaaa gttggtggta gctgtggcag tgtttttact gacattttat gttatttctc 240 aagtatttga aataaaaatg gatgcaagtt taggaaatct atttgcaaga tcagcattgg 300 acacagctgc acgttctaca aagcctccca gatataagtg tgggatctca aaagcttgcc 360 ctgagaagca ttttgctttt aaaatggcaa gtggagcagc caacgtggtg ggacccaaaa 420 tctgcctgga agataatgtt ttaatgagtg gtgttaagaa taatgttgga agagggatca 480 atgttgcctt ggcaaatgga aaaacaggag aagtattaga cactaaatat tttgacatgt 540 ggggaggaga tgtggcacca tttattgagt ttctgaaggc catacaagat ggaacaatag 600 ttttaatggg aacatacgat gatggagcaa ccaaactcaa tgatgaggca cggcggctca 660 ttgctgattt ggggagcaca tctattacta atcttggttt tagagacaac tgggtcttct 720 gtggtgggaa gggcattaag acaaaaagcc cttttgaaca gcacataaag aacaataagg 780 atacaaacaa atatgaagga tggcctgaag ttgtagaaat ggaaggatgc atcccccaga 840 agcaagacta atggaaatgt ggagagaatt gaagaaagcg cactttcact cttaatggga 900 gagctataaa tggcagagct atgtgtaaat attttaagag catgcagcca tcttggtgtg 960 tgcatgagta ttgtctcttt tgatatcagg attatttatt gctaacgtaa atagatagca 1020 ttgtaaataa tcatcacaat gatcaaatca ctgaaccatg tctccgcaca tttccctaaa 1080 agtacaatgt ttagactgct atggtaatac atattttaaa ttctaaaagc atacacaatg 1140 tgtaactgaa tggtttgtga aaaatatatt gatatatata ctagttgcta tgaaaatatc 1200 atggaataat agggatttta gggtggatac tttattttct tttatgtttc tatatgttgc 1260 gttgtgatga cattatcttt taaattaaaa agagatttgg ctagttgtgt gtgtaatgtt 1320 actttacagt ccgactctcc tgatgtacct cttttcatga tctttttctt tccttcccaa 1380 gaaactgagg aatgtttaat atgaaaacat acatcggata tgtgaaaagc acaacaaaat 1440 tcttaatgta cacagtaaaa aagtaaatat ataaatgtag atggcattta ggaccacagc 1500 ttgctggatt tgtgttagct atgggaataa cttgattttg tataagctat ttagagtgag 1560 gctggaggtg gcagcttcac agaactggag aaccaggcca agtcccctcc ccaacctaat 1620 taggtcattc aggacagcta agtcagtata tttagagcaa tactagcata cgtttttctt 1680 aattgttatc agcattgacc aagtggtttg gaaggaggca tgctttaata tcacaataat 1740 tttgatttgt aaaccaagaa attaatcctg tgtttatcta acttcataat agcaattatt 1800 gcccgaagct atagtggcat atttacaaaa gttcttatta ctgggcggac tgataacatt 1860 taaaaaataa ttgtgtttga ccccaaatga ctttataccc aattctacat aaaaatatag 1920 aagatctatc tttttttgtt accttcagat gttcactaaa taactcagtt tttaagcaga 1980 agttttcagg gcattaaata tatgttgtgt atgaagtatc tcaaactgga acataaattt 2040 agtgatcaaa ctgccattca cagtgtaagg cagcacttaa atttcgaacc taaagtttag 2100 atgcattgta taaaaaaacc taaaagcagt atctgttatt tagctgtaaa ccaagttgga 2160 agctattcgg ataatttctt aaatattgat gaactttgga gtactgtttc ttccttcaaa 2220 ctgaatgtaa ttaattcatg aataaatgca ccttatatgt ttaaacaatc tttgtatact 2280 tttgggattt ttggtgctta tatgctaaat cacattcagc atgtgtattt tgacatttaa 2340 aatacttccc tcaattctgt aaattaaaag aatagttatt ttacagttcc agggattgtg 2400 aaataaatgt tgcagttttt taaaataatg aaaataaata ctcttggttt tgctttgtga 2460 aaaaaaaaaa aaaaa 2475 180 823 DNA Homo sapiens misc_feature (1)...(823) n = A,T,C or G 180 gctggagaaa ggaatgtgct catcaccagt gccctccctt acgtcaacaa tgtcccccac 60 cttgggaaca tcattggttg tgtgctcagt gccgatgtct ttgccaggta ctctcgcctc 120 cgccagtgga acaccctcta tctgtgtggg acagatgagt atggtacagc aacagagacc 180 aaggctctgg gaggagggac taacccccca ggagatctgc gacaagtacc acatcatcca 240 tgctgacatc taccgctggt ttaacatttc ngtttgatat ttttggtcgc accaccactc 300 cacagcagga ccaaaatcac ccaggacatt ttccagcagt tgctgaaacg aggttttgtg 360 ctgcaagata ctgtgagaga ttcgtacatt tatttattac tgtccctatc tattaaagtg 420 actttctatg agccaaggtc ttttactttt tcttcttgcc tttaggggct tcagggggtt 480 tcccctcagc tacagccaac tgtttcttta gatccaagag tttcgccacc tccgcagcaa 540 cctcgttctt gtctgccttt tgtgctttca gttctcggac aatgtttcct tgttttgtca 600 cttcatccat cagcgcttgt atctgctgtg gcttggctgt tgtaacagtc tctacaactg 660 ctggcttcgg ggacgttttt gcctggcccc ctccaaagcg ctgccttaaa ctttcaatct 720 ggtcattttc caatttttgg aacaagggac tgactgtgcc aatctggtgt cctgctggta 780 aggtacacag gaagtttgtc agcaggatac tgcaggctgg gag 823 181 415 DNA Homo sapiens misc_feature (1)...(415) n = A,T,C or G 181 tttttttttt ttatggatgc actgttacat gtttatttag cgaaggtgac ttggaaaagg 60 agattcacat acttccactg tatcctccgg gtaagttttc cttctcttct gtanatgtct 120 ccatgttaca gtcaactata aaacatggct catgttcact ctgggcttcg ccttcagagg 180 agtttgatat tttggaagtg gtacctttgt tctgtgtgct tttcagacca accgcttctt 240 tcatttcttc aaggcttnct tccaaaggag ttaaatcatc atcatgtcct tttggaagag 300 cagggtcctc aatggtgtaa gaaaagccat ttccctntgg gcatgcgtct tctttcccag 360 cctgtctaca acaccttagg gcttcttcag gggcagaagt cacgcaactt gaagt 415 182 1601 DNA Homo sapiens 182 gcggccgctt aattaaagat cttttttttt tttttttttt ttttttcaca aataaaccaa 60 ctttaataga tattattttg tatttatata gtgccttctt caagaacctt aaatgcttta 120 cagacattat ctctaattaa tccccacaac aaccctgtga ggtaggtatt actcccattt 180 tacaagacag ggagactgaa gcacagagag gttaagtgac ttgcccaagg tcacacagtt 240 aaattcactg aagagccagg acatgagcgc tttagcctcc cagctcccag ccaaatacct 300 catgatagaa tctttaataa aaagtgtttt taaagaaagt atcaagagta gttatgttat 360 gaaaatgagg tctttctact gccatcaagg aaagaaaaaa ccctatactg atggttagag 420 gccccaagac ccatataata caacatttcc ctctttccct gttcccaagc ctcctggttc 480 ctgtcttaaa taatctttta aaggtaaaat ttccaagaca gaagccatgt gacttaagaa 540 gtgggactta atttagaata tttactttta gttacaataa tttatagaaa tttttattcc 600 aatatacaaa atatgggaca gccatcccaa caatcatgta catagttaca cggcaatcag 660 ccaccactta caacttacac cagccccgca ttttaatcac agtcaaccaa catacaacct 720 cacgatgctt tcttcatggg tcacttttct tacttactat acctgtattt ttcccccaac 780 cctgacccta tacgttttaa aagtacattt agtttctgat aaacttcaaa acattttact 840 tagatccagc tgcattaaga agaaaaagta aatgtaaaac tgtcacccca caatccctcc 900 cctgacaaat catactatga agtacggtgt agatgtgaac aagtatgtga ttaccaggaa 960 ctcaacacat acactagaac ttgctttaat atgaaattta acttggcttt tacggcatgt 1020 ttttttttaa tgcaaaaatg taaaaacaaa cacaacatag tatttcaatg ctgtaccttt 1080 atgcaaatga cttcatctat ctttcttaaa catgttgata tagctaatgt taaaactgac 1140 acagcttcac tttcctcttt ttctctgtac cgaaagctgc agaaatacag ctttaattcc 1200 aagacaattt ggtttaagcc ttcaaaataa aaagagtgca tccacttcca ctgccctgac 1260 tttccccaca ctgttgattg tgattctctg tggcatgttg gtagatcagg ctggcttata 1320 tataatttgt acaaaacacc tctagccagg gtaaggcttt aggaactatc ttaaaaagaa 1380 acttgtcaaa atactttttg atattttgta caaatactaa atattataat tttctcccag 1440 aacatccgtt taagcagccc aattaagtga ctctgttaaa ggtctgctta tggaaaaaat 1500 aggtgaagtc atttcctgag ccaaaagata cagataataa atgttaataa tagcagcaga 1560 ctaaaaaatt cctttttgtt gttttccctc gtgccgaatt c 1601 183 1056 DNA Homo sapiens 183 ctcgaggcca agaattcggc acgaggagtc atcagatatt ttagccacct acacaaaagc 60 aaactgcatt tttaaaaatc tttctgagat gggagaaaat gtattctcct ttcctatacc 120 gctctcccaa caaaaaaaca actagttagt tctactaatt agaaacttgc tgtacttttt 180 cttttctttt aggggtcaag gaccctcttt atagctacca tttgcctaca ataaattatt 240 gcagcagttt gcaatactaa aatatttttt atagacttta tatttttcct tttgataaag 300 ggatgctgca tagtagagtt ggtgtaatta aactatctca gccgtttccc tgctttccct 360 tctgctccat atgcctcatt gtccttccag ggagctcttt taatcttaaa gttctacatt 420 tcatgctctt agtcaaattc tgttaccttt ttaataactc ttcccactgc atatttccat 480 cttgaattgg tggttctaaa ttctgaaact gtagttgaga tacagctatt taatatttct 540 gggagatgtg catccctctt ctttgtggtt gcccaaggtt gttttgcgta actgagactc 600 cttgatatgc ttcagagaat ttaggcaaac actggccatg gccgtgggag tactgggagt 660 aaaataaaaa tatcgaggta tagactagca tccacataga gcacttgaac ctcctttgta 720 cctgtttggg gaaaaagtat aatgagtgta ctaccaatct aactaagatt attatagtct 780 ggttgtttga aataccattt ttttctcctt ttgtgttttt cccactttcc aatgtactca 840 agaaaattga acaaatgtaa tggatcaatt taaaatattt tatttcttaa aagccttttt 900 tgcctgttgt aatgtgcagg acccttctcc tttcatggga gagacaggta gttacctgaa 960 tataggttga aaaggttatg taaaaagaaa ttataataaa agggatactt tgcttttcaa 1020 aaaaaaaaaa aaaaaaaaaa aaattggtgc ggccgc 1056 184 1215 DNA Homo sapiens 184 gaattcggca cgaggaggtg aaggacccag aggacaaggt catcctggcc cggcagtatg 60 gctccgaggg caggttcact ttcacttccc atacccctgg tgagcaccag atctgtcttc 120 actccaattc caccaagttc tccctctttg ctggaggcat gctgagagtt cacctggaca 180 tccaggtagg tgaacatgcc aatgactatg cagaaattgc tgctaaagac aagttgagtg 240 agttgcagct acgagtgcga cagctggtgg aacaagtgga gcagatccag aaagagcaga 300 actaccagcg gtggcgagag gagcgattcc ggcagaccag tgagagcacc aaccagcggg 360 tgctgtggtg gtccattctg cagaccctca tcctcgtggc catcggtgtc tggcagatgc 420 ggcacctcaa gagcttcttt gaagccaaga agcttgtgta gctgtcccag gcgtcacaac 480 ccatcctccc aggctggggg agaaaggacc tcctggaact gacttcttct gtcaggagga 540 ctggtttcca gccatacctg ttctggaagg gagaggggct ggaggcaccc acaggcacaa 600 gctgaaggca gcagcttggc taatactgag caggtagtgg ggcaaattcc tgccctctct 660 ctctggcctc tgggccgttt ggtagtaatc acccaggggc tggtaaagcc cctcctcttg 720 gcacctcaga atcacagtgt tactgatcag ggatgtgagg ctgctgttgg gggtgggggg 780 aggggaatgg gcaggcaagc cagtcttctg tcttcctttg ctaacttagg gttttgagca 840 ggttggggta tggtgcctgt catacccacc tgccaccctg ggaacctcac tgttctctct 900 ttcagcctag acctgctgat ccagggtgtg tgtgagttga gggtgggtgg aggggtttgc 960 agtgtgggaa tgtggccctg cagttgacct gagctgcttc acatggttgt ccattctggg 1020 gcttaaagaa ctgggaccag accaagtaga ggccttggtg ctggttgggg tggggcctgc 1080 agagtcttag ttactgattt cattttcaat aaatgtaggt ttgttacatg agtttcccaa 1140 ttaaaaaaaa aatgacttct tgtccagtga aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 1200 aattggtgcg gccgc 1215 185 836 DNA Homo sapiens 185 ctcgaggcca agtattcggc acgaggggca agtctactgc gggctggtcc gggctcctca 60 ggttcagacc cgaccgttat ccagtcggtt cgtggagagg agaggtgcac tttacaggtc 120 cctgatgaac caagagaacc ctccaccata tccaggccct ggtccaacgg ccccataccc 180 accttatcca ccacaaccaa tgggtccagg acctatgggg ggaccctacc cacctcctca 240 agggtacccc taccaaggat acccacagta cggctggcag ggtggacctc aggagcctcc 300 taaaaccaca gtgtatgtgg tagaagacca aagaagagat gagctaggac catccacctg 360 cctcacagcc tgctggacgg ctctctgttg ctgctgtctc tgggacatgc tcacctgacc 420 agaccagccc agccgtcctg tcctgccagc tctgctgcca cctctgacag gtgtgcctgc 480 ccccatctct tctgattgct gttaacaaat gactagcttt gcacagacac ctctaccttc 540 agcactatgg gattctagat taatgggggt tgctactgtt taattcagtg acttgatctt 600 tttaatgtcc aaaatccatt tcttattgat ctttaaagat gtgctaaatg acttttttgg 660 ccaaaggctt agttgtgaaa aatataattt ttaaattata cattcaaggt agtggccaaa 720 tgtaacacat caatcatgga atgatttctc tgctaacagc cgcctgtatg tttcaataaa 780 tttgtccaaa gctcaaaaaa aaaaaaaaaa aaaaaaaaaa aaattggtgc ggccgc 836 186 495 DNA Homo sapiens 186 gcggccgcat cttttttttt tttttttttt tttttttttt tttttttttt tttttttttt 60 ttcaataaat acatgctgat ttattacagg gataagatgg tttcttgggg gatagattca 120 agaggagttg agaatgtttt attcatttac aatgtccctt tcctggaagg gtggacagca 180 agatttagga caagctaaaa tcatccccta tttaaaaaaa aaaaaaaaaa aaaagtcacc 240 agcaagtagt cccgggtggg aggtgggagc agaataaaaa aaaatctgca atgattccta 300 attgtttttc aatacagaag cttgggaagg ggtttctgcc agtttcatga ggaaggcaca 360 acttccaggt agtgttgggg aagggtatga ggtcctatgc aggctggcct cttatcccac 420 agatgccaag atgatgtcta ctggcagctc ctccaaactt ctggctgtcc ctcgtgccga 480 attcttggcc tcgag 495 187 525 DNA Homo sapiens misc_feature (1)...(525) n = A,T,C or G 187 tccttttttt tttttttttt aggtgattac aacagctgat ttttattttt cttnttgatt 60 ctcttctaca gttttcaaat tctctacaat gaacatgtac ttctttttaa tatcaaaaga 120 caaaagaatt ggtacgtaaa aagaacatcc ttcccatctt caaggtcaag attgaacgct 180 gactcctgca ggaagtcttc caggattccc aggcaggaat gatggctccc tgtccctgta 240 gctccaggag ttcttgcttc acgcacgcct cacataccag actgaatgtt ggcaggagga 300 gtgaccaggt cggtcatctg tgtccctacc acctacaaca ggccagcaat ctacccgtgt 360 gtgtttgttg gacagaatta accatgatgg gcggccgagg gcgcctggag ctatttgggg 420 gcttggagag aacctcttag gagagtgtca ggccctaggc cagtgtcacc agaggaggtc 480 agtctcagtc cttggagtgg tgggatggaa accagacggg actgg 525 188 2274 DNA Homo sapiens 188 gcggccgcac tttttttttt tttttttttt tttttttttt tttcacaacg cctatttatt 60 ccccacacgt cacgccctgc accccgggtg ggcttggcac acacctcacc gccatgaacg 120 gctgcagggc cgcggtggcc cccgttccta ctgctaccta cgatacacgg tactgcgcct 180 acctcacaga cggccaggag ccagggagcc ccaggatgct ccgactgaca accctgctgc 240 tgggaccacg gcgccgtggg ctcgtctgcc acccccaggc ctcaggaacc cagacaggct 300 gcccgctgtc cggctctccg gctgctttcc tggtggctgt tttagggcca aggtgggtgg 360 cacctgaggt gtcccgtggc ctccacccag cacaggaggg gtaagcttcc ctggggggcc 420 ccgggcccat gaaacatcca ggacagaagg acagcaggat gggacacaga cagaaacggc 480 ccagctgcct tccctgtgcc cggggctaag gcggccggga cagaaggtca tgatgtcgcc 540 cctggctctc agtcgcgagg accagaaaat gagggtggga ggaggggaaa catgtctgtc 600 aacatgccca actggagaaa agtcacagaa actggtccta tgcacccagg acggctcctg 660 agccacggag gcgtggggtg accgcagccg tctcttaggt gtctgccact aaagagttcc 720 tcatgcaaac acacatggcc cgcggtgccc aggccgcagc tggcagtgag ctcttccgag 780 caggcacagg gccggggtgg ccgggaggtc gactcggaaa gaggcttctc acagacggga 840 gagttcctgc agacagacca cgggatgggg ggcgggggct gtaaaaggct ttggaagcca 900 cacgatccgc cacacggctg aacgtgaaac ctgccacttc tctgagagcg gcccgggagc 960 accccaggat tctagaaaac actcaagtga ccgagctttc tgggggctgg aagggaggtc 1020 gctgctggtc tgtgctcagc ttgctggctc tcgtttcaag aagggtctgg gggctgtaag 1080 ggagttacaa aaagggagtg gaggagggca gagataaaag gggaaaatcc atcttgacat 1140 gcaggtccga ggtctctctc ttcccctctc tcaggcagtc caacaggagg aagtggcaga 1200 caaccagaag gcttccttcg ggtcggccag ggaaggacgc ggtcacaccg ggagcaggca 1260 gcgtcactcc tgctggtcgt cgttgctggc gctgggcgtc cgactccgga tctggctcct 1320 gagctgctct atcaactctg ggttctgctg ctgcatctgc tgggcaaact gctggcccgc 1380 ctggatgagg ctggccaggt cgttctgcga ggggctggtg ccgggagttc ccaaggggtt 1440 gttgccaccc gaaatcatgc cggacatgag ctgctgaatc tggggattgt tcattaggtt 1500 cgaagccatg ctcatgaagc cagggttgtt cagcaggccg gcgatgtcga agctgcccac 1560 gcctcccgtg gggctggggg cctcccgcag cttcagctcc gctatcttga ggttggactt 1620 gtatgtctcg ttgtcggggt ccagctccag cgccttcttg tagtaagcca cggcctccac 1680 gtgcttgttg aggctggaga gcgccaggcc catcctgccg taggccttgc tgtaggccgg 1740 gtcaatgcag atggcccgct cacagtcctg caccgcgcct gcgtagttgc cgagtttgct 1800 gtaggctgcg gctctgttgc agaaatagac ggcgttggct gggttgagct cgatggcttt 1860 tccgtagaaa tgcacggcag cttcaaagtt ttccactttc atctgctcgt ttccttcggt 1920 tttgaggcgc tctgcctctg ctgagtcctc ctcggaaggc ggggttcgcg ctgggctcct 1980 caggtcctgc ggcatctcct tgcccgtggc agccgcttca aatatctccg gcagagtctg 2040 agggagcgca aggtcactgt cttctaccgt caccccaaac gcagtctcca ggcactggat 2100 ggcgacttcc aagctctcct gagcatcgga cgagaggccc ccgtgccgga gctggtcatg 2160 caggaactgg atgatggcgt aggccaggcg cttcttgttg tccatcttga gcccagaaga 2220 ggtgatacct ctcaggcgac cgatccccga cccaccgacc ctcgtgccga attc 2274 189 2373 DNA Homo sapiens 189 gcacgagcgg ttctgagcat tagtttgaga actcgttccc gaatgtgctt tcctccctct 60 cccctgccca cctcaagttt aataaataag gttgtacttt tcttactata aaataaatgt 120 ctgtaactgc tgtgcactgc tgtaaacttg ttagagaaaa aaataacctg catgtgggct 180 cctcagttat tgagtttttg tgatcctatc tcagtctggg ggggaacatt ctcaagaggt 240 gaaatacaga aagccttttt ttcttgatct tttcccgaga ttcaaatctc cgattcccat 300 ttgggggcaa gtttttttct tcaccttcaa tatgagaatt cagcgaactt gaaagaaaaa 360 tcatctgtga gttccttcag gttctcactc atagtcatga tccttcagag ggaatatgca 420 ctggcgagtt taaagtaagg gctatgatat ttgatggtcc caaagtacgg cagctgcaaa 480 aagtagtgga aggaaattgt ctacgtgtct tggaaaaatt agttaggaat ttggatgggt 540 aaaaggtacc cttgccttac tccatcttat tttcttagcc ccctttgagt gttttaactg 600 gtttcatgtc ctagtaggaa gtgcattctc catcctcatc ctctgccctc ccaggaagtc 660 agtgattgtc tttttgggct tcccctccaa aggaccttct gcagtggaag tgccacatcc 720 agttcttttc ttttgttgct gctgtgttta gataattgaa gagatctttg tgccacacag 780 gatttttttt ttttttaaga aaaacctata gatgaaaaat tactaatgaa actgtgtgta 840 cgtgtctgtg cgtgcaacat aaaaatacag tagcacctaa ggagcttgaa tcttggttcc 900 tgtaaaattt caaattgatg tggtattaat aaaaaaaaaa aaaaaaaact cgctcgtgcc 960 gaattcggca cgaggaacaa cctgtgtgca tgctttttga gtatattaat cagggggatc 1020 tccatgagtt cctcatcatg agatccccac actctgatgt tggctgcagc agtgatgaag 1080 atgggactgt gaaatccagc ctggaccacg gagattttct gcacattgca attcagattg 1140 cagctggcat ggaatacctg tctagtcact tctttgtcca caaggacctt gcagctcgca 1200 atattttaat cggagagcaa cttcatgtaa agatttcaga cttggggctt tccagagaaa 1260 tttactccgc tgattactac agggtccaga gtaagtcctt gctgcccatt cgctggatgc 1320 cccctgaagc catcatgtat ggcaaattct cttctgattc agatatctgg tcctttgggg 1380 ttgtcttgtg ggagattttc agttttggac tccagccata ttatggattc agtaaccagg 1440 aagtgattga gatggtgaga aaacggcagc tcttaccatg ctctgaagac tgcccaccca 1500 gaatgtacag cctcatgaca gagtgctgga atgagattcc ttctaggaga ccaagattta 1560 aagatattca cgtccggctt cggtcctggg agggactctc aagtcacaca agctctacta 1620 ctccttcagg gggaaatgcc accacacaga caacctccct cagtgccagc ccagtgagta 1680 atctcagtaa ccccagatat cctaattaca tgttcccgag ccagggtatt acaccacagg 1740 gccagattgc tggtttcatt ggcccgccaa tacctcagaa ccagcgattc attcccatca 1800 atggataccc aatacctcct ggatatgcag cgtttccagc tgcccactac cagccaacag 1860 gtcctcccag agtgattcag cactgcccac ctcccaagag tcggtcccca agcagtgcca 1920 gtgggtcgac tagcactggc catgtgacta gcttgccctc atcaggatcc aatcaggaag 1980 caaatattcc tttactacca cacatgtcaa ttccaaatca tcctggtgga atgggtatca 2040 ccgtttttgg caacaaatct caaaaaccct acaaaattga ctcaaagcaa gcatctttac 2100 taggagacgc caatattcat ggacacaccg aatctatgat ttctgcagaa ctgtaaaatg 2160 cacaactttt gtaaatgtgg tatacaggac aaactagacg gccgtagaaa agatttatat 2220 tcaaatgttt ttattaaagt aaggttctca tttagcagac atcgcaacaa gtaccttctg 2280 tgaagtttca ctgtgtctta ccaagcagga cagacactcg gccagaaaaa aaaaaaaaaa 2340 aaaaaactcg agggggggcc cgtacccgat cgc 2373 190 566 DNA Homo sapiens misc_feature (1)...(566) n = A,T,C or G 190 agggantaag cttgcggccg cttaattaaa naanatttag cgtaaaatta cacttaaaca 60 ttatcagctg ctgctgggaa aaaatggaca aattgcccag gcagccacat tagaagaaga 120 aagtcattng aatacagnta tatacttatt tttattgaga cacatcttgc tgngtcaccc 180 agggttttgc tctgttgcca cagcttactg cagccgtgac ccaggctcaa gtgatccctc 240 ccacctcagg cccctctccc cgaccagtag ccgagactac aggcaggcac agactggcac 300 caccacactc ggctaatttt ttttttttga ggcagggtct cactatgttg tccaggctgg 360 tcttgaactc ctgagctcaa gtgatcctct naccttggct tccaaagtgc tgggattaca 420 gacaagtcat ggcanctggc tgagtacagt tattcancat aagcataaca aatacagaat 480 ggcagcccag ttcctttgnt aatgaaatng taaggggtgt actagggcaa gctggccctg 540 attatgtcac atgagtttgg tttaga 566 191 775 DNA Homo sapiens 191 gaattcggca cgaggcagga actccaatgt atcttgtgat ttttccagaa ggtacaaggt 60 ataatccaga gcaaacaaaa gtcctttcag ctagtcaggc atttgctgcc caacgtggcc 120 ttgcagtatt aaaacatgtg ctaacaccac gaataaaggc aactcacgtt gcttttgatt 180 gcatgaagaa ttatttagat gcaatttatg atgttacggt ggtttatgaa gggaaagacg 240 atggagggca gcgaagagag tcaccgacca tgacggaatt tctctgcaaa gaatgtccaa 300 aaattcatat tcacattgat cgtatcgaca aaaaagatgt cccagaagaa caagaacata 360 tgagaagatg gctgcatgaa cgtttcgaaa tcaaagataa gatgcttata gaattttatg 420 agtcaccaga tccagaaaga agaaaaagat ttcctgggaa aagtgttaat tccaaattaa 480 gtatcaagaa gactttacca tcaatgttga tcttaagtgg tttgactgca ggcatgctta 540 tgaccgatgc tggaaggaag ctgtatgtga acacctggat atatggaacc ctacttggct 600 gcctgtgggt tactattaaa gcatagacaa gtagctgtct ccagacagtg ggatgtgcta 660 cattgtctat ttttggcggc tgcacatgac atcaaattgt ttcctgaatt tattaaggag 720 tgtaaataaa gccttgttga ttgaaaaaaa aaaaaaaaaa aaaaaaggcg gccgc 775 

What is claimed is:
 1. A method for determining whether a compound can be used to treat prostate cancer, comprising: a) measuring the expression level of a nucleic acid comprising SEQ ID NO:1 in prostate cancer cell sample in the presence and absence of the compound; and b) identifying the compound as useful for treating prostate cancer when the expression level of the nucleic acid in the presence of the compound is less than the expression level of the nucleic acid in the absence of the compound.
 2. The method of claim 1 wherein the expression level of the nucleic acid is determined by measuring the mRNA encoded by the nucleic acid.
 3. The method of claim 1 wherein the expression level of the nucleic acid is determined by measuring the amount of protein encoded by the nucleic acid.
 4. The method of claim 1 wherein the expression level of the nucleic acid is determined by measuring the activity of the protein encoded by the nucleic acid. 